Curcumin analogue identified as hyaluronan export inhibitor by virtual docking to the ABC transporter MRP5

Food and Chemical Toxicology

Volumn 62, Issue , 2013, Pages 76-81

  Prehm, Peter ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Extracellular matrix; Hyaluronan export inhibitor; MRP5; Plasma membrane; Virtual docking

Indexed keywords

ADENOSINE TRIPHOSPHATE; CURCUMIN; CURCUMIN DERIVATIVE; HELICHRYSETIN; HYALURONAN EXPORT INHIBITOR; HYLIN; METHYLUMBELLIFERONE; MULTIDRUG RESISTANCE PROTEIN 5; NUCLEOTIDE BINDING DOMAIN 1; NUCLEOTIDE BINDING DOMAIN 2; NUCLEOTIDE BINDING PROTEIN; PHENOL DERIVATIVE; PROTEIN INHIBITOR; QUERCETIN; UNCLASSIFIED DRUG; XANTHOHUMOL; ABCC5 PROTEIN, HUMAN; FLAVONOID; GUAIACOL; HYALURONIC ACID; KETONE; MULTIDRUG RESISTANCE PROTEIN; PROPIOPHENONE DERIVATIVE;

ARTICLE; COMPUTER PROGRAM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; PROCESS OPTIMIZATION; PROTEIN CONFORMATION; VIRTUAL REALITY; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DRUG EFFECTS; HEK293 CELL LINE; IC50; METABOLISM; PROTEIN TERTIARY STRUCTURE; TRANSPORT AT THE CELLULAR LEVEL;

BINDING SITES; BIOLOGICAL TRANSPORT; CURCUMIN; FLAVONOIDS; GUAIACOL; HEK293 CELLS; HUMANS; HYALURONIC ACID; INHIBITORY CONCENTRATION 50; KETONES; MOLECULAR DOCKING SIMULATION; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROPIOPHENONES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY;

EID: 84883809004     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.08.028     Document Type: Article

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