Hybrid peptides endomophin-2/DAMGO: Design, synthesis and biological evaluation

European Journal of Medicinal Chemistry

Volumn 68, Issue , 2013, Pages 167-177

  Mollica, Adriano ^a   Costante, Roberto ^a   Stefanucci, Azzurra ^a   Pinnen, Francesco ^a   Luisi, Grazia ^a   Pieretti, Stefano ^b   Borsodi, Anna ^c   Bojnik, Engin ^c   Benyhe, Sándor ^c  

^a UNIVERSITY OF CHIETI   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Analgesics; DAMGO; Endomorphins; Hot plate; Nociception; Opioid; Tail flick

Indexed keywords

ANTINOCICEPTIVE AGENT; ENDOMORPHIN 2; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; HYBRID PROTEIN; MU OPIATE RECEPTOR; OPIATE PEPTIDE; ANALGESIC AGENT; NARCOTIC ANALGESIC AGENT; OLIGOPEPTIDE; OPIATE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HOT PLATE TEST; IC 50; IN VITRO STUDY; IN VIVO STUDY; METHYLATION; NOCICEPTION; NONHUMAN; PROTEIN BINDING; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; ENDOMORPHINS; ENZYME STABILITY; GUINEA PIG; HOT PLATE; HUMAN; MALE; SYNTHESIS; TAIL FLICK TEST; WISTAR RAT;

ANALGESICS; DAMGO; ENDOMORPHINS; HOT PLATE; NOCICEPTION; OPIOID; TAIL FLICK;

ANALGESICS, OPIOID; ANIMALS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENZYME STABILITY; GUINEA PIGS; HUMANS; MALE; MOLECULAR STRUCTURE; OLIGOPEPTIDES; RATS; RATS, WISTAR; RECEPTORS, OPIOID, MU;

EID: 84884480999     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.044     Document Type: Article

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