메뉴 건너뛰기




Volumn 13, Issue 8, 2013, Pages 1241-1249

iNOS: A potential therapeutic target for malignant glioma

Author keywords

Astrocytes; Brain tumor stem cells; Egfrviii; Glioblastoma; Inos; Invasiveness; No; Proliferation; Signaling; Stat3

Indexed keywords

CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 8; N (2 CYCLOHEXYLOXY 4 NITROPHENYL) METHANESULFONAMIDE; N (G) NITROARGININE METHYL ESTER; N [3 (AMINOMETHYL) BENZYL] ACETAMIDINE; NESTIN; NITRIC OXIDE; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; STAT3 PROTEIN; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

EID: 84884171936     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/1566524011313080002     Document Type: Article
Times cited : (55)

References (121)
  • 1
    • 0035256772 scopus 로고    scopus 로고
    • Gliomagenesis: Genetic alterations and mouse models
    • Holland EC. Gliomagenesis: genetic alterations and mouse models. Nat Rev Genet 2001; 2: 120-129.
    • (2001) Nat Rev Genet , vol.2 , pp. 120-129
    • Holland, E.C.1
  • 2
    • 34547122001 scopus 로고    scopus 로고
    • The 2007 WHO classification of tumours of the central nervous system
    • Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007; 114: 97-109.
    • (2007) Acta Neuropathol , vol.114 , pp. 97-109
    • Louis, D.N.1    Ohgaki, H.2    Wiestler, O.D.3
  • 3
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987-996.
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 4
    • 33846120980 scopus 로고    scopus 로고
    • Therapeutic advances for glioblastoma multiforme: Current status and future prospects
    • Robins HI, Chang S, Butowski N, Mehta M. Therapeutic advances for glioblastoma multiforme: current status and future prospects. Curr Oncol Reports 2007; 9: 66-70.
    • (2007) Curr Oncol Reports , vol.9 , pp. 66-70
    • Robins, H.I.1    Chang, S.2    Butowski, N.3    Mehta, M.4
  • 5
    • 0034987702 scopus 로고    scopus 로고
    • Malignant glioma: Genetics and biology of a grave matter
    • Maher EA, Furnari FB, Bachoo RM, et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev 2001; 15: 1311-1333.
    • (2001) Genes Dev , vol.15 , pp. 1311-1333
    • Maher, E.A.1    Furnari, F.B.2    Bachoo, R.M.3
  • 6
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma: Genetics, biology, and paths to treatment
    • Furnari FB, Fenton T, Bachoo RM, et al. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 2007; 21: 2683-2710.
    • (2007) Genes Dev , vol.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3
  • 7
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med 2008; 359: 492-507.
    • (2008) N Engl J Med , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 8
    • 19044397160 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
    • Bachoo RM, Maher EA, Ligon KL, et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 2002; 1:269-277.
    • (2002) Cancer Cell , vol.1 , pp. 269-277
    • Bachoo, R.M.1    Maher, E.A.2    Ligon, K.L.3
  • 9
    • 0036791177 scopus 로고    scopus 로고
    • Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt
    • Uhrbom L, Dai C, Celestino JC, et al. Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. Cancer Res 2002; 62: 5551-5558.
    • (2002) Cancer Res , vol.62 , pp. 5551-5558
    • Uhrbom, L.1    Dai, C.2    Celestino, J.C.3
  • 10
    • 33645732219 scopus 로고    scopus 로고
    • Molecular pathology of malignant gliomas
    • Louis DN: Molecular pathology of malignant gliomas. Annu Rev Pathol 2006; 1: 97-117.
    • (2006) Annu Rev Pathol , vol.1 , pp. 97-117
    • Louis, D.N.1
  • 11
    • 0346059618 scopus 로고    scopus 로고
    • Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity
    • Bajenaru ML, Hernandez MR, Perry A, et al. Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res 2003; 63: 8573-8577.
    • (2003) Cancer Res , vol.63 , pp. 8573-8577
    • Bajenaru, M.L.1    Hernandez, M.R.2    Perry, A.3
  • 12
    • 0037302119 scopus 로고    scopus 로고
    • Signaling pathways regulating gliomagenesis
    • Konopka G, Bonni A. Signaling pathways regulating gliomagenesis. Curr Mol Med 2003; 3: 73-84.
    • (2003) Curr Mol Med , vol.3 , pp. 73-84
    • Konopka, G.1    Bonni, A.2
  • 13
    • 84859183715 scopus 로고    scopus 로고
    • Malignant glioma: Lessons from genomics, mouse models, and stem cells
    • Chen J, McKay RM, Parada LF. Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell 2012; 149: 36-47.
    • (2012) Cell , vol.149 , pp. 36-47
    • Chen, J.1    McKay, R.M.2    Parada, L.F.3
  • 14
    • 0026548240 scopus 로고
    • Structural alterations of the epidermal growth factor receptor gene in human gliomas
    • Wong AJ, Ruppert JM, Bigner SH, et al. Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci USA 1992; 89: 2965-2969.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 2965-2969
    • Wong, A.J.1    Ruppert, J.M.2    Bigner, S.H.3
  • 15
    • 0035142469 scopus 로고    scopus 로고
    • Aberrant receptor signaling in human malignant gliomas: Mechanisms and therapeutic implications
    • Nagane M, Lin H, Cavenee WK, Huang HJ. Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications. Cancer Lett 2001; 162: S17-S21.
    • (2001) Cancer Lett , vol.162
    • Nagane, M.1    Lin, H.2    Cavenee, W.K.3    Huang, H.J.4
  • 16
    • 84858156041 scopus 로고    scopus 로고
    • Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations
    • Han W, Lo HW. Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations. Cancer Lett 2012; 318: 124-134.
    • (2012) Cancer Lett , vol.318 , pp. 124-134
    • Han, W.1    Lo, H.W.2
  • 17
    • 33845370278 scopus 로고    scopus 로고
    • Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: Correlation with EGFR status, tumor grade, and survival
    • Mizoguchi M, Betensky RA, Batchelor TT, et al. Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival. J Neuropath Exp Neur 2006; 65: 1181-1188.
    • (2006) J Neuropath Exp Neur , vol.65 , pp. 1181-1188
    • Mizoguchi, M.1    Betensky, R.A.2    Batchelor, T.T.3
  • 18
    • 3543025709 scopus 로고    scopus 로고
    • Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II
    • Boerner JL, Demory ML, Silva C, Parsons SJ. Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II. Mol Cell Biol 2004; 24: 7059-7071.
    • (2004) Mol Cell Biol , vol.24 , pp. 7059-7071
    • Boerner, J.L.1    Demory, M.L.2    Silva, C.3    Parsons, S.J.4
  • 19
    • 73649140612 scopus 로고    scopus 로고
    • Epidermal growth factor receptor translocation to the mitochondria: Regulation and effect
    • Demory ML, Boerner JL, Davidson R, et al. Epidermal growth factor receptor translocation to the mitochondria: regulation and effect. J Biol Chem 2009; 284: 36592-36604.
    • (2009) J Biol Chem , vol.284 , pp. 36592-36604
    • Demory, M.L.1    Boerner, J.L.2    Davidson, R.3
  • 20
    • 48249138450 scopus 로고    scopus 로고
    • Mitochondrially localized EGFR is subjected to autophagic regulation and implicated in cell survival
    • Yue X, Song W, Zhang W, et al. Mitochondrially localized EGFR is subjected to autophagic regulation and implicated in cell survival. Autophagy 2008; 4: 641-649.
    • (2008) Autophagy , vol.4 , pp. 641-649
    • Yue, X.1    Song, W.2    Zhang, W.3
  • 21
    • 0034855942 scopus 로고    scopus 로고
    • Nuclear localization of EGF receptor and its potential new role as a transcription factor
    • Lin SY, Makino K, Xia W, et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 2001; 3: 802-808.
    • (2001) Nat Cell Biol , vol.3 , pp. 802-808
    • Lin, S.Y.1    Makino, K.2    Xia, W.3
  • 23
    • 39449093328 scopus 로고    scopus 로고
    • Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
    • de la Iglesia N, Konopka G, Puram SV, et al. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev 2008; 22: 449-462.
    • (2008) Genes Dev , vol.22 , pp. 449-462
    • de la Iglesia, N.1    Konopka, G.2    Puram, S.V.3
  • 24
    • 77954759289 scopus 로고    scopus 로고
    • Nuclear trafficking of the epidermal growth factor receptor family membrane proteins
    • Wang YN, Yamaguchi H, Hsu JM, Hung MC. Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene 2010; 29: 3997-4006.
    • (2010) Oncogene , vol.29 , pp. 3997-4006
    • Wang, Y.N.1    Yamaguchi, H.2    Hsu, J.M.3    Hung, M.C.4
  • 25
    • 79151472321 scopus 로고    scopus 로고
    • Nuclear mode of the EGFR signaling network: Biology, prognostic value, and therapeutic implications
    • Lo HW. Nuclear mode of the EGFR signaling network: biology, prognostic value, and therapeutic implications. Discovery Med 2010; 10: 44-51.
    • (2010) Discovery Med , vol.10 , pp. 44-51
    • Lo, H.W.1
  • 26
    • 70350525582 scopus 로고    scopus 로고
    • STAT3 regulation of glioblastoma pathogenesis
    • de la Iglesia N, Puram SV, Bonni A. STAT3 regulation of glioblastoma pathogenesis. Curr Mol Med 2009, 9: 580-590.
    • (2009) Curr Mol Med , vol.9 , pp. 580-590
    • de la Iglesia, N.1    Puram, S.V.2    Bonni, A.3
  • 28
    • 0032525155 scopus 로고    scopus 로고
    • Multiple routes to astrocytic differentiation in the CNS
    • Rajan P, McKay RD. Multiple routes to astrocytic differentiation in the CNS. J Neurosci 1998; 18: 3620-3629.
    • (1998) J Neurosci , vol.18 , pp. 3620-3629
    • Rajan, P.1    McKay, R.D.2
  • 29
    • 0030708523 scopus 로고    scopus 로고
    • Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway
    • Bonni A, Sun Y, Nadal-Vicens M, et al. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 1997; 278: 477-483.
    • (1997) Science , vol.278 , pp. 477-483
    • Bonni, A.1    Sun, Y.2    Nadal-Vicens, M.3
  • 30
    • 33746397211 scopus 로고    scopus 로고
    • Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex
    • Yoshimatsu T, Kawaguchi D, Oishi K, et al. Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex. Development 2006; 133:2553-2563.
    • (2006) Development , vol.133 , pp. 2553-2563
    • Yoshimatsu, T.1    Kawaguchi, D.2    Oishi, K.3
  • 31
    • 44949176222 scopus 로고    scopus 로고
    • Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness
    • de la Iglesia N, Konopka G, Lim KL, et al. Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. J Neurosci 2008; 28: 5870-5878.
    • (2008) J Neurosci , vol.28 , pp. 5870-5878
    • de la Iglesia, N.1    Konopka, G.2    Lim, K.L.3
  • 32
    • 84861921204 scopus 로고    scopus 로고
    • STAT3-iNOS Signaling Mediates EGFRvIII-Induced Glial Proliferation and Transformation
    • Puram SV, Yeung CM, Jahani-Asl A, et al. STAT3-iNOS Signaling Mediates EGFRvIII-Induced Glial Proliferation and Transformation. J Neurosci 2012; 32: 7806-7818.
    • (2012) J Neurosci , vol.32 , pp. 7806-7818
    • Puram, S.V.1    Yeung, C.M.2    Jahani-Asl, A.3
  • 33
    • 1542349094 scopus 로고    scopus 로고
    • The STAT3 DNA-binding domain mediates interaction with NF-kappaB p65 and inducible nitric oxide synthase transrepression in mesangial cells
    • Yu Z, Kone BC. The STAT3 DNA-binding domain mediates interaction with NF-kappaB p65 and inducible nitric oxide synthase transrepression in mesangial cells. J Am Soc Nephrol (JASN) 2004; 15: 585-591.
    • (2004) J Am Soc Nephrol (JASN) , vol.15 , pp. 585-591
    • Yu, Z.1    Kone, B.C.2
  • 34
    • 0036797750 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB
    • Yu Z, Zhang W, Kone BC. Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB. Biochem J 2002; 367: 97-105.
    • (2002) Biochem J , vol.367 , pp. 97-105
    • Yu, Z.1    Zhang, W.2    Kone, B.C.3
  • 35
    • 3042748279 scopus 로고    scopus 로고
    • Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells
    • Konnikova L, Kotecki M, Kruger MM, Cochran BH. Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC Cancer 2003; 3: 23.
    • (2003) BMC Cancer , vol.3 , pp. 23
    • Konnikova, L.1    Kotecki, M.2    Kruger, M.M.3    Cochran, B.H.4
  • 36
    • 0037028249 scopus 로고    scopus 로고
    • Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells
    • Rahaman SO, Harbor PC, Chernova O, et al. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene 2002; 21: 8404-8413.
    • (2002) Oncogene , vol.21 , pp. 8404-8413
    • Rahaman, S.O.1    Harbor, P.C.2    Chernova, O.3
  • 37
    • 60349107511 scopus 로고    scopus 로고
    • Stat3 activation is required for the growth of U87 cell-derived tumours in mice
    • Dasgupta A, Raychaudhuri B, Haqqi T, et al. Stat3 activation is required for the growth of U87 cell-derived tumours in mice. Eur J Cancer 2009; 45: 677-684.
    • (2009) Eur J Cancer , vol.45 , pp. 677-684
    • Dasgupta, A.1    Raychaudhuri, B.2    Haqqi, T.3
  • 38
    • 75149195336 scopus 로고    scopus 로고
    • The transcriptional network for mesenchymal transformation of brain tumours
    • Carro MS, Lim WK, Alvarez MJ, et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 2010; 463: 318-325.
    • (2010) Nature , vol.463 , pp. 318-325
    • Carro, M.S.1    Lim, W.K.2    Alvarez, M.J.3
  • 39
    • 46949092766 scopus 로고    scopus 로고
    • Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells
    • Gu J, Li G, Sun T, et al. Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells. J Neuro-Oncol 2008, 89: 9-17.
    • (2008) J Neuro-Oncol , vol.89 , pp. 9-17
    • Gu, J.1    Li, G.2    Sun, T.3
  • 40
    • 79959969874 scopus 로고    scopus 로고
    • Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2
    • Eyler CE, Wu Q, Yan K, et al. Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Cell 2011;146: 53-66.
    • (2011) Cell , vol.146 , pp. 53-66
    • Eyler, C.E.1    Wu, Q.2    Yan, K.3
  • 41
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology, and pharmacology
    • Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109-142.
    • (1991) Pharmacol Rev , vol.43 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.2    Higgs, E.A.3
  • 42
    • 0036196417 scopus 로고    scopus 로고
    • NO as a signalling molecule in the nervous system
    • Esplugues JV. NO as a signalling molecule in the nervous system. Brit J Pharmacol 2002; 135: 1079-1095.
    • (2002) Brit J Pharmacol , vol.135 , pp. 1079-1095
    • Esplugues, J.V.1
  • 43
    • 70349109668 scopus 로고    scopus 로고
    • Cerebral blood flow regulation by nitric oxide in neurological disorders
    • Toda N, Ayajiki K, Okamura T. Cerebral blood flow regulation by nitric oxide in neurological disorders. Can. J Physiol Pharm 2009; 87: 581-594.
    • (2009) Can J Physiol Pharm , vol.87 , pp. 581-594
    • Toda, N.1    Ayajiki, K.2    Okamura, T.3
  • 44
  • 45
    • 9244232804 scopus 로고    scopus 로고
    • Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53
    • Forrester K, Ambs S, Lupold SE, et al. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53. Proc Natl Acad Sci USA 1996; 93: 2442-2447.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2442-2447
    • Forrester, K.1    Ambs, S.2    Lupold, S.E.3
  • 46
    • 0346690271 scopus 로고    scopus 로고
    • Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells
    • Cobbs CS, Whisenhunt TR, Wesemann DR, et al. Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells. Cancer Res 2003; 63: 8670-8673.
    • (2003) Cancer Res , vol.63 , pp. 8670-8673
    • Cobbs, C.S.1    Whisenhunt, T.R.2    Wesemann, D.R.3
  • 47
    • 79959582633 scopus 로고    scopus 로고
    • Nitric oxide: Role in tumour biology and iNOS/NO-based anticancer therapies
    • Singh S, Gupta AK. Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapies. Cancer Chemother Pharmacol 2011; 67: 1211-1224.
    • (2011) Cancer Chemother Pharmacol , vol.67 , pp. 1211-1224
    • Singh, S.1    Gupta, A.K.2
  • 48
    • 0035853035 scopus 로고    scopus 로고
    • Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): Potential role of cyclin D1
    • Pervin S, Singh R, Chaudhuri G. Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1. Proc Natl Acad Sci USA 2001; 98: 3583-3588.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3583-3588
    • Pervin, S.1    Singh, R.2    Chaudhuri, G.3
  • 49
    • 0035874941 scopus 로고    scopus 로고
    • Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: Implications in breast cancer
    • Pervin S, Singh R, Gau CL, et al. Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: implications in breast cancer. Cancer Res 2001; 61: 4701-4706.
    • (2001) Cancer Res , vol.61 , pp. 4701-4706
    • Pervin, S.1    Singh, R.2    Gau, C.L.3
  • 50
    • 33846416533 scopus 로고    scopus 로고
    • Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: Involvement of mammalian target of rapamycin/eIF4E pathway
    • Pervin S, Singh R, Hernandez E, Wu G, Chaudhuri G. Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway. Cancer Res 2007; 67: 289-299.
    • (2007) Cancer Res , vol.67 , pp. 289-299
    • Pervin, S.1    Singh, R.2    Hernandez, E.3    Wu, G.4    Chaudhuri, G.5
  • 51
    • 2942665472 scopus 로고    scopus 로고
    • Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide
    • Thomas DD, Espey MG, Ridnour LA, et al. Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proc Natl Acad Sci USA 2004; 101: 8894-8899.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8894-8899
    • Thomas, D.D.1    Espey, M.G.2    Ridnour, L.A.3
  • 52
    • 36749026266 scopus 로고    scopus 로고
    • Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways
    • Ridnour LA, Windhausen AN, Isenberg JS, et al. Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. Proc Natl Acad Sci USA 2007; 104: 16898-16903.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 16898-16903
    • Ridnour, L.A.1    Windhausen, A.N.2    Isenberg, J.S.3
  • 54
    • 2542455472 scopus 로고    scopus 로고
    • iNOS-mediated nitric oxide production and its regulation
    • Aktan F. iNOS-mediated nitric oxide production and its regulation. Life Sci 2004; 75: 639-653.
    • (2004) Life Sci , vol.75 , pp. 639-653
    • Aktan, F.1
  • 55
    • 0031196115 scopus 로고    scopus 로고
    • Nitric oxide and reproduction
    • Rosselli M. Nitric oxide and reproduction. Mol Hum Reprod 1997; 3: 639-641.
    • (1997) Mol Hum Reprod , vol.3 , pp. 639-641
    • Rosselli, M.1
  • 56
    • 84859487532 scopus 로고    scopus 로고
    • Nitric oxide synthases: Regulation and function
    • Forstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J 2012; 33: 829-837.
    • (2012) Eur Heart J , vol.33 , pp. 829-837
    • Forstermann, U.1    Sessa, W.C.2
  • 58
    • 0028035106 scopus 로고
    • The high-output nitric oxide pathway: Role and regulation
    • Xie Q, Nathan C. The high-output nitric oxide pathway: role and regulation. J Leukoc Biol 1994; 56: 576-582.
    • (1994) J Leukoc Biol , vol.56 , pp. 576-582
    • Xie, Q.1    Nathan, C.2
  • 59
  • 60
    • 0345547431 scopus 로고    scopus 로고
    • Regulation of the expression of inducible nitric oxide synthase
    • Kleinert H, Schwarz PM, Forstermann U. Regulation of the expression of inducible nitric oxide synthase. Biol Chem 2003; 384: 1343-1364.
    • (2003) Biol Chem , vol.384 , pp. 1343-1364
    • Kleinert, H.1    Schwarz, P.M.2    Forstermann, U.3
  • 61
    • 78649767464 scopus 로고    scopus 로고
    • Reciprocal activation of macrophages and breast carcinoma cells by nitric oxide and colony-stimulating factor-1
    • Lin CW, Shen SC, Ko CH, Lin HY, Chen YC. Reciprocal activation of macrophages and breast carcinoma cells by nitric oxide and colony-stimulating factor-1. Carcinogenesis 2010; 31: 2039-2048.
    • (2010) Carcinogenesis , vol.31 , pp. 2039-2048
    • Lin, C.W.1    Shen, S.C.2    Ko, C.H.3    Lin, H.Y.4    Chen, Y.C.5
  • 62
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo G, Musso T, Sica A, et al. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J Exp Med 1995; 182: 1683-1693.
    • (1995) J Exp Med , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3
  • 63
    • 33746864818 scopus 로고    scopus 로고
    • Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling
    • Du Q, Park KS, Guo Z, et al. Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling. Cancer Res 2006; 66: 7024-7031.
    • (2006) Cancer Res , vol.66 , pp. 7024-7031
    • Du, Q.1    Park, K.S.2    Guo, Z.3
  • 64
    • 39149132505 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase: Correlation with extracapsular spread and enhancement of tumor cell invasion in head and neck squamous cell carcinoma
    • Brennan PA, Dennis S, Poller D, et al. Inducible nitric oxide synthase: correlation with extracapsular spread and enhancement of tumor cell invasion in head and neck squamous cell carcinoma. Head Neck 2008; 30: 208-214.
    • (2008) Head Neck , vol.30 , pp. 208-214
    • Brennan, P.A.1    Dennis, S.2    Poller, D.3
  • 65
    • 0029024521 scopus 로고
    • Nitric oxide synthase activity in human breast cancer
    • Thomsen LL, Miles DW, Happerfield L, et al. Nitric oxide synthase activity in human breast cancer. Brit J Cancer 1995; 72: 41-44.
    • (1995) Brit J Cancer , vol.72 , pp. 41-44
    • Thomsen, L.L.1    Miles, D.W.2    Happerfield, L.3
  • 66
    • 0034083406 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas
    • Vakkala M, Kahlos K, Lakari E, et al. Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas. Clin Cancer Res 2000; 6: 2408-2416.
    • (2000) Clin Cancer Res , vol.6 , pp. 2408-2416
    • Vakkala, M.1    Kahlos, K.2    Lakari, E.3
  • 67
    • 0031984809 scopus 로고    scopus 로고
    • Frequent nitric oxide synthase-2 expression in human colon adenomas: Implication for tumor angiogenesis and colon cancer progression
    • Ambs S, Merriam WG, Bennett WP, et al. Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res 1998; 58: 334-341.
    • (1998) Cancer Res , vol.58 , pp. 334-341
    • Ambs, S.1    Merriam, W.G.2    Bennett, W.P.3
  • 68
    • 33747892706 scopus 로고    scopus 로고
    • Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer
    • Chen CN, Hsieh FJ, Cheng YM, Chang KJ, Lee PH. Expression of inducible nitric oxide synthase and cyclooxygenase-2 in angiogenesis and clinical outcome of human gastric cancer. J Surg Oncol 2006; 94: 226-233.
    • (2006) J Surg Oncol , vol.94 , pp. 226-233
    • Chen, C.N.1    Hsieh, F.J.2    Cheng, Y.M.3    Chang, K.J.4    Lee, P.H.5
  • 69
    • 0034488632 scopus 로고    scopus 로고
    • Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma
    • Marrogi AJ, Travis WD, Welsh JA, et al. Nitric oxide synthase, cyclooxygenase 2, and vascular endothelial growth factor in the angiogenesis of non-small cell lung carcinoma. Clin Cancer Res 2000; 6: 4739-4744.
    • (2000) Clin Cancer Res , vol.6 , pp. 4739-4744
    • Marrogi, A.J.1    Travis, W.D.2    Welsh, J.A.3
  • 70
    • 78049426509 scopus 로고    scopus 로고
    • Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients
    • Glynn SA, Boersma BJ, Dorsey TH, et al. Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. J Clin Invest 2010; 120: 3843-3854.
    • (2010) J Clin Invest , vol.120 , pp. 3843-3854
    • Glynn, S.A.1    Boersma, B.J.2    Dorsey, T.H.3
  • 71
    • 0028873889 scopus 로고
    • Expression of nitric oxide synthase in human central nervous system tumors
    • Cobbs CS, Brenman JE, Aldape KD, Bredt DS, Israel MA. Expression of nitric oxide synthase in human central nervous system tumors. Cancer Res 1995; 55: 727-730.
    • (1995) Cancer Res , vol.55 , pp. 727-730
    • Cobbs, C.S.1    Brenman, J.E.2    Aldape, K.D.3    Bredt, D.S.4    Israel, M.A.5
  • 72
    • 0028089793 scopus 로고
    • Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas
    • Garvey EP, Oplinger JA, Tanoury GJ, et al. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem 1994; 269: 26669-26676.
    • (1994) J Biol Chem , vol.269 , pp. 26669-26676
    • Garvey, E.P.1    Oplinger, J.A.2    Tanoury, G.J.3
  • 73
    • 14644387458 scopus 로고    scopus 로고
    • 1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats
    • Jafarian-Tehrani M, Louin G, Royo NC, et al. 1400W, a potent selective inducible NOS inhibitor, improves histopathological outcome following traumatic brain injury in rats. Nitric Oxide 2005; 12: 61-69.
    • (2005) Nitric Oxide , vol.12 , pp. 61-69
    • Jafarian-Tehrani, M.1    Louin, G.2    Royo, N.C.3
  • 74
    • 0028848015 scopus 로고
    • Isothioureas. potent inhibitors of nitric oxide synthases with variable isoform selectivity
    • Southan GJ, Szabo C, Thiemermann C. Isothioureas. potent inhibitors of nitric oxide synthases with variable isoform selectivity. Brit J Pharmacol 1995; 114: 510-516.
    • (1995) Brit J Pharmacol , vol.114 , pp. 510-516
    • Southan, G.J.1    Szabo, C.2    Thiemermann, C.3
  • 75
    • 0030859159 scopus 로고    scopus 로고
    • Differential effect of L-NAME and S-methyl-isothiourea on leukocyte emigration in carrageenin-soaked sponge implants in rat
    • Iuvone T, Van Osselaer N, D'Acquisto F, Carnuccio R, Herman AG. Differential effect of L-NAME and S-methyl-isothiourea on leukocyte emigration in carrageenin-soaked sponge implants in rat. Brit J Pharm 1997; 121: 1637-1644.
    • (1997) Brit J Pharm , vol.121 , pp. 1637-1644
    • Iuvone, T.1    van Osselaer, N.2    D'Acquisto, F.3    Carnuccio, R.4    Herman, A.G.5
  • 76
    • 0027403233 scopus 로고
    • Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor NO through a radical reaction
    • Akaike T, Yoshida M, Miyamoto Y, et al. Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor NO through a radical reaction. Biochemistry 1993; 3: 827-832.
    • (1993) Biochemistry , vol.3 , pp. 827-832
    • Akaike, T.1    Yoshida, M.2    Miyamoto, Y.3
  • 77
    • 0028104024 scopus 로고
    • Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: In vivo and in vitro studies
    • Tsunoda R, Okumura K, Ishizaka H, et al. Vasodilator effect of carboxy-2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl in the coronary circulation: in vivo and in vitro studies. Eur J Pharm 1994; 262: 55-63.
    • (1994) Eur J Pharm , vol.262 , pp. 55-63
    • Tsunoda, R.1    Okumura, K.2    Ishizaka, H.3
  • 78
    • 0029129181 scopus 로고
    • Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF
    • Rand MJ, Li CG. Discrimination by the NO-trapping agent, carboxy-PTIO, between NO and the nitrergic transmitter but not between NO and EDRF. Brit J Pharmacol 1995; 116: 1906-1910.
    • (1995) Brit J Pharmacol , vol.116 , pp. 1906-1910
    • Rand, M.J.1    Li, C.G.2
  • 79
    • 36448990795 scopus 로고    scopus 로고
    • Brain tumour stem cells: The undercurrents of human brain cancer and their relationship to neural stem cells
    • Dirks PB. Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells. Philos Trans R Soc Lond B Biol Sci 2008; 363: 139-152.
    • (2008) Philos Trans R Soc Lond B Biol Sci , vol.363 , pp. 139-152
    • Dirks, P.B.1
  • 80
    • 33846485093 scopus 로고    scopus 로고
    • Brain tumor stem cells: Identification and concepts
    • Singh S, Dirks PB. Brain tumor stem cells: identification and concepts. Neurosurg Clin N Am 2007; 18: 31-38.
    • (2007) Neurosurg Clin N Am , vol.18 , pp. 31-38
    • Singh, S.1    Dirks, P.B.2
  • 81
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature 2004; 432: 396-401.
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 82
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells
    • Clarke MF, Dick JE, Dirks PB, et al. Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006, 66: 9339-9344.
    • (2006) Cancer Res , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3
  • 83
    • 33646358694 scopus 로고    scopus 로고
    • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    • Lee J, Kotliarova S, Kotliarov Y, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006; 9:391-403.
    • (2006) Cancer Cell , vol.9 , pp. 391-403
    • Lee, J.1    Kotliarova, S.2    Kotliarov, Y.3
  • 84
    • 69849099673 scopus 로고    scopus 로고
    • Biology of glioma cancer stem cells
    • Park DM, Rich JN. Biology of glioma cancer stem cells. Mol Cells 2009; 28: 7-12.
    • (2009) Mol Cells , vol.28 , pp. 7-12
    • Park, D.M.1    Rich, J.N.2
  • 86
    • 33846029123 scopus 로고    scopus 로고
    • A perivascular niche for brain tumor stem cells
    • Calabrese C, Poppleton H, Kocak M, et al. A perivascular niche for brain tumor stem cells. Cancer Cell 2007; 11: 69-82.
    • (2007) Cancer Cell , vol.11 , pp. 69-82
    • Calabrese, C.1    Poppleton, H.2    Kocak, M.3
  • 87
    • 34648821254 scopus 로고    scopus 로고
    • Making a tumour's bed: Glioblastoma stem cells and the vascular niche
    • Gilbertson RJ, Rich JN. Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nat Rev Cancer 2007; 7: 733-736.
    • (2007) Nat Rev Cancer , vol.7 , pp. 733-736
    • Gilbertson, R.J.1    Rich, J.N.2
  • 89
    • 0032564409 scopus 로고    scopus 로고
    • Nitrosative stress: Metabolic pathway involving the flavohemoglobin
    • Hausladen A, Gow AJ, Stamler JS. Nitrosative stress: metabolic pathway involving the flavohemoglobin. Proc Natl Acad Sci USA 1998; 95: 14100-14105.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14100-14105
    • Hausladen, A.1    Gow, A.J.2    Stamler, J.S.3
  • 90
    • 0030877443 scopus 로고    scopus 로고
    • Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor
    • Thomsen LL, Scott JM, Topley P, et al. Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res 1997; 57: 3300-3304.
    • (1997) Cancer Res , vol.57 , pp. 3300-3304
    • Thomsen, L.L.1    Scott, J.M.2    Topley, P.3
  • 91
    • 0032850637 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors
    • Jadeski LC, Lala PK. Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors. Am J Pathol 1999; 155: 1381-1390.
    • (1999) Am J Pathol , vol.155 , pp. 1381-1390
    • Jadeski, L.C.1    Lala, P.K.2
  • 92
    • 0031018039 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine
    • Tozer GM, Prise VE, Chaplin DJ. Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine. Cancer Res 1997; 57: 948-955.
    • (1997) Cancer Res , vol.57 , pp. 948-955
    • Tozer, G.M.1    Prise, V.E.2    Chaplin, D.J.3
  • 93
    • 0035284055 scopus 로고    scopus 로고
    • Genetic disruption of host nitric oxide synthase II gene impairs melanoma-induced angiogenesis and suppresses pleural effusion
    • Wang B, Xiong Q, Shi Q, et al. Genetic disruption of host nitric oxide synthase II gene impairs melanoma-induced angiogenesis and suppresses pleural effusion. Int J Cancer 2001; 91: 607-611.
    • (2001) Int J Cancer , vol.91 , pp. 607-611
    • Wang, B.1    Xiong, Q.2    Shi, Q.3
  • 94
    • 0035300431 scopus 로고    scopus 로고
    • Nitric oxide synthase II gene disruption: Implications for tumor growth and vascular endothelial growth factor production
    • Konopka TE, Barker JE, Bamford TL, et al. Nitric oxide synthase II gene disruption: implications for tumor growth and vascular endothelial growth factor production. Cancer Res 2001; 61: 3182-3187.
    • (2001) Cancer Res , vol.61 , pp. 3182-3187
    • Konopka, T.E.1    Barker, J.E.2    Bamford, T.L.3
  • 95
    • 33846546058 scopus 로고    scopus 로고
    • Effect of nitric-oxide synthesis on tumour blood volume and vascular activity: A phase I study
    • Ng QS, Goh V, Milner J, et al. Effect of nitric-oxide synthesis on tumour blood volume and vascular activity: a phase I study. Lancet Oncol 2007; 8: 111-118.
    • (2007) Lancet Oncol , vol.8 , pp. 111-118
    • Ng, Q.S.1    Goh, V.2    Milner, J.3
  • 96
    • 0035823486 scopus 로고    scopus 로고
    • SET-related cell division autoantigen-1 (CDA1) arrests cell growth
    • Chai Z, Sarcevic B, Mawson A, Toh BH. SET-related cell division autoantigen-1 (CDA1) arrests cell growth. J Biol Chem 2001; 276: 33665-33674.
    • (2001) J Biol Chem , vol.276 , pp. 33665-33674
    • Chai, Z.1    Sarcevic, B.2    Mawson, A.3    Toh, B.H.4
  • 97
    • 46949091848 scopus 로고    scopus 로고
    • Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis
    • Kandalaft LE, Zudaire E, Portal-Nunez S, Cuttitta F, Jakowlew SB. Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis. Carcinogenesis 2008; 29: 1282-1289.
    • (2008) Carcinogenesis , vol.29 , pp. 1282-1289
    • Kandalaft, L.E.1    Zudaire, E.2    Portal-Nunez, S.3    Cuttitta, F.4    Jakowlew, S.B.5
  • 98
    • 34249694142 scopus 로고    scopus 로고
    • Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways
    • Tu Y, Wu W, Wu T, et al. Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. J Biol Chem 2007; 282: 11722-11731.
    • (2007) J Biol Chem , vol.282 , pp. 11722-11731
    • Tu, Y.1    Wu, W.2    Wu, T.3
  • 99
    • 33846600845 scopus 로고    scopus 로고
    • Inflammation and IGF-I activate the Akt pathway in breast cancer
    • Prueitt RL, Boersma BJ, Howe TM, et al. Inflammation and IGF-I activate the Akt pathway in breast cancer. Int J Cancer 2007; 120: 796-805.
    • (2007) Int J Cancer , vol.120 , pp. 796-805
    • Prueitt, R.L.1    Boersma, B.J.2    Howe, T.M.3
  • 102
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399: 601-605.
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3
  • 103
    • 0036841293 scopus 로고    scopus 로고
    • Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage
    • Kandel ES, Skeen J, Majewski N, et al. Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol Cell Biol 2002; 22: 7831-7841.
    • (2002) Mol Cell Biol , vol.22 , pp. 7831-7841
    • Kandel, E.S.1    Skeen, J.2    Majewski, N.3
  • 104
    • 0034828008 scopus 로고    scopus 로고
    • Regulation of interleukin-8 expression by nitric oxide in human pancreatic adenocarcinoma
    • Xiong Q, Shi Q, Le X, Wang B, Xie K. Regulation of interleukin-8 expression by nitric oxide in human pancreatic adenocarcinoma. J Interferon Cytokine Res 2001; 21: 529-537.
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 529-537
    • Xiong, Q.1    Shi, Q.2    Le, X.3    Wang, B.4    Xie, K.5
  • 105
    • 3042784053 scopus 로고    scopus 로고
    • Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation
    • Ma P, Cui X, Wang S, et al. Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation. J Leukoc Biol 2004, 76: 278-287.
    • (2004) J Leukoc Biol , vol.76 , pp. 278-287
    • Ma, P.1    Cui, X.2    Wang, S.3
  • 106
    • 4544257935 scopus 로고    scopus 로고
    • Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells
    • Sparkman L, Boggaram V. Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2004; 287: L764-773.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Sparkman, L.1    Boggaram, V.2
  • 107
    • 8444230395 scopus 로고    scopus 로고
    • Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival
    • Benoy IH, Salgado R, Van Dam P, et al. Increased serum interleukin-8 in patients with early and metastatic breast cancer correlates with early dissemination and survival. Clin Cancer Res 2004; 10: 7157-7162.
    • (2004) Clin Cancer Res , vol.10 , pp. 7157-7162
    • Benoy, I.H.1    Salgado, R.2    van Dam, P.3
  • 108
    • 79951866285 scopus 로고    scopus 로고
    • Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancer
    • Ambs S, Glynn SA. Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancer. Cell Cycle 2011; 10: 619-624.
    • (2011) Cell Cycle , vol.10 , pp. 619-624
    • Ambs, S.1    Glynn, S.A.2
  • 109
    • 0028046946 scopus 로고
    • Cytokine gene expression on glioma cell lines and specimens
    • Yamanaka R, Tanaka R, Saitoh T, Okoshi S. Cytokine gene expression on glioma cell lines and specimens. J Neuro-oncol 1994;21: 243-247.
    • (1994) J Neuro-oncol , vol.21 , pp. 243-247
    • Yamanaka, R.1    Tanaka, R.2    Saitoh, T.3    Okoshi, S.4
  • 110
    • 1642586297 scopus 로고    scopus 로고
    • The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis
    • Garkavtsev I, Kozin SV, Chernova O, et al. The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. Nature 2004; 428: 328-332.
    • (2004) Nature , vol.428 , pp. 328-332
    • Garkavtsev, I.1    Kozin, S.V.2    Chernova, O.3
  • 111
    • 0037424253 scopus 로고    scopus 로고
    • Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2
    • Heidemann J, Ogawa H, Dwinell MB, et al. Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. J Biol Chem 2003; 278: 8508-8515.
    • (2003) J Biol Chem , vol.278 , pp. 8508-8515
    • Heidemann, J.1    Ogawa, H.2    Dwinell, M.B.3
  • 112
    • 78650897830 scopus 로고    scopus 로고
    • The role of tumour-derived iNOS in tumour progression and angiogenesis
    • Kostourou V, Cartwright JE, Johnstone AP, et al. The role of tumour-derived iNOS in tumour progression and angiogenesis. Br J Cancer 2011; 104: 83-90.
    • (2011) Br J Cancer , vol.104 , pp. 83-90
    • Kostourou, V.1    Cartwright, J.E.2    Johnstone, A.P.3
  • 113
    • 61849083102 scopus 로고    scopus 로고
    • A highly invasive human glioblastoma pre-clinical model for testing therapeutics
    • Xie Q, Thompson R, Hardy K, et al. A highly invasive human glioblastoma pre-clinical model for testing therapeutics. J Transl Med 2008; 6: 77.
    • (2008) J Transl Med , vol.6 , pp. 77
    • Xie, Q.1    Thompson, R.2    Hardy, K.3
  • 115
    • 0028803728 scopus 로고
    • Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
    • Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 1995; 83: 493-501.
    • (1995) Cell , vol.83 , pp. 493-501
    • Tsujii, M.1    Dubois, R.N.2
  • 116
    • 80052927442 scopus 로고    scopus 로고
    • COX-2 regulates the proliferation of glioma stem like cells
    • Sharma V, Dixit D, Ghosh S, Sen E. COX-2 regulates the proliferation of glioma stem like cells. Neurochem Int 2011; 59: 567-571.
    • (2011) Neurochem Int , vol.59 , pp. 567-571
    • Sharma, V.1    Dixit, D.2    Ghosh, S.3    Sen, E.4
  • 117
    • 0030879456 scopus 로고    scopus 로고
    • Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: Independence from COX-2 protein expression
    • Elder DJ, Halton DE, Hague A, Paraskeva C. Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression. Clin Cancer Res 1997; 3: 1679-1683.
    • (1997) Clin Cancer Res , vol.3 , pp. 1679-1683
    • Elder, D.J.1    Halton, D.E.2    Hague, A.3    Paraskeva, C.4
  • 118
    • 0032188853 scopus 로고    scopus 로고
    • NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells
    • Liu XH, Yao S, Kirschenbaum A, Levine AC. NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells. Cancer Res 1998; 58: 4245-4249.
    • (1998) Cancer Res , vol.58 , pp. 4245-4249
    • Liu, X.H.1    Yao, S.2    Kirschenbaum, A.3    Levine, A.C.4
  • 119
    • 0034282530 scopus 로고    scopus 로고
    • Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398
    • Joki T, Heese O, Nikas DC, et al. Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398. Cancer Res 2000; 60: 4926-4931.
    • (2000) Cancer Res , vol.60 , pp. 4926-4931
    • Joki, T.1    Heese, O.2    Nikas, D.C.3
  • 121
    • 77249132723 scopus 로고    scopus 로고
    • Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes
    • Lo HW, Cao X, Zhu H, Ali-Osman F. Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. Mol Cancer Res 2010; 8: 232-245.
    • (2010) Mol Cancer Res , vol.8 , pp. 232-245
    • Lo, H.W.1    Cao, X.2    Zhu, H.3    Ali-Osman, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.