SCOPUS 정보 검색 플랫폼

Purinergic Signalling

Volumn 5, Issue 1, 2009, Pages 21-29

Progress in the discovery of selective, high affinity A2B adenosine receptor antagonists as clinical candidates

(2) Kalla, Rao V a Zablocki, Jeff a

a CV THERAPEUTICS INC (United States)

Author keywords

A2B; A2B antagonist; A2B receptor; Asthma; CVT 6883; LAS38096; MRE 2029 F20; OSIP339391

Indexed keywords

EID: 60449095600 PISSN: 15739538 EISSN: 15739546 Source Type: Journal
DOI: 10.1007/s11302-008-9119-x Document Type: Review

Times cited : (51)

References (48)

1
- 2942560494
- 2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma
- 2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. J Immunol 172:7726-7733
- (2004) J Immunol , vol.172 , pp. 7726-7733
- Ryzhov, S.¹ Goldstein, A.E.² Matafonov, A.³ Zeng, D.⁴ Biaggioni, I.⁵ Feoktistov, I.⁶

2
- 0038057340
- Targeting adenosine receptors: Novel therapeutic targets in asthma and chronic obstructive pulmonary disease
- Rorke S, Holgate ST (2002) Targeting adenosine receptors: Novel therapeutic targets in asthma and chronic obstructive pulmonary disease. Am J Respir Med 1:99-105
- (2002) Am J Respir Med , vol.1 , pp. 99-105
- Rorke, S.¹ Holgate, S.T.²

3
- 33746611084
- Recent progress in the development of adenosine receptor ligands as antiinflammatory drugs
- Akkari R, Burbiel JC, Hockemeyer J, Mueller CE (2006) Recent progress in the development of adenosine receptor ligands as antiinflammatory drugs. Curr Top Med Chem 6:1375-1399
- (2006) Curr Top Med Chem , vol.6 , pp. 1375-1399
- Akkari, R.¹ Burbiel, J.C.² Hockemeyer, J.³ Mueller, C.E.⁴

4
- 0032034239
- 2B receptors: A novel therapeutic target in asthma?
- 2B receptors: A novel therapeutic target in asthma? Trends Pharmacol Sci 19:148-153
- (1998) Trends Pharmacol Sci , vol.19 , pp. 148-153
- Feokistov, I.¹ Polosa, R.² Hogate, S.T.³ Biaggioni, I.⁴

5
- 0031283107
- 2B receptors
- 2B receptors. Pharmacol Rev 49:381-402
- (1997) Pharmacol Rev , vol.49 , pp. 381-402
- Feoktistov, I.¹ Biaggioni, I.²

6
- 0035209620
- International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
- Fredholm BB, Ijzerman AP, Jacobson KA, Klotz K-N, Linden J (2001) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53:527-552
- (2001) Pharmacol Rev , vol.53 , pp. 527-552
- Fredholm, B.B.¹ Ijzerman, A.P.² Jacobson, K.A.³ Klotz, K.-N.⁴ Linden, J.⁵

7
- 30444441037
- 2B receptor as a novel therapeutic target in asthma
- 2B receptor as a novel therapeutic target in asthma. Br J Pharmacol 145:1009-1015
- (2005) Br J Pharmacol , vol.145 , pp. 1009-1015
- Holgate, S.T.¹

8
- 33750348513
- 2B adenosine receptor antagonists and their potential indications
- 2B adenosine receptor antagonists and their potential indications. Expert Opin Ther Patents 16:1347-1357
- (2006) Expert Opin Ther Patents , vol.16 , pp. 1347-1357
- Zablocki, J.¹ Elzein, E.² Kalla, R.³

9
- 28444492060
- 2B adenosine receptor antagonists: Recent developments
- 2B adenosine receptor antagonists: Recent developments. Mini Rev Med Chem 5:1053-1060
- (2005) Mini Rev Med Chem , vol.5 , pp. 1053-1060
- Cacciari, B.¹ Pastorin, G.² Bolcato, C.³ Spalluto, G.⁴ Bacilieri, M.⁵ Moro, S.⁶

10
- 38749132550
- Adenosine receptor antagonists: Translating medicinal chemistry and pharmacology into clinical utility
- Baraldi PG, Aghazadeh M, Tabrizi A, Gessi S, Borea PA (2008) Adenosine receptor antagonists: Translating medicinal chemistry and pharmacology into clinical utility. Chem Rev 108:238-263
- (2008) Chem Rev , vol.108 , pp. 238-263
- Baraldi, P.G.¹ Aghazadeh, M.² Tabrizi, A.³ Gessi, S.⁴ Borea, P.A.⁵

11
- 0037805555
- 2B adenosine receptors
- 2B adenosine receptors. Curr Top Med Chem 3:427-443
- (2003) Curr Top Med Chem , vol.3 , pp. 427-443
- Volpini, R.¹ Costanzi, S.² Vittori, S.³ Cristalli, G.⁴ Koltz, K.-N.⁵

12
- 0033014225
- 2B adenosine receptors
- 2B adenosine receptors. Drug Dev Res 47:45-53
- (1999) Drug Dev Res , vol.47 , pp. 45-53
- Jacobson, K.A.¹ Ijzerman, A.P.² Linden, J.³

13
- 0026519168
- 1-adenosine receptors
- 1-adenosine receptors. J Med Chem 35:924-930
- (1992) J Med Chem , vol.35 , pp. 924-930
- Suzuki, F.¹ Nonaka, H.² Ishii, A.³

14
- 0032871686
- 2B adenosine receptors
- 2B adenosine receptors. Drug Dev Res 47:178-188
- (1999) Drug Dev Res , vol.47 , pp. 178-188
- Kim, Y.-C.¹ Karton, Y.² Ji, X.-D.³ Melman, N.⁴ Linden, J.⁵ Jacobson, K.A.⁶

15
- 0021957234
- 2-adenosine receptors
- 2-adenosine receptors. J Med Chem 28:487-492
- (1985) J Med Chem , vol.28 , pp. 487-492
- Daly, J.W.¹ Padgett, W.² Shamim, M.T.³ Butts-Lamb, P.⁴ Waters, J.⁵

16
- 0037161610
- 2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions
- 2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J Med Chem 45:2131-2138
- (2002) J Med Chem , vol.45 , pp. 2131-2138
- Kim, S.-A.¹ Marshall, M.A.² Melman, N.³ Kim, H.S.⁴ Muller, C.E.⁵ Linden, J.⁶ Jacobson, K.A.⁷

17
- 0037187362
- 2B-selective adenosine receptor antagonists
- 2B-selective adenosine receptor antagonists. J Med Chem 45:1500-1510
- (2002) J Med Chem , vol.45 , pp. 1500-1510
- Hayallah, A.M.¹ Sandoval-Ramirez, J.² Reith, U.³ Schobert, U.⁴ Preiss, B.⁵ Schumacher, B.⁶ Daly, J.W.⁷ Müller, C.E.⁸

18
- 19944431841
- 2B adenosine receptor antagonist for the potential treatment of asthma
- 2B adenosine receptor antagonist for the potential treatment of asthma. Bioorg Med Chem Lett 15:609-612
- (2005) Bioorg Med Chem Lett , vol.15 , pp. 609-612
- Zablocki, J.¹ Kalla, R.² Perry, T.³ Palle, V.⁴ Varkhedkar, V.⁵ Xiao, D.⁶ Piscopio, A.⁷ Maa, T.⁸ Gimbel, A.⁹ Hao, J.¹⁰ Chu, N.¹¹ Leung, K.¹² Zeng, D.¹³

19
- 33746649640
- 2B adenosine receptor antagonists
- US Patent 6,825,349, 30 Nov 2004
- 2B adenosine receptor antagonists, US Patent 6,825,349, 30 Nov 2004
- (2004)
- Kalla, R.¹ Perry, T.² Elzein, E.³ Varkhedkar, V.⁴ Li, X.⁵ Ibrahim, P.⁶ Palle, V.⁷ Xiao, D.⁸ Zablocki, J.⁹

20
- 33746649640
- 2B adenosine receptor antagonists
- WO Patent 2003/042214, 22 May 2003
- 2B adenosine receptor antagonists. WO Patent 2003/042214, 22 May 2003
- (2003)
- Kalla, R.¹ Perry, T.² Elzein, E.³ Varkhedkar, V.⁴ Li, X.⁵ Ibrahim, P.⁶ Palle, V.⁷ Xiao, D.⁸ Zablocki, J.⁹

21
- 33745169671
- 2B adenosine receptor antagonists
- 2B adenosine receptor antagonists. J Med Chem 49:3682-3692
- (2006) J Med Chem , vol.49 , pp. 3682-3692
- Kalla, R.¹ Elzein, E.² Perry, T.³ Li, X.⁴ Palle, V.⁵ Varkhedkar, V.⁶ Gimbel, A.⁷ Maa, T.⁸ Zeng, D.⁹ Zablocki, J.¹⁰

22
- 41849149631
- 2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases
- 2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases. J Med Chem 51:2267-2278
- (2008) J Med Chem , vol.51 , pp. 2267-2278
- Elzein, E.¹ Kalla, R.V.² Li, X.³ Perry, T.⁴ Gimbel, A.⁵ Zeng, D.⁶ Lustig, D.⁷ Leung, K.⁸ Zablocki, J.⁹

23
- 38949111028
- 2B adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines
- 2B adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines. Bioorg Med Chem Lett 18:1397-1401
- (2008) Bioorg Med Chem Lett , vol.18 , pp. 1397-1401
- Kalla, R.¹ Elzein, E.² Perry, T.³ Li, X.⁴ Gimbel, A.⁵ Yang, M.⁶ Zeng, D.⁷ Zablocki, J.⁸

24
- 27944489028
- 2B adenosine receptor antagonists
- 2B adenosine receptor antagonists. Bioorg Med Chem Lett 16:302-306
- (2006) Bioorg Med Chem Lett , vol.16 , pp. 302-306
- Elzein, E.¹ Kalla, R.² Li, X.³ Perry, T.⁴ Parkhill, E.⁵ Palle, V.⁶ Varkhedkar, V.⁷ Gimbel, A.⁸ Zeng, D.⁹ Lustig, D.¹⁰ Leung, K.¹¹ Zablocki, J.¹²

25
- 0347634268
- 2B adenosine receptors increase cytokine release by bronchial smooth muscle cells
- 2B adenosine receptors increase cytokine release by bronchial smooth muscle cells. Am J Respir Cell Mol Biol 30:118-125
- (2004) Am J Respir Cell Mol Biol , vol.30 , pp. 118-125
- Zhong, H.¹ Belardinelli, L.² Maa, T.³ Feoktistov, I.⁴ Biaggioni, I.⁵ Zeng, D.⁶

26
- 60449119065
- 2B receptor antagonists
- WO Patent 2003/063800, 7 Aug 2003
- 2B receptor antagonists. WO Patent 2003/063800, 7 Aug 2003
- (2003)
- Baraldi, P.G.¹ Borea, P.A.²

27
- 12144290205
- 2B adenosine receptor antagonists
- 2B adenosine receptor antagonists. J Med Chem 47:1434-1447
- (2004) J Med Chem , vol.47 , pp. 1434-1447
- Baraldi, P.G.¹ Tabrizi, M.A.² Preti, D.³ Bovero, A.⁴ Romagnoli, R.⁵ Fruttarolo, F.⁶ Zaid, N.A.⁷ Moorman, A.R.⁸ Varani, K.⁹ Gessi, S.¹⁰ Merighi, S.¹¹ Borea, P.A.¹²

28
- 2942626066
- 2B adenosine receptors
- 2B adenosine receptors. Bioorg Med Chem Lett 14:3607-3610
- (2004) Bioorg Med Chem Lett , vol.14 , pp. 3607-3610
- Baraldi, P.G.¹ Tabrizi, M.A.² Preti, D.³ Bovero, A.⁴ Fruttarolo, F.⁵ Romagnoli, R.⁶ Moorman, A.R.⁷ Gessi, S.⁸ Merighi, S.⁹ Varani, K.¹⁰ Borea, P.A.¹¹

29
- 60449097504
- Pyridyl substituted xanthines
- WO Patent 2006/091896, 31 Aug 2006
- Wang G, Rieger JM, Thompson RD (2006) Pyridyl substituted xanthines. WO Patent 2006/091896, 31 Aug 2006
- (2006)
- Wang, G.¹ Rieger, J.M.² Thompson, R.D.³

30
- 0028360136
- 2-adenosine receptor antagonists
- 2-adenosine receptor antagonists. J Med Chem 37:1526-1534
- (1994) J Med Chem , vol.37 , pp. 1526-1534
- Grahner, B.¹ Winiwarter, S.² Lanzner, W.³ Müller, C.E.⁴

31
- 33746774785
- 2B adenosine receptor antagonists
- 2B adenosine receptor antagonists. Bioorg Med Chem Lett 16:3642-3645
- (2006) Bioorg Med Chem Lett , vol.16 , pp. 3642-3645
- Esteve, C.¹ Nueda, A.² Diaz, J.L.³ Beleta, J.⁴ Cardenas, A.⁵ Lozoya, E.⁶ Cadavid, M.I.⁷ Loza, M.I.⁸ Ryder, H.⁹ Vidal, B.¹⁰

32
- 40949148593
- 2B adenosine receptor
- 2B adenosine receptor. Bioorg Med Chem 16:2852-2869
- (2008) Bioorg Med Chem , vol.16 , pp. 2852-2869
- Stefanchi, A.¹ Brea, J.M.² Cadavid, M.I.³ Centeno, N.B.⁴ Esteve, C.⁵ Loza, M.I.⁶ Martinez, A.⁷ Nieto, R.⁸ Raviña, E.⁹ Sanz, F.¹⁰ Segarra, V.¹¹ Sotelo, E.¹² Vidal, B.¹³ Carotti, A.¹⁴

33
- 33746649640
- 2B adenosine receptor antagonists
- WO Patent 2005/042534, 12 May 2005
- 2B adenosine receptor antagonists. WO Patent 2005/042534, 12 May 2005
- (2005)
- Kalla, R.¹ Elzein, E.² Marquart, T.³ Perry, T.⁴ Li, X.⁵ Zablocki, J.⁶

34
- 60449107499
- 2B adenosine receptor antagonists
- WO Patent 2005/100353, 27 Oct 2005
- 2B adenosine receptor antagonists. WO Patent 2005/ 100353, 27 Oct 2005
- (2005)
- Vidal, B.¹ Eastwood, P.R.² Rodriguez, J.G.³

35
- 60449114776
- 2B adenosine receptor antagonists
- WO Patent 2005/040155, 6 May 2005
- 2B adenosine receptor antagonists. WO Patent 2005/040155, 6 May 2005
- (2005)
- Vidal, B.¹ Trias, C.E.²

36
- 34250159423
- 2B adenosine receptor antagonist
- 2B adenosine receptor antagonist. J Med Chem 50:2732-2736
- (2007) J Med Chem , vol.50 , pp. 2732-2736
- Vidal, B.¹ Nueda, A.² Esteve, C.³ Domenech, T.⁴ Benito, S.⁵ Reinoso, R.F.⁶ Pont, M.⁷ Calbet, M.⁸ López, R.⁹ Cadavid, M.I.¹⁰ Loza, M.I.¹¹ Córdenas, A.¹² Godessart, N.¹³ Beleta, J.¹⁴ Warrellow, G.¹⁵ Ryder, H.¹⁶

37
- 2842546966
- Adenosine receptor antagonists: Structure and potential therapeutic applications
- Müller CE, Stein B (1996) Adenosine receptor antagonists: Structure and potential therapeutic applications. Curr Pharm Des 2:501-530
- (1996) Curr Pharm Des , vol.2 , pp. 501-530
- Müller, C.E.¹ Stein, B.²

38
- 0025925105
- 1 adenosine receptor
- 1 adenosine receptor. J Med Chem 34:2877-2882
- (1991) J Med Chem , vol.34 , pp. 2877-2882
- Thomson, R.D.¹ Secunda, S.² Daly, J.W.³ Olsson, R.A.⁴

39
- 0031776418
- New substituted 9-alkylpurines as adenosine receptor ligands
- Camaioni E, Costanzi S, Vittori S, Volpini R, Klotz K-N, Cristalli G (1998) New substituted 9-alkylpurines as adenosine receptor ligands. Bioorg Med Chem 6:523-533
- (1998) Bioorg Med Chem , vol.6 , pp. 523-533
- Camaioni, E.¹ Costanzi, S.² Vittori, S.³ Volpini, R.⁴ Klotz, K.-N.⁵ Cristalli, G.⁶

40
- 0035905833
- 2B receptor
- 2B receptor. J Med Chem 44:170-179
- (2001) J Med Chem , vol.44 , pp. 170-179
- Harada, H.¹ Asano, O.² Hoshino, Y.³ Yoshikawa, S.⁴ Matsukura, M.⁵ Kabasawa, Y.⁶ Niijima, J.⁷ Kotake, Y.⁸ Watanabe, N.⁹ Kawata, T.¹⁰ Inoue, T.¹¹ Horizoe, T.¹² Yasuda, N.¹³ Minami, H.¹⁴ Nagata, K.¹⁵ Murakami, M.¹⁶ Nagaoka, J.¹⁷ Kobayashi, S.¹⁸ Tanaka, I.¹⁹ Abe, S.²⁰ more..

41
- 0034842262
- 2B adenosine receptor
- 2B adenosine receptor. Bioorg Med Chem 9:2709-2726
- (2001) Bioorg Med Chem , vol.9 , pp. 2709-2726
- Harada, H.¹ Asano, O.² Kawata, T.³ Inoue, T.⁴ Horizoe, T.⁵ Yasuda, N.⁶ Nagata, K.⁷ Murakami, M.⁸ Nagaoka, J.⁹ Kobayashi, S.¹⁰ Tanaka, I.¹¹ Abe, S.¹²

42
- 2942546064
- 2B receptors
- 2B receptors. Biochem Pharmacol 68:305-312
- (2004) Biochem Pharmacol , vol.68 , pp. 305-312
- Stewart, M.¹ Steinig, A.G.² Ma, C.³ Song, J.-P.⁴ McKibben, B.⁵ Castelhano, A.L.⁶ MacLennan, S.J.⁷

43
- 7244234161
- 2B angiogenic phenotype
- 2B angiogenic phenotype. Hypertension 44:649-654
- (2004) Hypertension , vol.44 , pp. 649-654
- Feoktistov, I.¹ Ryzhov, S.² Zhong, H.³ Goldstein, A.E.⁴ Matafonov, A.⁵ Zeng, D.⁶ Biaggioni, I.⁷

44
- 11144230939
- 2B adenosine receptors and hypoxia in activating human lung fibroblasts
- 2B adenosine receptors and hypoxia in activating human lung fibroblasts. Am J Respir Cell Mol Biol 32:2-8
- (2005) Am J Respir Cell Mol Biol , vol.32 , pp. 2-8
- Zhong, H.¹ Belardinelli, L.² Maa, T.³ Zeng, D.⁴

45
- 21744443649
- 3H]MRE 2029-F20
- 3H]MRE 2029-F20. Mol Pharmacol 67:2137-2147
- (2005) Mol Pharmacol , vol.67 , pp. 2137-2147
- Gessi, S.¹ Varani, K.² Merighi, S.³ Cattabriga, E.⁴ Pancaldi, C.⁵ Szabadkai, Y.⁶ Rizzuto, R.⁷ Klotz, K.-N.⁸ Leung, E.⁹ Mac Lennan, S.¹⁰ Baraldi, P.G.¹¹ Borea, P.A.¹²

46
- 60449092241
- CV Therapeutics press release
- CV Therapeutics press release, www.cvt.com

47
- 33746666617
- 2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury
- 2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. J Clin Invest 116:2173-2182
- (2006) J Clin Invest , vol.116 , pp. 2173-2182
- Sun, C.-X.¹ Zhong, H.² Mohsenin, A.³ Morschi, E.⁴ Chunn, J.L.⁵ Molina, J.G.⁶ Belardinell, L.⁷ Zeng, D.⁸ Blackburn, M.⁹

48
- 33847159974
- 2B adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma
- 2B adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma. J Pharmacol Exp Ther 320:1246-1251
- (2007) J Pharmacol Exp Ther , vol.320 , pp. 1246-1251
- Mustafa, S.J.¹ Nadeem, A.² Fan, M.³ Zhong, H.⁴ Belardinelli, L.⁵ Zeng, D.⁶

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.