Roles of adenosine and serotonin receptors on the antinociception of sildenafil in the spinal cord of rats

Yonsei Medical Journal

Volumn 51, Issue 6, 2010, Pages 960-964

  Lee, Hyung Gon ^a   Kim, Woong Mo ^a   Park, Cheon Hee ^b   Yoon, Myung Ha ^a,c  

^a Chonnam National University Medical School   (South Korea)

^b Gwangju Christian Hospital   (South Korea)

^c Chonnam National University   (South Korea)

Author keywords

Adenosine; Antinociception; Serotonin; Sildenafil; Spinal cord

Indexed keywords

9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE RECEPTOR; DIHYDROERGOCRISTINE METHANESULFONATE; SEROTONIN RECEPTOR; SILDENAFIL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; MALE; NOCICEPTION; NONHUMAN; PAIN ASSESSMENT; RAT; SPINAL CORD; SUBARACHNOID SPACE;

ADENOSINE; ANALGESICS; ANIMALS; CYCLIC GMP; DIHYDROERGOCRISTINE; INJECTIONS, SPINAL; MALE; PAIN; PIPERAZINES; PURINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; RECEPTORS, SEROTONIN; SPINAL CORD; SULFONES; VASODILATOR AGENTS;

EID: 77954953527     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2010.51.6.960     Document Type: Article

References (31)

1. Gibson A. Phosphodiesterase 5 inhibitors and nitrergic transmission- from zaprinast to sildenafil. Eur J Pharmacol 2001;411: 1-10.
2. Mixcoatl-Zecuatl T, Aguirre-Bañuelos P, Granados-Soto V. Sildenafil produces antinociception and increases morphine antinociception in the formalin test. Eur J Pharmacol 2000;400:81-7.
3. Asomoza-Espinosa R, Alonso-López R, Mixcoatl-Zecuatl T, Aguirre-Bañuelos P, Torres-López JE, Granados-Soto V. Sildenafil increases diclofenac antinociception in the formalin test. Eur J Pharmacol 2001;418:195-200.
4. Araiza-Saldaña CI, Reyes-García G, Bermúdez-Ocaña DY, Pérez- Severiano F, Granados-Soto V. Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats. Eur J Pharmacol 2005;527:60-70.
5. Yoon MH, Kim WM, Lee HG, Kim YO, Huang LJ, An TH. Roles of opioid receptor subtypes on the antinociceptive effect of intrathecal sildenafil in the formalin test of rats. Neurosci Lett 2008; 441:125-8.
6. Jain NK, Patil CS, Singh A, Kulkarni SK. Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Brain Res 2001;909:170-8.
7. Jain NK, Patil CS, Singh A, Kulkarni SK. Sildenafil, a phosphodiesterase- 5 inhibitor, enhances the antinociceptive effect of morphine. Pharmacology 2003;67:150-6.
8. Vale ML, Rolim DE, Cavalcante IF, Ribeiro RA, Souza MH. Role of NO/cGMP/KATP pathway in antinociceptive effect of sildenafil in zymosan writhing response in mice. Inflamm Res 2007; 56:83-8.
9. Patil CS, Singh VP, Kulkarni SK. Peripheral and central activation of nitric oxide-cyclic GMP pathway by sildenafil. Inflammopharmacology 2005;13:467-78.
10. Kim WM, Yoon MH, Lee HG, Han YG, Kim YO, Huang LJ, et al. GABAB receptor modulation on the antinociception of intrathecal sildenafil in the rat formalin test. Korean J Pain 2007;20: 106-10.
11. Sawynok J, Liu XJ. Adenosine in the spinal cord and periphery: release and regulation of pain. Prog Neurobiol 2003;69:313-40.
12. Jacobson KA, Gao ZG. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 2006;5:247-64.
13. Fürst S. Transmitters involved in antinociception in the spinal cord. Brain Res Bull 1999;48:129-41.
14. Yoon MH, Bae HB, Choi JI. Antinociception of intrathecal adenosine receptor subtype agonists in rat formalin test. Anesth Analg 2005;101:1417-21.
15. Jeong CY, Choi JI, Yoon MH. Roles of serotonin receptor subtypes for the antinociception of 5-HT in the spinal cord of rats. Eur J Pharmacol 2004;502:205-11.
16. Zahn PK, Straub H, Wenk M, Pogatzki-Zahn EM. Adenosine A1 but not A2a receptor agonist reduces hyperalgesia caused by a surgical incision in rats: a pertussis toxin-sensitive G proteindependent process. Anesthesiology 2007;107:797-806.
17. Qu CL, Huo FQ, Huang FS, Li YQ, Tang JS, Jia H. The role of 5-HT receptor subtypes in the ventrolateral orbital cortex of 5- HT-induced antinociception in the rat. Neuroscience 2008;152: 487-94.
18. Akula KK, Dhir A, Kulkarni SK. Nitric oxide signaling pathway in the anti-convulsant effect of adenosine against pentylenetetrazol- induced seizure threshold in mice. Eur J Pharmacol 2008; 587:129-34.
19. Santos-Silva AJ, Cairrão E, Morgado M, Alvarez E, Verde I. PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries. Eur J Pharmacol 2008;582:102-9.
20. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976;17:1031-6.
21. Yoon MH, Choi JI, Jeong SW. Spinal gabapentin and antinociception: mechanisms of action. J Korean Med Sci 2003;18:255-61.
22. Yoon MH, Choi JI, Jeong SW. Antinociception of intrathecal cholinesterase inhibitors and cholinergic receptors in rats. Acta Anaesthesiol Scand 2003;47:1079-84.
23. Beavo JA, Reifsnyder DH. Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol Sci 1990;11:150-5.
24. Uckert S, Hedlund P, Andersson KE, Truss MC, Jonas U, Stief CG. Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future. Eur Urol 2006;50: 1194-207.
25. Pyne NJ, Arshavsky V, Lochhead A. cGMP signal termination. Biochem Soc Trans 1996;24:1019-22.
26. Beavo JA. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev 1995;75:725-48.
27. Ferreira SH, Nakamura M. I - Prostaglandin hyperalgesia, a cAMP/Ca2+ dependent process. Prostaglandins 1979;18:179-90.
28. Sousa AM, Prado WA. The dual effect of a nitric oxide donor in nociception. Brain Res 2001;897:9-19.
29. Tegeder I, Schmidtko A, Niederberger E, Ruth P, Geisslinger G. Dual effects of spinally delivered 8-bromo-cyclic guanosine monophosphate (8-bromo-cGMP) in formalin-induced nociception in rats. Neurosci Lett 2002;332:146-50.
30. Choca JI, Green RD, Proudfit HK. Adenosine A1 and A2 receptors of the substantia gelatinosa are located predominantly on intrinsic neurons: an autoradiography study. J Pharmacol Exp Ther 1988; 247:757-64.
31. Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 1999;38:1083-152.