Genetic loss of insulin receptors worsens cardiac efficiency in diabetes

Journal of Molecular and Cellular Cardiology

Volumn 52, Issue 5, 2012, Pages 1019-1026

  Bugger, Heiko ^a,d   Riehle, Christian ^a   Jaishy, Bharat ^a   Wende, Adam R ^a   Tuinei, Joseph ^a   Chen, Dong ^b   Soto, Jamie ^a   Pires, Karla M ^a   Boudina, Sihem ^a   Theobald, Heather A ^a   Luptak, Ivan ^c   Wayment, Benjamin ^a   Wang, Xiaohui ^a   Litwin, Sheldon E ^a,e   Weimer, Bart C ^b,f   Abel, E Dale ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UTAH STATE UNIVERSITY   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF FREIBURG   (Germany)

^e MEDICAL COLLEGE OF GEORGIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiac efficiency; Diabetes; Diabetic cardiomyopathy; Insulin signaling; Mitochondria

Indexed keywords

3 HYDROXYBUTYRIC ACID; ADENOSINE TRIPHOSPHATE; FATTY ACID; GLUCOSE; INSULIN; INSULIN RECEPTOR; LACTIC ACID; PALMITOYLCARNITINE; PYRUVIC ACID; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ECHOCARDIOGRAPHY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GENE LOSS; GENOTYPE; HEART FUNCTION; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HEART PERFUSION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN METABOLISM; ISOLATED HEART; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEOMICS; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; GENE KNOCKOUT TECHNIQUES; HEART; INSULIN; ION CHANNELS; MALE; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, KNOCKOUT; MITOCHONDRIA, HEART; MITOCHONDRIAL PROTEINS; MYOCARDIUM; ORGANELLE SIZE; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEOME; REACTIVE OXYGEN SPECIES; RECEPTOR, INSULIN;

MUS;

EID: 84862793562     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2012.02.001     Document Type: Article

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