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Volumn 60, Issue 8, 2012, Pages 1937-1944

Neuroprotective effects of xanthohumol, a prenylated flavonoid from hops (humulus lupulus), in ischemic stroke of rats

Author keywords

HIF 1 ; Hydroxyl radical; MCAO; Platelet activation; TNF ; Xanthohumol

Indexed keywords

ACTIVE CASPASE-3; CEREBRAL ISCHEMIA; CHEMOPREVENTIVE AGENTS; ELECTRON SPIN RESONANCE METHODS; HYDROXYL RADICALS; HYPOXIA-INDUCIBLE FACTORS; IN-CONTROL; INDUCIBLE NITRIC OXIDE SYNTHASE (INOS); INFARCT SIZE; INFLAMMATORY RESPONSE; INTRAPERITONEALLY; ISCHEMIA REPERFUSION; ISCHEMIC STROKES; MCAO; MIDDLE CEREBRAL ARTERY; NEUROPROTECTIVE ACTIVITY; NEUROPROTECTIVE EFFECTS; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET RICH PLASMA; PRENYLATED FLAVONOIDS; PROTEIN EXPRESSIONS; RADICAL FORMATION; SCAVENGING ACTIVITIES; SIGNAL INTENSITIES; THERAPEUTIC POTENTIALS; TUMOR GROWTH; TUMOR NECROSIS FACTORS; XANTHOHUMOL;

EID: 84859782882     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf204909p     Document Type: Article
Times cited : (86)

References (42)
  • 1
    • 0025165826 scopus 로고
    • Background review and current concepts of reperfusion injury
    • Hallenbeck, J. M.; Dutka, A. J. Background review and current concepts of reperfusion injury. Arch. Neurol. 1990, 47, 1245-1254. (Pubitemid 20381010)
    • (1990) Archives of Neurology , vol.47 , Issue.11 , pp. 1245-1254
    • Hallenbeck, J.M.1    Dutka, A.J.2
  • 2
    • 0030856804 scopus 로고    scopus 로고
    • Reperfusion injury: Demonstration of brain damage produced by reperfusion after transient focal ischemia in rats
    • Aronowski, J.; Strong, R.; Grotta, J. C. Reperfusion injury: demonstration of brain damage produced by reperfusion after transient focal ischemia in rats. J. Cereb. Blood Flow Metab. 1997, 17, 1048-1056. (Pubitemid 27459332)
    • (1997) Journal of Cerebral Blood Flow and Metabolism , vol.17 , Issue.10 , pp. 1048-1056
    • Aronowski, J.1    Strong, R.2    Grotta, J.C.3
  • 3
    • 0030976784 scopus 로고    scopus 로고
    • Reperfusion damage following focal ischemia: Pathophysiology and therapeutic windows
    • Kuroda, S.; Siesjo, B. K. Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin. Neurosci. 1997, 4, 199-212. (Pubitemid 27250687)
    • (1997) Clinical Neuroscience , vol.4 , Issue.4 , pp. 199-212
    • Kuroda, S.1    Siesjo, B.K.2
  • 4
    • 0029794869 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia
    • Iadecola, C.; Zhang, F.; Casey, R.; Clark, H. B.; Ross, M. E. Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia. Stroke 1996, 27, 1373-1380. (Pubitemid 26286171)
    • (1996) Stroke , vol.27 , Issue.8 , pp. 1373-1380
    • Iadecola, C.1    Zhang, F.2    Casey, R.3    Clark, H.B.4    Ross, M.E.5
  • 5
    • 0032845121 scopus 로고    scopus 로고
    • Ischemic cell death in brain neurons
    • Lipton, P. Ischemic cell death in brain neurons. Physiol. Rev. 1999, 79, 1431-1568. (Pubitemid 29473320)
    • (1999) Physiological Reviews , vol.79 , Issue.4 , pp. 1431-1568
    • Lipton, P.1
  • 6
    • 0242391822 scopus 로고    scopus 로고
    • Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production
    • Liou, K. T.; Shen, Y. C.; Chen, C. F.; Tsao, C. M.; Tsai, S. K. Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production. Brain Res. 2003, 992, 159-166.
    • (2003) Brain Res , vol.992 , pp. 159-166
    • Liou, K.T.1    Shen, Y.C.2    Chen, C.F.3    Tsao, C.M.4    Tsai, S.K.5
  • 7
    • 0034085158 scopus 로고    scopus 로고
    • Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia
    • discussion 1409-1410
    • Abumiya, T.; Fitridge, R.; Mazur, C.; Copeland, B. R.; Koziol, J. A.; Tschopp, J. F.; et al. Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia. Stroke 2000, 31, 1402-1409 discussion 1409-1410.
    • (2000) Stroke , vol.31 , pp. 1402-1409
    • Abumiya, T.1    Fitridge, R.2    Mazur, C.3    Copeland, B.R.4    Koziol, J.A.5    Tschopp, J.F.6
  • 9
    • 40249086705 scopus 로고    scopus 로고
    • Pharmacognostic and pharmacological profile of Humulus lupulus L
    • DOI 10.1016/j.jep.2008.01.011, PII S0378874108000391
    • Zanoli, P.; Zavatti, M. Pharmacognostic and pharmacological profile of Humulus lupulus L. J. Ethnopharmacol. 2008, 116, 383-396. (Pubitemid 351335198)
    • (2008) Journal of Ethnopharmacology , vol.116 , Issue.3 , pp. 383-396
    • Zanoli, P.1    Zavatti, M.2
  • 11
    • 0036728052 scopus 로고    scopus 로고
    • Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop
    • Gerhäuser, C.; Alt, A.; Heiss, E.; Gamal-Eldeen, A.; Klimo, K.; Knauft, J.; et al. Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop. Mol. Cancer Ther. 2002, 1, 959-969.
    • (2002) Mol. Cancer Ther , vol.1 , pp. 959-969
    • Gerhäuser, C.1    Alt, A.2    Heiss, E.3    Gamal-Eldeen, A.4    Klimo, K.5    Knauft, J.6
  • 12
    • 33845611585 scopus 로고    scopus 로고
    • Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells
    • DOI 10.1016/j.canlet.2006.02.015, PII S0304383506001236
    • Colgate, E. C.; Miranda, C. L.; Stevens, J. F.; Bray, T. M.; Ho, E. Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Cancer Lett. 2007, 246, 201-209. (Pubitemid 44959390)
    • (2007) Cancer Letters , vol.246 , Issue.1-2 , pp. 201-209
    • Colgate, E.C.1    Miranda, C.L.2    Stevens, J.F.3    Bray, T.M.4    Ho, E.5
  • 13
    • 61949193344 scopus 로고    scopus 로고
    • Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells
    • Harikumar, K. B.; Kunnumakkara, A. B.; Ahn, K. S.; Anand, P.; Krishnan, S.; Guha, S.; et al. Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. Blood 2009, 113, 2003-2013.
    • (2009) Blood , vol.113 , pp. 2003-2013
    • Harikumar, K.B.1    Kunnumakkara, A.B.2    Ahn, K.S.3    Anand, P.4    Krishnan, S.5    Guha, S.6
  • 14
    • 33645814383 scopus 로고    scopus 로고
    • Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-κB and Akt as targets
    • DOI 10.1096/fj.05-5128fje
    • Albini, A.; Dell'Eva, R.; Vene, R.; Ferrari, N.; Buhler, D. R.; Noonan, D. M.; et al. Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets. FASEB J. 2006, 20, 527-529. (Pubitemid 46671238)
    • (2006) FASEB Journal , vol.20 , Issue.3 , pp. 527-529
    • Albini, A.1    Dell'Eva, R.2    Vene, R.3    Ferrari, N.4    Buhler, D.R.5    Noonan, D.M.6    Fassina, G.7
  • 15
    • 70349197988 scopus 로고    scopus 로고
    • Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes
    • Lupinacci, E.; Meijerink, J.; Vincken, J. P.; Gabriele, B.; Gruppen, H.; Witkamp, R. F. Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes. J. Agric. Food Chem. 2009, 57, 7274-7281.
    • (2009) J. Agric. Food Chem , vol.57 , pp. 7274-7281
    • Lupinacci, E.1    Meijerink, J.2    Vincken, J.P.3    Gabriele, B.4    Gruppen, H.5    Witkamp, R.F.6
  • 16
    • 77956023748 scopus 로고    scopus 로고
    • Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis
    • Dorn, C.; Kraus, B.; Motyl, M.; Weiss, T. S.; Gehrig, M.; Scholmerich, J.; et al. Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis. Mol. Nutr. Food Res. 2010, 54 (Suppl.2), S205-213.
    • (2010) Mol. Nutr. Food Res , vol.54 , Issue.SUPPL. 2
    • Dorn, C.1    Kraus, B.2    Motyl, M.3    Weiss, T.S.4    Gehrig, M.5    Scholmerich, J.6
  • 17
    • 78651259607 scopus 로고    scopus 로고
    • Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells
    • Lee, I. S.; Lim, J.; Gal, J.; Kang, J. C.; Kim, H. J.; Kang, B. Y.; et al. Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells. Neurochem. Int. 2011, 58, 153-160.
    • (2011) Neurochem. Int , vol.58 , pp. 153-160
    • Lee, I.S.1    Lim, J.2    Gal, J.3    Kang, J.C.4    Kim, H.J.5    Kang, B.Y.6
  • 19
    • 0036605569 scopus 로고    scopus 로고
    • Acute administration of Ginkgo biloba extract (EGb 761) affords neuroprotection against permanent and transient focal cerebral ischemia in Sprague-Dawley rats
    • DOI 10.1002/jnr.10251
    • Lee, E. J.; Chen, H. Y.; Wu, T. S.; Chen, T. Y.; Ayoub, I. A.; Maynard, K. I. Acute administration of Ginkgo biloba extract (EGb 761) affords neuroprotection against permanent and transient focal cerebral ischemia in Sprague-Dawley rats. J. Neurosci. Res. 2002, 68, 636-645. (Pubitemid 34575630)
    • (2002) Journal of Neuroscience Research , vol.68 , Issue.5 , pp. 636-645
    • Lee, E.J.1    Chen, H.-Y.2    Wu, T.-S.3    Chen, T.-Y.4    Ayoub, I.A.5    Maynard, K.I.6
  • 21
    • 0034018372 scopus 로고    scopus 로고
    • Mechanisms involved in the antiplatelet activity of Staphylococcus aureus lipoteichoic acid in human platelets
    • Sheu, J. R.; Lee, C. R.; Lin, C. H.; Hsiao, G.; Ko, W. C.; Chen, Y. C.; et al. Mechanisms involved in the antiplatelet activity of Staphylococcus aureus lipoteichoic acid in human platelets. Thromb. Haemostasis 2000, 83, 777-784. (Pubitemid 30248529)
    • (2000) Thrombosis and Haemostasis , vol.83 , Issue.5 , pp. 777-784
    • Sheu, J.-R.1    Lee, C.-R.2    Lin, C.-H.3    Hsiao, G.4    Ko, W.-C.5    Chen, Y.-C.6    Yen, M.-H.7
  • 22
    • 33846529431 scopus 로고    scopus 로고
    • Neuroprotective effects of PMC, a potent α-tocopherol derivative, in brain ischemia-reperfusion: Reduced neutrophil activation and anti-oxidant actions
    • DOI 10.1016/j.bcp.2006.11.009, PII S0006295206007441
    • Hsiao, G.; Lee, J. J.; Chen, Y. C.; Lin, J. H.; Shen, M. Y.; Lin, K. H.; et al. Neuroprotective effects of PMC, a potent alpha-tocopherol derivative, in brain ischemia-reperfusion: reduced neutrophil activation and anti-oxidant actions. Biochem. Pharmacol. 2007, 73, 682-693. (Pubitemid 46161379)
    • (2007) Biochemical Pharmacology , vol.73 , Issue.5 , pp. 682-693
    • Hsiao, G.1    Lee, J.-J.2    Chen, Y.-C.3    Lin, J.-H.4    Shen, M.-Y.5    Lin, K.-H.6    Chou, D.-S.7    Sheu, J.-R.8
  • 23
    • 3042559902 scopus 로고    scopus 로고
    • Xanthohumol and related prenylflavonoids from hops and beer: To your good health!
    • DOI 10.1016/j.phytochem.2004.04.025, PII S0031942204001876
    • Stevens, J. F.; Page, J. E. Xanthohumol and related prenylflavonoids from hops and beer: to your good health! Phytochemistry 2004, 65, 1317-1330. (Pubitemid 38844716)
    • (2004) Phytochemistry , vol.65 , Issue.10 , pp. 1317-1330
    • Stevens, J.F.1    Page, J.E.2
  • 24
    • 0035049618 scopus 로고    scopus 로고
    • Influence of prenylated and non-prenylated flavonoids on liver microsomal lipid peroxidation and oxidative injury in rat hepatocytes
    • DOI 10.1016/S0278-6915(00)00159-9, PII S0278691500001599
    • Rodriguez, R. J.; Miranda, C. L.; Stevens, J. F.; Deinzer, M. L.; Buhler, D. R. Influence of prenylated and non-prenylated flavonoids on liver microsomal lipid peroxidation and oxidative injury in rat hepatocytes. Food Chem. Toxicol. 2001, 39, 437-445. (Pubitemid 32323976)
    • (2001) Food and Chemical Toxicology , vol.39 , Issue.5 , pp. 437-445
    • Rodriguez, R.J.1    Miranda, C.L.2    Stevens, J.F.3    Deinzer, M.L.4    Buhler, D.R.5
  • 25
    • 84857004572 scopus 로고    scopus 로고
    • Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration
    • Legette, L. C.; Ma, L.; Reed, R. L.; Miranda, C. L.; Christensen, J. M.; Proteau, R. R.; et al. Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration. Mol. Nutr. Food Res. 2011, 55, 1-9.
    • (2011) Mol. Nutr. Food Res , vol.55 , pp. 1-9
    • Legette, L.C.1    Ma, L.2    Reed, R.L.3    Miranda, C.L.4    Christensen, J.M.5    Proteau, R.R.6
  • 26
    • 77953540862 scopus 로고    scopus 로고
    • Xanthohumol feeding does not impair organ function and homoeostasis in mice
    • Dorn, C.; Bataille, F.; Gaebele, E.; Heilmann, J.; Hellerbrand, C. Xanthohumol feeding does not impair organ function and homoeostasis in mice. Food Chem. Toxicol. 2010, 48, 1890-1897.
    • (2010) Food Chem. Toxicol , vol.48 , pp. 1890-1897
    • Dorn, C.1    Bataille, F.2    Gaebele, E.3    Heilmann, J.4    Hellerbrand, C.5
  • 27
    • 0024805137 scopus 로고
    • Rodent models of cerebral ischemia
    • Ginsberg, M. D.; Busto, R. Rodent models of cerebral ischemia. Stroke 1989, 20, 1627-1642. (Pubitemid 20030870)
    • (1989) Stroke , vol.20 , Issue.12 , pp. 1627-1642
    • Ginsberg, M.D.1    Busto, R.2
  • 29
    • 27144452601 scopus 로고    scopus 로고
    • Neuroprotective flavonoids from Flemingia macrophylla
    • Shiao, Y. J.; Wang, C. N.; Wang, W. Y.; Lin, Y. L. Neuroprotective flavonoids from Flemingia macrophylla. Planta Med. 2005, 71, 835-840.
    • (2005) Planta Med , vol.71 , pp. 835-840
    • Shiao, Y.J.1    Wang, C.N.2    Wang, W.Y.3    Lin, Y.L.4
  • 31
    • 0035411785 scopus 로고    scopus 로고
    • Molecular steps of tumor necrosis factor receptor-mediated apoptosis
    • Gupta, S. Molecular steps of tumor necrosis factor receptormediated apoptosis. Curr. Mol. Med. 2001, 1, 317-324. (Pubitemid 33772960)
    • (2001) Current Molecular Medicine , vol.1 , Issue.3 , pp. 317-324
    • Gupta, S.1
  • 33
    • 0028786601 scopus 로고
    • A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
    • Melillo, G.; Musso, T.; Sica, A.; Taylor, L. S.; Cox, G. W.; Varesio, L. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. Exp. Med. 1995, 182, 1683-1693.
    • (1995) J. Exp. Med , vol.182 , pp. 1683-1693
    • Melillo, G.1    Musso, T.2    Sica, A.3    Taylor, L.S.4    Cox, G.W.5    Varesio, L.6
  • 35
    • 3142746742 scopus 로고    scopus 로고
    • HIF-1α reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion
    • DOI 10.1111/j.1471-4159.2004.02483.x
    • Matrone, C.; Pignataro, G.; Molinaro, P.; Irace, C.; Scorziello, A.; Di Renzo, G. F.; et al. HIF-1alpha reveals a binding activity to the promoter of iNOS gene after permanent middle cerebral artery occlusion. J. Neurochem. 2004, 90, 368-378. (Pubitemid 38938223)
    • (2004) Journal of Neurochemistry , vol.90 , Issue.2 , pp. 368-378
    • Matrone, C.1    Pignataro, G.2    Molinaro, P.3    Irace, C.4    Scorziello, A.5    Di Renzo, G.F.6    Annunziato, L.7
  • 36
    • 0030664096 scopus 로고    scopus 로고
    • Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene
    • Iadecola, C.; Zhang, F.; Casey, R.; Nagayama, M.; Ross, M. E. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J. Neurosci. 1997, 17, 9157-9164. (Pubitemid 27498443)
    • (1997) Journal of Neuroscience , vol.17 , Issue.23 , pp. 9157-9164
    • Iadecola, C.1    Zhang, F.2    Casey, R.3    Nagayama, M.4    Elizabeth Ross, M.5
  • 37
    • 0029099103 scopus 로고
    • Inactivation of glutathione peroxidase by nitric oxide. Implication for cytotoxicity
    • Asahi, M.; Fujii, J.; Suzuki, K.; Seo, H. G.; Kuzuya, T.; Hori, M.; et al. Inactivation of glutathione peroxidase by nitric oxide. Implication for cytotoxicity. J. Biol. Chem. 1995, 270, 21035-21039.
    • (1995) J. Biol. Chem , vol.270 , pp. 21035-21039
    • Asahi, M.1    Fujii, J.2    Suzuki, K.3    Seo, H.G.4    Kuzuya, T.5    Hori, M.6
  • 38
    • 0025940118 scopus 로고
    • Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse
    • Nowicki, J. P.; Duval, D.; Poignet, H.; Scatton, B. Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. Eur. J. Pharmacol. 1991, 204, 339-340.
    • (1991) Eur. J. Pharmacol , vol.204 , pp. 339-340
    • Nowicki, J.P.1    Duval, D.2    Poignet, H.3    Scatton, B.4
  • 39
    • 0035090064 scopus 로고    scopus 로고
    • Effects of nitric oxide synthesis inhibition on FK506-induced nephrotoxicity in rats
    • DOI 10.1081/JDI-100001279
    • Wang, L.; Kubodera, S.; Ueno, A.; Takeda, M. Effects of nitric oxide synthesis inhibition on FK506-induced nephrotoxicity in rats. Renal Failure 2001, 23, 11-19. (Pubitemid 32207289)
    • (2001) Renal Failure , vol.23 , Issue.1 , pp. 11-19
    • Wang, L.1    Kubodera, S.2    Ueno, A.3    Takeda, M.4
  • 40
    • 0035718736 scopus 로고    scopus 로고
    • BAX contributes to apoptotic-like death following neonatal hypoxia-ischemia: Evidence for distinct apoptosis pathways
    • Gibson, M. E.; Han, B. H.; Choi, J.; Knudson, C. M.; Korsmeyer, S. J.; Parsadanian, M.; et al. BAX contributes to apoptoticlike death following neonatal hypoxia-ischemia: evidence for distinct apoptosis pathways. Mol. Med. 2001, 7, 644-655. (Pubitemid 34175293)
    • (2001) Molecular Medicine , vol.7 , Issue.9 , pp. 644-655
    • Gibson, M.E.1    Byung, H.H.2    Choi, J.3    Knudson, C.M.4    Korsmeyer, S.J.5    Parsadanian, M.6    Holtzman, D.M.7
  • 41
    • 0035855668 scopus 로고    scopus 로고
    • Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia
    • DOI 10.1038/sj.onc.1204742
    • Suzuki, H.; Tomida, A.; Tsuruo, T. Dephosphorylated hypoxiainducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. Oncogene 2001, 20, 5779-5788. (Pubitemid 32937947)
    • (2001) Oncogene , vol.20 , Issue.41 , pp. 5779-5788
    • Suzuki, H.1    Tomida, A.2    Tsuruo, T.3
  • 42
    • 0033564062 scopus 로고    scopus 로고
    • Reduction in lipopolysaccharide-induced thrombocytopenia by triflavin in a rat model of septicemia
    • Sheu, J. R.; Hung, W. C.; Wu, C. H.; Ma, M. C.; Kan, Y. C.; Lin, C. H.; et al. Reduction in lipopolysaccharide-induced thrombocytopenia by triflavin in a rat model of septicemia. Circulation 1999, 99, 3056-3062.
    • (1999) Circulation , vol.99 , pp. 3056-3062
    • Sheu, J.R.1    Hung, W.C.2    Wu, C.H.3    Ma, M.C.4    Kan, Y.C.5    Lin, C.H.6


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