Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine

Drug Design, Development and Therapy

Volumn 7, Issue , 2013, Pages 945-952

  Hong, Xiaoyun ^a,b   Wei, Liangming ^b   Wu, Fei ^b   Wu, Zaozhan ^b   Chen, Lizhu ^b   Liu, Zhenguo ^a,b   Yuan, Weien ^b  

^a XINHUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Biodegradable; Dissolving; Microneedle; Sustained release

Indexed keywords

CHITOSAN; DIMETICONE; DNA VACCINE; PLASMID DNA; POLYACRYLIC ACID; POLYGLACTIN; POLYGLYCOLIC ACID; POLYLACTIC ACID; VACCINE;

AQUEOUS SOLUTION; BIODEGRADABLE MICRONEEDLE; CENTRIFUGATION; DISSOLVING MICRONEEDLE; DNA IMMUNIZATION; DRUG DELIVERY SYSTEM; DRUG MANUFACTURE; DRUG STORAGE; DRUG USE; EPIDERMIS; GEOMETRY; HUMAN; MICRONEEDLE; MICROTECHNOLOGY; NONHUMAN; REVIEW; SKIN CANCER; SKIN DISEASE; SKIN REDNESS; SKIN WATER LOSS; STRATUM CORNEUM; SUSTAINED DRUG RELEASE; TRANSDERMAL DRUG ADMINISTRATION; VACUUM;

BIODEGRADABLE; DISSOLVING; MICRONEEDLE; SUSTAINED RELEASE;

ABSORBABLE IMPLANTS; ADMINISTRATION, CUTANEOUS; ANIMALS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; EQUIPMENT DESIGN; HUMANS; NEEDLES; SOLUBILITY; VACCINES;

EID: 84884262830     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S44401     Document Type: Review

References (55)

1. Arendt-Nielsen L, Egekvist H, Bjerring P. Pain following controlled cutaneous insertion of needles with different diameters. Somatosens Mot Res. 2006;23(1-2):37-43.
2. Tarnow K, King N. Intradermal injections: traditional bevel up versus bevel down. Appl Nurs Res. 2004;17(4):275-282.
3. Giudice EL, Campbell JD. Needle-free vaccine delivery. Adv Drug Deliver Rev. 2006;58(1):68-89.
4. Arora A, Prausnitz MR, Mitragotri S. Micro-scale devices for transder-mal drug delivery. Int J Pharm. 2008;364(2):227-236.
5. Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. 2008;26(11):1261-1268.
6. Kempe S, Mäder K. In situ forming implants - an attractive formulation principle for parenteral depot formulations. J Control Release. 2012; 161(2):668-679.
7. Peng Q, Sun X, Gong T, et al. Injectable and biodegradable thermosensitive hydrogels loaded with PHBHHx nanoparticles for the sustained and controlled release of insulin. Acta Biomater. 2013;9(2):5063-5069.
8. Deadman CM, Kellaway IW, Yasin M, Dickinson PA, Murdan S. An investigation into the infuence of drug lipophilicity on the in vivo absorption profles from subcutaneous microspheres and in situ forming depots. J Control Release. 2007;122(1):79-85.
9. Donnelly RF, Garland MJ, Morrow DIJ, et al. Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution. J Control Release. 2010;147(3):333-341.
10. Ghosh P, Pinninti RR, Hammell DC, Paudel KS, Stinchcomb AL. Development of a codrug approach for sustained drug delivery across microneedle-treated skin. J Pharm Sci. 2013;102(5):1458-1467.
11. Felton LA. Transdermal and intradermal delivery of therapeutic agents application of physical technologies. Drug Dev Ind Pharm. 2012; 38(4):513.
12. Bariya SH, Gohel MC, Mehta TA, Sharma O P. Microneedles: an emerging transdermal drug delivery system. J Pharm Pharmacol. 2012; 64(1):11-29.
13. Gupta J, Park SS, Bondy B, Felner EI, Prausnitz MR. Infusion pressure and pain during microneedle injection into skin of human subjects. Biomaterials. 2011;32(28):6823-6831.
14. Hirobe S, Okada N, Nakagawa S. Transcutaneous vaccines - current and emerging strategies. Expert Opin Drug Deliv. 2013;10(4):485-498.
15. van der Maaden K, Jiskoot W, Bouwstra J. Microneedle technologies for (trans)dermal drug and vaccine delivery. J Control Release. 2012;161(2):645-655.
16. Jordan GH. Techniques of tissue handling and transfer. J Urol. 1999; 162(3):1213-1217.
17. Lambert PH, Laurent PE. Intradermal vaccine delivery: will new delivery systems transform vaccine administration? Vaccine. 2008;26(26): 3197-3208.
18. Nicolas J F, Guy B. Intradermal, epidermal and transcutaneous vaccination: from immunology to clinical practice. Expert Rev Vaccines. 2008;7(8):1201-1214.
19. Ya n G, Warner KS, Zhang J, Sharma S, Gale BK. Evaluation needle length and density of microneedle arrays in the pretreatment of skin for transdermal drug delivery. Int J Pharm. 2010;391(1/2):7-12.
20. Noh YW, Kim TH, Baek JS, et al. In vitro characterization of the invasiveness of polymer microneedle against skin. Int J Pharm. 2010;397(1-2):201-205.
21. Gomaa YA, Morrow DI, Garland MJ, Donnelly RF, El-Khordagui LK, Meidan VM. Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: assessments by transepidermal water loss. Toxicol In Vitro. 2010;24(7): 1971-1978.
22. Martanto W, Moore JS, Couse T, Prausnitz MR. Mechanism of fuid infusion during microneedle insertion and retraction. J Control Release. 2006;112(3):357-361.
23. Lee J W, Park JH, Prausnitz MR. Dissolving microneedles for transder-mal drug delivery. Biomaterials. 2008;29(13):2113-2124.
24. Migalska K, Morrow DI, Garland MJ, Thakur R, Woolfson AD, Donnelly RF. Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery. Pharm Res. 2011;28(8): 1919-1930.
25. Ito Y, Hagiwara E, Saeki A, Sugioka N, Takada K. Feasibility of microneedles for percutaneous absorption of insulin. Eur J Pharm Sci. 2006;29(1):82-88.
26. Donnelly RF, Majithiya R, Singh TR, et al. Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique. Pharm Res. 2011;28(1): 41-57.
27. Kumar V, Banga AK. Modulated iontophoretic delivery of small and large molecules through microchannels. Int J Pharm. 2012;434(1-2): 106-114.
28. Garland MJ, Caffarel-Salvador E, Migalska K, Woolfson AD, Donnelly RF. Dissolving polymeric microneedle arrays for electrically assisted trans-dermal drug delivery. J Control Release. 2012;159(1):52-59.
29. Wu XM, Todo H, Sugibayashi K. Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis. J Control Release. 2007;118(2):189-195.
30. Ito Y, Hagiwara E, Saeki A, Sugioka N, Takada K. Sustained-release self-dissolving micropiles for percutaneous absorption of insulin in mice. J Drug Target. 2007;15(5):323-326.
31. Park JH, Allen MG, Prausnitz MR. Polymer microneedles for controlled-release drug delivery. Pharm Res. 2006;23(5):1008-1019.
32. Kim M, Jung B, Park JH. Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin. Biomaterials. 2012;33(2):668-678.
33. Chu LY, Prausnitz MR. Separable arrowhead microneedles. J Control Release. 2011;149(3):242-249.
34. Tsioris K, Raja WK, Pritchard EM, Panilaitis B, Kaplan DL, Omenetto FG. Fabrication of silk microneedles for controlled-release drug delivery. Adv Funct Mater. 2012;22(2):330-335.
35. Ausiello D, Herman SJ, Prescott JH, Santini J, inventors. Method and device for the controlled delivery of parathyroid hormone. United States patent US 20040082937. April 29, 2004.
36. Gill HS, Söderholm J, Prausnitz MR, Sällberg M. Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine. Gene Ther. 2010;17(6):811-814.
37. DeMuth PC, Min Y, Huang B, et al. Polymer multilayer tattooing for enhanced DNA vaccination. Nat Mater. 2013;12(4):367-376.
38. Pearton M, Saller V, Coulman SA, et al. Microneedle delivery of plasmid DNA to living human skin: formulation coating, skin insertion and gene expression. J Control Release. 2012;160(3):561-569.
39. Olatunji O, Das DB. Drug delivery using microneedles In: Moo-Young M, editor. Comprehensive Biotechnology. 2nd ed. Burlington: Academic Press; 2011:625-642.
40. Martin CJ, Allender CJ, Brain KR, Morrissey A, Birchall JC. Low temperature fabrication of biodegradable sugar glass microneedles for transdermal drug delivery applications. J Control Release. 2012;158(1):93-101.
41. Demuth PC, Garcia-Beltran WF, Ai-Ling ML, Hammond PT, Irvine DJ. Composite dissolving microneedles for coordinated control of antigen and adjuvant delivery kinetics in transcutaneous vaccination. Adv Funct Mater. 2013;23(2):161-172.
42. Mefti S, Cachemaille A, Piveteau LD, Lemaire P, inventors. Soluble microneedle. World Intellectual Property Organization patent WO/2011/076537. June 30, 2011.
43. Nava-Arzaluz MG, Calderon-Lojero I, Quintanar-Guerrero D, Villalobos-Garcia R, Ganem-Quintanar A. Microneedles as transdermal delivery systems: combination with other enhancing strategies. Current Drug Deliver. 2012;9(1):57-73.
44. Matteucci M, Fanetti M, Casella M. Poly vinyl alcohol re-usable masters for microneedle replication. Microelectron Eng. 2009;86(4/6):752-756.
45. Sharma A, Saini S, Rana A. Transdermal drug delivery system: a review. Res J Pharm Technol. 2012;5(6):757-763.
46. Chen CH, Wang TL, Hung CF, et al. Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene. Cancer Res. 2000;60(4):1035-1042.
47. Yang ZY, Kong WP, Huang Y, et al. A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature. 2004;428(6982):561-564.
48. Tang DC, DeVit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature. 1992;356(6365): 152-154.
49. Ulmer JB, Wahren B, Liu MA. Gene-based vaccines: recent technical and clinical advances. Trends Mol Med. 2006;12(5):216-222.
50. Peters BS, Jaoko W, Vardas E, et al. Studies of a prophylactic HIV-1 vaccine candidate based on modified vaccinia virus Ankara (MVA) with and without DNA priming: effects of dosage and route on safety and immunogenicity. Vaccine. 2007;25(11):2120-2127.
51. Buchan S, Grønevik E, Mathiesen I, King CA, Stevenson FK, Rice J. Electroporation as a "prime/boost" strategy for naked DNA vaccination against a tumor antigen. J Immunol. 2005;174(10):6292-6298.
52. Jimenez GS, Planchon R, Wei Q, et al. Vaxfectin-formulated influenza DNA vaccines encoding NP and M2 viral proteins protect mice against lethal viral challenge. Hum Vaccin. 2007;3(5):157-164.
53. Kutzler MA, Weiner DB. DNA vaccines: ready for prime time? Nat Rev Genet. 2008;9(10):776-788.
54. Chen D, Maa YF, Haynes JR. Needle-free epidermal powder immunization. Expert Rev Vaccines. 2002;1(3):265-276.
55. Chen H, Zhu H, Zheng J, et al. Iontophoresis-driven penetration of nanovesicles through microneedle-induced skin microchannels for enhancing transdermal delivery of insulin. J Control Release. 2009;139(1):63-72.