Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis

Developmental Biology

Volumn 231, Issue 1, 2001, Pages 31-46

  Grisaru, Silviu ^a   Cano Gauci, Danielle ^a   Tee, James ^a   Filmus, Jorge ^a   Rosenblum, Norman D ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Apoptosis; BMP; Branching morphogenesis; Cell proliferation; Glypican 3; KGF

Indexed keywords

BONE MORPHOGENETIC PROTEIN; FIBROBLAST GROWTH FACTOR; GLYPICAN; KERATINOCYTE GROWTH FACTOR; MESSENGER RNA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; EMBRYO; IN SITU HYBRIDIZATION; KIDNEY COLLECTING TUBULE; KIDNEY DYSPLASIA; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; URETER;

TRIXIS;

EID: 0035281513     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2000.0127     Document Type: Article

References (36)

1. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
2. Functions of cell surface heparan sulfate proteoglycans
3. The morphogenesis of renal parenchymal maldevelopment (renal dysplasia)
4. Identification of glypican as a dual modulator of the biological activity of fibroblast growth factors
5. Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase
6. Glypican-3-deficient mice exhibit the overgrowth and renal abnormalities typical of the Simpson-Golabi-Behmel syndrome
7. Sulphated proteoglycan is required for collecting duct growth and branching but not nephron formation during kidney development
8. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
9. Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes
10. Pattern of keratinocyte growth factor and keratinocyte growth factor receptor expression during mouse fetal development suggests a role in mediating morphogenetic mesenchymal-epithelial interactions
11. OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner
12. HGF rescues BMP-2-mediated inhibition of renal collecting duct morphogenesis without interrupting Smad1 dependent signaling
13. Protein kinase A is a negative regulator of renal branching morphogenesis and modulates inhibitory and stimulatory bone morphogenetic proteins
14. Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila
15. dally, a drosophila glypican, controls cellular responses to the TGF-β-related morphogen, Dpp
16. Apoptosis in metanephric development
17. Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD)
18. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development
19. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
20. The division abnormally delayed (dally) gene: A putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila
21. Clinical and molecular aspects of the Simpson-Golabi-Behmel syndrome
22. Glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development
23. Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome
24. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome
25. BMP7 controls renal collecting system cell proliferation and apoptosis via Smad1 dependent and independent pathways
26. BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis
27. Branching morphogenesis during kidney development
28. FGF-7 modulates ureteric bud growth and nephron number in the developing kidney
29. In the clutches of proteoglycans: How does heparan sulfate regulate FGF binding?
30. OCI-5/Rat glypican-3 binds to fibroblast growth factor-2 but not to insulin-like growth factor-2
31. Structural analysis of glycosaminoglycans in Drosophila and Caenorhabditis elegans and demonstration that tout-velu, a Drosophila gene related to EXT tumor suppressors, affects heparan sulfate in vivo
32. The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila
33. (Alpha)3(beta)1 integrin regulates epithelial cytoskeletal organization
34. Deregulation of cell survival in cystic and dysplastic renal development
35. The PAX2 transcription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations
36. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development