N'-phenylindol-3-ylglyoxylohydrazide derivatives: Synthesis, structure- activity relationships, molecular modeling studies, and pharmacological action on brain benzodiazepine receptors

Journal of Medicinal Chemistry

Volumn 41, Issue 20, 1998, Pages 3821-3830

  Da Settimo, Antonio ^a   Primofiore, Giampaolo ^a   Da Settimo, Federico ^a   Marini, Anna Maria ^a   Novellino, Ettore ^b   Greco, Giovanni ^c   Gesi, Marco ^a   Martini, Claudia ^a   Giannaccini, Gino ^a   Lucacchini, Antonio ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE RECEPTOR; DIAZEPAM ANTAGONIST; FLUMAZENIL; HYDRAZIDE DERIVATIVE; N' PHENYLINDOL 3 YLGLYOXYLOHYDRAZIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; BIOAVAILABILITY; CONFORMATION; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SYNTHESIS;

ANIMALS; ANTICONVULSANTS; BINDING, COMPETITIVE; BRAIN; CATTLE; CEREBRAL CORTEX; CONVULSANTS; DIAZEPAM; FLUMAZENIL; GABA MODULATORS; GLYOXYLATES; HYDRAZINES; INDOLES; LIGANDS; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RECEPTORS, GABA-A; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15444349782     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9800301     Document Type: Article

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