Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation

Nature Cell Biology

Volumn 8, Issue 3, 2006, Pages 293-299

  Bacher, Christian P ^a   Guggiari, Michèele ^b   Brors, Benedikt ^a   Augui, Sandrine ^b   Clerc, Philippe ^c   Avner, Philip ^b   Eils, Roland ^a,d   Heard, Edith ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b CNRS   (France)

^c INSTITUT PASTEUR   (France)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RNA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CHROMATIN STRUCTURE; CHROMOSOME DELETION X; CHROMOSOME NUMBER; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOCUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RNA SEQUENCE; SEQUENCE ANALYSIS; TRANSGENE; X CHROMOSOME INACTIVATION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; EMBRYO; FEMALE; GENOMIC IMPRINTING; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MICE; RNA, UNTRANSLATED; STEM CELLS; X CHROMOSOME; X CHROMOSOME INACTIVATION;

ANIMALIA;

EID: 33644751726     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1365     Document Type: Article

References (27)

1. Rastan, S. Non-random X-chromosome inactivation in mouse X-autosome translocation embryos - location of the inactivation centre. J. Embryol. Exp. Morphol. 78, 1-22 (1983).
2. Rastan, S. & Robertson, E. J. X-chromosome deletions in embryo-derived (EK) cell lines associated with lack of X-chromosome inactivation. J. Embryol. Exp. Morphol. 90, 379-388 (1985).
3. Boumil, R. M. & Lee, J. T. Forty years of decoding the silence in X-chromosome inactivation. Hum. Mol. Genet. 10, 2225-2232 (2001).
4. Clerc, P. & Avner, P. Multiple elements within the Xic regulate random X inactivation in mice. Semin. Cell Dev. Biol. 14, 85-92 (2003).
5. Clerc, P. & Avner, P. Role of the region 3 to Xist exon 6 in the counting process of X-chromosome inactivation. Nature Genet. 19, 249-253 (1998).
6. Morey, C. et al. The region 3′ to Xist mediates X chromosome counting and H3 Lys-4 dimethylation within the Xist gene. EMBO J. 23, 594-604 (2004).
7. Heard, E., Mongelard, F., Arnaud, D. & Avner, P. Xist yeast artificial chromosome transgenes function as X-inactivation centers only in multicopy arrays and not as single copies. Mol. Cell Biol. 19, 3156-3166 (1999).
8. Marahrens, Y. X-inactivation by chromosomal pairing events. Genes Dev. 13, 2624-2632 (1999).
9. Osborne, C. S. et al. Active genes dynamically colocalize to shared sites of ongoing transcription. Nature Genet. 36, 1065-1071 (2004).
10. Spilianakis, C. G. et al. Interchromosomal associations between alternatively expressed loci. Nature 435, 637-645 (2005).
11. Spector, D. L. The dynamics of chromosome organization and gene regulation. Annu. Rev. Biochem. 72, 573-608 (2003).
12. Taddei, A., Hediger, F., Neumann, F. R. & Gasser, S. M. The function of nuclear architecture: A genetic approach. Annu. Rev. Genet. 38, 305-345 (2004).
13. Chambeyron, S. & Bickmore, W. A. Does looping and clustering in the nucleus regulate gene expression? Curr. Opin. Cell Biol. 16, 256-262 (2004).
14. Comings, D. E. The rationale for an ordered arrangement of chromatin in the interphase nucleus. Am. J. Hum. Genet. (1968).
15. Okamoto, I. et al. Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice. Nature 438, 369-373 (2005).
16. Morey, C., Arnaud, D., Avner, P. & Clerc, P. Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation. Hum. Mol. Genet. 10, 1403-1411 (2001).
17. Navarro, P. et al. Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation. Genes Dev. 19, 1474-1484 (2005).
18. Sado, T., Hoki, Y. & Sasaki, H. Tsix silences Xist through modification of chromatin structure. Dev. Cell 9, 159-165 (2005).
19. Stavropoulos, N., Rowntree, R. K. & Lee, J. T. Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation. Mol. Cell. Biol. 25, 2757-2769 (2005).
20. LaSalle, J. M. & Lalande, M. Homologous association of oppositely imprinted chromosomal domains. Science 272, 725-728 (1996).
21. Rougeulle, C. et al. Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol. Cell. Biol. 24, 5475-5484 (2004).
22. Bacher, C. P. et al. 4-D single particle tracking of synthetic and proteinaceous microspheres reveals preferential movement of nuclear particles along chromatin - poor tracks. BMC Cell Biol. 5, 45 (2004).
23. Tvarusko, W. et al. Time-resolved analysis and visualization of dynamic processes in living cells. Proc. Natl Acad. Sci. USA 96, 7950-7955 (1999).
24. Hollander, M. & Wolfe, D. A. in Nonparametric statistical inference 27-33 (John Wiley & Sons, New York, 1973).
25. Conover, W. J. in Practical nonparametric statistics (ed. Wiley, B.) 295-301 & 309-314 (John Wiley & Sons, New York, 1971).
26. Becker, R. A., Chambers, J. M. & Wilks, A. R. The New S Language (Wadsworth & Brooks/Cole, 1988).
27. Penny, G. et al. Requirement for Xist in X chromosome inactivation. Nature 379, 131-137 (1996).