Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway

Molecular Nutrition and Food Research

Volumn 49, Issue 9, 2005, Pages 837-843

  Pan, Lydia ^a   Becker, Hans ^b   Gerhäuser, Clarissa ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

40 16 Colon cancer cell line; Apoptosis; Bcl 2; Caspases; Chalcone; Humulus lupulus L.; Xanthohumol

Indexed keywords

CASP3 PROTEIN, HUMAN; CASP7 PROTEIN, HUMAN; CASP8 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; CASPASE; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROPIOPHENONE DERIVATIVE; PROTEIN BCL 2; XANTHOHUMOL;

APOPTOSIS; ARTICLE; CELL DIVISION; CHEMISTRY; COLON TUMOR; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMULUS; METABOLISM; MITOCHONDRION; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CASPASES; CELL DIVISION; CELL LINE, TUMOR; COLONIC NEOPLASMS; ENZYME ACTIVATION; HUMANS; HUMULUS; MITOCHONDRIA; POLY(ADP-RIBOSE) POLYMERASES; PROPIOPHENONES; PROTO-ONCOGENE PROTEINS C-BCL-2;

HUMULUS LUPULUS;

EID: 26244437262     PISSN: 16134125     EISSN: None     Source Type: Journal    
DOI: 10.1002/mnfr.200500065     Document Type: Article

References (26)

1. Kim, R., Recent advances in understanding the cell death pathways activated by anticancer therapy. Cancer 2005, 103, 1551-1560.
2. Khosravi-Far, R., Esposti, M. D., Death receptor signals to mitochondria. Cancer Biol. Ther. 2004, 3, 1051-1057.
3. Debatin, K. M., Krammer, P. H., Death receptors in chemotherapy and cancer. Oncogene 2004, 23, 2950-2966.
4. Rupnarain, C., Dlamini, Z., Naicker, S., Bhoola, K., Colon cancer: genomics and apoptotic events. Biol. Chem. 2004, 385, 449-464.
5. Soldani, C., Scovassi, A. I., Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis 2002, 7, 321-328.
6. Cory, S., Adams, J. M., The Bcl-2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2002, 2, 647-656.
7. Adams, J. M., Cory, S., Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci. 2001, 26, 61-66.
8. Reed, J. C., Apoptosis mechanisms: implications for cancer drug discovery. Oncology (Huntingt.) 2004, 18, 11-20.
9. Gerhauser, C., Alt, A., Heiss, E., Gamal-Eldeen, A., et al., Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop. Mol. Cancer Ther. 2002, 1, 959-969.
10. Gerhauser, C., Beer constituents as potential cancer chemopreventive agents, Eur. J. Cancer 2005, in press.
11. Miranda, C. L., Stevens, J. F., Helmrich, A., Henderson, M. C., et al., Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food Chem. Toxicol. 1999, 37, 271-285.
12. Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., et al., Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997, 275, 218-220.
13. Hsieh, T. C., Burfeind, P., Laud, K., Backer, J. M., et al., Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials. Int. J. Oncol. 1999, 15, 245-252.
14. Botta, B., Vitali, A., Menendez, P., Misiti, D., et al., Prenylated flavonoids: Pharmacology and Biotechnology. Curr. Med. Chem. 2005, 12, 713-739.
15. Chen, W. J., Lin, J. K., Mechanisms of cancer chemoprevention by hop bitter acids (beer aroma) through induction of apoptosis mediated by Fas and caspase cascades. J. Agric. Food Chem. 2004, 52, 55-64.
16. Avula, B., Ganzera, M., Warnick, J. E., Feltenstein, M. W., et al., High-performance liquid chromatographic determination of xanthohumol in rat plasma, urine, and fecal samples. J. Chromatogr. Sci. 2004, 42, 378-382.
17. Nookandeh, A., Frank, N., Steiner, F., Ellinger, R., et al., Xanthohumol metabolites in faeces of rats. Phytochemistry 2004, 65, 561-570.
18. Skehan, P., Storeng, R., Scudiero, D., Monks, A., et al., New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst. 1990, 82, 1107-1112.
19. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., et al., Measurement of protein using bicinchoninic acid. Anal. Biochem. 1985, 150, 76-85.
20. Kennedy, A. S., Harrison, G. H., Mansfield, C. M., Zhou, X. J., et al., Survival of colorectal cancer cell lines treated with paclitaxel, radiation, and 5-FU: effect of TP53 or hMLH1 deficiency. Int. J. Cancer 2000, 90, 175-185.
21. Go, M. L., Wu, X., Liu, X. L., Chalcones: an update on cytotoxic and chemoprotective properties. Curr. Med. Chem. 2005, 12, 481-499.
22. Galati, G., O'Brien, P. J., Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic. Biol. Med. 2004, 37, 287-303.
23. Sabzevari, O., Galati, G., Moridani, M. Y., Siraki, A., O'Brien, P. J., Molecular cytotoxic mechanisms of anticancer hydroxychalcones. Chem. Biol. Interact. 2004, 148, 57-67.
24. Stoetzer, O. J., Pogrebniak, A., Pelka-Fleischer, R., Hasmann, M., Hiddemann, W., Nuessler, V., Modulation of apoptosis by mitochondrial uncouplers: apoptosis-delaying features despite intrinsic cytotoxicity. Biochem. Pharmacol. 2002, 63, 471-483.
25. Ligeret, H., Barthelemy, S., Bouchard Doulakas, G., Carrupt, P. A., et al., Fluoride curcumin derivatives: new mitochondrial uncoupling agents. FEBS Lett. 2004, 569, 37-42.
26. Kowaltowski, A. J., Castilho, R. F., Vercesi, A. E., Mitochondrial permeability transition and oxidative stress. FEBS Lett. 2001, 495, 12-15.