Slit proteins: Molecular guidance cues for cells ranging from neurons to leukocytes

Current Opinion in Genetics and Development

Volumn 12, Issue 5, 2002, Pages 583-591

  Wong, Kit ^a   Park, Hwan Tae ^a   Wu, Jane Y ^a   Rao, Yi ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE RECEPTOR; ROUNDABOUT RECEPTOR; SLIT PROTEIN; UNCLASSIFIED DRUG;

CELL MIGRATION; DENDRITE; HUMAN; NERVE CELL; NERVE FIBER; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; SOMATIC CELL;

EID: 0036777901     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00343-X     Document Type: Review

References (74)

1. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome
2. Slit: An EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system
3. Slit: An extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains
4. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance
5. Slit is the midline repellent for the robo receptor in Drosophila
6. Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
7. Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching
8. Directional guidance of neuronal migration in the olfactory system by the secreted protein Slit
9. Axon repulsion from the midline of the Drosophila CNS requires slit function
10. Slit2-Mediated chemorepulsion and collapse of developing forebrain axons
11. Chemorepulsion of neuronal migration by Slit2 in the developing mammalian forebrain
12. Cellular and molecular guidance of GABAergic neuronal migration from the striatum to the neocortex
13. The mouse SLIT family: Secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance
14. Embryonic expression and extracellular secretion of Xenopus slit
15. C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor
16. Expression of slit-2 and slit-3 during chick development
17. Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis
18. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system
19. Spatiotemporal expression patterns of slit and robo genes in the rat brain
20. Expression of the vertebrate Slit gene family and their putative receptors, the Robo genes, in the developing murine kidney
21. The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors
22. Modularity of the slit protein. Characterization of a conserved carboxy-terminal sequence in secreted proteins and a motif implicated in extracellular protein interactions
23. The N-terminal leucine rich regions in Slit are sufficient to repel olfactory bulb axons and subventricular zone neurons
24. Repellent signaling by Slit requires the leucine-rich repeats
25. Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein
26. Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance
27. Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein
28. Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain
29. Characterization of Slit protein interactions with glypican-1
30. Mutations affecting growth cone guidance in Drosophila: Genes necessary for guidance toward or away from the midline
31. Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors
32. The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans
33. Crossing the midline: Roles and regulation of Robo receptors
34. Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS
35. Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance
36. Short-range and long-range guidance by Slit and its Robo receptors: A combinatorial code of Robo receptors controls lateral position
37. Identification and characterization of roundabout orthologs in zebrafish
38. Cloning and expression of three zebrafish roundabout homologs suggest roles in axon guidance and cell migration
39. Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system
40. Chimeric axon guidance receptors: The cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion
41. Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
42. Chemorepulsion of axons in the developing mammalian central nervous system
43. Short-range guidance of olfactory bulb axons is independent of repulsive factor slit
44. Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons
45. Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
46. Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system
47. Cortical axon guidance by the glial wedge during the development of the corpus callosum
48. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
49. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
50. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
51. Hierarchical organization of guidance receptors: Silencing of netrin attraction by slit through a Robo/DCC receptor complex
52. Squeezing axons out of the gray matter: A role for slit and semaphorin proteins from midline and ventral spinal cord
53. Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline
54. Retinal ganglion cell axon guidance in the mouse optic chiasm: Expression and function of robos and slits
55. Slit2 is a repellent for retinal ganglion cell axons
56. Slit inhibition of retinal axon growth and its role in retinal axon pathfinding and innervation patterns in the diencephalon
57. Astray, a zebrafish roundabout homolog required for retinal axon guidance
58. Pathfinding and error correction by retinal axons: The role of astray/robo2
59. Regulation of cortical dendrite development by Slit-Robo interactions
60. Slit2, a branching-arborization factor for sensory axons in the mammalian CNS
61. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
62. A septum-derived chemorepulsive factor for migrating olfactory interneuron precursors
63. Interneuron migration from basal forebrain to neocortex: Dependence on Dlx genes
64. Extracellular signals that regulate the tangential migration of olfactory bulb neuronal precursors: Inducers, inhibitors, and repellents
65. Switching repulsion to attraction: Changing responses to slit during transition in mesoderm migration
66. The function of leak and kuzbanian during growth cone and cell migration
67. Negative regulation of fibroblast motility by Ena/VASP proteins
68. Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility
69. Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway
70. Receptor tyrosine phosphatases regulate axon guidance across the midline of the Drosophila embryo
71. Integrins regulate responsiveness to slit repellent signals
72. Signal transduction underlying growth cone guidance by diffusible factors
73. Sensory axon response to substrate-bound Slit2 is modulated by laminin and cyclic GMP
74. Slit signaling promotes the terminal a symmetric division of neural precursor cells in the Drosophila CNS