메뉴 건너뛰기




Volumn 55, Issue 3, 2011, Pages 485-494

Inhibitors of hyaluronan export from hops prevent osteoarthritic reactions

Author keywords

Hyaluronan export; MRP5; Osteoarthritis; Prenylflavonoids; Xanthohumol

Indexed keywords

8 PRENYLNARINGENIN; 8-PRENYLNARINGENIN; ABC TRANSPORTER; COLLAGEN; CYCLIC GMP; FLAVANONE DERIVATIVE; FLAVONOID; HYALURONIC ACID; ISOXANTHOHUMOL; MULTIDRUG RESISTANCE PROTEIN; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; PLANT EXTRACT; PROPIOPHENONE DERIVATIVE; PROTEOGLYCAN; XANTHOHUMOL; XANTHONE DERIVATIVE;

EID: 79952128841     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201000210     Document Type: Article
Times cited : (14)

References (44)
  • 1
    • 3042697038 scopus 로고    scopus 로고
    • Hyaluronan: from extracellular glue to pericellular cue
    • Toole, B. P., Hyaluronan: from extracellular glue to pericellular cue. Nat. Rev. Cancer 2004, 4, 528-539.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 528-539
    • Toole, B.P.1
  • 2
    • 0034130726 scopus 로고    scopus 로고
    • Stimulation of hyaluronan metabolism by interleukin-1alpha in human articular cartilage
    • Nishida, Y., D'Souza, A. L., Thonar, E. J., Knudson, W., Stimulation of hyaluronan metabolism by interleukin-1alpha in human articular cartilage. Arthritis Rheum. 2000, 43, 1315-1326.
    • (2000) Arthritis Rheum. , vol.43 , pp. 1315-1326
    • Nishida, Y.1    D'Souza, A.L.2    Thonar, E.J.3    Knudson, W.4
  • 3
    • 0034141276 scopus 로고    scopus 로고
    • Differential effects of interleukin-1 on hyaluronan and proteoglycan metabolism in two compartments of the matrix formed by articular chondrocytes maintained in alginate
    • D'Souza, A. L., Masuda, K., Otten, L. M., Nishida, Y. et al., Differential effects of interleukin-1 on hyaluronan and proteoglycan metabolism in two compartments of the matrix formed by articular chondrocytes maintained in alginate. Arch. Biochem. Biophys. 2000, 374, 59-65.
    • (2000) Arch. Biochem. Biophys. , vol.374 , pp. 59-65
    • D'Souza, A.L.1    Masuda, K.2    Otten, L.M.3    Nishida, Y.4
  • 4
    • 79952157590 scopus 로고    scopus 로고
    • Hyaluronan, der Gewebe-Expander: "Weg da, jetzt komme ich"
    • Prehm, P., Hyaluronan, der Gewebe-Expander: "Weg da, jetzt komme ich". Biospektrum 2008, 5, 473-475.
    • (2008) Biospektrum , vol.5 , pp. 473-475
    • Prehm, P.1
  • 5
    • 39049115528 scopus 로고    scopus 로고
    • Inhibition of hyaluronan export reduces collagen degradation in IL-1 treated cartilage
    • Deiters, B., Prehm, P., Inhibition of hyaluronan export reduces collagen degradation in IL-1 treated cartilage. Arthritis Res. Ther. 2008, 10, R8.
    • (2008) Arthritis Res. Ther. , vol.10
    • Deiters, B.1    Prehm, P.2
  • 6
    • 17144425735 scopus 로고    scopus 로고
    • Inhibitors of hyaluronan export prevent proteoglycan loss from osteoarthritic cartilage
    • Prehm, P., Inhibitors of hyaluronan export prevent proteoglycan loss from osteoarthritic cartilage. J. Rheumatol. 2005, 32, 690-696.
    • (2005) J. Rheumatol. , vol.32 , pp. 690-696
    • Prehm, P.1
  • 7
    • 77951051360 scopus 로고    scopus 로고
    • Disease modifying osteoarthritis drugs: facing development challenges and choosing molecular targets
    • Le Graverand-Gastineau, M. P., Disease modifying osteoarthritis drugs: facing development challenges and choosing molecular targets. Curr. Drug Targets 2010.
    • (2010) Curr. Drug Targets
    • Le Graverand-Gastineau, M.P.1
  • 8
    • 4444286327 scopus 로고    scopus 로고
    • Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters
    • Prehm, P., Schumacher, U., Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters. Biochem. Pharmacol. 68, 2004, 1401-1410.
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 1401-1410
    • Prehm, P.1    Schumacher, U.2
  • 9
    • 57149111290 scopus 로고    scopus 로고
    • Inhibition of hyaluronan export attenuates cell migration and metastasis of human melanoma
    • Monz, K., Maas-Kuck, K., Schumacher, U., Schulz, T. et al., Inhibition of hyaluronan export attenuates cell migration and metastasis of human melanoma. J. Cell. Biochem. 2008, 105, 1260-1266.
    • (2008) J. Cell. Biochem. , vol.105 , pp. 1260-1266
    • Monz, K.1    Maas-Kuck, K.2    Schumacher, U.3    Schulz, T.4
  • 10
    • 34547099864 scopus 로고    scopus 로고
    • Hyaluronan export by the ABC-transporter MRP5 and its modulation by intracellular cGMP
    • Schulz, T., Schumacher, U., Prehm, P., Hyaluronan export by the ABC-transporter MRP5 and its modulation by intracellular cGMP. J. Biol. Chem. 2007, 282, 20999-21004.
    • (2007) J. Biol. Chem. , vol.282 , pp. 20999-21004
    • Schulz, T.1    Schumacher, U.2    Prehm, P.3
  • 11
    • 0037360716 scopus 로고    scopus 로고
    • Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities
    • Xin, Z. C., Kim, E. K., Lin, C. S., Liu, W. J. et al., Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. Asian J. Androl. 2003, 5, 15-18.
    • (2003) Asian J. Androl. , vol.5 , pp. 15-18
    • Xin, Z.C.1    Kim, E.K.2    Lin, C.S.3    Liu, W.J.4
  • 12
    • 0033856957 scopus 로고    scopus 로고
    • Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
    • O'Brien, J., Wilson, I., Orton, T., Pognan, F., Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur. J. Biochem. 2000, 267, 5421-5426.
    • (2000) Eur. J. Biochem. , vol.267 , pp. 5421-5426
    • O'Brien, J.1    Wilson, I.2    Orton, T.3    Pognan, F.4
  • 13
    • 0027300720 scopus 로고
    • Simultaneous preparation and quantitation of proteoglycans by precipitation with Alcian Blue
    • Bjornsson, S., Simultaneous preparation and quantitation of proteoglycans by precipitation with Alcian Blue. Anal. Biochem. 1993, 210, 282-291.
    • (1993) Anal. Biochem. , vol.210 , pp. 282-291
    • Bjornsson, S.1
  • 14
    • 0030910012 scopus 로고    scopus 로고
    • Assessment of the Alamar Blue assay for cellular growth and viability in vitro
    • Nakayama, G. R., Caton, M. C., Nova, M. P., Parandoosh, Z., Assessment of the Alamar Blue assay for cellular growth and viability in vitro. J. Immunol. Methods 1997, 204, 205-208.
    • (1997) J. Immunol. Methods , vol.204 , pp. 205-208
    • Nakayama, G.R.1    Caton, M.C.2    Nova, M.P.3    Parandoosh, Z.4
  • 15
    • 0019312005 scopus 로고
    • Neutrophil plasma membranes. I. High-yield purification of human neutrophil plasma membrane vesicles by nitrogen cavitation and differential centrifugation
    • Klempner, M. S., Mikkelsen, R. B., Corfman, D. H., Andre, S. J., Neutrophil plasma membranes. I. High-yield purification of human neutrophil plasma membrane vesicles by nitrogen cavitation and differential centrifugation. J. Cell Biol. 1980, 86, 21-28.
    • (1980) J. Cell Biol. , vol.86 , pp. 21-28
    • Klempner, M.S.1    Mikkelsen, R.B.2    Corfman, D.H.3    Andre, S.J.4
  • 16
    • 0026719419 scopus 로고
    • An ELISA-like assay for hyaluronidase and hyaluronidaseinhibitors
    • Stern, M., Stern, R., An ELISA-like assay for hyaluronidase and hyaluronidaseinhibitors. Matrix 1992, 12, 397-403.
    • (1992) Matrix , vol.12 , pp. 397-403
    • Stern, M.1    Stern, R.2
  • 17
    • 0034668082 scopus 로고    scopus 로고
    • Differential use of Alcian blue and toluidine blue dyes for the quantification and isolation of anionic glycoconjugates from cell cultures: application to proteoglycans and a high-molecular-weight glycoprotein synthesized by articular chondrocytes
    • Terry, D. E., Chopra, R. K., Ovenden, J., Anastassiades, T. P., Differential use of Alcian blue and toluidine blue dyes for the quantification and isolation of anionic glycoconjugates from cell cultures: application to proteoglycans and a high-molecular-weight glycoprotein synthesized by articular chondrocytes. Anal. Biochem. 2000, 285, 211-219.
    • (2000) Anal. Biochem. , vol.285 , pp. 211-219
    • Terry, D.E.1    Chopra, R.K.2    Ovenden, J.3    Anastassiades, T.P.4
  • 18
    • 0002779868 scopus 로고
    • Laboratory notes of technical methods for the nervous system
    • van Gieson, I., Laboratory notes of technical methods for the nervous system. N. Y. Med. J. 1889, 50, 57-60.
    • (1889) N. Y. Med. J. , vol.50 , pp. 57-60
    • van Gieson, I.1
  • 20
    • 0035990279 scopus 로고    scopus 로고
    • Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta
    • Benderdour, M., Tardif, G., Pelletier, J. P., Di Battista, J. A. et al., Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta. J. Rheumatol. 2002, 29, 1262-1272.
    • (2002) J. Rheumatol. , vol.29 , pp. 1262-1272
    • Benderdour, M.1    Tardif, G.2    Pelletier, J.P.3    Di Battista, J.A.4
  • 21
    • 1842365544 scopus 로고    scopus 로고
    • Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures
    • Kozaci, L. D., Buttle, D. J., Hollander, A. P., Degradation of type II collagen, but not proteoglycan, correlates with matrix metalloproteinase activity in cartilage explant cultures. Arthritis Rheum. 1997, 40, 164-174.
    • (1997) Arthritis Rheum. , vol.40 , pp. 164-174
    • Kozaci, L.D.1    Buttle, D.J.2    Hollander, A.P.3
  • 22
    • 0031939315 scopus 로고    scopus 로고
    • Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes
    • Sasaki, K., Hattori, T., Fujisawa, T., Takahashi, K. et al., Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. J. Biochem. (Tokyo) 1998, 123, 431-439.
    • (1998) J. Biochem. (Tokyo) , vol.123 , pp. 431-439
    • Sasaki, K.1    Hattori, T.2    Fujisawa, T.3    Takahashi, K.4
  • 23
    • 0034041424 scopus 로고    scopus 로고
    • Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase
    • Billinghurst, R. C., Wu, W., Ionescu, M., Reiner, A. et al., Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase. Arthritis Rheum. 2000, 43, 664-672.
    • (2000) Arthritis Rheum. , vol.43 , pp. 664-672
    • Billinghurst, R.C.1    Wu, W.2    Ionescu, M.3    Reiner, A.4
  • 24
    • 0034054670 scopus 로고    scopus 로고
    • The organization of aggrecan in human articular cartilage. Evidence for age-related changes in the rate of aggregation of newly synthesized molecules
    • Bayliss, M. T., Howat, S., Davidson, C., Dudhia, J., The organization of aggrecan in human articular cartilage. Evidence for age-related changes in the rate of aggregation of newly synthesized molecules. J. Biol. Chem. 2000, 275, 6321-6327.
    • (2000) J. Biol. Chem. , vol.275 , pp. 6321-6327
    • Bayliss, M.T.1    Howat, S.2    Davidson, C.3    Dudhia, J.4
  • 25
    • 77950516528 scopus 로고    scopus 로고
    • Xanthohumol inhibits IL-12 production and reduces chronic allergic contact dermatitis
    • Cho, Y. C., You, S. K., Kim, H. J., Cho, C. W. et al., Xanthohumol inhibits IL-12 production and reduces chronic allergic contact dermatitis. Int. Immunopharmacol. 2010, 10, 556-561.
    • (2010) Int. Immunopharmacol. , vol.10 , pp. 556-561
    • Cho, Y.C.1    You, S.K.2    Kim, H.J.3    Cho, C.W.4
  • 26
    • 75449084734 scopus 로고    scopus 로고
    • Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells
    • Dorn, C., Weiss, T. S., Heilmann, J., Hellerbrand, C., Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells. Int. J. Oncol. 2010, 36, 435-441.
    • (2010) Int. J. Oncol. , vol.36 , pp. 435-441
    • Dorn, C.1    Weiss, T.S.2    Heilmann, J.3    Hellerbrand, C.4
  • 27
    • 77956023748 scopus 로고    scopus 로고
    • Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis
    • Dorn, C., Kraus, B., Motyl, M., Weiss, T. S. et al., Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis. Mol. Nutr. Food Res. 2010, 54, S205-S213.
    • (2010) Mol. Nutr. Food Res. , vol.54
    • Dorn, C.1    Kraus, B.2    Motyl, M.3    Weiss, T.S.4
  • 28
    • 71949101502 scopus 로고    scopus 로고
    • Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia
    • Lust, S., Vanhoecke, B., Van, G. M., Boelens, J. et al., Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia. Anticancer Res. 2009, 29, 3797-3805.
    • (2009) Anticancer Res. , vol.29 , pp. 3797-3805
    • Lust, S.1    Vanhoecke, B.2    Van, G.M.3    Boelens, J.4
  • 29
    • 39949083016 scopus 로고    scopus 로고
    • Differential anti-inflammatory pathway by xanthohumol in IFN-gamma and LPS-activated macrophages
    • Cho, Y. C., Kim, H. J., Kim, Y. J., Lee, K. Y. et al., Differential anti-inflammatory pathway by xanthohumol in IFN-gamma and LPS-activated macrophages. Int. Immunopharmacol. 2008, 8, 567-573.
    • (2008) Int. Immunopharmacol. , vol.8 , pp. 567-573
    • Cho, Y.C.1    Kim, H.J.2    Kim, Y.J.3    Lee, K.Y.4
  • 30
    • 38949104738 scopus 로고    scopus 로고
    • Antimutagenicity of hops (Humulus lupulus L.): bioassay-directed fractionation and isolation of xanthohumol
    • Kac, J., Plazar, J., Mlinaric, A., Zegura, B. et al., Antimutagenicity of hops (Humulus lupulus L.): bioassay-directed fractionation and isolation of xanthohumol. Phytomedicine 2008, 15, 216-220.
    • (2008) Phytomedicine , vol.15 , pp. 216-220
    • Kac, J.1    Plazar, J.2    Mlinaric, A.3    Zegura, B.4
  • 31
    • 28044468215 scopus 로고    scopus 로고
    • Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer
    • Vanhoecke, B., Derycke, L., Van, M. V., Depypere, H. et al., Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer. Int. J. Cancer 2005, 117, 889-895.
    • (2005) Int. J. Cancer , vol.117 , pp. 889-895
    • Vanhoecke, B.1    Derycke, L.2    Van, M.V.3    Depypere, H.4
  • 32
    • 38549097194 scopus 로고    scopus 로고
    • Antigenotoxic effect of xanthohumol in rat liver slices
    • Plazar, J., Filipic, M., Groothuis, G. M., Antigenotoxic effect of xanthohumol in rat liver slices. Toxicol. In Vitro 2008, 22, 318-327.
    • (2008) Toxicol. In Vitro , vol.22 , pp. 318-327
    • Plazar, J.1    Filipic, M.2    Groothuis, G.M.3
  • 33
    • 70349197988 scopus 로고    scopus 로고
    • Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes
    • Lupinacci, E., Meijerink, J., Vincken, J. P., Gabriele, B. et al., Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes. J. Agric. Food Chem. 2009.
    • (2009) J. Agric. Food Chem.
    • Lupinacci, E.1    Meijerink, J.2    Vincken, J.P.3    Gabriele, B.4
  • 34
    • 61949193344 scopus 로고    scopus 로고
    • Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells
    • Harikumar, K. B., Kunnumakkara, A. B., Ahn, K. S., Anand, P. et al., Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells. Blood 2009, 113, 2003-2013.
    • (2009) Blood , vol.113 , pp. 2003-2013
    • Harikumar, K.B.1    Kunnumakkara, A.B.2    Ahn, K.S.3    Anand, P.4
  • 35
    • 36849093406 scopus 로고    scopus 로고
    • Inhibition of topoisomerase I activity and efflux drug transporters' expression by xanthohumol from hops
    • Lee, S. H., Kim, H. J., Lee, J. S., Lee, I. S., Kang, B. Y., Inhibition of topoisomerase I activity and efflux drug transporters' expression by xanthohumol from hops. Arch. Pharm. Res. 2007, 30, 1435-1439.
    • (2007) Arch. Pharm. Res. , vol.30 , pp. 1435-1439
    • Lee, S.H.1    Kim, H.J.2    Lee, J.S.3    Lee, I.S.4    Kang, B.Y.5
  • 36
    • 33846226681 scopus 로고    scopus 로고
    • Distinct modulation of alkaline phosphatase isoenzymes by 17beta-estradiol and xanthohumol in breast cancer MCF-7 cells
    • Guerreiro, S., Monteiro, R., Martins, M. J., Calhau, C. et al., Distinct modulation of alkaline phosphatase isoenzymes by 17beta-estradiol and xanthohumol in breast cancer MCF-7 cells. Clin. Biochem. 2007, 40, 268-273.
    • (2007) Clin. Biochem. , vol.40 , pp. 268-273
    • Guerreiro, S.1    Monteiro, R.2    Martins, M.J.3    Calhau, C.4
  • 37
    • 15344344829 scopus 로고    scopus 로고
    • Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes
    • Nikolic, D., Li, Y., Chadwick, L. R., Pauli, G. F., van Breemen, R. B., Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes. J. Mass Spectrom. 2005, 40, 289-299.
    • (2005) J. Mass Spectrom. , vol.40 , pp. 289-299
    • Nikolic, D.1    Li, Y.2    Chadwick, L.R.3    Pauli, G.F.4    van Breemen, R.B.5
  • 38
    • 0034753762 scopus 로고    scopus 로고
    • Identification, quantitation and biological activity of phytoestrogens in a dietary supplement for breast enhancement
    • Coldham, N. G., Sauer, M. J., Identification, quantitation and biological activity of phytoestrogens in a dietary supplement for breast enhancement. Food Chem. Toxicol. 2001, 39, 1211-1224.
    • (2001) Food Chem. Toxicol. , vol.39 , pp. 1211-1224
    • Coldham, N.G.1    Sauer, M.J.2
  • 39
    • 33745670638 scopus 로고    scopus 로고
    • The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine
    • Possemiers, S., Bolca, S., Grootaert, C., Heyerick, A. et al., The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine. J. Nutr. 2010, 136, 1862-1867.
    • (2010) J. Nutr. , vol.136 , pp. 1862-1867
    • Possemiers, S.1    Bolca, S.2    Grootaert, C.3    Heyerick, A.4
  • 40
    • 3042559902 scopus 로고    scopus 로고
    • Xanthohumol and related prenylflavonoids from hops and beer: to your good health
    • Stevens, J. F., Page, J. E., Xanthohumol and related prenylflavonoids from hops and beer: to your good health. Phytochemistry 2004, 65, 1317-1330.
    • (2004) Phytochemistry , vol.65 , pp. 1317-1330
    • Stevens, J.F.1    Page, J.E.2
  • 41
    • 33748673123 scopus 로고    scopus 로고
    • Extracellular matrix of the cumulus-oocyte complex
    • Russell, D. L., Salustri, A., Extracellular matrix of the cumulus-oocyte complex. Semin. Reprod. Med. 2006, 24, 217-227.
    • (2006) Semin. Reprod. Med. , vol.24 , pp. 217-227
    • Russell, D.L.1    Salustri, A.2
  • 42
    • 35648969643 scopus 로고    scopus 로고
    • PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion
    • Scarchilli, L., Camaioni, A., Bottazzi, B., Negri, V. et al., PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion. J. Biol. Chem. 2007, 282, 30161-30170.
    • (2007) J. Biol. Chem. , vol.282 , pp. 30161-30170
    • Scarchilli, L.1    Camaioni, A.2    Bottazzi, B.3    Negri, V.4
  • 43
    • 5144221343 scopus 로고    scopus 로고
    • Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships
    • Ko, W. C., Shih, C. M., Lai, Y. H., Chen, J. H., Huang, H. L., Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships. Biochem. Pharmacol. 2004, 68, 2087-2094.
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 2087-2094
    • Ko, W.C.1    Shih, C.M.2    Lai, Y.H.3    Chen, J.H.4    Huang, H.L.5
  • 44
    • 47849102104 scopus 로고    scopus 로고
    • Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase
    • Dell'Agli, M., Maschi, O., Galli, G. V., Fagnani, R. et al., Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase. Br. J. Nutr. 2008, 99, 945-951.
    • (2008) Br. J. Nutr. , vol.99 , pp. 945-951
    • Dell'Agli, M.1    Maschi, O.2    Galli, G.V.3    Fagnani, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.