Effect of protein and solution properties on the donnan effect during the ultrafiltration of proteins

Biotechnology Progress

Volumn 27, Issue 1, 2011, Pages 140-152

  Bolton, Glen R ^a   Boesch, Austin W ^a   Basha, Jonida ^a   LaCasse, Daniel P ^a   Kelley, Brian D ^b   Acharya, Hari ^c  

^a PFIZER INC   (United States)

^b GENENTECH INC   (United States)

^c RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

Concentration; Donnan effect; Protein charge; Protein formulation; Ultrafiltration

Indexed keywords

BIOPHARMACEUTICALS; BUFFER PH; BUFFERING CAPACITIES; CHARGED PROTEINS; CONCENTRATION; DIAFILTRATION; DIVALENT IONS; DONNAN EFFECT; DONNAN EFFECTS; DRUG SUBSTANCES; FUSION PROTEINS; ION BINDING; LOW TEMPERATURES; MASS CONSERVATION LAW; PROTEIN CHARGE; PROTEIN FORMULATION; PROTEIN SOLUTION; SOLUTION PROPERTY; TARGET VALUES; ULTRA-FILTRATION MEMBRANES;

ALLERGIES; CONCENTRATION (PROCESS); LAKES; MONOCLONAL ANTIBODIES; PH EFFECTS; SUPPLY CHAINS; SURFACE PLASMON RESONANCE; ULTRAFILTRATION;

PROTEINS;

BUFFER; PROTEIN;

ARTICLE; CHEMISTRY; ISOLATION AND PURIFICATION; METHODOLOGY; PH; THEORETICAL MODEL; ULTRAFILTRATION;

BUFFERS; HYDROGEN-ION CONCENTRATION; MODELS, THEORETICAL; PROTEINS; ULTRAFILTRATION;

EID: 79851492106     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.523     Document Type: Article

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