Effect of sildenafil on neuropathic pain and hemodynamics in rats

Yonsei Medical Journal

Volumn 51, Issue 1, 2010, Pages 82-87

  Huang, Lan Ji ^b   Yoon, Myung Ha ^a,b   Choi, Jeong Il ^a   Kim, Woong Mo ^a   Lee, Hyung Gon ^a   Kim, Yeo Ok ^a  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Antinociception; GABA receptor; Hemodynamics; Neuropathic pain; Sildenafil; Sprague Dawley rat

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; BICUCULLINE; CYCLIC GMP; PHOSPHODIESTERASE V; SACLOFEN; SILDENAFIL;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CATHETERIZATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HEART RATE; HEMODYNAMICS; MALE; MEAN ARTERIAL PRESSURE; NEUROPATHIC PAIN; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; TAIL ARTERY; TECHNIQUE; VON FREY FILAMENT;

ANIMALS; BACLOFEN; BICUCULLINE; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HEMODYNAMICS; MALE; NEURALGIA; PAIN THRESHOLD; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; RECEPTORS, GABA-B; SULFONES;

EID: 75749143128     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2010.51.1.82     Document Type: Article

References (38)

1. Dworkin RH, O'Connor AB, Backonja M, Farrar JT, Finnerup NB, Jensen TS, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 2007;132:237-51.
2. Finnerup NB, Sindrup SH, Jensen TS. Chronic neuropathic pain: mechanisms, drug targets and measurement. Fundam Clin Pharmacol 2007;21:129-36.
3. Wallace JM. Update on pharmacotherapy guidelines for treatment of neuropathic pain. Curr Pain Headache Rep 2007;11:208-14.
4. Chizh BA, Göhring M, Tröster A, Quartey GK, Schmelz M, Koppert W. Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers. Br J Anaesth 2007;98:246-54.
5. Shim B, Kim DW, Kim BH, Nam TS, Leem JW, Chung JM. Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy. Neuroscience 2005;132:193-201.
6. Beavo JA. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 1995;75:725-48.
7. Pyne NJ, Arshavsky V, Lochhead A. cGMP signal termination. Biochem Soc Trans 1996;24:1019-22.
8. Ferreira SH, Nakamura M. I-Prostaglandin hyperalgesia, a cAMP/Ca2+ dependent process. Prostaglandins 1979;18:179-90.
9. Sousa AM, Prado WA. The dual effect of a nitric oxide donor in nociception. Brain Res 2001;897:9-19.
10. Araiza-Saldaña CI, Reyes-García G, Bermúdez- Ocaña DY, Pérez-Severiano F, Granados-Soto V. Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats. Eur J Pharmacol 2005;527:60-70.
11. Asomoza-Espinosa R, Alonso-López R, Mixcoatl-Zecuatl T, Aguirre-Ban?uelos P, Torres-López JE, Granados-Soto V. Sildenafil increases diclofenac antinociception in the formalin test. Eur J Pharmacol 2001;418:195-200.
12. Jain NK, Patil CS, Singh A, Kulkarni SK. Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Brain Res 2001;909:170-8.
13. Jain NK, Patil CS, Singh A, Kulkarni SK. Sildenafil, a phosphodiesterase-5 inhibitor, enhances the antinociceptive effect of morphine. Pharmacology 2003;67:150-6.
14. Mixcoatl-Zecuatl T, Aguirre-Bañuelos P, Granados-Soto V. Sildenafil produces antinociception and increases morphine antinociception in the formalin test. Eur J Pharmacol 2000;400:81-7.
15. Saransaari P, Oja SS. Characteristics of GABA release induced by free radicals in mouse hippocampal slices. Neurochem Res 2008;33:384-93.
16. B receptor modulation on the antinociception of intrathecal sildenafil in the rat formalin test. Korean J Pain 2007;20:106-110.
17. Wallis RM, Corbin JD, Francis SH, Ellis P. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am J Cardiol 1999;83:3C-12C.
18. Matsumoto T, Kobayashi T, Kamata K. Phosphodiesterases in the vascular system. J Smooth Muscle Res 2003;39:67-86.
19. Santos-Silva AJ, Cairrão E, Morgado M, Alvarez E, Verde I. PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries. Eur J Pharmacol 2008;582:102-9.
20. Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992;50:355-63.
21. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994;53:55-63.
22. Blandizzi C, Bernardini MC, Natale G, Martinotti E, Del Tacca M. Peripheral 2-hydroxy-saclofen-sensitive GABA-B receptors mediate both vagal-dependent and vagal-independent acid secretory responses in rats. J Auton Pharmacol 1992;12:149-56.
23. Dogrul A, Ossipov MH, Lai J, Malan TP Jr, Porreca F. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neurosci Lett 2000;292:115-8.
24. Dworkin RH, O'Connor AB, Backonja M, Farrar JT, Finnerup NB, Jensen TS, et al. Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 2007;132:237-51.
25. Dray A. Neuropathic pain: emerging treatments. Br J Anaesth 2008;101:48-58.
26. Torrance N, Smith BH, Bennett MI, Lee AJ. The epidemiology of chronic pain of predominantly neuropathic origin. Results from a general population survey. J Pain 2006;7:281-9.
27. Beavo JA, Reifsnyder DH. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol Sci 1990;11:150-5.
28. Uckert S, Hedlund P, Andersson KE, Truss MC, Jonas U, Stief CG. Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future. Eur Urol 2006;50:1194-207.
29. Freund TF, Buzsáki G. Alterations in excitatory and GABAergic inhibitory connections in hippocampal transplants. Neuroscience 1988;27:373-85.
30. Frotscher M, Léránth C, Lübbers K, Oertel WH. Commissural afferents innervate glutamate decarboxylase immunoreactive non-pyramidal neurons in the guinea pig hippocampus. Neurosci Lett 1984;46:137-43.
31. Grudt TJ, Jahr CE. Quisqualate activates N-methyl-D-aspartate receptor channels in hippocampal neurons maintained in culture. Mol Pharmacol 1990;37:477-81.
32. Li DP, Chen SR, Finnegan TF, Pan HL. Signalling pathway of nitric oxide in synaptic GABA release in the rat paraventricular nucleus. J Physiol 2004;554:100-10.
33. Yang Q, Chen SR, Li DP, Pan HL. Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus. Neuroscience 2007;149:315-27.
34. Soares AC, Duarte ID. Dibutyryl-cyclic GMP induces perip-heral antinociception via activation of ATP-sensitive K(+) channels in the rat PGE2-induced hyperalgesic paw. Br J Pharmacol 2001;134:127-31.
35. Zusman RM, Morales A, Glasser DB, Osterloh IH. Overall cardiovascular profile of sildenafil citrate. Am J Cardiol 1999;83:35C-44C.
36. Jackson G, Benjamin N, Jackson N, Allen MJ. Effects of sildenafil citrate on human hemodynamics. Am J Cardiol 1999;83:13C-20C.
37. Ishikura F, Beppu S, Hamada T, Khandheria BK, Seward JB, Nehra A. Effects of sildenafil citrate (Viagra) combined with nitrate on the heart. Circulation 2000;102:2516-21.
38. Ravipati G, McClung JA, Aronow WS, Peterson SJ, Frishman WH. Type 5 phosphodiesterase inhibitors in the treatment of erectile dysfunction and cardiovascular disease. Cardiol Rev 2007;15:76-86.