The 2.2-kilobase latency-associated transcript of herpes simplex virus type 2 does not modulate viral replication, reactivation, or establishment of latency in transgenic mice

Journal of Virology

Volumn 75, Issue 17, 2001, Pages 8166-8172

  Wang, K ^a   Pesnicak, L ^a   Guancial, E ^a   Krause, P R ^a   Straus, S E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DELETION MUTANT; DNA FLANKING REGION; FEMALE; FIBROBLAST CULTURE; HERPES SIMPLEX VIRUS 2; LATENT VIRUS INFECTION; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE; VIROGENESIS; VIRUS GENE; VIRUS LATENCY; VIRUS REACTIVATION; VIRUS REPLICATION; VIRUS TRANSCRIPTION;

ANIMALS; BRAIN; CELLS, CULTURED; EYE; FIBROBLASTS; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 2, HUMAN; KERATITIS, HERPETIC; LUNG; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; TRANSGENES; TRIGEMINAL GANGLION; VIRAL LOAD; VIRUS ACTIVATION; VIRUS LATENCY; VIRUS REPLICATION;

EID: 0034869213     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.17.8166-8172.2001     Document Type: Article

References (29)

1. A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation
2. A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus
3. Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections
4. Ocular herpes simplex virus reactivation in mice latently infected with latency-associated transcript mutants
5. Characterization of herpes simplex virus type 2 latency-associated transcription in human sacral ganglia and in cell culture
6. Latent herpes simplex virus in human trigeminal ganglia. Detection of an immediate early gene "anti-sense" transcript by in situ hybridization
7. RNA from an immediate early region of the type 1 herpes simplex virus genome is present in the trigeminal ganglia of latently infected mice
8. Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency
9. Herpes simplex virus latency-associated transcript is a stable intron
10. In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370-base-pair region located between the promoter and the 5′ end of the 2.0-kilobase latency-associated transcript
11. Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture
12. Detection and preliminary characterization of herpes simplex virus type 1 transcripts in latently infected human trigeminal ganglia
13. Expression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs
14. Treatment of HSV-1 infection with immunoglobulin or acyclovir: Comparison of their effects on viral spread, latency, and reactivation
15. The quantity of latent viral DNA correlates with the relative rates at which herpes simplex virus types 1 and 2 cause recurrent genital herpes outbreaks
16. The comparative biology of latent herpes simplex virus type 1 and type 2 infections: Latency-associated transcript promoter activity and expression in vitro and in infected mice
17. Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line
18. Detection of latency-related viral RNAs in trigeminal ganglia of rabbits latently infected with herpes simplex virus type 1
19. Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency
20. Herpes simlex virus type 1 latency-associated transcription plays no role in establishment or maintenance of a latent infection in murine secsory neurons
21. RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons
22. Expression of herpes simplex virus type 2 latency-associated transcript in neurons and nonneurons
23. Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latency
24. The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency
25. In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model
26. Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcripts
27. Mutations in the 5′ end of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpes
28. Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latency
29. The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine