Molecular and Cellular Mechanisms of Kidney Development

Seldin and Geibisch's The Kidney

Volumn 1, Issue , 2013, Pages 859-890

  Bush, Kevin T ^a   Sakurai, Hiroyuki ^b   Nigam, Sanjay K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KYORIN UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84884048901     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-381462-3.00025-2     Document Type: Chapter

References (288)

1. Bouchard M., Souabni A., Mandler M., Neubuser A., Busslinger M. Nephric lineage specification by Pax2 and Pax8. Genes Dev 2002, 16(22):2958-2970.
2. Mauch T.J., Yang G., Wright M., Smith D., Schoenwolf G.C. Signals from trunk paraxial mesoderm induce pronephros formation in chick intermediate mesoderm. Dev Biol 2000, 220(1):62-75.
3. Obara-Ishihara T., Kuhlman J., Niswander L., Herzlinger D. The surface ectoderm is essential for nephric duct formation in intermediate mesoderm. Development 1999, 126(6):1103-1108.
4. Vize P.D., Seufert D.W., Carroll T.J., Wallingford J.B. Model systems for the study of kidney development: use of the pronephros in the analysis of organ induction and patterning. Dev Biol 1997, 188(2):189-204.
5. Smith C., Mackay S. Morphological development and fate of the mouse mesonephros. J Anat 1991, 174:171-184.
6. Kobayashi A., Valerius M.T., Mugford J.W., Carroll T.J., Self M., Oliver G., et al. Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 2008, 3(2):169-181.
7. Saxen L, Organogenesis of the Kidney. In: Barlow P, Green P, White C, editors. Cambridge, U.K.: Cambridge University Press; 1987; 184.
8. Costantini F. GDNF/Ret signaling and renal branching morphogenesis: from mesenchymal signals to epithelial cell behaviors. Organogenesis 2010, 6(4):252-262.
9. Sajithlal G., Zou D., Silvius D., Xu P.X. Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol 2005, 284(2):323-336.
10. Osathanondh V., Potter E.L. Development of human kidney as shown by microdissection. III. Formation and interrelationship of collecting tubules and nephrons. Arch Pathol 1963, 76:290-302.
11. Osathanondh V., Potter E.L. Development of human kidney as shown by microdissection. II. Renal pelvis, calyces, and papillae. Arch Pathol 1963, 76:277-289.
12. Osathanondh V., Potter E.L. Development of human kidney as shown by microdissection. V. Development of vascular pattern of glomerulus. Arch Pathol 1966, 82(5):403-411.
13. Sequeira Lopez M.L., Gomez R.A. Development of the renal arterioles. J Am Soc Nephrol 2011, 22(12):2156-2165.
14. Grobstein C. Morphogenetic interaction between embryonic mouse tissues separated by a membrane filter. Nature 1953, 172(4384):869-870.
15. Grobstein C. Inductive epitheliomesenchymal interaction in cultured organ rudiments of the mouse. Science 1953, 118(3054):52-55.
16. Grobstein C. Inductive tissue interaction in development. Adv Cancer Res 1956, 4:187-236.
17. Ekblom P., Thesleff I., Miettinen A., Saxen L. Organogenesis in a defined medium supplemented with transferrin. Cell Differ 1981, 10(5):281-288.
18. Laitinen L., Virtanen I., Saxen L. Changes in the glycosylation pattern during embryonic development of mouse kidney as revealed with lectin conjugates. J Histochem Cytochem 1987, 35(1):55-65.
19. Durbeej M., Soderstrom S., Ebendal T., Birchmeier C., Ekblom P. Differential expression of neurotrophin receptors during renal development. Development 1993, 119(4):977-989.
20. Davies J.A., Ladomery M., Hohenstein P., Michael L., Shafe A., Spraggon L., et al. Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation. Hum Mol Genet 2004, 13(2):235-246.
21. Sakai T., Larsen M., Yamada K.M. Fibronectin requirement in branching morphogenesis. Nature 2003, 423(6942):876-881.
22. Brophy P.D., Ostrom L., Lang K.M., Dressler G.R. Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 2001, 128(23):4747-4756.
23. Maeshima A., Sakurai H., Choi Y., Kitamura S., Vaughn D.A., Tee J.B., et al. Glial cell-derived neurotrophic factor independent ureteric bud outgrowth from the Wolffian duct. J Am Soc Nephrol 2007, 18(12):3147-3155.
24. Maeshima A., Vaughn D.A., Choi Y., Nigam S.K. Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev Biol 2006, 295(2):473-485.
25. Rosines E., Sampogna R.V., Johkura K., Vaughn D.A., Choi Y., Sakurai H., et al. Staged in vitro reconstitution and implantation of engineered rat kidney tissue. Proc Natl Acad Sci USA 2007, 104(52):20938-20943.
26. Tang M.J., Cai Y., Tsai S.J., Wang Y.K., Dressler G.R. Ureteric bud outgrowth in response to RET activation is mediated by phosphatidylinositol 3-kinase. Dev Biol 2002, 243(1):128-136.
27. Bush K.T., Vaughn D.A., Li X., Rosenfeld M.G., Rose D.W., Mendoza S.A., et al. Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system. Dev Biol 2006, 298(2):571-584.
28. Choi Y., Tee J.B., Gallegos T.F., Shah M.M., Oishi H., Sakurai H., et al. Neuropeptide Y functions as a facilitator of GDNF-induced budding of the Wolffian duct. Development 2009, 136(24):4213-4224.
29. Rosines E., Johkura K., Zhang X., Schmidt H.J., Decambre M., Bush K.T., et al. Constructing kidney-like tissues from cells based on programs for organ development: toward a method of in vitro tissue engineering of the kidney. Tissue Eng Part A 2010, 6(18):2441-2455.
30. Tee J.B., Choi Y., Shah M.M., Dnyanmote A., Sweeney D.E., Gallegos T.F., et al. Protein kinase A regulates GDNF/RET-dependent but not GDNF/Ret-independent ureteric bud outgrowth from the Wolffian duct. Dev Biol 2010, 347(2):337-347.
31. Qiao J., Sakurai H., Nigam S.K. Branching morphogenesis independent of mesenchymal-epithelial contact in the developing kidney. Proc Natl Acad Sci USA 1999, 96(13):7330-7335.
32. Meyer T.N., Schwesinger C., Bush K.T., Stuart R.O., Rose D.W., Shah M.M., et al. Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney. Dev Biol 2004, 275(1):44-67.
33. Li Z., Stuart R.O., Qiao J., Pavlova A., Bush K.T., Pohl M., et al. A role for Timeless in epithelial morphogenesis during kidney development. Proc Natl Acad Sci USA 2000, 97(18):10038-10043.
34. Pohl M., Sakurai H., Bush K.T., Nigam S.K. Matrix metalloproteinases and their inhibitors regulate in vitro ureteric bud branching morphogenesis. Am J Physiol Renal Physiol 2000, 279(5):F891-F900.
35. Karihaloo A., Karumanchi S.A., Barasch J., Jha V., Nickel C.H., Yang J., et al. Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud. Proc Natl Acad Sci USA 2001, 98(22):12509-12514.
36. Qiao J., Bush K.T., Steer D.L., Stuart R.O., Sakurai H., Wachsman W., et al. Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis. Mech Dev 2001, 109(2):123-135.
37. Sakurai H., Bush K.T., Nigam S.K. Identification of pleiotrophin as a mesenchymal factor involved in ureteric bud branching morphogenesis. Development 2001, 128(17):3283-3293.
38. Zent R., Bush K.T., Pohl M.L., Quaranta V., Koshikawa N., Wang Z., et al. Involvement of laminin binding integrins and laminin-5 in branching morphogenesis of the ureteric bud during kidney development. Dev Biol 2001, 238(2):289-302.
39. Stuart R.O., Bush K.T., Nigam S.K. Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in models of kidney development. Kidney Int 2003, 64(6):1997-2008.
40. Bush K.T., Sakurai H., Steer D.L., Leonard M.O., Sampogna R.V., Meyer T.N., et al. TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Dev Biol 2004, 266(2):285-298.
41. Steer D.L., Shah M.M., Bush K.T., Stuart R.O., Sampogna R.V., Meyer T.N., et al. Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Dev Biol 2004, 272(2):310-327.
42. Sakurai H., Bush K.T., Nigam S.K. Heregulin induces glial cell line-derived neurotrophic growth factor-independent, non-branching growth and differentiation of ureteric bud epithelia. J Biol Chem 2005, 280(51):42181-42187.
43. Meyer T.N., Schwesinger C., Sampogna R.V., Vaughn D.A., Stuart R.O., Steer D.L., et al. Rho kinase acts at separate steps in ureteric bud and metanephric mesenchyme morphogenesis during kidney development. Differentiation 2006, 74(9-10):638-647.
44. Shah M.M., Tee J.B., Meyer T., Meyer-Schwesinger C., Choi Y., Sweeney D.E., et al. The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects. Am J Physiol Renal Physiol 2009, 297(5):F1330-F1341.
45. Wu W., Kitamura S., Truong D.M., Rieg T., Vallon V., Sakurai H., et al. Beta1-integrin is required for kidney collecting duct morphogenesis and maintenance of renal function. Am J Physiol Renal Physiol 2009, 297(1):F210-F217.
46. Shah M.M., Sakurai H., Sweeney D.E., Gallegos T.F., Bush K.T., Esko J.D., et al. Hs2st mediated kidney mesenchyme induction regulates early ureteric bud branching. Dev Biol 2010, 339(2):354-365.
47. Shah M.M., Sakurai H., Gallegos T.F., Sweeney D.E., Bush K.T., Esko J.D., et al. Growth factor-dependent branching of the ureteric bud is modulated by selective 6-O sulfation of heparan sulfate. Dev Biol 2011, 356(1):19-27.
48. Grobstein C. Trans-filter induction of tubules in mouse metanephrogenic mesenchyme. Exp Cell Res 1956, 10(2):424-440.
49. Saxen L., Lehtonen E. Embryonic kidney in organ culture. Differentiation 1987, 36(1):2-11.
50. Lehtonen E., Wartiovaara J., Nordling S., Saxen L. Demonstration of cytoplasmic processes in Millipore filters permitting kidney tubule induction. J Embryol Exp Morphol 1975, 33(1):187-203.
51. Barasch J., Yang J., Ware C.B., Taga T., Yoshida K., Erdjument-Bromage H., et al. Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell 1999, 99(4):377-386.
52. Plisov S.Y., Yoshino K., Dove L.F., Higinbotham K.G., Rubin J.S., Perantoni A.O. TGF beta 2, LIF and FGF2 cooperate to induce nephrogenesis. Development 2001, 128(7):1045-1057.
53. Bullock S.L., Fletcher J.M., Beddington R.S., Wilson V.A. Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Genes Dev 1998, 12(12):1894-1906.
54. Capecchi M.R. Altering the genome by homologous recombination. Science 1989, 244(4910):1288-1292.
55. Capecchi M.R. Targeted gene replacement. Sci Am 1994, 270(3):52-59.
56. Galli-Taliadoros L.A., Sedgwick J.D., Wood S.A., Korner H. Gene knock-out technology: a methodological overview for the interested novice. J Immunol Methods 1995, 181(1):1-15.
57. Lechner M.S., Dressler G.R. The molecular basis of embryonic kidney development. Mech Dev 1997, 62(2):105-120.
58. Yu J., McMahon A.P., Valerius M.T. Recent genetic studies of mouse kidney development. Curr Opin Genet Dev 2004, 14(5):550-557.
59. Miyamoto N., Yoshida M., Kuratani S., Matsuo I., Aizawa S. Defects of urogenital development in mice lacking Emx2. Development 1997, 124(9):1653-1664.
60. Ly J.P., Onay T., Quaggin S.E. Mouse models to study kidney development, function and disease. Curr Opin Nephrol Hypertens 2011, 20(4):382-390.
61. Birling M.C., Gofflot F., Warot X. Site-specific recombinases for manipulation of the mouse genome. Methods Mol Biol 2009, 561:245-263.
62. Gawlik A., Quaggin S.E. Deciphering the renal code: advances in conditional gene targeting. Physiology (Bethesda) 2004, 19:245-252.
63. Zhang X., Mernaugh G., Yang D.H., Gewin L., Srichai M.B., Harris R.C., et al. beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development 2009, 136(19):3357-3366.
64. Santos O.F., Moura L.A., Rosen E.M., Nigam S.K. Modulation of HGF-induced tubulogenesis and branching by multiple phosphorylation mechanisms. Dev Biol 1993, 159(2):535-548.
65. Barros E.J., Santos O.F., Matsumoto K., Nakamura T., Nigam S.K. Differential tubulogenic and branching morphogenetic activities of growth factors: implications for epithelial tissue development. Proc Natl Acad Sci USA 1995, 92(10):4412-4416.
66. Cantley L.G., Barros E.J., Gandhi M., Rauchman M., Nigam S.K. Regulation of mitogenesis, motogenesis, and tubulogenesis by hepatocyte growth factor in renal collecting duct cells. Am J Physiol 1994, 267(2 Pt 2):F271-F280.
67. Sakurai H., Nigam S.K. Transforming growth factor-beta selectively inhibits branching morphogenesis but not tubulogenesis. Am J Physiol 1997, 272(1 Pt 2):F139-F146.
68. Sakurai H., Tsukamoto T., Kjelsberg C.A., Cantley L.G., Nigam S.K. EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney. Am J Physiol 1997, 273(3 Pt 2):F463-F472.
69. Sakurai H., Barros E.J., Tsukamoto T., Barasch J., Nigam S.K. An in vitro tubulogenesis system using cell lines derived from the embryonic kidney shows dependence on multiple soluble growth factors. Proc Natl Acad Sci USA 1997, 94(12):6279-6284.
70. Zegers M.M., O'Brien L.E., Yu W., Datta A., Mostov K.E. Epithelial polarity and tubulogenesis in vitro. Trends Cell Biol 2003, 13(4):169-176.
71. Stuart R.O., Barros E.J., Ribeiro E., Nigam S.K. Epithelial tubulogenesis through branching morphogenesis: relevance to collecting system development. J Am Soc Nephrol 1995, 6(4):1151-1159.
72. Stuart R.O., Bush K.T., Nigam S.K. Changes in global gene expression patterns during development and maturation of the rat kidney. Proc Natl Acad Sci USA 2001, 98(10):5649-5654.
73. Tsigelny I.F., Kouznetsova V.L., Sweeney D.E., Wu W., Bush K.T., Nigam S.K. Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Sci Signal 2008, 1(49):ra16.
74. Schmidt-Ott K.M., Masckauchan T.N., Chen X., Hirsh B.J., Sarkar A., Yang J., et al. Beta-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors. Development 2007, 134(17):3177-3190.
75. Sweeney D.E., Vallon V., Rieg T., Wu W., Gallegos T.F., Nigam S.K. Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney. Mol Pharmacol 2011, 80(1):147-154.
76. Brunskill E.W., Aronow B.J., Georgas K., Rumballe B., Valerius M.T., Aronow J., et al. Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell 2008, 15(5):781-791.
77. Georgas K.M., Chiu H.S., Lesieur E., Rumballe B.A., Little M.H. Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Dev Dyn 2011, 240(6):1600-1612.
78. Harding S.D., Armit C., Armstrong J., Brennan J., Cheng Y., Haggarty B., et al. The GUDMAP database-an online resource for genitourinary research. Development 2011, 138(13):2845-2853.
79. Little M.H., Brennan J., Georgas K., Davies J.A., Davidson D.R., Baldock R.A., et al. A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns 2007, 7(6):680-699.
80. McMahon A.P., Aronow B.J., Davidson D.R., Davies J.A., Gaido K.W., Grimmond S., et al. GUDMAP: the genitourinary developmental molecular anatomy project. J Am Soc Nephrol 2008, 19(4):667-671.
81. Nigam S.K., Shah M.M. How does the ureteric bud branch?. J Am Soc Nephrol 2009, 20(7):1465-1469.
82. Sampogna R.V., Nigam S.K. Implications of gene networks for understanding resilience and vulnerability in the kidney branching program. Physiology (Bethesda) 2004, 19:339-347.
83. Ishibe S., Karihaloo A., Ma H., Zhang J., Marlier A., Mitobe M., et al. Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology. Development 2009, 136(2):337-345.
84. Pastorelli L.M., Wells S., Fray M., Smith A., Hough T., Harfe B.D., et al. Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mamm Genome 2009, 20(3):140-151.
85. Patel S.R., Kim D., Levitan I., Dressler G.R. The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex. Dev Cell 2007, 13(4):580-592.
86. Nagalakshmi V.K., Ren Q., Pugh M.M., Valerius M.T., McMahon A.P., Yu J. Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int 2011, 79(3):317-330.
87. Harvey S.J., Jarad G., Cunningham J., Goldberg S., Schermer B., Harfe B.D., et al. Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol 2008, 19(11):2150-2158.
88. Ho J., Ng K.H., Rosen S., Dostal A., Gregory R.I., Kreidberg J.A. Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury. J Am Soc Nephrol 2008, 19(11):2069-2075.
89. Ho J.J., Marsden P.A. Dicer cuts the kidney. J Am Soc Nephrol 2008, 19(11):2043-2046.
90. Saal S., Harvey S.J. MicroRNAs and the kidney: coming of age. Curr Opin Nephrol Hypertens 2009, 18(4):317-323.
91. Shi S., Yu L., Chiu C., Sun Y., Chen J., Khitrov G., et al. Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol 2008, 19(11):2159-2169.
92. Tang K.F., Song G.B., Shi Y.S., Yuan L., Li Y.H. Dicer knockdown induces fibronectin-1 expression in HEK293T cells via induction of Egr1. Biochim Biophys Acta 2010, 1800(3):380-384.
93. Wei Q., Bhatt K., He H.Z., Mi Q.S., Haase V.H., Dong Z. Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury. J Am Soc Nephrol 2010, 21(5):756-761.
94. Monte J.C., Sakurai H., Bush K.T., Nigam S.K. The developmental nephrome: systems biology in the developing kidney. Curr Opin Nephrol Hypertens 2007, 16(1):3-9.
95. Nigam S.K. From the ureteric bud to the penome. Kidney Int 2003, 64(6):2320-2322.
96. Costantini F., Kopan R. Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Dev Cell 2010, 18(5):698-712.
97. Dressler G.R. Patterning and early cell lineage decisions in the developing kidney: the role of Pax genes. Pediatr Nephrol 2011, 26(9):1387-1394.
98. Little M., Georgas K., Pennisi D., Wilkinson L. Kidney development: two tales of tubulogenesis. Curr Top Dev Biol 2010, 90:193-229.
99. Miner J.H. Organogenesis of the kidney glomerulus: focus on the glomerular basement membrane. Organogenesis 2011, 7(2):75-82.
100. Chapin H.C., Caplan M.J. The cell biology of polycystic kidney disease. J Cell Biol 2010, 191(4):701-710.
101. Reidy K.J., Rosenblum N.D. Cell and molecular biology of kidney development. Semin Nephrol 2009, 29(4):321-337.
102. Davis A.P., Witte D.P., Hsieh-Li H.M., Potter S.S., Capecchi M.R. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11. Nature 1995, 375(6534):791-795.
103. Wellik D.M., Hawkes P.J., Capecchi M.R. Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev 2002, 16(11):1423-1432.
104. Dressler G.R., Deutsch U., Chowdhury K., Nornes H.O., Gruss P. Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development 1990, 109(4):787-795.
105. Dressler G.R., Douglass E.C. Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor. Proc Natl Acad Sci USA 1992, 89(4):1179-1183.
106. Torres M., Gomez-Pardo E., Dressler G.R., Gruss P. Pax-2 controls multiple steps of urogenital development. Development 1995, 121(12):4057-4065.
107. Plachov D., Chowdhury K., Walther C., Simon D., Guenet J.L., Gruss P. Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development 1990, 110(2):643-651.
108. Mansouri A., Chowdhury K., Gruss P. Follicular cells of the thyroid gland require Pax8 gene function. Nat Genet 1998, 19(1):87-90.
109. Narlis M., Grote D., Gaitan Y., Boualia S.K., Bouchard M. Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J Am Soc Nephrol 2007, 18(4):1121-1129.
110. Wawersik S., Purcell P., Maas R.L. Pax6 and the genetic control of early eye development. Results Probl Cell Differ 2000, 31:15-36.
111. Xu P.X., Adams J., Peters H., Brown M.C., Heaney S., Maas R. Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet 1999, 23(1):113-117.
112. Li X., Oghi K.A., Zhang J., Krones A., Bush K.T., Glass C.K., et al. Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature 2003, 426(6964):247-254.
113. Xu P.X., Zheng W., Huang L., Maire P., Laclef C., Silvius D. Six1 is required for the early organogenesis of mammalian kidney. Development 2003, 130(14):3085-3094.
114. Gong K.Q., Yallowitz A.R., Sun H., Dressler G.R., Wellik D.M. A Hox-Eya-Pax complex regulates early kidney developmental gene expression. Mol Cell Biol 2007, 27(21):7661-7668.
115. Nishinakamura R., Matsumoto Y., Nakao K., Nakamura K., Sato A., Copeland N.G., et al. Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. Development 2001, 128(16):3105-3115.
116. Kiefer S.M., Robbins L., Stumpff K.M., Lin C., Ma L., Rauchman M. Sall1-dependent signals affect Wnt signaling and ureter tip fate to initiate kidney development. Development 2010, 137(18):3099-3106.
117. Nishinakamura R., Osafune K. Essential roles of Sall family genes in kidney development. J Physiol Sci 2006, 56(2):131-136.
118. Kume T., Deng K., Hogan B.L. Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. Development 2000, 127(7):1387-1395.
119. Fujii T., Pichel J.G., Taira M., Toyama R., Dawid I.B., Westphal H. Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system. Dev Dyn 1994, 199(1):73-83.
120. Shawlot W., Behringer R.R. Requirement for Lim1 in head-organizer function. Nature 1995, 374(6521):425-430.
121. Tsang T.E., Shawlot W., Kinder S.J., Kobayashi A., Kwan K.M., Schughart K., et al. Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryo. Dev Biol 2000, 223(1):77-90.
122. Drummond I.A., Madden S.L., Rohwer-Nutter P., Bell G.I., Sukhatme V.P., Rauscher F.J. Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1. Science 1992, 257(5070):674-678.
123. Werner H., Re G.G., Drummond I.A., Sukhatme V.P., Rauscher F.J., Sens D.A., et al. Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product. Proc Natl Acad Sci USA 1993, 90(12):5828-5832.
124. Ryan G., Steele-Perkins V., Morris J.F., Rauscher F.J., Dressler G.R. Repression of Pax-2 by WT1 during normal kidney development. Development 1995, 121(3):867-875.
125. Hewitt S.M., Hamada S., McDonnell T.J., Rauscher F.J., Saunders G.F. Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res 1995, 55(22):5386-5389.
126. Kreidberg J.A., Sariola H., Loring J.M., Maeda M., Pelletier J., Housman D., et al. WT-1 is required for early kidney development. Cell 1993, 74(4):679-691.
127. Donovan M.J., Natoli T.A., Sainio K., Amstutz A., Jaenisch R., Sariola H., et al. Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Dev Genet 1999, 24(3-4):252-262.
128. Mundlos S., Pelletier J., Darveau A., Bachmann M., Winterpacht A., Zabel B. Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues. Development 1993, 119(4):1329-1341.
129. Kim H.S., Kim M.S., Hancock A.L., Harper J.C., Park J.Y., Poy G., et al. Identification of novel Wilms' tumor suppressor gene target genes implicated in kidney development. J Biol Chem 2007, 282(22):16278-16287.
130. Maas R., Elfering S., Glaser T., Jepeal L. Deficient outgrowth of the ureteric bud underlies the renal agenesis phenotype in mice manifesting the limb deformity (ld) mutation. Dev Dyn 1994, 199(3):214-228.
131. Chan D.C., Wynshaw-Boris A., Leder P. Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud. Development 1995, 121(10):3151-3162.
132. Mass R.L., Zeller R., Woychik R.P., Vogt T.F., Leder P. Disruption of formin-encoding transcripts in two mutant limb deformity alleles. Nature 1990, 346(6287):853-855.
133. Wynshaw-Boris A., Ryan G., Deng C.X., Chan D.C., Jackson-Grusby L., Larson D., et al. The role of a single formin isoform in the limb and renal phenotypes of limb deformity. Mol Med 1997, 3(6):372-384.
134. Mugrauer G., Ekblom P. Contrasting expression patterns of three members of the myc family of protooncogenes in the developing and adult mouse kidney. J Cell Biol 1991, 112(1):13-25.
135. Charron J., Malynn B.A., Fisher P., Stewart V., Jeannotte L., Goff S.P., et al. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev 1992, 6(12A):2248-2257.
136. Davis A.C., Wims M., Spotts G.D., Hann S.R., Bradley A. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev 1993, 7(4):671-682.
137. Stanton B.R., Perkins A.S., Tessarollo L., Sassoon D.A., Parada L.F. Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev 1992, 6(12A):2235-2247.
138. Gotter A.L., Manganaro T., Weaver D.R., Kolakowski L.F., Possidente B., Sriram S., et al. A time-less function for mouse timeless. Nat Neurosci 2000, 3(8):755-756.
139. Guo B., Panagiotaki N., Warwood S., Sharrocks A.D. Dynamic modification of the ETS transcription factor PEA3 by sumoylation and p300-mediated acetylation. Nucleic Acids Res 2011, 39(15):6403-6413.
140. Kuure S., Chi X., Lu B., Costantini F. The transcription factors Etv4 and Etv5 mediate formation of the ureteric bud tip domain during kidney development. Development 2010, 137(12):1975-1979.
141. Lu B.C., Cebrian C., Chi X., Kuure S., Kuo R., Bates C.M., et al. Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nat Genet 2009, 41(12):1295-1302.
142. Reginensi A., Clarkson M., Neirijnck Y., Lu B., Ohyama T., Groves A.K., et al. SOX9 controls epithelial branching by activating RET effector genes during kidney development. Hum Mol Genet 2011, 20(6):1143-1153.
143. Hatini V., Huh S.O., Herzlinger D., Soares V.C., Lai E. Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Genes Dev 1996, 10(12):1467-1478.
144. Levinson R.S., Batourina E., Choi C., Vorontchikhina M., Kitajewski J., Mendelsohn C.L. Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development 2005, 132(3):529-539.
145. Zhang H., Palmer R., Gao X., Kreidberg J., Gerald W., Hsiao L., et al. Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. Curr Biol 2003, 13(18):1625-1629.
146. Quaggin S.E., Vanden Heuvel G.B., Igarashi P. Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney. Mech Dev 1998, 71(1-2):37-48.
147. Quaggin S.E., Schwartz L., Cui S., Igarashi P., Deimling J., Post M., et al. The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. Development 1999, 126(24):5771-5783.
148. Cui S., Schwartz L., Quaggin S.E. Pod1 is required in stromal cells for glomerulogenesis. Dev Dyn 2003, 226(3):512-522.
149. Schnabel C.A., Godin R.E., Cleary M.L. Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney. Dev Biol 2003, 254(2):262-276.
150. Wilson J.G., Roth C.B., Warkany J. An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation. Am J Anat 1953, 92(2):189-217.
151. Batourina E., Gim S., Bello N., Shy M., Clagett-Dame M., Srinivas S., et al. Vitamin A controls epithelial/mesenchymal interactions through Ret expression. Nat Genet 2001, 27(1):74-78.
152. Mendelsohn C., Batourina E., Fung S., Gilbert T., Dodd J. Stromal cells mediate retinoid-dependent functions essential for renal development. Development 1999, 126(6):1139-1148.
153. Pontoglio M., Barra J., Hadchouel M., Doyen A., Kress C., Bach J.P., et al. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell 1996, 84(4):575-585.
154. Nakai S., Sugitani Y., Sato H., Ito S., Miura Y., Ogawa M., et al. Crucial roles of Brn1 in distal tubule formation and function in mouse kidney. Development 2003, 130(19):4751-4759.
155. Wong K., Park H.T., Wu J.Y., Rao Y. Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. Curr Opin Genet Dev 2002, 12(5):583-591.
156. Grieshammer U., Le M., Plump A.S., Wang F., Tessier-Lavigne M., Martin G.R. SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell 2004, 6(5):709-717.
157. Kramer S., Okabe M., Hacohen N., Krasnow M.A., Hiromi Y. Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila. Development 1999, 126(11):2515-2525.
158. Basson M.A., Akbulut S., Watson-Johnson J., Simon R., Carroll T.J., Shakya R., et al. Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell 2005, 8(2):229-239.
159. Michos O., Cebrian C., Hyink D., Grieshammer U., Williams L., D'Agati V., et al. Kidney development in the absence of Gdnf and Spry1 requires Fgf10. PLoS Genet 2010, 6(1):e1000809.
160. Esquela A.F., Lee S.J. Regulation of metanephric kidney development by growth/differentiation factor 11. Dev Biol 2003, 257(2):356-370.
161. McPherron A.C., Lawler A.M., Lee S.J. Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11. Nat Genet 1999, 22(3):260-264.
162. Oh S.P., Yeo C.Y., Lee Y., Schrewe H., Whitman M., Li E. Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning. Genes Dev 2002, 16(21):2749-2754.
163. Oh S.P., Li E. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev 1997, 11(14):1812-1826.
164. Zhao H., Kegg H., Grady S., Truong H.T., Robinson M.L., Baum M., et al. Role of fibroblast growth factor receptors 1 and 2 in the ureteric bud. Dev Biol 2004, 276(2):403-415.
165. Santos O.F., Barros E.J., Yang X.M., Matsumoto K., Nakamura T., Park M., et al. Involvement of hepatocyte growth factor in kidney development. Dev Biol 1994, 163(2):525-529.
166. Moore M.W., Klein R.D., Farinas I., Sauer H., Armanini M., Phillips H., et al. Renal and neuronal abnormalities in mice lacking GDN. Nature 1996, 382(6586):76-79.
167. Pichel J.G., Shen L., Sheng H.Z., Granholm A.C., Drago J., Grinberg A., et al. Defects in enteric innervation and kidney development in mice lacking GDN. Nature 1996, 382(6586):73-76.
168. Sanchez M.P., Silos-Santiago I., Frisen J., He B., Lira S.A., Barbacid M. Renal agenesis and the absence of enteric neurons in mice lacking GDN. Nature 1996, 382(6586):70-73.
169. Enomoto H., Araki T., Jackman A., Heuckeroth R.O., Snider W.D., Johnson E.M., et al. GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys. Neuron 1998, 21(2):317-324.
170. Durbec P., Marcos-Gutierrez C.V., Kilkenny C., Grigoriou M., Wartiowaara K., Suvanto P., et al. GDNF signalling through the Ret receptor tyrosine kinase. Nature 1996, 381(6585):789-793.
171. Schuchardt A., D'Agati V., Pachnis V., Costantini F. Renal agenesis and hypodysplasia in ret-k-mutant mice result from defects in ureteric bud development. Development 1996, 122(6):1919-1929.
172. Sainio K., Suvanto P., Davies J., Wartiovaara J., Wartiovaara K., Saarma M., et al. Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development 1997, 124(20):4077-4087.
173. Cullen-McEwen L.A., Drago J., Bertram J.F. Nephron endowment in glial cell line-derived neurotrophic factor (GDNF) heterozygous mice. Kidney Int 2001, 60(1):31-36.
174. Cancilla B., Davies A., Cauchi J.A., Risbridger G.P., Bertram J.F. Fibroblast growth factor receptors and their ligands in the adult rat kidney. Kidney Int 2001, 60(1):147-155.
175. Celli G., LaRochelle W.J., Mackem S., Sharp R., Merlino G. Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. Embo J 1998, 17(6):1642-1655.
176. Qiao J., Uzzo R., Obara-Ishihara T., Degenstein L., Fuchs E., Herzlinger D. FGF-7 modulates ureteric bud growth and nephron number in the developing kidney. Development 1999, 126(3):547-554.
177. Ohuchi H., Hori Y., Yamasaki M., Harada H., Sekine K., Kato S., et al. FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem Biophys Res Commun 2000, 277(3):643-649.
178. Revest J.M., Spencer-Dene B., Kerr K., De Moerlooze L., Rosewell I., Dickson C. Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4. Dev Biol 2001, 231(1):47-62.
179. Bates C.M. Role of fibroblast growth factor receptor signaling in kidney development. Am J Physiol Renal Physiol 2011, 301(2):F245-F251.
180. Sims-Lucas S., Argyropoulos C., Kish K., McHugh K., Bertram J.F., Quigley R., et al. Three-dimensional imaging reveals ureteric and mesenchymal defects in Fgfr2-mutant kidneys. J Am Soc Nephrol 2009, 20(12):2525-2533.
181. Li Y.S., Milner P.G., Chauhan A.K., Watson M.A., Hoffman R.M., Kodner C.M., et al. Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science 1990, 250(4988):1690-1694.
182. Mitsiadis T.A., Salmivirta M., Muramatsu T., Muramatsu H., Rauvala H., Lehtonen E., et al. Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis. Development 1995, 121(1):37-51.
183. Amet L.E., Lauri S.E., Hienola A., Croll S.D., Lu Y., Levorse J.M., et al. Enhanced hippocampal long-term potentiation in mice lacking heparin-binding growth-associated molecule. Mol Cell Neurosci 2001, 17(6):1014-1024.
184. Lin Y., Liu A., Zhang S., Ruusunen T., Kreidberg J.A., Peltoketo H., et al. Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis. Dev Dyn 2001, 222(1):26-39.
185. Majumdar A., Vainio S., Kispert A., McMahon J., McMahon A.P. Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development 2003, 130(14):3175-3185.
186. Karner C.M., Chirumamilla R., Aoki S., Igarashi P., Wallingford J.B., Carroll T.J. Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet 2009, 41(7):793-799.
187. Yu J., Carroll T.J., Rajagopal J., Kobayashi A., Ren Q., McMahon A.P.A. Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 2009, 136(1):161-171.
188. Lescher B., Haenig B., Kispert A. sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. Dev Dyn 1998, 213(4):440-451.
189. Yoshino K., Rubin J.S., Higinbotham K.G., Uren A., Anest V., Plisov S.Y., et al. Secreted Frizzled-related proteins can regulate metanephric development. Mech Dev 2001, 102(1-2):45-55.
190. Ritvos O., Tuuri T., Eramaa M., Sainio K., Hilden K., Saxen L., et al. Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse. Mech Dev 1995, 50(2-3):229-245.
191. Miyazaki Y., Oshima K., Fogo A., Hogan B.L., Ichikawa I. Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. J Clin Invest 2000, 105(7):863-873.
192. Raatikainen-Ahokas A., Hytonen M., Tenhunen A., Sainio K., Sariola H. BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney. Dev Dyn 2000, 217(2):146-158.
193. Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M. The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell 1998, 1(5):673-683.
194. Michos O., Panman L., Vintersten K., Beier K., Zeller R., Zuniga A. Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 2004, 131(14):3401-3410.
195. Goncalves A., Zeller R. Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos. PLoS One 2011, 6(4):e19370.
196. Michos O., Goncalves A., Lopez-Rios J., Tiecke E., Naillat F., Beier K., et al. Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development 2007, 134(13):2397-2405.
197. Nie X., Xu J., El-Hashash A., Xu P.X. Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis. Dev Biol 2011, 352(1):141-151.
198. Bladt F., Riethmacher D., Isenmann S., Aguzzi A., Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 1995, 376(6543):768-771.
199. Schmidt C., Bladt F., Goedecke S., Brinkmann V., Zschiesche W., Sharpe M., et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 1995, 373(6516):699-702.
200. Massague J., Pandiella A. Membrane-anchored growth factors. Annu Rev Biochem 1993, 62:515-541.
201. Rogers S.A., Ryan G., Hammerman M.R. Metanephric transforming growth factor-alpha is required for renal organogenesis in vitro. Am J Physiol 1992, 262(4 Pt 2):F533-F539.
202. Montesano R., Matsumoto K., Nakamura T., Orci L. Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell 1991, 67(5):901-908.
203. -/- kidneys express epithelial cells that chemotax and form tubules in response to EGF receptor ligands. Am J Physiol 1997, 272(2 Pt 2):F222-F228.
204. Luetteke N.C., Qiu T.H., Peiffer R.L., Oliver P., Smithies O., Lee D.C. TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 1993, 73(2):263-278.
205. Mann G.B., Fowler K.J., Gabriel A., Nice E.C., Williams R.L., Dunn A.R. Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 1993, 73(2):249-261.
206. Threadgill D.W., Dlugosz A.A., Hansen L.A., Tennenbaum T., Lichti U., Yee D., et al. Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype. Science 1995, 269(5221):230-234.
207. Rogers S.A., Ryan G., Hammerman M.R. Insulin-like growth factors I and II are produced in the metanephros and are required for growth and development in vitro. J Cell Biol 1991, 113(6):1447-1453.
208. Wada J., Liu Z.Z., Alvares K., Kumar A., Wallner E., Makino H., et al. Cloning of cDNA for the alpha subunit of mouse insulin-like growth factor I receptor and the role of the receptor in metanephric development. Proc Natl Acad Sci USA 1993, 90(21):10360-10364.
209. Baker J., Liu J.P., Robertson E.J., Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993, 75(1):73-82.
210. Powell-Braxton L., Hollingshead P., Warburton C., Dowd M., Pitts-Meek S., Dalton D., et al. IGF-I is required for normal embryonic growth in mice. Genes Dev 1993, 7(12B):2609-2617.
211. Kanwar Y.S., Wada J., Lin S., Danesh F.R., Chugh S.S., Yang Q., et al. Update of extracellular matrix, its receptors, and cell adhesion molecules in mammalian nephrogenesis. Am J Physiol Renal Physiol 2004, 286(2):F202-F215.
212. Santos O.F., Nigam S.K. HGF-induced tubulogenesis and branching of epithelial cells is modulated by extracellular matrix and TGF-beta. Dev Biol 1993, 160(2):293-302.
213. Schuger L., O'Shea S., Rheinheimer J., Varani J. Laminin in lung development: effects of anti-laminin antibody in murine lung morphogenesis. Dev Biol 1990, 137(1):26-32.
214. Ekblom P., Ekblom M., Fecker L., Klein G., Zhang H.Y., Kadoya Y., et al. Role of mesenchymal nidogen for epithelial morphogenesis in vitro. Development 1994, 120(7):2003-2014.
215. Kreidberg J.A., Donovan M.J., Goldstein S.L., Rennke H., Shepherd K., Jones R.C., et al. Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development 1996, 122(11):3537-3547.
216. Kjellen L., Lindahl U. Proteoglycans: structures and interactions. Annu Rev Biochem 1991, 60:443-475.
217. Klein D.J., Brown D.M., Moran A., Oegema T.R., Platt J.L. Chondroitin sulfate proteoglycan synthesis and reutilization of beta-D-xyloside-initiated chondroitin/dermatan sulfate glycosaminoglycans in fetal kidney branching morphogenesis. Dev Biol 1989, 133(2):515-528.
218. Lelongt B., Makino H., Dalecki T.M., Kanwar Y.S. Role of proteoglycans in renal development. Dev Biol 1988, 128(2):256-276.
219. Kispert A., Vainio S., Shen L., Rowitch D.H., McMahon A.P. Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development 1996, 122(11):3627-3637.
220. Grisaru S., Cano-Gauci D., Tee J., Filmus J., Rosenblum N.D. Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis. Dev Biol 2001, 231(1):31-46.
221. Pohl M., Sakurai H., Stuart R.O., Nigam S.K. Role of hyaluronan and CD44 in in vitro branching morphogenesis of ureteric bud cells. Dev Biol 2000, 224(2):312-325.
222. Rosines E., Schmidt H.J., Nigam S.K. The effect of hyaluronic acid size and concentration on branching morphogenesis and tubule differentiation in developing kidney culture systems: potential applications to engineering of renal tissues. Biomaterials 2007, 28(32):4806-4817.
223. Kanwar Y.S., Ota K., Yang Q., Kumar A., Wada J., Kashihara N., et al. Isolation of rat fibrillin-1 cDNA and its relevance in metanephric development. Am J Physiol 1998, 275(5 Pt 2):F710-F723.
224. Montesano R., Soriano J.V., Pepper M.S., Orci L. Induction of epithelial branching tubulogenesis in vitro. J Cell Physiol 1997, 173(2):152-161.
225. Lelongt B., Trugnan G., Murphy G., Ronco P.M. Matrix metalloproteinases MMP2 and MMP9 are produced in early stages of kidney morphogenesis but only MMP9 is required for renal organogenesis in vitro. J Cell Biol 1997, 136(6):1363-1373.
226. Andrews K.L., Betsuyaku T., Rogers S., Shipley J.M., Senior R.M., Miner J.H., et al. (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome. Am J Pathol 2000, 157(1):303-311.
227. Arnould C., Lelievre-Pegorier M., Ronco P., Lelongt B. MMP9 limits apoptosis and stimulates branching morphogenesis during kidney development. J Am Soc Nephrol 2009, 20(10):2171-2180.
228. Kanwar Y.S., Ota K., Yang Q., Wada J., Kashihara N., Tian Y., et al. Role of membrane-type matrix metalloproteinase 1 (MT-1-MMP), MMP-2, and its inhibitor in nephrogenesis. Am J Physiol 1999, 277(6 Pt 2):F934-F947.
229. Unsworth B., Grobstein C. Induction of kidney tubules in mouse metanephrogenic mesenchyme by various embryonic mesenchymal tissues. Dev Biol 1970, 21(4):547-556.
230. Lombard M.N., Grobstein C. Activity in various embryonic and postembryonic sources for induction of kidney tubules. Dev Biol 1969, 19(1):41-51.
231. Koseki C., Herzlinger D., al-Awqati Q. Apoptosis in metanephric development. J Cell Biol 1992, 119(5):1327-1333.
232. Coles H.S., Burne J.F., Raff M.C. Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Development 1993, 118(3):777-784.
233. Barasch J., Pressler L., Connor J., Malik A. A ureteric bud cell line induces nephrogenesis in two steps by two distinct signals. Am J Physiol 1996, 271(1 Pt 2):F50-F61.
234. Barasch J., Qiao J., McWilliams G., Chen D., Oliver J.A., Herzlinger D. Ureteric bud cells secrete multiple factors, including bFGF, which rescue renal progenitors from apoptosis. Am J Physiol 1997, 273(5 Pt 2):F757-F767.
235. Karavanova I.D., Dove L.F., Resau J.H., Perantoni A.O. Conditioned medium from a rat ureteric bud cell line in combination with bFGF induces complete differentiation of isolated metanephric mesenchyme. Development 1996, 122(12):4159-4167.
236. Dudley A.T., Lyons K.M., Robertson E.J. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 1995, 9(22):2795-2807.
237. Luo G., Hofmann C., Bronckers A.L., Sohocki M., Bradley A., Karsenty G. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 1995, 9(22):2808-2820.
238. Vukicevic S., Kopp J.B., Luyten F.P., Sampath T.K. Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7). Proc Natl Acad Sci USA 1996, 93(17):9021-9026.
239. Lehtonen E. Epithelio-mesenchymal interface during mouse kidney tubule induction in vivo. J Embryol Exp Morphol 1975, 34(3):695-705.
240. Yang J., Blum A., Novak T., Levinson R., Lai E., Barasch J. An epithelial precursor is regulated by the ureteric bud and by the renal stroma. Dev Biol 2002, 246(2):296-310.
241. Herzlinger D., Qiao J., Cohen D., Ramakrishna N., Brown A.M. Induction of kidney epithelial morphogenesis by cells expressing Wnt-1. Dev Biol 1994, 166(2):815-818.
242. Wilkinson D.G., Bailes J.A., McMahon A.P. Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell 1987, 50(1):79-88.
243. Stark K., Vainio S., Vassileva G., McMahon A.P. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 1994, 372(6507):679-683.
244. Carroll T.J., Park J.S., Hayashi S., Majumdar A., McMahon A.P. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 2005, 9(2):283-292.
245. Grieshammer U., Cebrian C., Ilagan R., Meyers E., Herzlinger D., Martin G.R. FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development 2005, 132(17):3847-3857.
246. Perantoni A.O., Timofeeva O., Naillat F., Richman C., Pajni-Underwood S., Wilson C., et al. Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development. Development 2005, 132(17):3859-3871.
247. Poladia D.P., Kish K., Kutay B., Hains D., Kegg H., Zhao H., et al. Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme. Dev Biol 2006, 291(2):325-339.
248. Cheng H.T., Kim M., Valerius M.T., Surendran K., Schuster-Gossler K., Gossler A., et al. Notch2 but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 2007, 134(4):801-811.
249. Kopan R., Cheng H.T., Surendran K. Molecular insights into segmentation along the proximal-distal axis of the nephron. J Am Soc Nephrol 2007, 18(7):2014-2020.
250. Surendran K., Boyle S., Barak H., Kim M., Stomberski C., McCright B., et al. The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Dev Biol 2010, 337(2):386-395.
251. Mitsiadis T.A., Lardelli M., Lendahl U., Thesleff I. Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. J Cell Biol 1995, 130(2):407-418.
252. Mitsiadis T.A., Gayet O., Zhang N., Carroll P. Expression of Deltex1 during mouse embryogenesis: comparison with Notch1, 2 and 3 expression. Mech Dev 2001, 109(2):399-403.
253. McCright B. Notch signaling in kidney development. Curr Opin Nephrol Hypertens 2003, 12(1):5-10.
254. Chen L., Al-Awqati Q. Segmental expression of Notch and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol 2005, 288(5):F939-F952.
255. Cheng H.T., Kopan R. The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney. Kidney Int 2005, 68(5):1951-1952.
256. McCright B., Gao X., Shen L., Lozier J., Lan Y., Maguire M., et al. Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development 2001, 128(4):491-502.
257. Cheng H.T., Miner J.H., Lin M., Tansey M.G., Roth K., Kopan R. Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development 2003, 130(20):5031-5042.
258. Wang P., Pereira F.A., Beasley D., Zheng H. Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis. Development 2003, 130(20):5019-5029.
259. Oswald F., Kostezka U., Astrahantseff K., Bourteele S., Dillinger K., Zechner U., et al. SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. Embo J 2002, 21(20):5417-5426.
260. Oswald F., Winkler M., Cao Y., Astrahantseff K., Bourteele S., Knochel W., et al. RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol Cell Biol 2005, 25(23):10379-10390.
261. Tsuji M., Shinkura R., Kuroda K., Yabe D., Honjo T. Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling. Proc Natl Acad Sci USA 2007, 104(5):1610-1615.
262. Yabe D., Fukuda H., Aoki M., Yamada S., Takebayashi S., Shinkura R., et al. Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP. Genesis 2007, 45(5):300-306.
263. Ekblom M., Klein G., Mugrauer G., Fecker L., Deutzmann R., Timpl R., et al. Transient and locally restricted expression of laminin A chain mRNA by developing epithelial cells during kidney organogenesis. Cell 1990, 60(2):337-346.
264. Klein G., Ekblom M., Fecker L., Timpl R., Ekblom P. Differential expression of laminin A and B chains during development of embryonic mouse organs. Development 1990, 110(3):823-837.
265. Klein G., Langegger M., Timpl R., Ekblom P. Role of laminin A chain in the development of epithelial cell polarity. Cell 1988, 55(2):331-341.
266. Falk M., Salmivirta K., Durbeej M., Larsson E., Ekblom M., Vestweber D., et al. Integrin alpha 6B beta 1 is involved in kidney tubulogenesis in vitro. J Cell Sci 1996, 109(Pt 12):2801-2810.
267. Schuger L., Skubitz A.P., Zhang J., Sorokin L., He L. Laminin alpha1 chain synthesis in the mouse developing lung: requirement for epithelial-mesenchymal contact and possible role in bronchial smooth muscle development. J Cell Biol 1997, 139(2):553-562.
268. Muller U., Bossy B., Venstrom K., Reichardt L.F. Integrin alpha 8 beta 1 promotes attachment, cell spreading, and neurite outgrowth on fibronectin. Mol Biol Cell 1995, 6(4):433-448.
269. Lopez-Nieto C.E., You G., Bush K.T., Barros E.J., Beier D.R., Nigam S.K. Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. J Biol Chem 1997, 272(10):6471-6478.
270. Preminger G.M., Koch W.E., Fried F.A., Mandell J. Utilization of the chick chorioallantoic membrane for in vitro growth of the embryonic murine kidney. Am J Anat 1980, 159(1):17-24.
271. Ekblom P., Sariola H., Karkinen-Jaaskelainen M., Saxen L. The origin of the glomerular endothelium. Cell Differ 1982, 11(1):35-39.
272. Sariola H., Ekblom P., Lehtonen E., Saxen L. Differentiation and vascularization of the metanephric kidney grafted on the chorioallantoic membrane. Dev Biol 1983, 96(2):427-435.
273. Hyink D.P., Abrahamson D.R. Origin of the glomerular vasculature in the developing kidney. Semin Nephrol 1995, 15(4):300-314.
274. Robert B., St John P.L., Hyink D.P., Abrahamson D.R. Evidence that embryonic kidney cells expressing flk-1 are intrinsic, vasculogenic angioblasts. Am J Physiol 1996, 271(3 Pt 2):F744-F753.
275. Faa G., Gerosa C., Fanni D., Monga G., Zaffanello M., Van Eyken P., et al. Morphogenesis and molecular mechanisms involved in human kidney development. J Cell Physiol 2012, 227(3):1257-1268.
276. Sariola H., Kuusela P., Ekblom P. Cellular origin of fibronectin in interspecies hybrid kidneys. J Cell Biol 1984, 99(6):2099-2107.
277. Sariola H., Timpl R., von der Mark K., Mayne R., Fitch J.M., Linsenmayer T.F., et al. Dual origin of glomerular basement membrane. Dev Biol 1984, 101(1):86-96.
278. Leveen P., Pekny M., Gebre-Medhin S., Swolin B., Larsson E., Betsholtz C. Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev 1994, 8(16):1875-1887.
279. Soriano P. Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev 1994, 8(16):1888-1896.
280. Humphreys B.D., Valerius M.T., Kobayashi A., Mugford J.W., Soeung S., Duffield J.S., et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008, 2(3):284-291.
281. Wilkinson L., Gilbert T., Sipos A., Toma I., Pennisi D.J., Peti-Peterdi J., et al. Loss of renal microvascular integrity in postnatal Crim1 hypomorphic transgenic mice. Kidney Int 2009, 76(11):1161-1171.
282. Wilkinson L., Gilbert T., Kinna G., Ruta L.A., Pennisi D., Kett M., et al. Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development. J Am Soc Nephrol 2007, 18(6):1697-1708.
283. Pennisi D.J., Wilkinson L., Kolle G., Sohaskey M.L., Gillinder K., Piper M.J., et al. Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. Dev Dyn 2007, 236(2):502-511.
284. Reidy K., Tufro A. Semaphorins in kidney development and disease: modulators of ureteric bud branching, vascular morphogenesis, and podocyte-endothelial crosstalk. Pediatr Nephrol 2011, 26(9):1407-1412.
285. Reidy K.J., Villegas G., Teichman J., Veron D., Shen W., Jimenez J., et al. Semaphorin3a regulates endothelial cell number and podocyte differentiation during glomerular development. Development 2009, 136(23):3979-3989.
286. Tufro A., Norwood V.F., Carey R.M., Gomez R.A. Vascular endothelial growth factor induces nephrogenesis and vasculogenesis. J Am Soc Nephrol 1999, 10(10):2125-2134.
287. Tufro A. VEGF spatially directs angiogenesis during metanephric development in vitro. Dev Biol 2000, 227(2):558-566.
288. Hartman H.A., Lai H.L., Patterson L.T. Cessation of renal morphogenesis in mice. Dev Biol 2007, 310(2):379-387.