Defects of urogenital development in mice lacking Emx2

Development

Volumn 124, Issue 9, 1997, Pages 1653-1664

  Miyamoto, Norimasa ^a,b   Yoshida, Michio ^a   Kuratani, Shigeru ^a   Matsuo, Isao ^a   Aizawa, Shinichi ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b EISAI CO LTD   (Japan)

Author keywords

Emx2; Gonadal development; Homeobox; Kidney development; Metanephrogenesis; Mutant mouse; Ureteric bud

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DEVELOPMENTAL GENETICS; EMBRYO; EMBRYONIC STRUCTURES; FEMALE; GENE EXPRESSION; GENITAL SYSTEM; GONAD; GONAD DEVELOPMENT; HOMEOBOX; KIDNEY DEVELOPMENT; MALE; MESENCHYME; MOUSE; MOUSE MUTANT; NONHUMAN; ONCOGENE RET; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TUMOR SUPPRESSOR GENE; URETER; UROGENITAL SYSTEM;

ABNORMALITIES; ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA; EMBRYONIC AND FETAL DEVELOPMENT; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GENES, WILMS TUMOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GONADS; HOMEODOMAIN PROTEINS; HOMOZYGOTE; KIDNEY; MALE; MICE; MICE, MUTANT STRAINS; NERVE GROWTH FACTORS; NUCLEAR PROTEINS; ORGAN CULTURE TECHNIQUES; POLYMERASE CHAIN REACTION; SEX DETERMINATION (ANALYSIS); SEX-DETERMINING REGION Y PROTEIN; TELENCEPHALON; TRANSCRIPTION FACTORS; URETER; UROGENITAL ABNORMALITIES; UROGENITAL SYSTEM; WT1 PROTEINS;

ANIMALIA; WOLFFIA;

EID: 0030997340     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Armstrong, J. F., Pritchard-Jones, K., Bickmore, W. A., Hastie, N. D. and Bard, J. B. L. (1992). The expression of the Wilms' tumour gene, WT-1, in the developing mammalian embryo. Mech. Dev. 40, 85-97.
2. Bard, J. B. L., McCornell, J. E. and Davies, J. A. (1994). Towards a genetic basis for kidney development. Mech. Dev. 48, 3-11.
3. Barnes, J. D., Crosby, J. L., Jones, C. M., Wright, C. V. E. and Hogan, B. L. M. (1994). Embryonic expression of Lim-1, the mouse homolog of Xenopus XLim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev. Biol. 161, 168-178.
4. Briata, P., Blas, E.D., Gulisana, M., Mallamaci, A., Iannone, R., Boncinelli, E. and Corte, G. (1996). EMX1 homeoprotein is expressed in cell nuclei of the developing cerebral cortex and in the axons of the olfactory sensory neurons. Mech. Dev. 57, 169-180.
5. Buehr, M., Gu, S. and McLaren, A. (1993). Mesonephric contribution to testis differentiation in the fetal mouse. Development 117, 273-281.
6. Camp, V. and Martin, P. (1996). Programmed cell death and its clearance in the developing mammalian kidney. Exp. Nephrol. 4, 105-111.
7. Coles, H. S. R., Burne, J. F. and Raff, M. C. (1993). Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor. Development 118, 777-784.
8. Davis, J. A., and Bard, J. B. L. (1996). Inductive interactions between the mesenchyme and the ureteric bud. Exp. Nephrol. 4, 77-85.
9. Dressler, G. R., Deutsch, U., Chowdhury, K., Nornes, H. O. and Grass, P. (1990). Pax-2, a new murine paired-box-containing gene and its expression in the developing excretory system, Development 109, 787-795.
10. Dressler, G. R. and Douglass, E. C. (1992). Pax-2 is a DNA binding protein expressed in embryonic kidney and Wilms tumor. Proc. Natl. Acad. Sci. USA 89, 1179-1183.
11. Dudley, A. T., Lyons, K. M. and Robertson, E. J. (1995). A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 9, 2795-2807.
12. Durbec, P., Marcos-Gutierrez, C. V., Kilkenny, C., Grigoriou, M., Wartiowaara, K., Suvanto, P., Smith, D., Ponder, B., Costantini, F., Saarma, M., Sariola, H. and Pachnis, V. (1996). GDNF signaling through the Ret receptor tyrosine kinase. Nature 381, 789-793.
13. Ekblom, P. (1996). Extracellular matrix and cell adhesion molecules in nephrogenesis. Exp. Nephrol. 4, 92-96.
14. Fujii, T., Pichel, J. G., Taira, M., Toyama, R., Dawid, I. B. and Westphal, H. (1994). Expression pattern of the murine LIM class homeobox gene lim1 in the developing brain and excretory system. Dev. Dyn. 199, 73-83.
15. Gluecksohn-Schoenheimer, S. (1943). The morphological manifestations of a dominant mutation in mice affecting tail and urogenital system. Genetics 28, 341-348.
16. Grobstein, C. (1953). Inductive epithelio-mesenchymal interaction on cultured organ rudiments of the mouse. Science 118, 52-55.
17. Grobstein, C. (1955). Inductive interaction in the development of the mouse metanephros. J. Exp. Zool. 130, 319-340.
18. Harlow, E. and Lane, D. (1988). Antibodies: A Laboratory Manual. pp. 406-407. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
19. Hatini, V., Huh, S. O., Herzlinger, D., Soares, V. C. and Lai, E. (1996). Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Genes Dev. 10, 1467-1478.
20. Hellmich, H. L., Kos, L., Cho, E. S., Mahon, K. A. and Zimmer, A. (1996). Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. Mech. Dev. 54, 95-105.
21. Herzlinger, D. (1995). Inductive interactions during kidney development. Semin. Nephrol. 15, 255-262.
22. Hogan, B., Beddington, R., Costantini, F., and Lacy, E. (1994). Manipulating the Mouse Embryo: A Laboratory Manual. pp. 382-383. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
23. Jiménez, R., Sánchez, A., Burgos, M. and De La Guardia, R. D. (1996). Puzzling out the genetics of mammalian sex determination. Trends Genet. 12, 164-166.
24. Jing, S., Wen, D., Yu, Y., Holst, P. L., Luo, Y., Fang, M., Tamir, R., Antonio, L., Hu, Z., Cupples, R., Louis, J.-C., Hu, S., Altrock, B. W. and Fox, G. M. (1996). GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-a, a novel receptor for GDNF. Cell 85, 1113-1124.
25. Koseki, C., Herzlinger, D. and Al-Awqati, Q. (1992). Apoptosis in metanephric development. J. Cell. Biol. 119, 1327-1333.
26. Kreidberg, J. A., Sariola, H., Loring, J. M., Maeda, M., Pelletier, J., Housman, D. and Janisch, R. (1993). WT-1 is required for early kidney development. Cell 74, 679-691.
27. Kudoh, T., Ishidate, T., Moriyama, M., Toshima, K. and Akiyama, T. (1995). G1 phase arrest induced by Wilms tumor protein WT-1 is abrogated by cyclin/CDK complexes. Proc. Natl. Acad. Sci. USA 92, 4517-4521.
28. Luo, G., Hofmann, C., Bronckers, A. L. J. J., Sohocki, M., Bradley, A. and Karsenty, G. (1995). BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev. 9, 2808-2820.
29. Luo, X., Ikeda, Y. and Parker, K. L. (1994). A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77, 481-490.
30. Mesrobian, H. G. and Sulik, K. K. (1992). Characterization of the upper urinary tract anatomy in the Danforth spontaneous murine mutation. J. Urol. 148, 752-755.
31. Moore M. M., Klein, R. D., Fariñas, I., Sauer, H., Armanini, M., Phillips, H., Reichardt, L. F., Ryan, A. M., Carver-Moore, K. and Rosenthal, A. (1996). Renal and neuronal abnormalities in mice lacking GDNF. Nature 382, 76-79.
32. Pachinis, V., Mankoo, B. and Costantini, F. (1993). Expression of the c-ret proto-oncogene during mouse embryogenesis. Development 119, 1005-1017.
33. Pelletier, J., Schalling, M., Buckler, A. J., Rogers, A., Haber, D.A. and Housman, D. (1991). Expression of the Wilms' tumor gene WT-1 in the murine urogenital system. Genes Dev. 5, 1345-1356.
34. Pichel, J. G., Shen, L., Sheng, H. Z., Granholm, A.-C., Drago, J., Grinberg, A., Lee, E. J., Huang, S. P., Saarma, M., Hoffer, B. J., Sariola, H. and Westphal, H. (1996). Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 382, 73-76.
35. Rothenpieler, U. W. and Dressler, G. R. (1993). Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development. Development 119, 711-720.
36. Rothenpieler, U. W. (1996). Roles of Pax genes in nephrogenesis. Exp. Nephrol. 4, 86-91.
37. Sánchez, M. P., Silos-Santiago, I., Frisén, J., He, B., Lira, S. A. and Barbacid, M. (1996). Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 382, 70-73.
38. Sariola, H. (1996). Does the kidney express redundant or important molecules during nephrogenesis? Exp. Nephrol. 4, 70-76.
39. Saxén, L. (1987). Organogenesis of the Kidney. Cambridge: Cambridge Univ. Press.
40. Saxén, L. and Lehtonen, E. (1987). Embryonic kidney in organ culture. Differentiation 36, 2-11.
41. Schofield, P. N. and Boulter, C. A. (1996). Growth factors and metanephrogenesis. Exp. Nephrol. 4, 97-104.
42. Schuchardt, A., D'Agati, V., Larsson-Blomberg, L., Costantini, F. and Pachnis, V. (1994). Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367, 380-383.
43. Schuchardt, A., D'Agati, V., Pachnis, V. and Costantini, F. (1996). Renal agenesis and hypodysplasia in ret-k-mutant mice result from defects in ureteric bud development. Development 122, 1919-1929.
44. Simeone, A., Gulisano, M., Acampora, D., Stornaiuolo, A., Rambaldi, M. and Boncinelli, E. (1992a). Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 11, 2541-2550.
45. Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A. and Boncinelli, E. (1992b). Nested expression domains of four homeobox genes in developing rostral brain. Nature 358, 687-690.
46. Stark, K., Vainio, S., Vassileva, G. and McMahon, A. P. (1994). Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 372, 679-683.
47. Torres, M., Gómez-Pardo, E., Dressler, G. R. and Gruss, P. (1995). Pax-2 controls multiple steps of urogenital development. Development 121, 4057-4065.
48. Treanor, J.J.S., Goodman, L., de Sauvage, F., Stone, D. M., Poulsen, K. T., Beck, C. D., Gray, C., Armanini, M. P., Pollock, R. A., Hefti, F., Phillips, H. S., Goddard, A., Moor, M. W., Buj-Bello, A., Davies, A. M., Asai, N., Takahashi, M., Vandlen, R., Henderson, C. E. and Rosenthal, A. (1996). Characterization of a multicomponent receptor for GDNF. Nature 382, 80-83.
49. Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A.-S., Sieber, B.-A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumäe, U., Sariola, H., Saarma, M. and Ibáñez, C. F. (1996). Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature 381, 785-789.
50. Tsuzuki, T., Takahashi, M., Asai, N., Iwashita, T., Matsuyama, M. and Asai, J. (1995). Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues. Oncogene 10, 191-198.
51. Wilkinson, D. G. (1993). In situ hybridization. In Essential Developmental Biology: A Practical Approach (ed. C. D. Stern and P. W. H. Holland), pp. 257-274. Oxford: IRL Press at Oxford Univ. Press.
52. Yoshida, M., Suda, Y., Matsuo, I., Miyamoto, N., Takeda, N., Kuratani, S. and Aizawa, S. (1997). Emx1 and Emx2 functions in development of dorsal telencephalon. Development 124, 101-111.