Efforts toward broadening the spectrum of arylomycin antibiotic activity

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 20, 2013, Pages 5654-5659

  Liu, Jian ^a   Smith, Peter A ^b   Steed, Danielle Barrios ^a   Romesberg, Floyd ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b RQx Pharmaceuticals Inc   (United States)

Author keywords

C terminal electrophile; Latent antibiotic; Protein secretion; Signal peptidase

Indexed keywords

ANTIBIOTIC AGENT; ARYLOMYCIN; MACROCYCLIC COMPOUND; SIGNAL PEPTIDASE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

C-TERMINAL ELECTROPHILE; LATENT ANTIBIOTIC; PROTEIN SECRETION; SIGNAL PEPTIDASE;

ANTI-BACTERIAL AGENTS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; PEPTIDES, CYCLIC;

EID: 84884279425     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.026     Document Type: Article

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