Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: Assessments by transepidermal water loss

Toxicology in Vitro

Volumn 24, Issue 7, 2010, Pages 1971-1978

  Gomaa, Yasmine A ^a   Morrow, Desmond I J ^b   Garland, Martin J ^b   Donnelly, Ryan F ^b   El Khordagui, Labiba K ^c   Meidan, Victor M ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Human skin; Microneedles; Skin barrier function; Transepidermal water loss; Trypan blue assay

Indexed keywords

ARTICLE; CONTROLLED STUDY; DENSITY; ELASTICITY; EQUIPMENT DESIGN; FEMALE; HUMAN; HUMAN TISSUE; INJECTION; MICRONEEDLE; NEEDLE; PERMEABILITY BARRIER; SKIN FUNCTION; SKIN PERMEABILITY; SKIN WATER LOSS; TRANSPORT KINETICS;

ADMINISTRATION, CUTANEOUS; AGED; COLORING AGENTS; DRUG DELIVERY SYSTEMS; ELASTICITY; FEMALE; HUMANS; NEEDLES; POLYMERS; SKIN; TIME FACTORS; TRYPAN BLUE; WATER LOSS, INSENSIBLE;

EID: 77957019129     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2010.08.012     Document Type: Article

References (24)

1. Badran M.M., Kuntsche J., Fahr A. Skin penetration enhancement by a microneedle device (Dermaroller®) in vitro: dependency on needle size and applied formulation. Eur. J. Pharm. Sci. 2009, 36:511-523.
2. Bal S.M., Caussin J., Pavel S., Bouwstra J.A. In vivo assessment of safety of microneedle arrays in human skin. Eur. J. Pharm. Sci. 2008, 35:193-202.
3. Birchall, J.C., Clemo, R., Anstey, A., John, D.N., in press. Microneedles in clinical practice-an exploratory study into the opinions of healthcare professionals and the public. Pharm. Res.
4. Chilcott R.P., Dalton A.J., Emmanuel C.E., Allen C.E., Bradley S.T. Transepidermal water loss does not correlate with skin barrier function in vitro. J. Invest. Dermatol. 2002, 118:871-875.
5. Donnelly R.F., Singh T.R., Tunney M.M., Morrow D.I., McCarron P.A., O'Mahony C., Woolfson A.D. Microneedle arrays allow lower microbial penetration than hypodermic needles in vitro. Pharm. Res. 2009, 26:2513-2522.
6. Donnelly R.F., Raj Singh T.R., Woolfson A.D. Microneedle-based drug delivery systems: microfabrication, drug delivery and safety. Drug Deliver. 2010, 17:187-207.
7. Donnelly, R.F., Majithiya, R., Thakur, R.R.S., Morrow, D.I.J., Garland, M.J., Demir, Y.K., Migalska, K., Ryan, E., Gillen, D., Scott, C.J., Woolfson, A.D., in press. Design and physicochemical characterization of optimised polymeric microneedle arrays prepared by a novel laser-based micromoulding technique. Pharm. Res.
8. Elkeeb R., Hui X., Chan H., Tian L., Maibach H.I. Correlation of transepidermal water loss with skin barrier properties in vitro: comparison of three evaporimeters. Skin Res. Technol. 2010, 16:9-15.
9. Elmahjoubi E., Frum Y., Eccleston G.M., Wilkinson S.C., Meidan V.M. Transepidermal water loss for probing full-thickness skin barrier function: correlation with tritiated water flux, sensitivity to punctures and diverse surfactant exposures. Toxicol. In Vitro 2009, 23:1429-1435.
10. Farahmand S., Tien L., Hui X., Maibach H.I. Measuring transepidermal water loss: a comparative in vivo study of condenser-chamber and open-chamber systems. Skin Res. Technol. 2009, 15:392-398.
11. Fluhr J.W., Elsner P., Berardesca E., Maibach H.I. Bioengineering of the Skin: Water and the Stratum Corneum 2005, CRC Press, Boca Raton, FL. third ed.
12. Haq M.I., Smith E., John D.N., Kalavala M., Edwards C., Anstey A., Morrissey A., Birchall J.C. Clinical administration of microneedles: skin puncture, pain and sensation. Biomed Microdev. 2009, 11:35-47.
13. Imhof R.E., De Jesus M.E.P., Xiao P., Ciortea L.I., Berg E.P. Closed chamber transepidermal water loss measurement: microclimate, calibration and performance. Int. J. Cosmetic Sci. 2009, 31:97-118.
14. Li G., Badkar A., Kalluri H., Banga A.K. Microchannels created by sugar and metal microneedles: characterization by microscopy, macromolecular flux and other techniques. J. Pharm. Sci. 2010, 99:1931-1941.
15. Martanto W., Moore J.S., Couse J.S., Prausnitz M.R. Mechanism of fluid infusion during microneedle insertion and retraction. J. Controlled Release 2006, 112:357-361.
16. Meidan V.M., Michniak B.B. Emerging technologies in transdermal therapeutics. Am. J. Ther. 2004, 11:312-316.
17. Meidan V.M., Roper C.S. Inter- and intra-individual variability in human skin barrier function: a large scale retrospective study. Toxicol. In Vitro 2008, 22:1062-1069.
18. Milewski M., Brogden N.K., Stinchcomb A.L. Current aspects of formulation efforts and pore lifetime related to microneedle treatment of skin. Expert Opin. Drug Deliver. 2010, 7:617-629.
19. Prausnitz M.R. Microneedles for transdermal drug delivery. Adv. Drug Deliver. Rev. 2004, 56:581-587.
20. Prausnitz M.R., Langer R. Transdermal drug delivery. Nat. Biotechnol. 2008, 26:1261-1268.
21. Sivamani R.K., Stoeber B., Liepmann D., Maibach H.I. Microneedle penetration and injection past stratum corneum in humans. J. Dermatol. Treat 2009, 20:156-159.
22. Verbaan F.J., Bal S.M., van den Berg D.J., Groenink W.H.H., Verpoorten H., Lüttge R., Bouwstra J.A. Assembled microneedle arrays enhance the transport of compounds varying over a large range of molecular weight across human dermatomed skin. J. Controlled Release 2007, 117:238-245.
23. Wermeling D.P., Banks S.L., Hudson D.A., Gill H.S., Gupta J., Prausnitz M.R., Stinchcomb A.L. Microneedles permit transdermal delivery of a skin-impermeant medication to humans. Proc. Natl. Acad. Sci. USA 2008, 105:258-263.
24. Yan G., Warner K.S., Zhang J., Sharma S., Gale B.K. Evaluation needle length and density of microneedle arrays in the pretreatment of skin for transdermal drug delivery. Int. J. Pharm. 2010, 391:7-12.