Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: Synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships

Journal of Medicinal Chemistry

Volumn 44, Issue 14, 2001, Pages 2286-2297

  Primofiore, G ^a   Da Settimo, F ^a   Taliani, S ^a   Marini, A M ^a   Novellino, E ^b   Greco, G ^b   Lavecchia, A ^b   Besnard, F ^c   Trincavelli, L ^a   Costa, B ^a   Martini, C ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c Synthèlabo ^*  (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; BENZODIAZEPINE RECEPTOR; FLUMAZENIL; INDOLE DERIVATIVE; ISOINDOLINYLAMIDE; N (INDOL 3 YLGLYOXYLYL)ALANINE DERIVATIVE; N BENZYLINDOL 3 YLGLYOXYLYLAMIDE; N' PHENYLINDOL 3 YLGLYOXYLOHYDRAZIDE; PHENYLHYDRAZINE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BRAIN MEMBRANE; CONFORMATION; ENANTIOMER; GEOMETRY; HYDROPHILICITY; MOLECULAR MODEL; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SYNTHESIS;

AMIDES; ANIMALS; BRAIN; CATTLE; GLYOXYLATES; INDOLES; LIGANDS; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035811446     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010827j     Document Type: Article

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