Effect of sildenafil, a selective phosphodiesterase 5 inhibitor, on the anticonvulsant action of some antiepileptic drugs in the mouse 6-Hz psychomotor seizure model

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 47, Issue , 2013, Pages 104-110

  Nieoczym, Dorota ^a   Socała, Katarzyna ^a   Jedziniak, Piotr ^b   Olejnik, Małgorzata ^b   Wlaź, Piotr ^a  

^a MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

^b NATIONAL VETERINARY RESEARCH INSTITUTE   (Poland)

Author keywords

6Hz psychomotor seizure test; Antiepileptic drugs; Mice; Sildenafil

Indexed keywords

CLONAZEPAM; CLONAZEPAMUM; ETHOSUXIMIDE; ETIRACETAM; OXCARBAZEPINE; PHENOBARBITAL; SILDENAFIL; TIAGABINE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; ELECTRIC SHOCK; LONG TERM MEMORY; MALE; MOTOR COORDINATION; MOTOR DYSFUNCTION; MOUSE; MUSCLE STRENGTH; NONHUMAN; SEIZURE; SEIZURE THRESHOLD; SINGLE DRUG DOSE; STIMULATION;

6HZ PSYCHOMOTOR SEIZURE TEST; AED; ANTIEPILEPTIC DRUG; ANTIEPILEPTIC DRUGS; CARBAMAZEPINE; CBZ; CGMP; CGMP-DEPENDENT PROTEIN KINASE; CLONAZEPAM; CYCLIC GUANOSINE 3′,5′-MONOPHOSPHATE; CZP; ETHOSUXIMIDE; ETS; GABAPENTIN; GBP; GC; GUANYLATE CYCLASE; LC-MS/MS; LEV; LEVETIRACETAM; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MAXIMAL ELECTROSHOCK SEIZURE THRESHOLD; MAXIMAL ELECTROSHOCK SEIZURES; MES; MEST; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NO; NOS; OXC; OXCARBAZEPINE; PB; PDE; PENTYLENETETRAZOLE; PHENOBARBITAL; PHOSPHODIESTERASE; PKG; PTZ; SILDENAFIL; TGB; TIAGABINE; TOPIRAMATE; TPM; VALPROATE; VGB; VIGABATRIN; VPA;

ANALYSIS OF VARIANCE; ANIMALS; ANTIEMETICS; AVOIDANCE LEARNING; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; HAND STRENGTH; MALE; MICE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PSYCHOMOTOR PERFORMANCE; PURINES; SEIZURES; SULFONES;

EID: 84884375759     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2013.08.009     Document Type: Article

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