L-NAME inhibits pentylenetetrazole and strychnine-induced seizures in mice

Brain Research

Volumn 753, Issue 1, 1997, Pages 98-101

  Kaputlu, Irfan ^a   Uzbay, Tayfun ^b  

^a AKDENIZ UNIVERSITY   (Turkey)

^b GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

mouse; N( ) nitro L arginine methylester; nitric oxide; pentylenetetrazole; seizure; strychnine

Indexed keywords

4 AMINOBUTYRIC ACID; ARGININE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PENTETRAZOLE; STRYCHNINE;

ANIMAL EXPERIMENT; ARTICLE; CONVULSION; ENZYME INHIBITION; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; TONIC CLONIC SEIZURE;

ANIMALS; CONVULSANTS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; MALE; MICE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PENTYLENETETRAZOLE; SEIZURES; STRYCHNINE;

EID: 0030968905     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01496-5     Document Type: Article

References (26)

1. Bredt, D.S. and Snyder, S.H., Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum, Proc. Natl. Acad. Sci. USA, 86 (1989) 9030-9033.
2. Bredt, D.S., Hwang, P.M. and Snyder, S.H., Localization of nitric oxide indicating a neural role for nitric oxide, Nature, 347 (1990) 768-770.
3. Bredt, D.S., Glatt, C.E., Hwang, P.M., Fotuhi, M., Dawson, T.M. and Snyder, S.H., Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of mammalian CNS together with NADPH diaphorase, Neuron, 7 (1991) 615-624.
4. Dawson, T.M., Bredt, T.S., Fotuhi, M., Hwang, P.M. and Snyder, S.H., Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues, Proc. Natl. Acad. Sci. USA, 88 (1991) 7797-7801.
5. Dawson, T.M., Dawson, V.L. and Snyder, S.H., A novel neuronal messenger molecule in brain: the free radical, nitric oxide, Ann. Neurol., 32, (1992) 297-311.
6. G-nitroarginine in brain in vitro and in vivo, Biochem. Biophys. Res. Commun., 176 (1991) 1136-1141.
7. Ferendelli, J.A., Blank, A.C. and Gross, R.A., Relationships between seizure activity and cyclic nucleotide levels in brain, Brain Res., 200 (1980) 93-103.
8. Garthwaite, J., Charles, S.L. and Chess-Williams, R., Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain, Nature, 336 (1988) 385-388.
9. Garthwaite, J., Southam, E. and Anderton, M.J., A kainate receptor linked to nitric oxide synthesis from arginine, J. Neurochem., 53 (1989) 1952-1954.
10. Gilman, A.G., Rall, T.W., Nies, A.S. and Taylor, P., The Pharmacological Basis of Therapeutics, 8th edn., Pergamon Press, New York, 1990, 1632 pp.
11. Griffith, O.W. and Stuehr, D.J., Nitric oxide synthase: properties and catalytic mechanism, Ann. Rev. Physiol., 57 (1995) 707-736.
12. Hoffer, B.J., Seiger, A., Taylor, D., Olson, L. and Freedman, R., Seizures and related epileptiform activity in hippocampus transplanted to the anterior chamber of the eye. I. Characterization of seizures, interictal spikes and synchronous activity, Exp. Neurol., 54 (1977) 233-250.
13. Iadecola, C., Xu, X., Zhang, F., Hu, J. and El-Fakahany, E.E., Prolonged inhibition of brain nitric oxide synthase by short-term systemic administration of nitro-L-arginine methyl ester, Neurochem. Res., 4 (1994) 501-505.
14. Knowles, R.G., Palacios, M., Palmer, R.M.J. and Moncada, S., Formation of nitric oxide from L-arginine in the central nervous system, Proc. Natl. Acad. Sci., 86 (1989) 5159-5162.
15. Macdonald, R.L. and Barker, J.L., Pentylenetetrazole and penicillin are selective antagonists of GABA-mediated post-synaptic inhibition in cultured mammalian neurons, Nature, 267 (1977) 720-721.
16. McBain, C.J. and Mayer, M.L., N-Methyl-D-Aspartic acid receptor structure and function, Pharmacol. Rev., 74 (1994) 723-770.
17. McCaslin, P.P. and Morgan, W.W., Continuously infused 2-amino-7-phosphonoheptanoic acid antagonizes N-methyl-D-aspartate-induced elevations of cyclic GMP in multiple brain areas and chemically induced seizure activity, Neuropharmacology, 25 (1986) 905-911.
18. Moncada, S., Palmer, R.M.J. and Higgs, E.A., Nitric oxide: physiology, and pharmacology, Pharmacol. Rev., 43 (1991) 109-142.
19. Nevins, M.E. and Arnolde, S.M., A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor, Brain Res., 503 (1989) 1-4.
20. Osonoe, K., Mori, N., Suzuki, K. and Osonoe, M., Antiepileptic effects of nitric oxide synthase examined in pentylenetetrazol-induced seizures in rats, Brain Res., 663 (1994) 338-340.
21. Palmer, R.M.J., Ferrige, A.G. and Moncada, S., Nitric oxide release accounts for the biological activity of endothelum-derived relaxing factor, Nature (Lond.), 327 (1987) 524-526.
22. Penix, L.P., Davis, W. and Subramaniam, S., Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents, Epilepsy Res., 18 (1994) 177-184.
23. Rondouin, G., Lerner-Natoli, M., Chicheportiche, R. et al. Involvement of excitatory amino acids in the mechanisms of kindling. In J.A. Vada (Ed.), Kindling, Plenum Press, New York, 1990, pp. 227-240.
24. Saito, S., Kidd, G.J., Trapp, B.D., Dawson, T.M., Bredt, D.S., Wilson, D.A., Traystman, P.J., Snyder, S.H. and Hanley, D.F., Rat spinal cord neurons contain nitric oxide synthase, Neuroscience, 59 (1994) 447-456.
25. Wood, P.L., Emmett, M.R., Rao, T.S., Cler, J., Mick, S. and Iyengar, S., Inhibition of nitric oxide synthase blocks N-methyl-D-aspartate-, quisqualate-, kainate-, harmaline-, and pentylenetetrazole-dependent increases in cerebellar cyclic GMP in vivo, J. Neurochem., 55 (1990) 346-348.
26. Wu, V. and Li, L., Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion, Neurosci. Lett., 153 (1993) 121-124.