Allosteric modulation of GAB AA receptor subtypes: Effects on visual recognition and visuospatial working memory in rhesus monkeys

Neuropsychopharmacology

Volumn 38, Issue 11, 2013, Pages 2315-2325

  Soto, Paul L ^a   Ator, Nancy A ^a   Rallapalli, Sundari K ^b   Biawat, Poonam ^b   Clayton, Terry ^c   Cook, James M ^b   Weed, Michael R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^c Chromatic Technologies Inc   (United States)

Author keywords

Benzodiazepine; Cognition; Delayed matching to sample; GABAA receptor; Rhesus monkey; Self ordered spatial search

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA3; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5; 8 ETHYNYL 6 (2 FLUOROPHENYL) 4 METHYL 4H 2,5,10B TRIAZ BENZO[3]AZULENE 3 CARBOXYLIC ACID ETHYL ESTER; 8 ETHYNYL 6 (2 FLUOROPHENYL) 4METHYL 4H 2,5,10B TRIAZ BENZO[3]AZULENE 3 CARBOXYLIC ACID ETHYL ESTER; METHYL(8 CHLORO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZOL[1,5 A][1,4]BENZODIAZEPINE 3 YL) METHYL ESTER; PWZ 029; RECEPTOR SUBTYPE; RY 23; RY 24; TERT BUTYL 8 [(TRIMETHYLSILYL)ETHYNYL] 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4] BENZODIAZEPINE 3 CARBOXYLATE; TERT BUTYL 8 ETHYNYL 5,6 DIHYDRO 5METHYL 6 OXO 4H IMIDAZO[1,5 A[1,4]BENZODIAZEPINE 3 CARBOXYLATE; TRIAZOLAM; UNCLASSIFIED DRUG; ZALEPLON; ZOLPIDEM; 7-(1,1-DIMETHYLETHYL)-6-(2-ETHYL-2H-1,2,4-TRIAZOL-3-YLMETHOXY)-3-(2-FLUOROPHENYL)-1,2,4-TRIAZOLO(4,3-B)PYRIDAZINE; ACETAMIDE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; DIAZEPAM; IMIDAZOLE DERIVATIVE; PWZ-029; PYRIDAZINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; RY 023; RY 024; SH-053-2'F-R-CH3; TRIAZOLE DERIVATIVE; 7 (1,1 DIMETHYLETHYL) 6 (2 ETHYL 2H 1,2,4 TRIAZOL 3 YLMETHOXY) 3 (2 FLUOROPHENYL) 1,2,4 TRIAZOLO(4,3 B)PYRIDAZINE; DRUG DERIVATIVE; SH 053 2'F R CH3;

ALLOSTERISM; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; MALE; MODULATION; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SPATIAL MEMORY; VISUAL MEMORY; WORKING MEMORY; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; CLASSIFICATION; DRUG EFFECTS; INSTRUMENTAL CONDITIONING; METABOLISM; RECOGNITION; SHORT TERM MEMORY;

ACETAMIDES; ALLOSTERIC REGULATION; ANIMALS; BENZODIAZEPINES; CONDITIONING, OPERANT; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; MACACA MULATTA; MALE; MEMORY, SHORT-TERM; PYRIDAZINES; PYRIDINES; PYRIMIDINES; RECEPTORS, GABA-A; RECOGNITION (PSYCHOLOGY); TRIAZOLAM; TRIAZOLES;

EID: 84884287810     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.137     Document Type: Article

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