Proteomic analysis of hearts from Akita mice suggests that increases in soluble epoxide hydrolase and antioxidative programming are key changes in early stages of diabetic cardiomyopathy

Journal of Proteome Research

Volumn 12, Issue 9, 2013, Pages 3920-3933

  Dewey, Shannamar ^a   Lai, Xianyin ^c   Witzmann, Frank A ^c   Sohal, Mandeep ^a   Gomes, Aldrin V ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

diabetes mellitus (DM); diabetic cardiomyopathy (DC); heart; mass spectrometry (MS); murine

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTIOXIDANT; BUTYRYL COENZYME A DEHYDROGENASE; COLLAGEN; COLLAGEN ALPHA 1 CHAIN; COPPER ZINC SUPEROXIDE DISMUTASE; ELONGATION FACTOR 1; ELONGATION FACTOR 1ALPHA; ELONGATION FACTOR 1ALPHA 1; EPOXIDE HYDROLASE; GLUCOSIDASE; GLUCOSIDASE ALPHA NEUTRAL C; GLUTATHIONE; GLUTATHIONE TRANSFERASE KAPPA 1; HEME OXYGENASE 2; HISTIDINE; HISTIDINE RICH CALCIUM BINDING PROTEIN; MESSENGER RNA; PLAKOPHILIN; PLAKOPHILIN 2; PLECKSTRIN; PROBABLE PLECKSTRIN HOMOLOGY DOMAIN CONTAINING FAMILY N MEMBER 1; RAP1 PROTEIN; RAP1A PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DISEASE COURSE; FEMALE; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HEART; HEART SIZE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SKELETAL MUSCLE; UPREGULATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; DIABETIC CARDIOMYOPATHIES; EPOXIDE HYDROLASES; FEMALE; GLUTATHIONE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MYOCARDIUM; OXIDATION-REDUCTION; PROTEOME; PROTEOMICS; TANDEM MASS SPECTROMETRY; TRANSCRIPTOME;

EID: 84883769110     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr4004739     Document Type: Article

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