Transgenic mice overproducing human thioredoxin-1, an antioxidative and anti-apoptotic protein, prevents diabetic embryopathy

Diabetologia

Volumn 53, Issue 9, 2010, Pages 2046-2055

  Kamimoto, Y ^a   Sugiyama, T ^a   Kihira, T ^a   Zhang, L ^a   Murabayashi, N ^a   Umekawa, T ^a   Nagao, K ^a   Ma, N ^b   Toyoda, N ^a   Yodoi, J ^c   Sagawa, N ^a  

^a MIE UNIVERSITY   (Japan)

^b SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Congenital malformations; Oxidative stress; Pregnancy; Thioredoxin

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CASPASE 3; MESSENGER RNA; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOREDOXIN 1; THIOREDOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DIABETIC EMBRYOPATHY; EMBRYO; EMBRYOPATHY; FEMALE; FETAL WELL BEING; FETUS; FETUS WEIGHT; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INCIDENCE; MALE; MOUSE; NEUROEPITHELIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PLACENTA CIRCULATION; PLACENTA WEIGHT; PREGNANCY; PRIORITY JOURNAL; STREPTOZOCIN DIABETES; TRANSGENIC MOUSE; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CYTOLOGY; EXPERIMENTAL DIABETES MELLITUS; FETAL DISEASES; GENETICS; HUMAN; METABOLISM; NEUROEPITHELIUM CELL; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PREGNANCY IN DIABETICS;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; FETAL DISEASES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL; NEUROEPITHELIAL CELLS; POLYMERASE CHAIN REACTION; PREGNANCY; PREGNANCY IN DIABETICS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; THIOREDOXINS;

EID: 77955557018     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1784-y     Document Type: Article

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