Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives and evaluation of their activities against human colon cancer cell lines

European Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2010, Pages 1453-1458

  Tangeda, Saritha Jyostna ^a   Garlapati, Achaiah ^a  

^a KAKATIYA UNIVERSITY   (India)

Author keywords

Apoptosis; Cytotoxicity; Pyrrolo(2,3 d)pyrimidine

Indexed keywords

2 AMINO 6 METHYL 5 [(2' PYRIMIDINY)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO [2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [2' (1' METHYLIMIDAZOLYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO [2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [2' (5' BROMOBENZIMIDAZOLYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO [2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [2' (5' CHLOROBENZIMIDAZOLYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO [2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [2' (5' METHYLBENZIMIDAZOLYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO [2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [2' (5' NITROBENZIMIDAZOLYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO [2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [2' (5' PHENYL 1',3',4' OXADIZOLYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO [2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [2' (BENZIMIDAZOLYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO [2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [2' (BENZOTHIAZOLYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO [2,3 D]PYRIMIDINE; 2 AMINO 6 METHYL 5 [2' (PYRIMIDINYL)SULFANYL] 3,4 DIHYDRO 4 OXO 7H PYRROLO [2,3 I]PYRIMIDINE; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE; BENZOTHIAZOLE; FLUOROURACIL; PYRROLO[2,3 B]PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

APOPTOSIS; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; HCT116 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; PYRIMIDINES; PYRROLES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77349101269     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.12.050     Document Type: Article

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