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Volumn 1064, Issue , 2013, Pages 315-336

Gene targeting in mice: A review

Author keywords

Cre loxP; ES cell lines; FRT FLP; Gene targeting; Knockout mice; MultiSite Gateway Cloning; Reporter mice; Targeting vector; Transgenic mice

Indexed keywords

ANTIVIRUS AGENT; CRE RECOMBINASE;

EID: 84884171118     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-601-6_23     Document Type: Review
Times cited : (134)

References (114)
  • 1
    • 0032080880 scopus 로고    scopus 로고
    • Cellular mechanisms involved in protection against influenza virus infection in transgenic mice expressing a TCR receptor specific for class II hemagglutinin peptide in CD4+ and CD8+ T cells
    • Bot A, Casares S, Bot S, von Boehmer H, Bona C (1998) Cellular mechanisms involved in protection against influenza virus infection in transgenic mice expressing a TCR receptor specific for class II hemagglutinin peptide in CD4+ and CD8+ T cells. J Immunol 160:4500-4507
    • (1998) J Immunol , vol.160 , pp. 4500-4507
    • Bot, A.1    Casares, S.2    Bot, S.3    Von Boehmer, H.4    Bona, C.5
  • 2
    • 0028359368 scopus 로고
    • Thymic selection of CD8+ single positive cells with a class II major histocompatibility complexrestricted receptor
    • Kirberg J, Baron A, Jakob S, Rolink A, Karjalainen K, von Boehmer H (1994) Thymic selection of CD8+ single positive cells with a class II major histocompatibility complexrestricted receptor. J Exp Med 180:25-34
    • (1994) J Exp Med , vol.180 , pp. 25-34
    • Kirberg, J.1    Baron, A.2    Jakob, S.3    Rolink, A.4    Karjalainen, K.5    Von Boehmer, H.6
  • 3
    • 0031975635 scopus 로고    scopus 로고
    • Virus-specific MHCclass II-restricted TCR-transgenic mice: Effects on humoral and cellular immune responses after viral infection
    • Oxenius A, Bachmann MF, Zinkernagel RM, Hengartner H (1998) Virus-specific MHCclass II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol 28:390-400
    • (1998) Eur J Immunol , vol.28 , pp. 390-400
    • Oxenius, A.1    Bachmann, M.F.2    Zinkernagel, R.M.3    Hengartner, H.4
  • 4
    • 0024307348 scopus 로고
    • Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    • Pircher H, Burki K, Lang R, Hengartner H, Zinkernagel RM (1989) Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342:559-561
    • (1989) Nature , vol.342 , pp. 559-561
    • Pircher, H.1    Burki, K.2    Lang, R.3    Hengartner, H.4    Zinkernagel, R.M.5
  • 5
    • 0034608196 scopus 로고    scopus 로고
    • The application of transgenic and knockout mouse technology for the study of viral pathogenesis
    • Rall GF, Lawrence DM, Patterson CE (2000) The application of transgenic and knockout mouse technology for the study of viral pathogenesis. Virology 271:220-226
    • (2000) Virology , vol.271 , pp. 220-226
    • Rall, G.F.1    Lawrence, D.M.2    Patterson, C.E.3
  • 6
    • 0242577745 scopus 로고    scopus 로고
    • Transgenic mouse with the herpes simplex virus type 1 latency-associated gene: Expression and function of the transgene
    • Mador N, Braun E, Haim H, Ariel I, Panet A, Steiner I (2003) Transgenic mouse with the herpes simplex virus type 1 latency-associated gene: expression and function of the transgene. J Virol 77:12421-12429
    • (2003) J Virol , vol.77 , pp. 12421-12429
    • Mador, N.1    Braun, E.2    Haim, H.3    Ariel, I.4    Panet, A.5    Steiner, I.6
  • 7
    • 0034869213 scopus 로고    scopus 로고
    • The 2.2-kilobase latencyassociated transcript of herpes simplex virus type 2 does not modulate viral replication, reactivation, or establishment of latency in transgenic mice
    • Wang K, Pesnicak L, Guancial E, Krause PR, Straus SE (2001) The 2.2-kilobase latencyassociated transcript of herpes simplex virus type 2 does not modulate viral replication, reactivation, or establishment of latency in transgenic mice. J Virol 75:8166-8172
    • (2001) J Virol , vol.75 , pp. 8166-8172
    • Wang, K.1    Pesnicak, L.2    Guancial, E.3    Krause, P.R.4    Straus, S.E.5
  • 9
    • 0025852445 scopus 로고
    • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene
    • Kitamura D, Roes J, Kuhn R, Rajewsky K (1991) A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350:423-426
    • (1991) Nature , vol.350 , pp. 423-426
    • Kitamura, D.1    Roes, J.2    Kuhn, R.3    Rajewsky, K.4
  • 12
    • 0027400726 scopus 로고
    • Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    • Dalton DK, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA (1993) Multiple defects of immune cell function in mice with disrupted interferon-gamma genes. Science 259:1739-1742
    • (1993) Science , vol.259 , pp. 1739-1742
    • Dalton, D.K.1    Pitts-Meek, S.2    Keshav, S.3    Figari, I.S.4    Bradley, A.5    Stewart, T.A.6
  • 13
    • 0028864798 scopus 로고
    • A null mutation in the gene encoding a type i interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses
    • Hwang SY, Hertzog PJ, Holland KA, Sumarsono SH, Tymms MJ, Hamilton JA, Whitty G, Bertoncello I, Kola I (1995) A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses. Proc Natl Acad Sci USA 92:11284-11288
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11284-11288
    • Hwang, S.Y.1    Hertzog, P.J.2    Holland, K.A.3    Sumarsono, S.H.4    Tymms, M.J.5    Hamilton, J.A.6    Whitty, G.7    Bertoncello, I.8    Kola, I.9
  • 14
    • 0028958281 scopus 로고
    • Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice
    • Steinhoff U, Muller U, Schertler A, Hengartner H, Aguet M, Zinkernagel RM (1995) Antiviral protection by vesicular stomatitis virus-specific antibodies in alpha/beta interferon receptor-deficient mice. J Virol 69:2153-2158
    • (1995) J Virol , vol.69 , pp. 2153-2158
    • Steinhoff, U.1    Muller, U.2    Schertler, A.3    Hengartner, H.4    Aguet, M.5    Zinkernagel, R.M.6
  • 16
    • 63649108380 scopus 로고    scopus 로고
    • The roles of TLRs, RLRs and NLRs in pathogen recognition
    • Kawai T, Akira S (2009) The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol 21:317-337
    • (2009) Int Immunol , vol.21 , pp. 317-337
    • Kawai, T.1    Akira, S.2
  • 17
    • 82955187324 scopus 로고    scopus 로고
    • Resisting viral infection: The gene by gene approach
    • Moresco EM, Beutler B (2011) Resisting viral infection: the gene by gene approach. Curr Opin Virol 1:513-518
    • (2011) Curr Opin Virol , vol.1 , pp. 513-518
    • Moresco, E.M.1    Beutler, B.2
  • 18
    • 77955415407 scopus 로고    scopus 로고
    • Activation of host pattern recognition receptors by viruses
    • Brennan K, Bowie AG (2010) Activation of host pattern recognition receptors by viruses. Curr Opin Microbiol 13:503-507
    • (2010) Curr Opin Microbiol , vol.13 , pp. 503-507
    • Brennan, K.1    Bowie, A.G.2
  • 19
    • 84865411904 scopus 로고    scopus 로고
    • C-type lectin receptors orchestrate antifungal immunity
    • Hardison SE, Brown GD (2012) C-type lectin receptors orchestrate antifungal immunity. Nat Immunol 13:817-822
    • (2012) Nat Immunol , vol.13 , pp. 817-822
    • Hardison, S.E.1    Brown, G.D.2
  • 21
    • 0032934156 scopus 로고    scopus 로고
    • Functional roles of STAT family proteins: Lessons from knockout mice
    • Akira S (1999) Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 17:138-146
    • (1999) Stem Cells , vol.17 , pp. 138-146
    • Akira, S.1
  • 23
    • 78649981849 scopus 로고    scopus 로고
    • Cytokine reporter mice in immunological research: Perspectives and lessons learned
    • Croxford AL, Buch T (2011) Cytokine reporter mice in immunological research: perspectives and lessons learned. Immunology 132:1-8
    • (2011) Immunology , vol.132 , pp. 1-8
    • Croxford, A.L.1    Buch, T.2
  • 24
    • 84861466939 scopus 로고    scopus 로고
    • Cytokine reporter mice: The special case of IL-10
    • Bouabe H (2012) Cytokine reporter mice: the special case of IL-10. Scand J Immunol 75:553-567
    • (2012) Scand J Immunol , vol.75 , pp. 553-567
    • Bouabe, H.1
  • 25
    • 77952254962 scopus 로고    scopus 로고
    • Bioluminescence imaging of reporter mice for studies of infection and inflammation
    • Luker KE, Luker GD (2010) Bioluminescence imaging of reporter mice for studies of infection and inflammation. Antiviral Res 86:93-100
    • (2010) Antiviral Res , vol.86 , pp. 93-100
    • Luker, K.E.1    Luker, G.D.2
  • 27
    • 0242568295 scopus 로고
    • Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus
    • Jaenisch R (1976) Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus. Proc Natl Acad Sci USA 73:1260-1264
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 1260-1264
    • Jaenisch, R.1
  • 29
    • 0019855228 scopus 로고
    • Introduction of a rabbit beta-globin gene into the mouse germ line
    • Costantini F, Lacy E (1981) Introduction of a rabbit beta-globin gene into the mouse germ line. Nature 294:92-94
    • (1981) Nature , vol.294 , pp. 92-94
    • Costantini, F.1    Lacy, E.2
  • 30
    • 0019859395 scopus 로고
    • Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs
    • Brinster RL, Chen HY, Trumbauer M, Senear AW, Warren R, Palmiter RD (1981) Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 27:223-231
    • (1981) Cell , vol.27 , pp. 223-231
    • Brinster, R.L.1    Chen, H.Y.2    Trumbauer, M.3    Senear, A.W.4    Warren, R.5    Palmiter, R.D.6
  • 31
    • 0019790422 scopus 로고
    • The human beta-globin gene and a functional viral thymidine kinase gene in developing mice
    • Wagner EF, Stewart TA, Mintz B (1981) The human beta-globin gene and a functional viral thymidine kinase gene in developing mice. Proc Natl Acad Sci USA 78:5016-5020
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 5016-5020
    • Wagner, E.F.1    Stewart, T.A.2    Mintz, B.3
  • 32
    • 0019845629 scopus 로고
    • Microinjection of cloned retroviral genomes into mouse zygotes: Integration and expression in the animal
    • Harbers K, Jahner D, Jaenisch R (1981) Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal. Nature 293:540-542
    • (1981) Nature , vol.293 , pp. 540-542
    • Harbers, K.1    Jahner, D.2    Jaenisch, R.3
  • 33
    • 84855342178 scopus 로고    scopus 로고
    • Animal models of dementia
    • In: Conlon RA (ed). Springer Science + Business Media, New York
    • De Deyn PP, Van Dam D (2011) Animal models of dementia. In: Conlon RA (ed) Transgenic and gene targeted models of dementia, vol 48. Springer Science + Business Media, New York, pp 77-90
    • (2011) Transgenic and Gene Targeted Models of Dementia , vol.48 , pp. 77-90
    • De Deyn, P.P.1    Van Dam, D.2
  • 35
    • 0023646810 scopus 로고
    • Sitedirected mutagenesis by gene targeting in mouse embryo-derived stem cells
    • Thomas KR, Capecchi MR (1987) Sitedirected mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503-512
    • (1987) Cell , vol.51 , pp. 503-512
    • Thomas, K.R.1    Capecchi, M.R.2
  • 36
    • 0024494423 scopus 로고
    • Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells
    • Thompson S, Clarke AR, Pow AM, Hooper ML, Melton DW (1989) Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells. Cell 56:313-321
    • (1989) Cell , vol.56 , pp. 313-321
    • Thompson, S.1    Clarke, A.R.2    Pow, A.M.3    Hooper, M.L.4    Melton, D.W.5
  • 37
    • 0024420342 scopus 로고
    • Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells
    • Zijlstra M, Li E, Sajjadi F, Subramani S, Jaenisch R (1989) Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342:435-438
    • (1989) Nature , vol.342 , pp. 435-438
    • Zijlstra, M.1    Li, E.2    Sajjadi, F.3    Subramani, S.4    Jaenisch, R.5
  • 38
    • 0020396492 scopus 로고
    • Patterns of integration of DNA microinjected into cultured mammalian cells: Evidence for homologous recombination between injected plasmid DNA molecules
    • Folger KR, Wong EA, Wahl G, Capecchi MR (1982) Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol 2:1372-1387
    • (1982) Mol Cell Biol , vol.2 , pp. 1372-1387
    • Folger, K.R.1    Wong, E.A.2    Wahl, G.3    Capecchi, M.R.4
  • 40
    • 0022389290 scopus 로고
    • Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination
    • Smithies O, Gregg RG, Boggs SS, Koralewski MA, Kucherlapati RS (1985) Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature 317:230-234
    • (1985) Nature , vol.317 , pp. 230-234
    • Smithies, O.1    Gregg, R.G.2    Boggs, S.S.3    Koralewski, M.A.4    Kucherlapati, R.S.5
  • 41
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos
    • Evans MJ, Kaufman MH (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292:154-156
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 42
    • 0022461705 scopus 로고
    • Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector
    • Robertson E, Bradley A, Kuehn M, Evans M (1986) Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature 323:445-448
    • (1986) Nature , vol.323 , pp. 445-448
    • Robertson, E.1    Bradley, A.2    Kuehn, M.3    Evans, M.4
  • 43
    • 0001007610 scopus 로고
    • Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
    • Martin GR (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78:7634-7638
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 7634-7638
    • Martin, G.R.1
  • 44
    • 0024296027 scopus 로고
    • Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
    • Mansour SL, Thomas KR, Capecchi MR (1988) Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336:348-352
    • (1988) Nature , vol.336 , pp. 348-352
    • Mansour, S.L.1    Thomas, K.R.2    Capecchi, M.R.3
  • 46
    • 0025074908 scopus 로고
    • Targeted disruption of the murine int-1 protooncogene resulting in severe abnormalities in midbrain and cerebellar development
    • Thomas KR, Capecchi MR (1990) Targeted disruption of the murine int-1 protooncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature 346:847-850
    • (1990) Nature , vol.346 , pp. 847-850
    • Thomas, K.R.1    Capecchi, M.R.2
  • 47
    • 79952660821 scopus 로고    scopus 로고
    • Control of the embryonic stem cell state
    • Young RA (2011) Control of the embryonic stem cell state. Cell 144:940-954
    • (2011) Cell , vol.144 , pp. 940-954
    • Young, R.A.1
  • 48
    • 1242267927 scopus 로고    scopus 로고
    • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
    • Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH (2004) Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 10:55-63
    • (2004) Nat Med , vol.10 , pp. 55-63
    • Sato, N.1    Meijer, L.2    Skaltsounis, L.3    Greengard, P.4    Brivanlou, A.H.5
  • 50
    • 56249121926 scopus 로고    scopus 로고
    • Laminin-511 but not -332, -111, or -411 enables mouse embryonic stem cell self-renewal in vitro
    • Domogatskaya A, Rodin S, Boutaud A, Tryggvason K (2008) Laminin-511 but not -332, -111, or -411 enables mouse embryonic stem cell self-renewal in vitro. Stem Cells 26:2800-2809
    • (2008) Stem Cells , vol.26 , pp. 2800-2809
    • Domogatskaya, A.1    Rodin, S.2    Boutaud, A.3    Tryggvason, K.4
  • 51
    • 10444228229 scopus 로고    scopus 로고
    • Technical assessment of the first 20 years of research using mouse embryonic stem cell lines
    • Downing GJ, Battey JF Jr (2004) Technical assessment of the first 20 years of research using mouse embryonic stem cell lines. Stem Cells 22:1168-1180
    • (2004) Stem Cells , vol.22 , pp. 1168-1180
    • Downing, G.J.1    Battey Jr., J.F.2
  • 53
    • 0023150598 scopus 로고
    • HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells
    • Hooper M, Hardy K, Handyside A, Hunter S, Monk M (1987) HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature 326:292-295
    • (1987) Nature , vol.326 , pp. 292-295
    • Hooper, M.1    Hardy, K.2    Handyside, A.3    Hunter, S.4    Monk, M.5
  • 54
    • 0021891053 scopus 로고
    • The in vitro development of blastocyst-derived embryonic stem cell lines: Formation of visceral yolk sac, blood islands and myocardium
    • Doetschman TC, Eistetter H, Katz M, Schmidt W, Kemler R (1985) The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J Embryol Exp Morphol 87:27-45
    • (1985) J Embryol Exp Morphol , vol.87 , pp. 27-45
    • Doetschman, T.C.1    Eistetter, H.2    Katz, M.3    Schmidt, W.4    Kemler, R.5
  • 55
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li E, Bestor TH, Jaenisch R (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69:915-926
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 56
    • 0027321548 scopus 로고
    • Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
    • Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC (1993) Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA 90:8424-8428
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8424-8428
    • Nagy, A.1    Rossant, J.2    Nagy, R.3    Abramow-Newerly, W.4    Roder, J.C.5
  • 57
    • 0026023289 scopus 로고
    • Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
    • Soriano P, Montgomery C, Geske R, Bradley A (1991) Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64:693-702
    • (1991) Cell , vol.64 , pp. 693-702
    • Soriano, P.1    Montgomery, C.2    Geske, R.3    Bradley, A.4
  • 59
    • 35848962495 scopus 로고    scopus 로고
    • Derivation and comparison of C57BL/6 embryonic stem cells to a widely used 129 embryonic stem cell line
    • Keskintepe L, Norris K, Pacholczyk G, Dederscheck SM, Eroglu A (2007) Derivation and comparison of C57BL/6 embryonic stem cells to a widely used 129 embryonic stem cell line. Transgenic Res 16:751-758
    • (2007) Transgenic Res , vol.16 , pp. 751-758
    • Keskintepe, L.1    Norris, K.2    Pacholczyk, G.3    Dederscheck, S.M.4    Eroglu, A.5
  • 63
    • 0026317793 scopus 로고
    • Establishment of a germ-line competent C57BL/6 embryonic stem cell line
    • Ledermann B, Burki K (1991) Establishment of a germ-line competent C57BL/6 embryonic stem cell line. Exp Cell Res 197:254-258
    • (1991) Exp Cell Res , vol.197 , pp. 254-258
    • Ledermann, B.1    Burki, K.2
  • 67
    • 70149086288 scopus 로고    scopus 로고
    • Generation of gene knockout mice by ES cell microinjection
    • Chapter 19:Unit 19.14
    • Longenecker G, Kulkarni AB (2009) Generation of gene knockout mice by ES cell microinjection. Curr Protoc Cell Biol Chapter 19:Unit 19.14 19.14.11-36
    • (2009) Curr Protoc Cell Biol , pp. 11-36
    • Longenecker, G.1    Kulkarni, A.B.2
  • 68
    • 84858200042 scopus 로고    scopus 로고
    • Generation of chimeras by microinjection
    • Pluck A, Klasen C (2009) Generation of chimeras by microinjection. Methods Mol Biol 561:199-217
    • (2009) Methods Mol Biol , vol.561 , pp. 199-217
    • Pluck, A.1    Klasen, C.2
  • 69
    • 70349234213 scopus 로고    scopus 로고
    • Generation of chimeras by morula aggregation
    • Pluck A, Klasen C (2009) Generation of chimeras by morula aggregation. Methods Mol Biol 561:219-229
    • (2009) Methods Mol Biol , vol.561 , pp. 219-229
    • Pluck, A.1    Klasen, C.2
  • 72
  • 73
    • 0024118441 scopus 로고
    • Homologous integration in mammalian cells without target gene selection
    • Jasin M, Berg P (1988) Homologous integration in mammalian cells without target gene selection. Genes Dev 2:1353-1363
    • (1988) Genes Dev , vol.2 , pp. 1353-1363
    • Jasin, M.1    Berg, P.2
  • 74
    • 0026753186 scopus 로고
    • Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus
    • Deng C, Capecchi MR (1992) Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol Cell Biol 12:3365-3371
    • (1992) Mol Cell Biol , vol.12 , pp. 3365-3371
    • Deng, C.1    Capecchi, M.R.2
  • 75
    • 0025943412 scopus 로고
    • The length of homology required for gene targeting in embryonic stem cells
    • Hasty P, Rivera-Perez J, Bradley A (1991) The length of homology required for gene targeting in embryonic stem cells. Mol Cell Biol 11:5586-5591
    • (1991) Mol Cell Biol , vol.11 , pp. 5586-5591
    • Hasty, P.1    Rivera-Perez, J.2    Bradley, A.3
  • 76
    • 0026771287 scopus 로고
    • Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs
    • te Riele H, Maandag ER, Berns A (1992) Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. Proc Natl Acad Sci USA 89:5128-5132
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5128-5132
    • Te Riele, H.1    Maandag, E.R.2    Berns, A.3
  • 77
    • 0022542596 scopus 로고
    • High frequency targeting of genes to specific sites in the mammalian genome
    • Thomas KR, Folger KR, Capecchi MR (1986) High frequency targeting of genes to specific sites in the mammalian genome. Cell 44:419-428
    • (1986) Cell , vol.44 , pp. 419-428
    • Thomas, K.R.1    Folger, K.R.2    Capecchi, M.R.3
  • 78
    • 0025672645 scopus 로고
    • Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection
    • Yagi T, Ikawa Y, Yoshida K, Shigetani Y, Takeda N, Mabuchi I, Yamamoto T, Aizawa S (1990) Homologous recombination at c-fyn locus of mouse embryonic stem cells with use of diphtheria toxin A-fragment gene in negative selection. Proc Natl Acad Sci USA 87:9918-9922
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9918-9922
    • Yagi, T.1    Ikawa, Y.2    Yoshida, K.3    Shigetani, Y.4    Takeda, N.5    Mabuchi, I.6    Yamamoto, T.7    Aizawa, S.8
  • 79
    • 40349097939 scopus 로고    scopus 로고
    • Overview of gene targeting by homologous recombination
    • Chapter 23:Unit 23.21
    • Mortensen R (2006) Overview of gene targeting by homologous recombination. Curr Protoc Mol Biol Chapter 23:Unit 23.21
    • (2006) Curr Protoc Mol Biol
    • Mortensen, R.1
  • 80
    • 84856217353 scopus 로고    scopus 로고
    • Enhanced selection for homologousrecombinant embryonic stem cell clones by Cre recombinase-mediated deletion of the positive selection marker
    • doi:10.1007/s11248-011-9522-x
    • Bouabe H, Moser M, Heesemann J (2011) Enhanced selection for homologousrecombinant embryonic stem cell clones by Cre recombinase-mediated deletion of the positive selection marker. Transgenic Res. doi:10.1007/s11248- 011-9522-x
    • (2011) Transgenic Res.
    • Bouabe, H.1    Moser, M.2    Heesemann, J.3
  • 81
    • 0019888362 scopus 로고
    • Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites
    • Sternberg N, Hamilton D (1981) Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. J Mol Biol 150:467-486
    • (1981) J Mol Biol , vol.150 , pp. 467-486
    • Sternberg, N.1    Hamilton, D.2
  • 82
    • 1842394365 scopus 로고
    • P1 site-specific recombination: Nucleotide sequence of the recombining sites
    • Hoess RH, Ziese M, Sternberg N (1982) P1 site-specific recombination: nucleotide sequence of the recombining sites. Proc Natl Acad Sci USA 79:3398-3402
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 3398-3402
    • Hoess, R.H.1    Ziese, M.2    Sternberg, N.3
  • 83
    • 0022626134 scopus 로고
    • Bacteriophage P1 CreloxP site-specific recombination. Site-specific DNA topoisomerase activity of the Cre recombination protein
    • Abremski K, Wierzbicki A, Frommer B, Hoess RH (1986) Bacteriophage P1 CreloxP site-specific recombination. Site-specific DNA topoisomerase activity of the Cre recombination protein. J Biol Chem 261:391-396
    • (1986) J Biol Chem , vol.261 , pp. 391-396
    • Abremski, K.1    Wierzbicki, A.2    Frommer, B.3    Hoess, R.H.4
  • 84
    • 0026764280 scopus 로고
    • Tissueand site-specific DNA recombination in transgenic mice
    • Orban PC, Chui D, Marth JD (1992) Tissueand site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci USA 89:6861-6865
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6861-6865
    • Orban, P.C.1    Chui, D.2    Marth, J.D.3
  • 85
    • 0028059099 scopus 로고
    • Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
    • Gu H, Marth JD, Orban PC, Mossmann H, Rajewsky K (1994) Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265:103-106
    • (1994) Science , vol.265 , pp. 103-106
    • Gu, H.1    Marth, J.D.2    Orban, P.C.3    Mossmann, H.4    Rajewsky, K.5
  • 90
    • 0021972533 scopus 로고
    • The FLP recombinase of the 2 micron circle DNA of yeast: Interaction with its target sequences
    • Andrews BJ, Proteau GA, Beatty LG, Sadowski PD (1985) The FLP recombinase of the 2 micron circle DNA of yeast: interaction with its target sequences. Cell 40:795-803
    • (1985) Cell , vol.40 , pp. 795-803
    • Andrews, B.J.1    Proteau, G.A.2    Beatty, L.G.3    Sadowski, P.D.4
  • 91
    • 0029954688 scopus 로고    scopus 로고
    • Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice
    • Dymecki SM (1996) Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice. Proc Natl Acad Sci USA 93:6191-6196
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6191-6196
    • Dymecki, S.M.1
  • 92
    • 0022378550 scopus 로고
    • The FLP recombinase of the yeast 2-micron plasmid: Characterization of its recombination site
    • Senecoff JF, Bruckner RC, Cox MM (1985) The FLP recombinase of the yeast 2-micron plasmid: characterization of its recombination site. Proc Natl Acad Sci USA 82:7270-7274
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 7270-7274
    • Senecoff, J.F.1    Bruckner, R.C.2    Cox, M.M.3
  • 93
    • 0020132004 scopus 로고
    • Recombination within the yeast plasmid 2mu circle is site-specific
    • Broach JR, Guarascio VR, Jayaram M (1982) Recombination within the yeast plasmid 2mu circle is site-specific. Cell 29:227-234
    • (1982) Cell , vol.29 , pp. 227-234
    • Broach, J.R.1    Guarascio, V.R.2    Jayaram, M.3
  • 94
    • 0031874849 scopus 로고    scopus 로고
    • Improved properties of FLP recombinase evolved by cycling mutagenesis
    • Buchholz F, Angrand PO, Stewart AF (1998) Improved properties of FLP recombinase evolved by cycling mutagenesis. Nat Biotechnol 16:657-662
    • (1998) Nat Biotechnol , vol.16 , pp. 657-662
    • Buchholz, F.1    Angrand, P.O.2    Stewart, A.F.3
  • 95
    • 0029860719 scopus 로고    scopus 로고
    • Different thermostabilities of FLP and Cre recombinases: Implications for applied site-specific recombination
    • Buchholz F, Ringrose L, Angrand PO, Rossi F, Stewart AF (1996) Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res 24:4256-4262
    • (1996) Nucleic Acids Res , vol.24 , pp. 4256-4262
    • Buchholz, F.1    Ringrose, L.2    Angrand, P.O.3    Rossi, F.4    Stewart, A.F.5
  • 97
    • 0025992469 scopus 로고
    • Promoter traps in embryonic stem cells: A genetic screen to identify and mutate developmental genes in mice
    • Friedrich G, Soriano P (1991) Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev 5:1513-1523
    • (1991) Genes Dev , vol.5 , pp. 1513-1523
    • Friedrich, G.1    Soriano, P.2
  • 98
    • 0030990991 scopus 로고    scopus 로고
    • Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells
    • Zambrowicz BP, Imamoto A, Fiering S, Herzenberg LA, Kerr WG, Soriano P (1997) Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci USA 94:3789-3794
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3789-3794
    • Zambrowicz, B.P.1    Imamoto, A.2    Fiering, S.3    Herzenberg, L.A.4    Kerr, W.G.5    Soriano, P.6
  • 99
    • 62849096347 scopus 로고    scopus 로고
    • Lymphocyte signaling: Beyond knockouts
    • Saveliev A, Tybulewicz VL (2009) Lymphocyte signaling: beyond knockouts. Nat Immunol 10:361-364
    • (2009) Nat Immunol , vol.10 , pp. 361-364
    • Saveliev, A.1    Tybulewicz, V.L.2
  • 104
    • 24944540703 scopus 로고    scopus 로고
    • Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells
    • Prisco A, Vanes L, Ruf S, Trigueros C, Tybulewicz VL (2005) Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells. Immunity 23:263-274
    • (2005) Immunity , vol.23 , pp. 263-274
    • Prisco, A.1    Vanes, L.2    Ruf, S.3    Trigueros, C.4    Tybulewicz, V.L.5
  • 105
    • 0031663369 scopus 로고    scopus 로고
    • The green fluorescent protein
    • Tsien RY (1998) The green fluorescent protein. Annu Rev Biochem 67:509-544
    • (1998) Annu Rev Biochem , vol.67 , pp. 509-544
    • Tsien, R.Y.1
  • 106
    • 80053060390 scopus 로고    scopus 로고
    • Novel highly sensitive IL-10-{beta}-lactamase reporter mouse reveals cells of the innate immune system as a substantial source of IL-10 in vivo
    • Bouabe H, Liu Y, Moser M, Bosl MR, Heesemann J (2011) Novel highly sensitive IL-10-{beta}-lactamase reporter mouse reveals cells of the innate immune system as a substantial source of IL-10 in vivo. J Immunol 187:3165-3176
    • (2011) J Immunol , vol.187 , pp. 3165-3176
    • Bouabe, H.1    Liu, Y.2    Moser, M.3    Bosl, M.R.4    Heesemann, J.5
  • 107
    • 0029740012 scopus 로고    scopus 로고
    • Chemiluminescence: Sensitive detection technology for reporter gene assays
    • Bronstein I, Martin CS, Fortin JJ, Olesen CE, Voyta JC (1996) Chemiluminescence: sensitive detection technology for reporter gene assays. Clin Chem 42:1542-1546
    • (1996) Clin Chem , vol.42 , pp. 1542-1546
    • Bronstein, I.1    Martin, C.S.2    Fortin, J.J.3    Olesen, C.E.4    Voyta, J.C.5
  • 108
    • 1942438169 scopus 로고    scopus 로고
    • Realization of betalactamase as a versatile fluorogenic reporter
    • Campbell RE (2004) Realization of betalactamase as a versatile fluorogenic reporter. Trends Biotechnol 22:208-211
    • (2004) Trends Biotechnol , vol.22 , pp. 208-211
    • Campbell, R.E.1
  • 110
  • 111
    • 41149177031 scopus 로고    scopus 로고
    • Overview of genetic reporter systems
    • Chapter 9:Unit9.6
    • Kain SR, Ganguly S (2001) Overview of genetic reporter systems. Curr Protoc Mol Biol Chapter 9:Unit9.6
    • (2001) Curr Protoc Mol Biol
    • Kain, S.R.1    Ganguly, S.2
  • 112
    • 56249108736 scopus 로고    scopus 로고
    • Recent developments of biological reporter technology for detecting gene expression
    • Jiang T, Xing B, Rao J (2008) Recent developments of biological reporter technology for detecting gene expression. Biotechnol Genet Eng Rev 25:41-75
    • (2008) Biotechnol Genet Eng Rev , vol.25 , pp. 41-75
    • Jiang, T.1    Xing, B.2    Rao, J.3
  • 113
    • 0030631801 scopus 로고    scopus 로고
    • Chemiluminescent immunoassay for the detection of chloramphenicol acetyltransferase and human growth hormone reporter proteins
    • Olesen CE, Voyta JC, Bronstein I (1997) Chemiluminescent immunoassay for the detection of chloramphenicol acetyltransferase and human growth hormone reporter proteins. Methods Mol Biol 63:71-76
    • (1997) Methods Mol Biol , vol.63 , pp. 71-76
    • Olesen, C.E.1    Voyta, J.C.2    Bronstein, I.3
  • 114
    • 33847708244 scopus 로고    scopus 로고
    • Beta-lactamase: An ideal reporter system for monitoring gene expression in live eukaryotic cells
    • Qureshi SA (2007) Beta-lactamase: an ideal reporter system for monitoring gene expression in live eukaryotic cells. Biotechniques 42:91-96
    • (2007) Biotechniques , vol.42 , pp. 91-96
    • Qureshi, S.A.1


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