New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 17, 2010, Pages 6275-6281

  Quincoces Suarez, José Agustín ^a   Rando, Daniela Gonales ^b   Santos, Reginaldo Pereira ^a   Gonalves, Carolina Passarelli ^a   Ferreira, Elizabeth ^b   De Carvalho, João Ernesto ^c   Kohn, Luciana ^c   Maria, Durvanei Augusto ^d   Faião Flores, Fernanda ^d   Michalik, Dirk ^e   Marcucci, Maria Cristina ^a   Vogel, Christian ^f  

^a Universidade Bandeirante de Sao Paulo   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

^d INSTITUTO BUTANTAN   (Brazil)

^e LEIBNIZ INSTITUT FÜR KATALYSE E V AN DER UNIVERSITÄT ROSTOCK   (Germany)

^f UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Antineoplastic agents; Cytotoxicity; Diarylpentadienone derivatives; LD50 toxicity; Synthesis

Indexed keywords

1,5 BIS( 3,4 DIMETHOXYPHENYL) 1,4 PENTADIEN 3 ONE; 1,5 BIS( 4 ACETOXY 3 METHOXYPHENYL) 1,4 PENTADIEN 3 ONE; 1,5 BIS( 4 HYDROXY 3 METHOXYPHENYL) 1,4 PENTADIEN 3 ONE; 1,5 BIS( 4 HYDROXY 3 METHOXYPHENYL) 1,4 PENTADIEN 3 YLIDEN MALONONITRILE; 1,5 BIS[ 3 METHOXY 4 ( 3 METHYL BUT 2 ENYLOXY)PHENYL] 1,4 PENTADIEN 3 ONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; ETOPOSIDE; KETONE DERIVATIVE; PACLITAXEL; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CANCER RESISTANCE; CELL STRAIN MCF 7; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG MEGADOSE; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CANCER; LEUKEMIA CELL; LUNG CARCINOMA; LYMPHATIC LEUKEMIA; MACROPHAGE; MALE; MELANOMA CELL; MOUSE; NONHUMAN; OVARY CANCER; PHENOTYPE; PROSTATE CANCER; TUMOR CELL LINE;

ANIMALS; ANISOLES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; KETONES; MICE; STRUCTURE-ACTIVITY RELATIONSHIP;

MURINAE;

EID: 77955984610     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.07.026     Document Type: Article

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