Acute effects of zolpidem extended-release on cognitive performance and sleep in healthy males after repeated nightly use

Experimental and Clinical Psychopharmacology

Volumn 20, Issue 1, 2012, Pages 28-39

  Kleykamp, Bethea A ^a   Griffiths, Roland R ^b   McCann, Una D ^b   Smith, Michael T ^b   Mintzer, Miriam Z ^b  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ambien; Cognition; Cognitive performance; Extended release; Memory; Psychomotor; Sleep; Tolerance; Zolpidem

Indexed keywords

ZOLPIDEM TARTRATE; HYPNOTIC SEDATIVE AGENT; PYRIDINE DERIVATIVE; ZOLPIDEM;

ADULT; ARTICLE; ATTENTION; BEDTIME DOSAGE; COGNITION; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DRUG FORMULATION; DRUG TOLERANCE; EPISODIC MEMORY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; POLYSOMNOGRAPHY; PSYCHOMOTOR ACTIVITY; SLEEP; SLEEP AROUSAL DISORDER; TASK PERFORMANCE; WORKING MEMORY; CLINICAL TRIAL; CONTROLLED STUDY; DELAYED RELEASE FORMULATION; DRUG EFFECT; METHODOLOGY; PSYCHOMOTOR PERFORMANCE; TIME;

ADULT; ATTENTION; COGNITION; DELAYED-ACTION PREPARATIONS; DOUBLE-BLIND METHOD; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MEMORY, EPISODIC; POLYSOMNOGRAPHY; PSYCHOMOTOR PERFORMANCE; PYRIDINES; SLEEP; TIME FACTORS; YOUNG ADULT;

EID: 84858850599     PISSN: 10641297     EISSN: 19362293     Source Type: Journal    
DOI: 10.1037/a0025237     Document Type: Article

References (51)

1. Allain, H., Bentué-Ferrer, D., Polard, E., Akwa, Y., & Patat, A. (2005). Postural instability and consequent falls and hip fractures associated with use of hypnotics in the elderly: A comparative review. Drugs and Aging, 22, 749-765.
2. Bacon, E., Danion, J. M., Kauffmann-Muller, F., Schelstraete, M. A., Bruant, A., Sellal, F., & Grange, D. (1998). Confidence level and feeling of knowing for episodic and semantic memory: An investigation of lorazepam effects on metamemory. Psychopharmacology, 138, 318-325.
3. Baker, F. C., & Driver, H. S. (2004). Self-reported sleep across the menstrual cycle in young, healthy women. Journal of Psychosomatic Research, 56, 239-243.
4. Barker, M. J., Greenwood, K. M., Jackson, M., & Crowe, S. F. (2004). Cognitive effects of long-term benzodiazepine use: A meta-analysis. CNS Drugs, 18, 37-48.
5. Berlin, I., Warot, D., Hergueta, T., Molinier, P., Bagot, C., & Puech, A. J. (1993). Comparison of the effects of zolpidem and triazolam on memory functions, psychomotor performance, and postural sway in healthy subjects. Journal of Clinical Psychopharmacoly,13, 100-106.
6. Buysse, D. J., Reynolds, C. F. 3rd, Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Research, 28, 193-213.
7. Caldwell, J. A., & Caldwell, J. L. (2005). Fatigue in military aviation: An overview of U.S. Military-Approved Pharmacological Countermeasures. Aviation, Space, and Environmental Medicine, 76, C39-C51.
8. Carter, L. P., Griffiths, R. R., & Mintzer, M. Z. (2009). Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteers. Psychopharmacology, 206, 141-154.
9. Cubala, W. J., Wiglusz, M., Burkiewicz, A., & Galuszko-Wegielnik, M. (2010). Zolpidem pharmacokinetics and pharmacodynamics in metabolic interactions involving CYP3A: Sex as a differentiating factor. European Journal of Clinical Pharmacology, 66, 955.
10. Curran, H. V., Bond, A., O'Sullivan, G., Bruce, M., Marks, I., Lelliot, P., . . . Lader, M. (1994). Memory functions, alprazolam and exposure therapy: A controlled longitudinal study of patients with agoraphobia and panic disorder. Psychological Medicine, 24, 969-976.
11. Curran, H. V., Collins, R., Fletcher, S., Kee, S. C., Woods, B., & Iliffe, S. (2003). Older adults and withdrawal from benzodiazepine hypnotics in general practice: Effects on cognitive function, sleep, mood and quality of life. Psychological Medicine, 33, 1223-1237.
12. Danjou, P., Paty, I., Fruncillo, R., Worthington, P., Unruh, M., Cevallos, W., & Martin, P. (1999). A comparison of the residual effects of zaleplon and zolpidem following administration 5 to 2 h before awakening. British Journal of Clinical Pharmacology, 48, 367-374.
13. DeClerk, A. C., & Bisserbe, J. C. (1998). Short-term safety profile of zolpidem: Objective measures of cognitive effects. European Journal of Psychiatry, 12, 15s-20s.
14. Dougherty, D. M., Moeeller, F. G., Steinberg, J. L., Marsh, D. M., Hines, S. E., & Bjork, J. M. (1999). Alcohol increased commission error rates for a continuous performance test. Alcoholism, Clinical and Experimental Research, 23, 1342-1351.
15. Fillmore, M. T., Kelly, T. H., Rush, C. R., & Hays, L. (2001). Retrograde facilitation of memory by triazolam: Effects on automatic processes. Psychopharmacology, 158, 314-321.
16. Ghoneim, M. M., Mewaldt, S. P., Berie, J. L., & Hinrichs, V. (1981). Memory and performance effects of single and 3 week administration of diazepam. Psychopharmacology, 73, 147-151.
17. Goodman, L., A., & Kruskal, W. H. (1954). Measures of association for cross classifications. Journal of the American Statistical Association, 49, 732-764.
18. Gustavsen, I., Bramness, J. G., Skurtveit, S., Engeland, A., Neutel, I., & Mørland, J. (2008). Road traffic accident risk related to prescriptions of the hypnotics zopiclone, zolpidem, flunitrazepam and nitrazepam. Sleep Medicine, 9, 818-822.
19. Hindmarch, I., Patat, A., Stanley, N., Paty, I., & Rigney. U. (2001). Residual effects of zaleplon and zolpidem following middle of the night administration five hours to one hour before awakening. Human Psychopharmacology, 16, 159-167.
20. Hinrichs, J. V., Ghoneim, M. M., & Mewaldt, S. P. (1984). Diazepam and memory: Retrograde facilitation produced by interference reduction. Psychopharmacology, 84, 158-162.
21. Jonides, J., Schumacher, E. H., Smith, E. E., Lauber, E. J., Awh, E., Minoshima, S., & Koeppe, R. A. (1997). Verbal working memory load affects regional brain activation as measured by PET. Journal of Cognitive Neuroscience, 9, 462-475.
22. Keppel, G. (1991). Design and analysis: A research's handbook, 3rd edn. Prentice Hall, Englewood Cliffs.
23. Kleykamp, B. A., Griffiths, R. R., & M. Z. Mintzer. (2010). Dose effects of triazolam and alcohol on cognitive performance in healthy volunteers. Experimental and Clinical Psychopharmacology, 18, 1-16.
24. Kushida, C. A., Littner, M. R., Morgenthaler, T., Alessi, C. A., Bailey, D., Coleman, J. Jr., . . . Wise, M. (2005). Practice parameters for the indications for polysomnography and related procedures: An update for 2005. Sleep, 28, 499-521.
25. Massin-Krauss, M., Bacon, E., & Danion, J. M. (2002). Effects of the benzodiazepine lorazepam on monitoring and control processes in semantic memory. Consciousness and Cognition, 11, 123-137.
26. McBeth, B. D., McNamara, R. M., Ankel, F. K., Mason, E. J., Ling, L. J., Flottemesch, T. J., & Asplin, B. R. (2009). Modafinil and zolpidem use by emergency medicine residents. Academic Emergency Medicine, 16, 1311-1317.
27. McLeod, D. R., Griffiths, R. R., Bigelow, G. E., & Yingling, J. (1982). An automated version of the digit symbol substitution test (DSST). Behavioral Research Methods and Instruments, 14, 463-466.
28. Mintzer, M. Z., Allen, R. P., & Griffiths, R. R. (2001). Investigation of preference for nightly triazolam versus placebo in moderate social alcohol drinkers. Journal of Psychopharmacology, 15, 3-8.
29. Mintzer, M. Z., Frey, J. M., Yingling, J. E., & Griffiths, R. R. (1997). Triazolam and zolpidem: A comparison of their psychomotor, cognitive, and subjective effects in healthy volunteers. Behavioural Pharmacology, 8, 561-574.
30. Mintzer, M. Z., & Griffiths, R. R. (1999a). Selective effects of zolpidem on human memory functions. Journal of Psychopharmacology, 13, 18-31.
31. Mintzer, M. Z., & Griffiths, R. R. (1999b). Triazolam and zolpidem: Effects on human memory and attentional processes. Psychopharmacology, 144, 8-19
32. Mintzer, M. Z., & Griffiths, R. R. (2003). Lorazepam and scopolamine: A single-dose comparison of effects on human memory and attentional processes. Experimental and Clinical Psychopharmacology, 11, 56-72.
33. Mintzer, M. Z., & Griffiths, R. R. (2005). Drugs, memory, and metamemory: A dose-effect study with lorazepam and scopolamine. Exp. Clin. Psychopharm., 13, 336-347
34. Mintzer, M. Z., & Stitzer, M. L. (2002). Cognitive impairment in methadone maintenance patients. Drug and Alcohol Dependence, 67, 41-51.
35. Olubodun, J. O., Ochs, H. R., von Moltke, L. L., Roubenoff, R., Hesse, L. M., Harmatz, J. S., . . . Greenblatt, D. J. (2003). Pharmacokinetic properties of zolpidem in elderly and young adults: Possible modulation by testosterone in men. British Journal of Clinical Pharmacology, 56, 297-304
36. Otmani, S., Demazières, A., Staner, C., Jacob, N., Nir, T., Zisapel, N., & Staner, L. (2008). Effects of prolonged-release melatonin, zolpidem, and their combination on psychomotor functions, memory recall, and driving skills in healthy middle aged and elderly volunteers. Human Psychopharmacology, 23, 693-705.
37. Physician's Desk Reference, 57 ed. Montvale: Thomson PDR2003.
38. Rhalimi, M., Helou, R., & Jaecker, P. (2009). Medication use and increased risk of falls in hospitalized elderly patients: A retrospective, case-control study. Drugs and Aging, 26, 847-852.
39. Roache, J. D., Cherek, D. R., Bennett, R. H., Schenkler, J. C., & Cowan, K. A. (1993). Differential effects of triazolam and ethanol on awareness, memory, and psychomotor performance. Journal of Clinical Psychopharmacology, 13, 3-15.
40. Roache, J. D., & Griffiths, R. R. (1985). Comparison of triazolam and pentobarbital: Performance impairment, subjective effects and abuse liability. Journal of Pharmacology and Experimental Therapeutics, 234, 120-133.
41. Roache, J. D., & Griffiths, R. R. (1987). Lorazepam and meprobamate dose effects in humans: Behavioral effects and abuse liability. The Journal of Pharmacology and Experimental Therapeutics, 243, 978-988.
42. Rosenberg, R. P. (2006). Sleep maintenance insomnia: Strengths and weaknesses of current pharmacologic therapies. Annals of Clinical Psychiatry, 18, 49-56.
43. Schultz, D., & Miller, J. (2004). Fatigue and use of GO/NO GO pills in F-16 pilots subjected to extraordinarily long combat sorties. Human effectiveness directorate, Brooks city Base. AFRL Report No AFRL-HE-BR-TR-2004-0014.
44. Siddiqui, F., Osuna, E., & Chokroverty, S. (2009). Writing emails as part of sleepwalking after increase in Zolpidem. Sleep Med, 10, 262-264.
45. Snodgrass, J. G., & Corwin, J. (1988). Pragmatics of measuring recognition memory: Applications to dementia and amnesia. Journal of Experimental Psychology: General, 117, 34-50.
46. Stoops, W. W., & Rush, C. R. (2003). Differential effects in humans after repeated administrations of zolpidem and triazolam. The American Journal of Drug and Alcohol Abuse, 29, 281-299.
47. Tata, P. R., Rollings, J., Collins, M., Pickering, A., & Jacobson, R. R. (1994). Lack of cognitive recovery following withdrawal from long-term benzodiazepine use. Psychological Medicine, 24, 203-213.
48. Thorndike, E. L., & Lorge, I. (1944). The teacher's word book of 30,000 words. New York, NY: Teacher's College, Columbia University.
49. Verster, J. C., Volkerts, E. R., Schreuder, A. H., Eijken, E. J., van Heuckelum, J. H., Veldhuijzen, D. S., . . . Patat, A. (2002). Residual effects of middle-of-the-night administration of zaleplon and zolpidem on driving ability, memory functions, and psychomotor performance. Journal of Clinical Psychopharmacology, 22, 576-583.
50. Wechsler, D. (1981). WAIS-R manual. New York, NY: Psychological Corporation.
51. Weinling, E., McDougall, S., Andre, F., Bianchetti, G., & Dubruc, C. (2006). Pharmacokinetic profile of a new modified release formulation of zolpidem designed to improve sleep maintenance. Fundamental & Clinical Pharmacology, 20, 397-403.