Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene

Development

Volumn 128, Issue 23, 2001, Pages 4747-4756

  Brophy, P D ^a   Ostrom, L ^a   Lang, K M ^a   Dressler, G R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

BMP4; GDNF; Kidney Development; Mouse; Pax2; RET signaling; Ureteric Bud

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; NEURITE PROMOTING FACTOR; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; EPITHELIUM; GENE ACTIVATION; GENE EXPRESSION; GROWTH REGULATION; KIDNEY DEVELOPMENT; MESENCHYME; MORPHOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN CULTURE; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION; URETER;

ANIMALS; BASE SEQUENCE; BINDING SITES; DNA; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; KIDNEY; MICE; MICE, MUTANT STRAINS; MUTAGENESIS, SITE-DIRECTED; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; PAX2 TRANSCRIPTION FACTOR; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; SEQUENCE HOMOLOGY, NUCLEIC ACID; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; URETER;

ANIMALIA;

EID: 0035215311     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family
2. Signaling complexes and protein-protein interactions involved in the activation of the Ras and PI3K pathways by the c-Ret receptor tyrosine kinase
3. GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney
4. Differential expression and function of cadherin-6 during renal epithelium development
5. The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1)
6. Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud
7. Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor
8. Pax2, a new murine paired-box containing gene and its expression in the developing excretory system
9. Shc and Enigma are both required for mitogenic signaling by Ret/ptc2
10. Identification of a Pax paired domain recognition sequence and evidence for DNA dependent conformational changes
11. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells
12. Analysis of the human GDNF gene reveals an inducible promoter, three exons, a triplet repeat within the 3′-UTR and alternative splice products
13. Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions
14. WT1 is required for early kidney development
15. Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract
16. Kidney morphogenesis: Cellular and molecular regulation
17. Mapping of Pax-2 transcription activation domains
18. The molecular basis of embryonic kidney development
19. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
20. Expression of multiple endocrine neoplasia 2B RET in neuroblastoma cells alters cell adhesion in vitro, enhances metastatic behavior in vivo, and activates Jun kinase
21. Cloning and structural organization of the gene encoding the mouse glial cell line-derived neurotrophic factor, GDNF
22. Signals from trunk paraxial mesoderm induce pronephros formation in chick intermediate mesoderm
23. Sequencing end labeled DNA with base specific chemical cleavages
24. Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2
25. Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter
26. Renal and neuronal abnormalities in mice lacking GDNF
27. Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation
28. The surface ectoderm is essential for nephric duct formation in intermediate mesoderm
29. Expression of the c-ret proto-oncogene during mouse embryogenesis
30. Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary
31. Aberrant expression of Pax-2 in Danforth's short tail (Sd) mice
32. Identification of novel Pax-2 binding sites by chromatin precipitation
33. Defects in enteric innervation and kidney development in mice lacking GDNF
34. How they begin and how they end: Classic and new theories for the development and deterioration of congenital anomalies of the kidney and urinary tract, CAKUT
35. Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development
36. Repression of Pax-2 by WT1 during normal kidney development
37. Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium
38. Renal agenesis and the absence of enteric neurons in mice lacking GDNF
39. Cross-talk in kidney development
40. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
41. - mutant mice result from defects in ureteric bud development
42. Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway
43. Promoter analysis and characteristics of the 5′-untranslated region of the mouse glial cell line-derived neurotrophic factor gene
44. The RET-glial cell-derived neurotrophic factor (GDNF) pathway stimulates migration and chemoattraction of epithelial cells
45. Pax-2 controls multiple steps of urogenital development
46. Glial cell line-derived meurotrophic factor activates RET and promotes kidney morphogenesis
47. Whole mount in situ hybridization of vertebrate embryos
48. Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia