Influence of benzodiazepine binding site ligands on fear-conditioned contextual memory

European Journal of Pharmacology

Volumn 426, Issue 1-2, 2001, Pages 45-54

  DeLorey, Timothy M ^a   Lin, Richard C ^a   McBrady, Brian ^a   He, Xiaohui ^b   Cook, James M ^b   Lameh, Jelveh ^a   Loew, Gilda H ^a  

^a MOLECULAR RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

Benzodiazepine; Contextual; Fear conditioning; GABAA receptor; Memory

Indexed keywords

2 (4 CHLORO PHENYL) 4 (4 N ETHYLAMIDE PIPERAZINYL)QUINOLINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; 5 ISOPROPOXY 4 METHYL BETA CARBOLINE 3 CARBOXYLIC ACID ETHYL ESTER; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE DERIVATIVE; BETA CARBOLINE 3 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; ENFLURANE; ETHYL 8 ETHYL 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLATE; FLUMAZENIL; FLUNITRAZEPAM; METHYLSCOPOLAMINE; QUINOLINE DERIVATIVE; RO 23 1590; RY 10; SCOPOLAMINE; UNCLASSIFIED DRUG;

AFFECT; ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONDITIONED REFLEX; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BINDING SITE; DRUG EFFECT; DRUG POTENTIATION; DRUG STRUCTURE; FEAR; LIGAND BINDING; MALE; MEMORY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; AZIDES; BENZODIAZEPINES; BINDING SITES; BINDING, COMPETITIVE; CARBOLINES; CONDITIONING (PSYCHOLOGY); CONVULSANTS; FEAR; FLUMAZENIL; GABA ANTAGONISTS; GABA MODULATORS; IMIDAZOLES; LIGANDS; MALE; MEMORY; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; N-METHYLSCOPOLAMINE; PIPERAZINES; QUINOLINES; RECEPTORS, GABA-A; SCOPOLAMINE; SILANES; TRITIUM;

EID: 0035943336     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01199-2     Document Type: Article

References (40)

1. Effects of S-8510, a novel benzodiazepine receptor partial inverse agonist, on basal forebrain lesioning-induced dysfunction in rats
2. Scopolamine selectively disrupts the acquisition of contextual fear conditioning in rats
3. Peripheral-type benzodiazepine receptors: Autoradiographic localization in whole-body sections of neonatal rats
4. Theta, a novel gamma-aminobutyric acid type A receptor subunit
5. Cholinergic agents and delay-dependent performance in the rat
6. Nucleus basalis and thalamic control of neocortical activity in the freely moving rat
7. Hippocampal lesions impair cotextual fear conditioning in two strains of mice
8. Putative benzodiazepine partial agonists demonstrate receptor heterogeneity
9. Behavioural and convulsant actions of two methyl esters of beta-carboline-3-carboxylic acid in photosensitive baboons and in DBA/2 mice
10. Evidence for central benzodiazepine receptor heterogeneity from behavior tests
11. The effects of a benzodiazepine receptor antagonist beta-carboline ZK-93426 on scopolamine-induced impairment on attention, memory and psychomotor skills
12. Scopolamine model of dementia: Electroencephalogram findings and cognitive performance
13. Evaluation of two rodent delayed-response memory tasks. A method with retractable levers versus a method with closing doors
14. Naloxone and shock-elicited freezing in the rat
15. Systematic regional variations in the loss of cortical cholinergic fibers in Alzheimer's disease
16. Predictive models for GABAA/benzodiazepine receptor subtypes: Studies of quantitative structure-acitivity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [axb3g2 (x=1-3, 5, and 6)] via comparative molecular field analysis
17. Bidirectional effects of beta-carbolines and benzodiazepines on cognitive processes
18. Modality-specific retrogade amnesia of fear
19. N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning
20. Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease
21. The amnesic action of benzodiazepines in man
22. Possible mechanism for atrophy of the human hippocampus
23. Behavioral vigilance following infusions of 192 IgG-saporin into the basal forebrain: Selectivity of the behavioral impairment and relation to cortical acetylcholineE-positive fiber density
24. Assessment of a cholinergic contribution to chlordiazepoxide-induced deficits of place learning in the Morris water maze
25. Positron emission tomography measures of benzodiazepine binding in Alzheimer's disease
26. Immunohistochemical study of GABA(A) receptor beta2/3 subunits in the hippocampal formation of aged brains with Alzheimer-related neuropathologic changes
27. GABA and glycine
28. Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: Implications of genetic background for single gene mutations and quantitative trait loci analyses
29. Learning and memory-enhancing effects of Ro 15-4513: A comparison with flumazenil
30. Pharmacokinetics of MDL 26,479, a novel benzodiazepine inverse agonist, in normal volunteers
31. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes
32. Effects of scopolamine (0.25-0.75 mg i.m.) on the quantitative EEG and the neuropsychological status of healthy volunteers
33. Trans-synaptic stimulation of cortical acetylcholine and enhancement of attentional functions: A rational approach for the development of cognition enhancers
34. Spontaneous exploration of a 6-arm radial tunnel maze by basal forebrain lesioned rats: Effects of the benzodiazepine receptor antagonist beta-carboline ZK 93426
35. Behavioral screening for cognition enhancers: From indiscriminate to valid testing: Part I
36. Synthesis and structure-activity relationships of fused imidazopyridines: A new series of benzodiazepine receptor ligands
37. Benzodiazepine impairs and beta-carboline enhances performance in learning and memory tasks
38. The cholinergic deficit in Alzheimer's disease
39. Validation criteria for animal models of human mental disorders: Learned helplessness as a paradigm case
40. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain: I. Telencephalon, diencephalon, mesencephalon