Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: A role for oxidative stress in valproic acid-induced neural tube defects

Molecular Pharmacology

Volumn 80, Issue 6, 2011, Pages 979-987

  Tung, Emily W Y ^a   Winn, Louise M ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; 8 HYDROXYDEOXYGUANOSINE; ANTIOXIDANT; CATALASE; REACTIVE OXYGEN METABOLITE; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; EMBRYO GROWTH; FEMALE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NEURAL TUBE DEFECT; NIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; TERATOLOGY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC DEVELOPMENT; FEMALE; MICE; NEURAL TUBE DEFECTS; ORGAN CULTURE TECHNIQUES; OXIDATIVE STRESS; PREGNANCY; REACTIVE OXYGEN SPECIES; VALPROIC ACID;

EID: 81555195488     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.072314     Document Type: Article

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