Transgenic Mouse with the Herpes Simplex Virus Type 1 Latency-Associated Gene: Expression and Function of the Transgene

Journal of Virology

Volumn 77, Issue 23, 2003, Pages 12421-12429

  Mador, Nurith ^a   Braun, Efrat ^a   Haim, Hillel ^a   Ariel, Ilana ^a   Panet, Amos ^a   Steiner, Israel ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; VIRUS RNA;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION REGULATION; GENE FUNCTION; HEART; HERPES SIMPLEX VIRUS 1; LAT GENE; MOUSE; NERVE CELL; NONHUMAN; PERIPHERAL NERVE; PRIORITY JOURNAL; PROBABILITY; PROMOTER REGION; SENSORY GANGLION; SKELETAL MUSCLE; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION; TRANSGENIC MOUSE; TRIGEMINUS GANGLION; VIRUS GENE; VIRUS INHIBITION; VIRUS LATENCY; VIRUS MUTANT; VIRUS REACTIVATION; VIRUS REPLICATION; WILD TYPE;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; DNA, VIRAL; GENE EXPRESSION; GENES, VIRAL; HERPESVIRUS 1, HUMAN; MICE; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; TRANSGENES; VIRAL PROTEINS; VIRUS LATENCY; VIRUS REPLICATION;

EID: 0242577745     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.23.12421-12429.2003     Document Type: Article

References (53)

1. Ahmed, M., and N. W. Fraser. 2001. Herpes simplex virus type 1 2-kilobase latency-associated transcript intron associates with ribosomal proteins and splicing factors. J. Virol. 75:12070-12080.
2. Ahmed, M., M. Lock, C. G. Miller, and N. W. Fraser. 2002. Regions of the herpes simplex virus type 1 latency-associated transcript that protect cells from apoptosis in vitro and protect neuronal cells in vivo. J. Virol. 76:717-729.
3. Alexander, D. L., S. E. Eltom, and C. R. Jefcoate. 1997. A receptor regulation of CYP1B1 expression in primary mouse embryo-derived cells. Cancer Res. 57:4498-4506.
4. Baskar, J. F., P. P. Smith, G. Nilaver, R. A. Jupp, S. Hoffmann, N. J. Peffer, D. J. Tenney, A. M. Colberg-Poley, P. Ghazal, and J. A. Nelson. 1996. The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell-type-specific statement in transgenic mice. J. Virol. 70:3207-3214.
5. Batchelor, A. H., and P. O'Hare. 1990. Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1. J. Virol. 64:3269-3279.
6. Bloom, D. C., J. M. Hill, G. Devi-Rao, E. K. Wagner, L. T. Feldman, and J. G. Stevens. 1996. A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation. J. Virol. 70:2449-2459.
7. Chen, S.-H., M. F. Kramer, P. A. Schaffer, and D. M. Coen. 1997. A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus. J. Virol. 71:5878-5884.
8. Devi-Rao, G. B., D. C. Bloom, J. G. Stevens, and E. K. Wagner. 1994. Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia. J. Virol. 68:1271-1282.
9. Fareed, M. U., and J. G. Spivack. 1994. Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency. J. Virol. 68:8071-8081.
10. Fraser, N. W., W. C. Lawrence, Z. Wroblewska, D. H. Gilden, and H. Koprowski. 1981. Herpes simplex type 1 DNA in human brain tissue. Proc. Natl. Acad. Sci. USA 78:6461-6465.
11. Furth, P. A., L. Hennighausen, C. Baker, B. Beatty, and R. Woychick. 1991. The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice. Nucleic Acids Res. 19:6205-6208.
12. Goldenberg, D., N. Mador, M. Ball, A. Panet, and I. Steiner. 1997. The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia. J. Virol. 71:2897-2904.
13. Goldenberg, D., N. Mador, A. Panet, and I. Steiner. 1998. Tissue specific distribution of the herpes simplex virus type 1 latency-associated transcripts on polyribosomes during latent infection. J. Neurovirol. 4:426-432.
14. Grabowski, P. J., and D. L. Black. 2001. Alternative RNA splicing in the nervous system. Prog. Neurobiol. 65:289-308.
15. Hill, J. M., F. Sedarat, R. T. Javier, E. K. Wagner, and J. G. Stevens. 1990. Herpes simplex virus latent phase transcription facilitates in vivo reactivation. Virology 174:117-125.
16. Hogan, B., F. Constantini, and E. Lacey. 1986. Manipulating the mouse embryo, p. 92-94. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
17. Inman, M., G. C. Perng, G. Henderson, H. Ghiasi, A. B. Nesburn, S. L. Wechsler, and C. Jones. 2001. Region of herpes simplex virus type 1 latency-associated transcript sufficient for wild-type spontaneous reactivation promotes cell survival in tissue culture. J. Virol. 75:3636-3646.
18. Javier, R. T., J. G. Stevens, V. B. Dissette, and E. K. Wagner. 1988. A herpes simplex virus transcript abundant in latently infected neurons is dispensable for establishment of the latent state. Virology 166:254-257.
19. Jerome, K. R., M.-L. Huang, A. Wald, S. Selke, and L. Corey. 2002. Quantitative stability of DNA after extended storage of clinical specimens as determined by real-time PCR. J. Clin. Microbiol. 40:2609-2611.
20. LaCasse, E. C., S. Baird, R. G. Korneluk, and A. E. MacKenzie. 1998. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene 17:3247-3259.
21. Leib, D. A., C. I. Bogard, M. Kosz-Vnenchak, K. A. Hicks, D. M. Coen, D. M. Knipe, and P. A. Scheffer. 1989. A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. J. Virol. 63:2893-2900.
22. Mador, N., A. Panet, D. Latchman, and I. Steiner. 1995. Expression and splicing of the latency-associated transcripts of herpes simplex virus type 1 in neuronal and non-neuronal cell lines. J. Biochem. 117:1288-1297.
23. Mador, N., D. Goldenberg, O. Cohen, A. Panet, and I. Steiner. 1998. Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate early gene mRNA levels in a neuronal cell line. J. Virol. 72:5067-5075.
24. Mador, N., A. Panet, and I. Steiner. 2002. The latency-associated gene of herpes simplex virus type 1 (HSV-1) interferes with superinfection by HSV-1. J. Neurovirol. 8:1-6.
25. Miller, R. R., and C. A. McDevitt. 1991. A quantitative microwell assay for chondrocyte cell adhesion. Anal. Biochem. 192:380-383.
26. Millhouse, S., and B. Wigdahl. 2000. Molecular circuitry regulating herpes simplex virus type 1 latency in neurons. J. Neurovirol. 6:6-24.
27. Minty, A. J., M. Caravatti, B. Robert, A. Cohen, P. Daubas, A. Weydert, F. Gros, and M. E. Buckingham. 1981. Mouse actin messenger RNAs, Construction and characterization of a recombinant plasmid molecule containing a complementary DNA transcript of mouse alpha-actin mRNA. J. Biol. Chem. 256:1008-1014.
28. Mitchell, W., J. R. P. Lirette, and N. W. Fraser. 1990. Mapping of low abundance latency associated RNA in the trigeminal ganglia of mice latently infected with herpes simplex virus type 1. J. Gen. Virol. 71:125-132.
29. Nicosia, M., J. M. Zabolotny, R. P. Lirette, and N. W. Fraser. 1994. The HSV-1 2-kb latency-associated transcript is found in the cytoplasm comigrating with ribosomal subunits during productive infection. Virology 204:717-728.
30. Perng, G. C., C. Jones, J. Ciacei-Zanella, M. Stone, G. Henderson, A. Yukht, S. M. Slanina, F. M. Hofman, H. Ghiasi, A. B. Nesburn, and S. L. Wechsler. 2000. Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript. Science 287:1500-1503.
31. Perry, L. J., and D. J. MaGeoch. 1998. The DNA sequences of the long repeat region and adjoining parts of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69:2831-2846.
32. Saldanha, C. E., J. Lubinski, C. Martin, T. Nagashunmugam, L. Wang, H. van Der Keyl, R. Tal-Singer, and H. M. Friedman. 2000. Herpes simplex virus type 1 glycoprotein E domains involved in virus spread and disease. J. Virol. 74:6712-6719.
33. Sawtell, N. M., D. K. Poon, C. S. Tansky, and R. L. Thompson. 1998. The latent herpes simplex virus type 1 genome copy number in individual neurons is virus strain specific and correlates with reactivation. J. Virol. 72:5343-5350.
34. Spivack, J. G., and N. W. Fraser. 1987. Detection of herpes simplex virus type 1 transcripts during latent infection in mice. J. Virol. 61:3841-3847.
35. Spivack, J. G., G. M. Woods, and N. W. Fraser. 1991. Identification of a novel latency-specific splice donor signal within the herpes simplex virus type 1 2.0-kilobase latency-associated transcript (LAT); translation inhibition of LAT open reading frames by the intron within the 2.0-kilobase LAT. J. Virol. 65:6800-6810.
36. Steiner, I., J. G. Spivack, D. R. O'Boyle II, E. Lavi, and N. W. Fraser. 1988. Latent herpes simplex virus type 1 transcription in human trigeminal ganglia. J. Virol. 62:3493-3496.
37. Steiner, I., J. G. Spivack, R. P. Lirette, S. M. Brown, A. R. MacLean, J. H. Subak-Sharpe, and N. W. Fraser. 1989. Herpes simplex virus type 1 latency-associated transcripts are evidently not essential for latent infection. EMBO J. 8:505-511.
38. Steiner, I., J. G. Spivack, S. L. Deshmane, C. I. Ace, C. M. Preston, and N. W. Fraser. 1990. A herpes simplex virus type 1 mutant containing a nontransinducing Vmw65 protein establishes latent infection in vivo in the absence of viral replication and reactivates efficiently from explanted trigeminal ganglia. J. Virol. 64:1630-1638.
39. Steiner, I., N. Mador, I. Reibstein, J. G. Spivack, and N. W. Fraser. 1994. Herpes simplex virus type 1 latency in human and mouse central nervous systems. Neuropathol. Appl. Neurobiol. 20:253-260.
40. Steiner, I., and P. G. E. Kennedy. 1995. Herpes simplex virus latent infection in the nervous system. J. Neurovirol. 1:19-29.
41. Stevens, J. G., E. K. Wagner, G. B. Devi-Rao, M. L. Cook, and L. T. Feldman. 1987. RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons. Science 235:1056-1059.
42. Tanaka, S., H. Minagawa, Y. Toh, Y. Liu, and R. Mori. 1994. Analysis by RNA-PCR of latency and reactivation of herpes simplex virus in multiple neuronal tissues. J. Gen. Virol. 75:2691-2698.
43. Thomas, D. L., M. Lock, J. M. Zabolotny, B. R. Mohan, and N. W. Fraser. 2002. The 2-kilobase intron of the herpes simplex virus type 1 latency-associated transcript has a half-life of approximately 24 hours in SY5Y and COS-1 cells. J. Virol. 76:532-540.
44. Thomas, S. K., C. E. Lilley, D. S. Latchman, and R. S. Coffin. 2002. A protein encoded by the herpes simplex virus (HSV) type 1 2-kilobase latency-associated transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted into the quiescent HSV genome. J. Virol. 76:4056-4067.
45. Thompson, R. L., and N. M. Sawtell. 1997. The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency. J. Virol. 71:5432-5440.
46. Thompson, R. L., and N. M. Sawtell. 2001. Herpes simplex virus type 1 latency-associated transcript gene promotes neuronal survival. J. Virol. 75:6660-6675.
47. Trousdale, M. D., I. Steiner, J. G. Spivack, S. L. Deshmane, S. M. Brown, A. R. MacLean, J. H. Subak-Sharpe, and N. W. Fraser. 1991. In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model. J. Virol. 65:6989-6993.
48. Tsumoto, H. 1990. Autoradiography of new era replacing traditional X-ray film. Cell Technol. 9:456-462.
49. Wang, K., L. Pesnicak, E. Guancial, P. R. Krause, and S. E. Straus. 2001. The 2.2-kilobase latency-associated transcript of herpes simplex virus type 2 does not modulate viral replication, reactivation, or establishment of latency in transgenic mice. J. Virol. 75:8166-8172.
50. Whitley, R. J. 1990. Herpes simplex viruses, p. 1843-1886. In B. N. Fields, D. M. Knipe, et al. (ed.), Virology, 2nd ed. Raven Press, New York, N.Y.
51. Wu, T. T., Y. H. Su, T. M. Block, and J. M. Taylor. 1998. Atypical splicing of the latency associated transcripts of herpes simplex type 1. Virology 243:140-149.
52. Zhan, Y., J. L. Brady, A. M. Johnston, and A. M. Lew. 2000. Predominant transgene statement in exocrine pancreas directed by the CMV promoter. DNA Cell Biol. 19:639-645.
53. Zwaagstra, J. C., H. Ghiasi, S. M. Slanina, A. B. Nesburn, S. C. Wheatley, K. Lillycrop, J. Wood, D. S. Latchman, K. Patel, and S. L. Wechsler. 1990. Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J. Virol. 64:5019-5028.