Xanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin wound healing model. Involvement of local adipocytes

Journal of Cellular Biochemistry

Volumn 113, Issue 1, 2012, Pages 100-109

  Negrão, Rita ^a   Costa, Raquel ^a   Duarte, Delfim ^a   Gomes, Tiago Taveira ^a   Coelho, Pedro ^a,b   Guimarães, João T ^a,c   Guardão, Luísa ^a   Azevedo, Isabel ^a   Soares, Raquel ^a  

^a University of Porto   (Portugal)

^b Institute of Health Technologies   (Portugal)

^c HOSPITAL DE SÃO JOÃO   (Portugal)

Author keywords

Angiogenesis; Beer; Blood vessels; Inflammation; Polyphenols; Wound healing; Xanthohumol

Indexed keywords

ACETYLGLUCOSAMINIDASE; ALCOHOL; DRINKING WATER; GLUTATHIONE; GLUTATHIONE DISULFIDE; INTERLEUKIN 1BETA; LIVER ENZYME; NITRIC OXIDE; POLYPHENOL; VASCULOTROPIN; XANTHOHUMOL;

ADIPOCYTE; ADIPOSE TISSUE; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEER; BEVERAGE; BIOCHEMISTRY; BLOOD VESSEL; BODY WEIGHT; CELL COUNT; CELL SIZE; CELL STRUCTURE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; FOOD INTAKE; GRANULATION TISSUE; GRANULOMA; INFLAMMATION; LIVER FUNCTION; LIVER METABOLISM; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROLONGED STOUT BEER; RAT; SKIN DEFECT; SKIN INJURY; WOUND HEALING;

ACETYLGLUCOSAMINIDASE; ADIPOCYTES; ANIMALS; BEER; DIETARY SUPPLEMENTS; FLAVONOIDS; GLUTATHIONE; GRANULOMA; INFLAMMATION; INTERLEUKIN-1BETA; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROPIOPHENONES; RATS; RATS, WISTAR; SKIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 84055177148     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23332     Document Type: Article

References (50)

1. Albini A, Dell'Eva R, Vene R, Ferrari N, Buhler DR, Noonan DM, Fassina G,. 2006. Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets. FASEB J 20: 527-529. (Pubitemid 46671238)
2. Altavilla D, Saitta A, Cucinotta D, Galeano M, Deodato B, Colonna M, Torre V, Russo G, Sardella A, Urna G, Campo GM, Cavallari V, Squadrito G, Squadrito F,. 2001. Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse. Diabetes 50: 667-674. (Pubitemid 32195234)
3. Assuncao M, Santos-Marques MJ, Monteiro R, Azevedo I, Andrade JP, Carvalho F, Martins MJ,. 2009. Red wine protects against ethanol-induced oxidative stress in rat liver. J Agric Food Chem 57: 6066-6073.
4. Biesalski HK,. 2007. Polyphenols and inflammation: Basic interactions. Curr Opin Clin Nutr Metab Care 10: 724-728. (Pubitemid 350293773)
5. Bolca S, Li J, Nikolic D, Roche N, Blondeel P, Possemiers S, De Keukeleire D, Bracke M, Heyerick A, van Breemen RB, Depypere H,. 2010. Disposition of hop prenylflavonoids in human breast tissue. Mol Nutr Food Res 54 (Suppl 2): S284-S294.
6. Bora PS, Kaliappan S, Xu Q, Kumar S, Wang Y, Kaplan HJ, Bora NS,. 2006. Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization. FEBS J 273: 1403-1414. (Pubitemid 44029106)
7. Cho YC, Kim HJ, Kim YJ, Lee KY, Choi HJ, Lee IS, Kang BY,. 2008. Differential anti-inflammatory pathway by xanthohumol in IFN-gamma and LPS-activated macrophages. Int Immunopharmacol 8: 567-573.
8. Chung AS, Lee J, Ferrara N,. 2010. Targeting the tumour vasculature: Insights from physiological angiogenesis. Nat Rev Cancer 10: 505-514.
9. Costa C, Incio J, Soares R,. 2007. Angiogenesis and chronic inflammation: Cause or consequence? Angiogenesis 10: 149-166. (Pubitemid 47305203)
10. Dorn C, Bataille F, Gaebele E, Heilmann J, Hellerbrand C,. 2010. Xanthohumol feeding does not impair organ function and homoeostasis in mice. Food Chem Toxicol 48: 1890-1897.
11. Eming SA, Brachvogel B, Odorisio T, Koch M,. 2007. Regulation of angiogenesis: Wound healing as a model. Prog Histochem Cytochem 42: 115-170. (Pubitemid 350016248)
12. Folkman J,. 2007. Angiogenesis: An organizing principle for drug discovery? Nat Rev Drug Discov 6: 273-286. (Pubitemid 46505878)
13. Fraga CG, Galleano M, Verstraeten SV, Oteiza PI,. 2010. Basic biochemical mechanisms behind the health benefits of polyphenols. Mol Aspects Med 31: 435-445.
14. Friedewald WT, Levy RI, Fredrickson DS,. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
15. Gasowski B, Leontowicz M, Leontowicz H, Katrich E, Lojek A, Ciz M, Trakhtenberg S, Gorinstein S,. 2004. The influence of beer with different antioxidant potential on plasma lipids, plasma antioxidant capacity, and bile excretion of rats fed cholesterol-containing and cholesterol-free diets. J Nutr Biochem 15: 527-533. (Pubitemid 39209395)
16. Gerhauser C,. 2005. Beer constituents as potential cancer chemopreventive agents. Eur J Cancer 41: 1941-1954. (Pubitemid 41557680)
17. Gollisch KS, Brandauer J, Jessen N, Toyoda T, Nayer A, Hirshman MF, Goodyear LJ,. 2009. Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed rats. Am J Physiol Endocrinol Metab 297: E495-E504.
18. Gu JW, Bailey AP, Sartin A, Makey I, Brady AL,. 2005. Ethanol stimulates tumor progression and expression of vascular endothelial growth factor in chick embryos. Cancer 103: 422-431. (Pubitemid 40129304)
19. Guerreiro S, Monteiro R, Martins MJ, Calhau C, Azevedo I, Soares R,. 2007. Distinct modulation of alkaline phosphatase isoenzymes by 17beta-estradiol and xanthohumol in breast cancer MCF-7 cells. Clin Biochem 40: 268-273. (Pubitemid 46108701)
20. Holst B, Williamson G,. 2008. Nutrients and phytochemicals: From bioavailability to bioefficacy beyond antioxidants. Curr Opin Biotechnol 19: 73-82.
21. Jones DP,. 2006. Redefining oxidative stress. Antioxid Redox Signal 8: 1865-1879. (Pubitemid 44726359)
22. Kagawa S, Matsuo A, Yagi Y, Ikematsu K, Tsuda R, Nakasono I,. 2009. The time-course analysis of gene expression during wound healing in mouse skin. Leg Med (Tokyo) 11: 70-75.
23. Kawai Y, Tanaka H, Murota K, Naito M, Terao J,. 2008. (-)-Epicatechin gallate accumulates in foamy macrophages in human atherosclerotic aorta: implication in the anti-atherosclerotic actions of tea catechins. Biochem Biophys Res Commun 374: 527-532.
24. Loots MA, Lamme EN, Zeegelaar J, Mekkes JR, Bos JD, Middelkoop E,. 1998. Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J Invest Dermatol 111: 850-857. (Pubitemid 28509329)
25. Magalhaes PJ, Carvalho DO, Cruz JM, Guido LF, Barros AA,. 2009. Fundamentals and health benefits of xanthohumol, a natural product derived from hops and beer. Nat Prod Commun 4: 591-610.
26. Mahdavian Delavary B, van der Veer WM, van Egmond M, Niessen FB, Beelen RH,. 2011. Macrophages in skin injury and repair. Immunobiology 216: 753-762.
27. Monteiro R,. 2009. Chronic inflammation in the metabolic syndrome: Emphasis on adipose tissue. In:, C, SRaC, editor. Oxidative stress, inflammation and angiogenesis in the metabolic syndrome. Milton Keynes, UK: Springer Science. Hardcover, pp 65-83.
28. Monteiro R, de Castro PM, Calhau C, Azevedo I,. 2006. Adipocyte size and liability to cell death. Obes Surg 16: 804-806. (Pubitemid 43874842)
29. Monteiro R, Calhau C, Silva AO, Pinheiro-Silva S, Guerreiro S, Gartner F, Azevedo I, Soares R,. 2008. Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts. J Cell Biochem 104: 1699-1707.
30. Morrow D, Cullen JP, Cahill PA, Redmond EM,. 2008. Ethanol stimulates endothelial cell angiogenic activity via a Notch- and angiopoietin-1-dependent pathway. Cardiovasc Res 79: 313-321. (Pubitemid 351951614)
31. Nascimento AP, Costa AM,. 2006. Overweight induced by high-fat diet delays rat cutaneous wound healing. Br J Nutr 96: 1069-1077. (Pubitemid 46470170)
32. Negrao R, Costa R, Duarte D, Taveira Gomes T, Mendanha M, Moura L, Vasques L, Azevedo I, Soares R,. 2010. Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells. J Cell Biochem 111: 1270-1279.
33. Nozawa H,. 2005. Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice. Biochem Biophys Res Commun 336: 754-761. (Pubitemid 41338333)
34. Oak MH, El Bedoui J, Schini-Kerth VB,. 2005. Antiangiogenic properties of natural polyphenols from red wine and green tea. J Nutr Biochem 16: 1-8. (Pubitemid 40052710)
35. Pond CM,. 2003. Paracrine interactions of mammalian adipose tissue. J Exp Zool A Comp Exp Biol 295: 99-110. (Pubitemid 37529129)
36. Qiao L, Lu SL, Dong JY, Song F,. 2011. Abnormal regulation of neo-vascularisation in deep partial thickness scalds in rats with diabetes mellitus. Burns 37: 1015-1022.
37. Radek KA, Kovacs EJ, Gallo RL, DiPietro LA,. 2008. Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells. Am J Physiol Heart Circ Physiol 295: H174-H184.
38. Reagan-Shaw S, Nihal M, Ahmad N,. 2008. Dose translation from animal to human studies revisited. FASEB J 22: 659-661. (Pubitemid 351348146)
39. Rodero MP, Khosrotehrani K,. 2010. Skin wound healing modulation by macrophages. Int J Clin Exp Pathol 3: 643-653.
40. Roig R, Cascon E, Arola L, Blade C, Salvado MJ,. 1999. Moderate red wine consumption protects the rat against oxidation in vivo. Life Sci 64: 1517-1524. (Pubitemid 29170407)
41. Shoab SS, Scurr JH, Coleridge-Smith PD,. 1999. Plasma VEGF as a marker of therapy in patients with chronic venous disease treated with oral micronised flavonoid fraction-a pilot study. Eur J Vasc Endovasc Surg 18: 334-338. (Pubitemid 29481457)
42. Soares R, Azevedo I,. 2007. Inhibition of S1P by polyphenols prevents inflammation and angiogenesis: NFkappaB, a downstream effector? Free Radic Biol Med 42: 311. (Pubitemid 44959741)
43. Soares RCC,. 2009. Oxidative stress, inflammation and angiogenesis in the metabolic syndrome. Milton Keynes, UK: Springer Science. Hardcover.
44. Stevens JF, Page JE,. 2004. Xanthohumol and related prenylflavonoids from hops and beer: To your good health. Phytochemistry 65: 1317-1330. (Pubitemid 38844716)
45. Stevenson DE, Hurst RD,. 2007. Polyphenolic phytochemicals-just antioxidants or much more? Cell Mol Life Sci 64: 2900-2916. (Pubitemid 351152245)
46. Strathmann J, Klimo K, Sauer SW, Okun JG, Prehn JH, Gerhauser C,. 2010. Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism. FASEB J 24: 2938-2950.
47. Tan W, Bailey AP, Shparago M, Busby B, Covington J, Johnson JW, Young E, Gu JW,. 2007. Chronic alcohol consumption stimulates VEGF expression, tumor angiogenesis and progression of melanoma in mice. Cancer Biol Ther 6: 1211-1217. (Pubitemid 351590374)
48. Tosetti F, Noonan DM, Albini A,. 2009. Metabolic regulation and redox activity as mechanisms for angioprevention by dietary phytochemicals. Int J Cancer 125: 1997-2003.
49. Winkelmann LSM,. 2004. Highly innovative products rich in xanthohumol. Brauwelt Int 5: 300-301.
50. Xan P,. 2011. SCHULTZEPLUS, Germany.