Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-α,β-didehydrophenylalanine (δZPhe) residues

Journal of Medicinal Chemistry

Volumn 53, Issue 11, 2010, Pages 4550-4554

  Torino, Domenica ^a   Mollica, Adriano ^b   Pinnen, Francesco ^b   Feliciani, Federica ^b   Lucente, Gino ^a   Fabrizi, Giancarlo ^a   Portalone, Gustavo ^a   Davis, Peg ^c   Lai, Josephine ^c   Ma, Shou Wu ^c   Porreca, Frank ^c   Hruby, Victor J ^d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA,BETA DIDEHYDROPHENYLALANINE; ENDORPHIN DERIVATIVE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; MU OPIATE RECEPTOR AGONIST; OPIATE RECEPTOR; PHENYLALANINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BRAIN MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE;

AMINO ACID SEQUENCE; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OLIGOPEPTIDES; PHENYLALANINE; RECEPTORS, OPIOID; STEREOISOMERISM;

EID: 77953200832     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1001343     Document Type: Article

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