Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d] Pyrimidine derivatives for their anti-inflammator

European Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2010, Pages 2994-3004

  Mohamed, Mosaad S ^a   Kamel, Rehab ^a   Fatahala, Samar S ^a  

^a Helwan   (Egypt)

Author keywords

Anti inflammatory activity; Anti microbial activity; Pyrrolo 2,3 d pyrimidine

Indexed keywords

(5,6 DIPHENYL 2,4 DITHIOXO 3,4 DIHYDRO 1H PYRROLO[2,3 D]PYRIMI DIN 7(2H)YL) 1,4 DIMETHYL 2 PHENYL 1H PYRAZOL 3(2H)ONE; 2 BENZYLIDENE 8 (2,4 DIMETHYL 5 OXO 1 PHENYL 2,5 DIHYDRO 1H PYRAZOL 3 YL) 6,7 DIPHENYL 5 THIOXO 5,8 DIHYDROPYRROLO[2,3 D]THIAZOLO[3,2 A]PYRIMIDIN 3(2H) ONE; 2 BENZYLIDENE 8 (3,4 DICHLOROPHENYL) 6 PHENYL 5 THIOXO 5,8 DIHYDRO PYRROLO[2,3 D]THIAZOLO[3,2 A]PYRIMIDIN 3(2H) ONE; 4 AMINO 7 (3,4 DICHLOROPHENYL) 5 PHENYL 1H PYRROLO[2,3 D]PYRAM IDINE 2(7H) THIONE; 4 AMINO 7 BENZYL 5,6 DIPHENYL 1H PYRROLO[2,3 D]PYRIMIDINE 2(7H) THIONE; 5 (4 AMINO 2 HYDRAZINYL 5,6 DIPHENYL 7H PYRROLO[2,3 D]PYRIMIDIN 7 YL) 1,4 DIMETHYL 2 PHENYL 1H PYRAZOL 3(2H) ONE; 5 (4 AMINO 5,6 DIPHENYL 2 THIOXO 1H PYRROLO[2,3 D]PYRIMIDIN 7(2H)YL) 1,4 DIMETHYL 2 PHENYL 1H PYRAZOL 3(2H)ONE; 5 (4 IMINO 3,5,6 TRIPHENYL 2 THIOXO 3,4 DIHYDRO 1H PYRROLO[2,3D]PYRIMIDIN 7(2H)YL) 1,4 DIMETHYL 2 PHENYL 1H PYRAZOL 3(2H) ONE; 7 (3,4 DICHLOROPHENYL) 2 HYDRAZINYL 5 PHENYL 7H PYRROLO[2,3 D]PYRIMIDIN 4 AMINE; 7 (3,4 DICHLOROPHENYL) 4 IMINO 3,5 DIPHENYL 3,4 DIHYDRO 1H PYRROLO[2,3 D]PYRIMIDINE 2(7H) THIONE; 7 (3,4 DICHLOROPHENYL) 5 PHENYL 1H PYRROLO[2,3 D]PYRIMIDINE 2,4(3H,7H) DITHIONE; 7 BENZYL 2 HYDRAZINYL 5,6 DIPHENYL 7H PYRROLO[2,3 D]PYRIMIDIN 4 AMINE; 7 BENZYL 4 IMINO 3,5,6 TRIPHENYL 3,4 DIHYDRO 1H PYRROLO[2,3 D]PYRIMIDINE 2(7H) THIONE; 7 BENZYL 5,6 DIPHENYL 1H PYRROLO[2,3 D]PYRIMIDINE 2,4(3H,7H) DITHIONE; 8 (2,4 DIMETHYL 5 OXO 1 PHENYL 2,5 DIHYDRO 1H PYRAZOL 3 YL) 6,7 DIPHENYL 5 THIOXO 5,8 DIHYDROPYRROLO[2,3 D]THIAZOLO[3,2 A]PYRIMIDIN 3(2H) ONE; 8 (3,4 DICHLOROPHENYL) 6 PHENYL 5 THIOXO 5,8 DIHYDROPYRROLO[2,3 D]THIAZOLO[3,2 A]PYRIMIDIN 3(2H) ONE; 8 BENZYL 2 BENZYLIDENE 6,7 DIPHENYL 5 THIOXO 5,8 DIHYDROPYRROLO[2,3 D]THIAZOLO[3,2 A]PYRIMIDIN 3(2H) ONE; 8 BENZYL 6,7 DIPHENYL 5 THIOXO 5,8 DIHYDROPYRROLO[2,3 D]THIAZOLO[3,2 A]PYRIMIDIN 3(2H) ONE; IBUPROFEN; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PAW EDEMA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

EID: 77954384344     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.03.028     Document Type: Article

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