Proteome changes in the myocardium of experimental chronic diabetes and hypertension. Role of PPARα in the associated hypertrophy

Journal of Proteomics

Volumn 75, Issue 6, 2012, Pages 1816-1829

  Ares Carrasco, S ^a   Picatoste, B ^a   Camafeita, E ^b   Carrasco Navarro, S ^a   Zubiri, I ^a   Ortiz, A ^a   Egido, J ^a   Lopez J A ^b   Tunon J ^a   Lorenzo, O ^a  

^a 28400 Madrid   (Spain)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

Hypertension; Hypertrophy; PPAR; Type I diabetes

Indexed keywords

CYTOSKELETON PROTEIN; FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; STREPTOZOCIN;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOINFORMATICS; CHRONIC DISEASE; CONTROLLED STUDY; DOWN REGULATION; FATTY ACID OXIDATION; GENE OVEREXPRESSION; HEART HYPERTROPHY; HEART MUSCLE; HYPERTENSION; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEOMICS; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANIMALS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; HYPERTENSION; HYPERTROPHY; METABOLIC NETWORKS AND PATHWAYS; MITOCHONDRIA, HEART; MYOCARDIUM; MYOCYTES, CARDIAC; PPAR ALPHA; PROTEOME; RATS; RATS, INBRED SHR;

RATTUS;

EID: 84857653408     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2011.12.023     Document Type: Article

References (50)

1. Wild S., Roglic G., Green A., Sicree R., King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27:1047-1053.
2. Frustaci A., Kajstura J., Chimenti C., Jakoniuk I., Leri A., Maseri A., et al. Myocardial cell death in human diabetes. Circ Res 2000, 87:1123-1132.
3. Ares-Carrasco S., Picatoste B., Benito-Martín A., Zubiri I., Sanz A.B., Sánchez-Niño M.D., et al. Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes. Am J Physiol Heart Circ Physiol 2009, 297:H2109-H2119.
4. Fiordaliso F., De Angelis N., Bai A., Cuccovillo I., Salio M., Serra D.M., et al. Effect of beta-adrenergic and renin-angiotensin system blockade on myocyte apoptosis and oxidative stress in diabetic hypertensive rats. Life Sci 2007, 81:951-959.
5. Kai H., Kuwahara F., Tokuda K., Imaizumi T. Diastolic dysfunction in hypertensive hearts: roles of perivascular inflammation and reactive myocardial fibrosis. Hypertens Res 2005, 28:483-490.
6. Tuñón J., Martín-Ventura J.L., Blanco-Colio L.M., Lorenzo O., López J.A., Egido J. Proteomic strategies in the search of new biomarkers in atherothrombosis. J Am Coll Cardiol 2010, 55:2009-2016.
7. Hamblin M., Friedman D.B., Hill S., Caprioli R.M., Smith H.M., Hill M.F. Alterations in the diabetic myocardial proteome coupled with increased myocardial oxidative stress underlies diabetic cardiomyopathy. J Mol Cell Cardiol 2007, 42:884-895.
8. Johnson D.T., Harris R.A., French S., Aponte A., Balaban R.S. Proteomic changes associated with diabetes in the BB-DP rat. Am J Physiol Endocrinol Metab 2009, 296:E422-E432.
9. Turko I.V., Murad F. Quantitative protein profiling in heart mitochondria from diabetic rats. J Biol Chem 2003, 278:35844-35849.
10. Bugger H., Chen D., Riehle C., Soto J., Theobald H.A., Hu X.X., et al. Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic Akita mice. Diabetes 2009, 58(9):1986-1997.
11. Baseler W.A., Dabkowski E.R., Williamson C.L., Croston T.L., Thapa D., Powell M.J., et al. Proteomic alterations of distinct mitochondrial subpopulations in the type 1 diabetic heart: contribution of protein import dysfunction. Am J Physiol Regul Integr Comp Physiol 2011, 300(2):R186-R200.
12. Gallego-Delgado J., Lazaro A., Osende J.I., Barderas M.G., Duran M.C., Vivanco F., et al. Comparison of the protein profile of established and regressed hypertension-induced left ventricular hypertrophy. J Proteome Res 2006, 5:404-413.
13. Gallego-Delgado J., Lazaro A., Osende J.I., Esteban V., Barderas M.G., Gomez-Guerrero C., et al. Proteomic analysis of early left ventricular hypertrophy secondary to hypertension: modulation by antihypertensive therapies. J Am Soc Nephrol 2006, 17:S159-S164.
14. Meng C., Jin X., Xia L., Shen S.-M., Wang X.L., Cai J., et al. Alterations of mitochondrial enzymes contribute to cardiac hypertrophy before hypertension development in spontaneously hypertensive rats. J Proteome Res 2009, 8:2463-2475.
15. Finck B.N., Kelly D.P. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest 2006, 116(3):615-622.
16. Lee K.S., Park J.H., Lee S., Lim H.J., Park H.Y. PPARdelta activation inhibits angiotensin II induced cardiomyocyte hypertrophy by suppressing intracellular Ca2+ signaling pathway. J Cell Biochem 2009, 106:823-834.
17. Alibin C.P., Kopilas M.A., Anderson H.D.I. Suppression of cardiac myocyte hypertrophy by conjugated linoleic acid: role of peroxisome proliferator-activated receptors alpha and gamma. J Biol Chem 2008, 283:10707-10715.
18. Finck B.N., Han X., Courtois M., Aimond F., Nerbonne J.M., Kovacs A., et al. A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Proc Natl Acad Sci U S A 2003, 100:1226-1231.
19. Baraka A., AbdelGawad H. Targeting apoptosis in the heart of streptozotocin-induced diabetic rats. J Cardiovasc Pharmacol Ther 2010, 15:175-181.
20. Pérez-Pérez R., Ortega-Delgado F.J., García-Santos E., López J.A., Camafeita E., Ricart W., et al. Differential proteomics of omental and subcutaneous adipose tissue reflects their unalike biochemical and metabolic properties. J Proteome Res 2009, 8:1682-1693.
21. Sardão V.A., Oliveira P.J., Holy J., Oliveira C.R., Wallace K.B. Vital imaging of H9c2 myoblasts exposed to tert-butylhydroperoxide-characterization of morphological features of cell death. BMC Cell Biol 2007, 8:11.
22. van Genderen H.O., Kenis H., Hofstra L., Narula J., Reutelingsperger C.P. Extracellular annexin A5: functions of phosphatidylserine-binding and two-dimensional crystallization. Biochim Biophys Acta 2008, 1783:953-963.
23. Côté M.C., Lavoie J.R., Houle F., Poirier A., Rousseau S., Huot J. Regulation of vascular endothelial growth factor-induced endothelial cell migration by LIM kinase 1-mediated phosphorylation of annexin 1. J Biol Chem 2010, 285:8013-8021.
24. Camors E., Monceau V., Charlemagne D. Annexins and Ca2+ handling in the heart. Cardiovasc Res 2005, 65:793-802.
25. Osorio J.C., Stanley W.C., Linke A., Castellari M., Diep Q.N., Panchal A.R., et al. Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid X receptor-alpha in pacing-induced heart failure. Circulation 2002, 106:606-612.
26. Schroeder F., Petrescu A.D., Huang H., Atshaves B.P., McIntosh A.L., Martin G.G., et al. Role of fatty acid binding proteins and long chain fatty acids in modulating nuclear receptors and gene transcription. Lipids 2008, 43:1-17.
27. Young M.E., McNulty P., Taegtmeyer H. Adaptation and maladaptation of the heart in diabetes: Part II: potential mechanisms. Circulation 2002, 105:1861-1870.
28. Feingold K.R., Shigenaga J.K., Patzek S.M., Chui L.G., Moser A., Grunfeld C. Endotoxin, zymosan, and cytokines decrease the expression of the transcription factor, carbohydrate response element binding protein, and its target genes. Innate Immun 2011, 17:174-182.
29. Tatsumi T., Matoba S., Kawahara A., Keira N., Shiraishi J., Akashi K., et al. Cytokine-induced nitric oxide production inhibits mitochondrial energy production and impairs contractile function in rat cardiac myocytes. J Am Coll Cardiol 2000, 35:1338-1346.
30. Guilherme L., Ramasawmy R., Kalil J. Rheumatic fever and rheumatic heart disease: genetics and pathogenesis. Scand J Immunol 2007, 66(2-3):199-207.
31. Zhang M., Chen L. Status of cytokines in ischemia reperfusion induced heart injury. Cardiovasc Hematol Disord Drug Targets 2008, 8:161-172.
32. Vidyasagar A., Reese S., Acun Z., Hullett D., Djamali A. HSP27 is involved in the pathogenesis of kidney tubulointerstitial fibrosis. Am J Physiol Renal Physiol 2008, 295:F707-F716.
33. Campo G.M., Avenoso A., Campo S., D'Ascola A., Traina P., Samà D., et al. The antioxidant effect exerted by TGF-1beta-stimulated hyaluronan production reduced NF-kB activation and apoptosis in human fibroblasts exposed to FeSo4 plus ascorbate. Mol Cell Biochem 2008, 311:167-177.
34. Vaulont S., Vasseur-Cognet M., Kahn A. Glucose regulation of gene transcription. J Biol Chem 2000, 275:31555-31558.
35. Martens G.A., Jiang L., Verhaeghen K., Connolly J.B., Geromanos S.G., Stangé G., et al. Protein markers for insulin-producing beta cells with higher glucose sensitivity. PLoS One 2010, 5(12):e14214.
36. Florholmen G., Aas V., Rustan A.C., Lunde P.K., Straumann N., Eid H., et al. Leukemia inhibitory factor reduces contractile function and induces alterations in energy metabolism in isolated cardiomyocytes. J Mol Cell Cardiol 2004, 37:1183-1193.
37. Knowlton A.A., Kapadia S., Torre-Amione G., Durand J.B., Bies R., Young J., et al. Differential expression of heat shock proteins in normal and failing human hearts. J Mol Cell Cardiol 1998, 30:811-818.
38. Monceau V., Belikova Y., Kratassiouk G., Charue D., Camors E., Communal C., et al. Externalization of endogenous annexin A5 participates in apoptosis of rat cardiomyocytes. Cardiovasc Res 2004, 64:496-506.
39. Huang X., Walker J.W. Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes. J Cell Sci 2004, 117:1971-1978.
40. von Nandelstadh P., Ismail M., Gardin C., Suila H., Zara I., Belgrano A., et al. A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins: a common link for Z-disc myopathies. Mol Cell Biol 2009, 29:822-834.
41. Nagatomo F., Gu N., Fujino H., Takeda I., Tsuda K., ishihara A. Skeletal muscle characteristics of rats with obesity, diabetes, hypertension, and hyperlipidemia. J Atheroscler Thromb 2009, 16(5):576-585.
42. Liang F., Wang F., Zhang S., Gardner D.G. Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes. Endocrinology 2003, 144:4187-4194.
43. Linz W., Wohlfart P., Baader M., Breitschopf K., Falk E., Schäfer H.L., et al. The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist, AVE8134, attenuates the progression of heart failure and increases survival in rats. Acta Pharmacol Sin 2009, 30:935-946.
44. Li C.B., Li X.-X., Chen Y.-G., Zhang C., Zhang M.X., Zhao X.Q., et al. Effects and mechanisms of PPARalpha activator fenofibrate on myocardial remodelling in hypertension. J Cell Mol Med 2009, 13:4444-4452.
45. Purushothaman S., Renuka Nair R., Harikrishnan V.S., Fernandez A.C. Temporal relation of cardiac hypertrophy, oxidative stress, and fatty acid metabolism in spontaneously hypertensive rat. Mol Cell Biochem 2011, 351(1-2):59-64.
46. Burkart E.M., Sambandam N., Han X., Gross R.W., Courtois M., Gierasch C.M., et al. Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. J Clin Invest 2007, 117:3930-3939.
47. Niehof M., Borlak J. HNF4 alpha and the Ca-channel TRPC1 are novel disease candidate genes in diabetic nephropathy. Diabetes 2008, 57:1069-1077.
48. Sun J., Yan G., Ren A., You B., Liao J.K. FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1. Circ Res 2006, 99(5):468-476.
49. Zhang Y., Jiang D.S., Yan L., Cheng K.J., Bian Z.Y., Lin G.S. HSP75 protects against cardiac hypertrophy and fibrosis. J Cell Biochem 2011, 112(7):1787-1794.
50. Xiang F., Huang Y.S., Shi X.H., Zhang Q. Mitochondrial chaperone tumour necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxic injury by regulating mitochondrial permeability transition pore opening. FEBS J 2010, 277(8):1929-1938.