Cognition-impairing effects of benzodiazepine-type drugs: Role of GABA A receptor subtypes in an executive function task in rhesus monkeys

Pharmacology Biochemistry and Behavior

Volumn 104, Issue 1, 2013, Pages 62-68

  Makaron, Leah ^a   Moran, Casey A ^a   Namjoshi, Ojas ^b   Rallapalli, Sundari ^b   Cook, James M ^b   Rowlett, James K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

Benzodiazepines; Executive function; GABAA receptor; Object retrieval with detours; Rhesus macaques

Indexed keywords

1,3 BIS(8 ETHYNYL 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5A][1,4]BENZODIAZEPINE 3 CARBOXY)PROPYL DIESTER; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BETA CARBOLINE 3 CARBOXYLIC ACID BUTYL ESTER; TRIAZOLAM; UNCLASSIFIED DRUG; XLI 093; ZALEPLON; ZOLPIDEM;

ANIMAL EXPERIMENT; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG MECHANISM; EXECUTIVE FUNCTION; FEMALE; FOOD AVAILABILITY; LATENT PERIOD; MENTAL PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RHESUS MONKEY; TASK PERFORMANCE;

ACETAMIDES; ANIMALS; ANTI-ANXIETY AGENTS; BENZODIAZEPINES; BENZODIAZEPINONES; CARBOLINES; COGNITION; EXECUTIVE FUNCTION; FEMALE; GABA-A RECEPTOR ANTAGONISTS; HYPNOTICS AND SEDATIVES; IMIDAZOLES; MACACA MULATTA; PYRIDINES; PYRIMIDINES; RECEPTORS, GABA-A; TRIAZOLAM;

MACACA MULATTA;

EID: 84873421746     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.12.018     Document Type: Article

References (39)

1. M.P. Arolfo, and J.D. Brioni Diazepam impairs place learning in the Morris water maze Behav Neural Biol 55 1991 131 136
2. T.J. Balkin, V.M. O'Donnell, N. Wesensten, U. McCann, and G. Belenky Comparison of the daytime sleep and performance effects of zolpidem versus triazolam Psychopharmacology (Berl) 107 1992 83 88
3. A alpha5 subunit-containing receptors Psychopharmacology (Berl) 202 2009 207 223
4. C. Belzung, A.M. Le Guisquet, and G. Griebel Beta-CCT, a selective BZ-omega1 receptor antagonist, blocks the anti-anxiety but not the amnesic action of chlordiazepoxide in mice Behav Pharmacol 11 2000 125 131
5. J. Brown, and M.W. Brown The effects of repeating a recognition test in lorazepam-induced amnesia: evidence for impaired contextual memory as a cause of amnesia Q J Exp Psychol A 42 1990 279 290
6. S.E. Buffett-Jerrott, and S.H. Stewart Cognitive and sedative effects of benzodiazepine use Curr Pharm Des 8 2002 45 58
7. A.M. Coenen, H.C. van Poppel, F.W. Gribnau, J.M. Vossen, and E.L. van Luijtelaar Benzodiazepines and cognition: effects on intentional and incidental learning J. Horne, Sleep '88 1989 Gustav Fischer Verlag Stuttgart, New York 201 204
8. J.T. Coull, H.C. Middleton, T.W. Robbins, and B.J. Sahakian Clonidine and diazepam have differential effects on tests of attention and learning Psychopharmacology (Berl) 120 1995 322 332
9. J.T. Coull, C.D. Frith, and R.J. Dolan Dissociating neuromodulatory effects of diazepam on episodic memory encoding and executive function Psychopharmacology (Berl) 145 1999 213 222
10. H.V. Curran, and B. Birch Differentiating the sedative, psychomotor and amnesic effects of benzodiazepines: a study with midazolam and the benzodiazepine antagonist, flumazenil Psychopharmacology (Berl) 103 1991 519 523
11. A. Diamond, S. Zola-Morgan, and L.R. Squire Successful performance by monkeys with lesions of the hippocampal formation on AB and object retrieval, two tasks that mark developmental changes in human infants Behav Neurosci 103 1989 526 537
12. R. Dias, T.W. Robbins, and A.C. Roberts Primate analogue of the Wisconsin Card Sorting Test: effects of excitotoxic lesions of the prefrontal cortex in the marmoset Behav Neurosci 110 1996 872 886
13. T. Duka, H.V. Curran, J.M. Rusted, and H.J. Weingartner Perspectives on cognitive psychopharmacology research Behav Pharmacol 7 1996 401 410
14. J.M. Fritschy, D. Benke, S. Mertens, W.H. Oertel, T. Bachi, and H. Mohler Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies Proc Natl Acad Sci U S A 89 1992 6726 6730
15. A receptors containing the alpha 1 subunit to neurochemically distinct subpopulations of rat hippocampal interneurons Eur J Neurosci 6 1994 837 853
16. M.M. Ghoneim, and S.P. Mewaldt Effects of diazepam and scopolamine on storage, retrieval and organizational processes in memory Psychopharmacologia 44 1975 257 262
17. M.M. Ghoneim, J.V. Hinrichs, and S.P. Mewaldt Dose-response analysis of the behavioral effects of diazepam: I. Learning and memory Psychopharmacology (Berl) 82 1984 291 295
18. M.M. Ghoneim, S.P. Mewaldt, and J.V. Hinrichs Dose-response analysis of the behavioral effects of diazepam: II. Psychomotor performance, cognition and mood Psychopharmacology (Berl) 82 1984 296 300
19. K.L. Hadingham, P. Wingrove, B. Le Bourdelles, K.J. Palmer, C.I. Ragan, and P.J. Whiting Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric acidA receptors Mol Pharmacol 43 1993 970 975
20. J.D. Jentsch, J.R. Taylor, J.D. Elsworth, D.E. Redmond Jr., and R.H. Roth Altered frontal cortical dopaminergic transmission in monkeys after subchronic phencyclidine exposure: involvement in frontostriatal cognitive deficits Neuroscience 90 1999 823 832
21. A.A. Kehagia, R.A. Barker, and T.W. Robbins Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease Lancet Neurol 9 2010 1200 1213
22. M.T. Koh, S. Rosenzweig-Lipson, and M. Gallagher Selective GABA(A) alpha5 positive allosteric modulators improve cognitive function in aged rats with memory impairment Neuropharmacology 64 2013 145 152
23. X. Li, H. Cao, C. Zhang, R. Furtmueller, K. Fuchs, and S. Huck Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]-[1,4] benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist J Med Chem 46 2003 5567 5570
24. R.G. Lister The amnesic action of benzodiazepines in man Neurosci Biobehav Rev 9 1985 87 94
25. A-receptor subtypes really occur in the brain? Trends Neurosci 19 1996 139 143
26. N. McNaughton, and R.G. Morris Chlordiazepoxide, an anxiolytic benzodiazepine, impairs place navigation in rats Behav Brain Res 24 1987 39 46
27. M.Z. Mintzer, and R.R. Griffiths Triazolam and zolpidem: effects on human memory and attentional processes Psychopharmacology (Berl) 144 1999 8 19
28. M.Z. Mintzer, and R.R. Griffiths Drugs, memory, and metamemory: a dose-effect study with lorazepam and scopolamine Exp Clin Psychopharmacol 13 2005 336 347
29. M.Z. Mintzer, J.M. Frey, J.E. Yingling, and R.R. Griffiths Triazolam and zolpidem: a comparison of their psychomotor, cognitive, and subjective effects in healthy volunteers Behav Pharmacol 8 1997 561 574
30. H. Noguchi, K. Kitazumi, M. Mori, and T. Shiba Effect of zaleplon on learning and memory in rats Naunyn Schmiedebergs Arch Pharmacol 366 2002 183 188
31. A. Peters, D.L. Rosene, M.B. Moss, T.L. Kemper, C.R. Abraham, and J. Tigges Neurobiological bases of age-related cognitive decline in the rhesus monkey J Neuropathol Exp Neurol 55 1996 861 874
32. D.M. Platt, G. Carey, and R.D. Spealman Models of neurological disease (substance abuse): self-administration in monkeys In: Curr Protoc Pharmacol 2012 John Wiley & Sons, Inc. Hoboken, NJ p. 10.5.1-10.5.17
33. A receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates Proc Natl Acad Sci U S A 102 2005 915 920
34. A receptor subtypes Nat Rev Drug Discov 10 2011 685 697
35. D.J. Sanger, D. Joly, and B. Zivkovic Effects of zolpidem, a new imidazopyridine hypnotic, on the acquisition of conditioned fear in mice. Comparison with triazolam and CL 218,872 Psychopharmacology (Berl) 90 1986 207 210
36. M.M. Savic, T. Clayton, R. Furtmuller, I. Gavrilovic, J. Samardzic, and S. Savic PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats Brain Res 1208 2008 150 159
37. W. Sieghart, and G. Sperk Subunit composition, distribution and function of GABA(A) receptor subtypes Curr Top Med Chem 2 2002 795 816
38. S.A. Stewart The effects of benzodiazepines on cognition J Clin Psychiatry 66 Suppl. 2 2005 9 13
39. J.R. Taylor, J.D. Elsworth, R.H. Roth, J.R. Sladek Jr., and D.E. Redmond Jr. Cognitive and motor deficits in the acquisition of an object retrieval/detour task in MPTP-treated monkeys Brain 113 Pt. 3 1990 617 637