SiRNA delivery with chitosan nanoparticles: Molecular properties favoring efficient gene silencing

Journal of Controlled Release

Volumn 158, Issue 2, 2012, Pages 261-268

  Malmo, Jostein ^a   Sørgård, Hanne ^a   Vårum, Kjell M ^a   Strand, Sabina P ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Chain architecture; Chain length; Chitosan; Nanoparticles; siRNA

Indexed keywords

CELL LINES; CELLULAR UPTAKE; CHAIN ARCHITECTURE; CHEMICAL COMPOSITIONS; CHITOSAN NANOPARTICLES; DEGREES OF POLYMERIZATIONS; ENDOGENOUS TARGET GENES; GENE SILENCING; MAMMALIAN CELLS; MEMBRANE INTEGRITY; METABOLIC ACTIVITY; MOLECULAR PROPERTIES; PROTEIN LEVEL; SIRNA; SIRNA DELIVERY; STRUCTURE ACTIVITY RELATIONSHIPS;

CELL CULTURE; CHAIN LENGTH; GENES; GENETIC ENGINEERING; MULTILAYERS; NANOPARTICLES; RNA;

CHITOSAN;

CHITOSAN; MESSENGER RNA; NANOPARTICLE; SMALL INTERFERING RNA;

ARTICLE; CELL LINE; CELL MEMBRANE; CELL METABOLISM; CELL TRANSPORT; CHEMICAL COMPOSITION; CONTROLLED STUDY; CYTOTOXICITY; GENE DELIVERY SYSTEM; GENE SILENCING; HUMAN; HUMAN CELL; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; CELL SURVIVAL; CHITOSAN; DRUG CARRIERS; GENE SILENCING; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE (NADP+); GREEN FLUORESCENT PROTEINS; HUMANS; NANOPARTICLES; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84858709347     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.11.012     Document Type: Article

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