Stachydrine ameliorates high-glucose induced endothelial cell senescence and SIRT1 downregulation

Journal of Cellular Biochemistry

Volumn 114, Issue 11, 2013, Pages 2522-2530

  Servillo, Luigi ^a   D'Onofrio, Nunzia ^a   Longobardi, Lara ^b   Sirangelo, Ivana ^a   Giovane, Alfonso ^a   Cautela, Domenico ^c   Castaldo, Domenico ^c   Giordano, Antonio ^d,e   Balestrieri, Maria Luisa ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c Stazione Sperimentale per le Industrie Delle Essenze e Dei Derivati Dagli Agrumi SSEA   (Italy)

^d Temple University   (United States)

^e UNIVERSITY OF SIENA   (Italy)

Author keywords

Endothelial Cells; Hyperglycaemia; Senescence; Stachydrine

Indexed keywords

BETAINE DERIVATIVE; CITRUS FRUIT EXTRACT; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GLUCOSE; SIRTUIN 1; STACHYDRINE; UNCLASSIFIED DRUG;

ARTICLE; CARDIOVASCULAR DISEASE; CELL AGING; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PHASE; CELL CYCLE REGULATION; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; EATING; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENUS; HUMAN; HUMAN CELL; HYPERGLYCEMIA; LASER MICROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; UPREGULATION; WESTERN BLOTTING;

ENDOTHELIAL CELLS; HYPERGLYCAEMIA; SENESCENCE; STACHYDRINE;

ANIMALS; BLOTTING, WESTERN; CATTLE; CELL AGING; CELL LINE; CELL PROLIFERATION; ENDOTHELIAL CELLS; GLUCOSE; MICROSCOPY, CONFOCAL; PROLINE; SIRTUIN 1;

EID: 84884273184     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24598     Document Type: Article

References (42)

1. Alexander D, Lombardi R, Rodriguez G, Mitchell MM, Marian AJ,. 2011. Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy. Eur J Clin Invest 41: 527-538.
2. Atkinson W, Downer P, Lever M, Chambers ST, George PM,. 2007. Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthy male subjects. Eur J Nutr 46: 446-452.
3. Balestrieri ML, Rienzo M, Felice F, Rossiello R, Grimaldi V, Milone L, Casamassimi A, Servillo L, Farzati B, Giovane A, Napoli C,. 2008a. High glucose downregulates endothelial progenitor cell number via SIRT1. Biochim Biophys Acta 1784: 936-945.
4. Balestrieri ML, Balestrieri A, Mancini FP, Napoli C,. 2008b. Understanding the immunoangiostatic CXC chemokine network. Cardiovasc Res 78: 250-256.
5. Balestrieri ML, Giovane A, Milone L, Servillo L,. 2010. Endothelial progenitor cells express PAF receptor and respond to PAF via Ca(2+)-dependent signaling. Biochim Biophys Acta 1801: 123-132.
6. Balestrieri ML, Servillo L, Esposito A, D' Onofrio N, Giovane A, Casale R, Barbieri M, Paolisso P, Rizzo MR, Paolisso G, Marfella R,. 2013. Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signaling via platelet-activating factor receptor activation. Diabetologia 56: 162-172.
7. Berg CM, Lappas G, Strandhagen E, Wolk A, Torén K, Rosengren A, Aires N, Thelle DS, Lissner L,. 2008. Food patterns and cardiovascular disease risk factors: The Swedish INTERGENE research program. Am J Clin Nutr 88: 289-297.
8. Chen J, Brodsky SV, Goligorsky DM, Hampel DJ, Li H, Gross SS, Goligorsky MS,. 2002. Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells. Circ Res 90: 1290-1298.
9. Chen YH, Guh JY, Chuang TD, Chen HC, Chiou SJ, Huang JS, Yang YL, Chuang LY,. 2007. High glucose decreases endothelial cell proliferation via the extracellular signal regulated kinase/p15(INK4b) pathway. Arch Biochem Biophys 465: 164-171.
10. Cohen HY, Miller C, Bitterman KJ, Hekking B, Kesseler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA,. 2004. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 16: 390-392.
11. Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL,. 2010. SIRT1 activation by small molecules: Kinetic and biophysical evidence for direct interaction of enzyme and activator. J Biol Chem 285: 32695-32703.
12. Eringa EC, Serne EH, Meijer RI, Schalkwijk CG, Houben AJ, Stehouwer CD, Smulders YM, van Hinsbergh VW,. 2013. Endothelial dysfunction in (pre)diabetes: Characteristics, causative mechanisms, and pathogenic role in type 2 diabetes. Rev Endocr Metab Disord 14: 39-48.
13. Fadini GP, Miorin M, Facco M, Bonamico S, Baesso I, Grego F, Menegolo M, de Kreutzenberg SV, Tiengo A, Agostini C, Avogaro A,. 2005. Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol 45: 1449-1457.
14. Fiorito C, Rienzo M, Crimi E, Rossiello R, Balestrieri ML, Casamassimi A, Muto F, Grimaldi V, Giovane A, Farzati B, Mancini FP, Napoli C,. 2008. Antioxidants increase number of progenitor endothelial cells through multiple gene expression pathways. Free Radic Res 42: 754-762.
15. Hasegawa PM, Bressan RA, Kang Zhu J, Bohnert J,. 2000. Plant cellular and molecular responses to high salinity. Annu Rev Plant Physiol Plant Mol Biol 51: 463-499.
16. Heinzmann SS, Brown IJ, Chan Q, Bictash M, Dumas ME, Kochhar S, Stamler J, Holmes E, Elliott P, Nicholson JK,. 2010. Metabolic profiling strategy for discovery of nutritional biomarkers: Proline betaine as a marker of citrus consumption. Am J Clin Nutr 92: 436-443.
17. Hu YY, He KW, Guo RL,. 2012. Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1, and E-selectin in LPS-induced endothelial cells. Immunol Invest 41: 261-274.
18. Ignarro LJ, Balestrieri ML, Napoli C,. 2007. Nutrition, physical activity, and cardiovascular disease: An update. Cardiovasc Res 73: 326-340.
19. Kavi Kishor PB, Sangam S, Amrutha RN, Sri Laxmi P, Naidu KR, Rao KRSS, Rao S, Reddy KJ, Theriappan P, Sreenivasulu N,. 2005. Regulation of proline biosynthesis, degradation, uptake, and transport in higher plants: Its implications in plant growth and abiotic stress tolerance. Curr Sci 88: 424-438.
20. Kuki S, Imanishi T, Kobayashi K, Matsuo Y, Obana M, Akasaka T,. 2006. Hyperglycemia accelerated endothelial progenitor cell senescence via the activation of p38 mitogen-activated protein kinase. Circ J 70: 1076-1081.
21. Liu XH, Xin H, Hou AJ, Zhu YZ,. 2009. Protective effects of leonurine in neonatal rat hypoxic cardiomyocytes and rat infarcted heart. Clin Exp Pharmacol Physiol 36: 696-703.
22. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ,. 1951. Protein measurement with the 743Folin phenol reagent. J Biol Chem 193: 265-275.
23. Lundberg AS, Hahn WC, Gupta P, Weinberg RA,. 2000. Genes involved in senescence and immortalization. Curr Opin Cell Biol 12: 705-709.
24. Mente A, de Koning L, Shannon HS, Anand SS,. 2009. A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch Intern Med 169: 659-669.
25. Mortuza R, Chen S, Feng B, Sen S, Chakrabarti S,. 2013. High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway. PLoS ONE 8: e54514. doi: 10.1371/journal.pone. 0054514
26. Napoli C, William-Ignarro S, Byrns R, Balestrieri ML, Crimi E, Farzati B, Mancini FP, de Nigris F, Matarazzo A, D'Amora M, Abbondanza C, Fiorito C, Giovane A, Florio A, Varricchio E, Palagiano A, Minucci PB, Tecce MF, Giordano A, Pavan A, Ignarro LJ,. 2008. Therapeutic targeting of the stem cell niche in experimental hindlimb ischemia. Nat Clin Pract Cardiovasc Med 5: 571-579.
27. Ota H, Akishita M, Eto M, Iijima K, Kanei M, Ouchi Y,. 2007. Sirt1 modulates premature senescence-like phenotype in human endothelial cells. J Mol Cell Cardiol 43: 571-579.
28. Revollo JR, Li X,. 2013. The ways and means that fine tune Sirt1 activity. Trends Biochem Sci 38: 160-167.
29. Riboli E, Norat T,. 2003. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 78: 559S-569S.
30. Sanchez-Fidalgo S, Villegas I, Sanchez-Hidalgo M, de la Lastra CA,. 2012. Sirtuin modulators: Mechanisms and potential clinical implications. Curr Med Chem 19: 2414-2441.
31. Servillo L, Giovane A, Balestrieri ML, Bata-Csere A, Cautela D, Castaldo D,. 2011a. Betaines in fruits of citrus genus plants. J Agric Food Chem 59: 9410-9416.
32. Servillo L, Giovane A, Balestrieri ML, Cautela D, Castaldo D,. 2011b. Proline derivatives in fruits of bergamot (Citrus bergamia Risso et Poit): Presence of N-methylproline and 4-hydroxyprolinebetaine. J Agric Food Chem 59: 274-281.
33. Servillo L, Giovane A, Cautela D, Castaldo D, Balestrieri ML,. 2013. The methylarginines NMMA, ADMA, and SDMA are ubiquitous constituents of the main vegetables of human nutrition. Nitric Oxide 30: 43-48.
34. Sheetz MJ, King GL,. 2002. Molecular understanding of hyperglycemia's adverse effects for diabetic complications, Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA 288: 2579-2588.
35. Stret TO, Bolen DW, Rose GD,. 2006. A molecular mechanism for osmollyte-induced protein stability. Proc Natl Acad Sci USA 103: 13997-14002.
36. Thomazella MC, Gões MF, Andrade CR, Debbas V, Barbeiro DF, Correia RL, Marie SK, Cardounel AJ, daLuz PL, Laurindo Fr,. 2011. Effects of high adherence to mediterranean or low-fat diets in medicated secondary prevention patients. Am J Cardiol 108: 1523-1529.
37. Wang MX, Ren LM,. 2006. Growth inhibitory effect and apoptosis induced by extracellular ATP and adenosine on human gastric carcinoma cells: Involvement of intracellular uptake of adenosine. Acta Pharmacol Sin 27: 1085-1092.
38. Yin J, Zhang ZW, Yu WJ, Liao JY, Luo XG, Shen YJ,. 2010. Stachydrine, a major constituent of the Chinese herb Leonurus Heterophyllus Sweet, ameliorates human umbilical vein endothelial cells injury induced by anoxia-reoxygenation. Am J Chin Med 38: 157-171.
39. Yokoi T, Fukuo K, Yasuda O, Hotta M, Miyazaki J, Takemura Y, Kawamoto H, Ichijo H, Ogihara T,. 2006. Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells. Diabetes 55: 1660-1665.
40. Yuan Q, Peng J, Liu SY, Wang CJ, Xiang DX, Xiong XM, Hu CP, Li YJ,. 2010. Inhibitory effect of resveratrol derivative BTM-0512 on high glucose-induced cell senescence involves dimethylaminohydrolase/asymmetric dimethylarginine pathway. Clin Exp Pharmacol Physiol 37: 630-635.
41. Zanetti M, Zwacka R, Engelhardt J, Katusic Z, O'Brien T,. 2001. Superoxide anions and endothelial cell proliferation in normoglycemia and hyperglycemia. Arterioscler Thromb Vasc Biol 21: 195-200.
42. Zeisel SH, Mar MH, Howe JC, Holden JM,. 2003. Concentrations of Choline-containing compounds and Betaine in common foods. J Nutr 133: 1302-1307.