Discovery of LAS101057: A potent, selective, and orally efficacious A 2B Adenosine Receptor Antagonist

ACS Medicinal Chemistry Letters

Volumn 2, Issue 3, 2011, Pages 213-218

  Eastwood, Paul ^a   Esteve, Cristina ^a   González, Jacob ^a   Fonquerna, Silvia ^a   Aiguadé, Josep ^a   Carranco, Inés ^a   Doménech, Teresa ^a   Aparici, Mònica ^a   Miralpeix, Montserrat ^a   Albertí, Joan ^a   Córdoba, Mónica ^a   Fernández, Raquel ^a,c   Pont, Mercè ^a   Godessart, Núria ^a   Prats, Neus ^a   Loza, María Isabel ^b   Cadavid, María Isabel ^b   Nueda, Arsenio ^a   Vidal, Bernat ^a  

^a RandD Centre ^*  (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c Laboratorios Esteve   (Spain)

Author keywords

A2B adenosine receptor antagonist; clinical candidate; ovalbumin mouse model

Indexed keywords

ADENOSINE RECEPTOR BLOCKING AGENT; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; DEXAMETHASONE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN 6; LAS 101057; METHACHOLINE; OVALBUMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; ASTHMA; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; TH2 CELL; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 79952685389     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100249e     Document Type: Article

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