-
1
-
-
59149084039
-
Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: Identification of a novel mechanism of vasodilation
-
Behm DJ, Ogbonna A, Wu C, et al. Epoxyeicosatrienoic acids function as selective, endogenous antagonists of native thromboxane receptors: identification of a novel mechanism of vasodilation. J Pharmacol Exp Ther 2009; 328: 231-9.
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 231-239
-
-
Behm, D.J.1
Ogbonna, A.2
Wu, C.3
-
2
-
-
77955421347
-
14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP(2) receptors in rat mesenteric artery
-
Yang C, Kwan YW, Au AL, et al. 14,15-Epoxyeicosatrienoic acid induces vasorelaxation through the prostaglandin EP(2) receptors in rat mesenteric artery. Prostaglandins Other Lipid Mediat 2010; 93: 44-51.
-
(2010)
Prostaglandins Other Lipid Mediat
, vol.93
, pp. 44-51
-
-
Yang, C.1
Kwan, Y.W.2
Au, A.L.3
-
3
-
-
0037123925
-
Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids
-
Sun J, Sui X, Bradbury JA, et al. Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids. Circ Res 2002; 90: 1020-7.
-
(2002)
Circ Res
, vol.90
, pp. 1020-1027
-
-
Sun, J.1
Sui, X.2
Bradbury, J.A.3
-
4
-
-
0242720683
-
Epoxyeicosatrienoic acids (EETs): Metabolism and biochemical function
-
Spector AA, Fang X, Snyder GD, et al. Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. Prog Lipid Res 2004; 43: 55-90.
-
(2004)
Prog Lipid Res
, vol.43
, pp. 55-90
-
-
Spector, A.A.1
Fang, X.2
Snyder, G.D.3
-
5
-
-
0016243499
-
Mammalian metabolism and environmental degradation of the juvenoid 1-(4-ethylphenoxy)3,7-dimethyl-6, 7-epoxy-trans2-octene and related compounds
-
Gill SS, Hammock BD, Casida JE. Mammalian metabolism and environmental degradation of the juvenoid 1-(4-ethylphenoxy)3,7-dimethyl-6, 7-epoxy-trans2-octene and related compounds. J Agric Food Chem 1974; 22: 386-95.
-
(1974)
J Agric Food Chem
, vol.22
, pp. 386-395
-
-
Gill, S.S.1
Hammock, B.D.2
Casida, J.E.3
-
6
-
-
0037452577
-
The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity
-
Newman JW, Morisseau C, Harris TR, et al. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Natl Acad Sci USA 2003; 100: 1558-63.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1558-1563
-
-
Newman, J.W.1
Morisseau, C.2
Harris, T.R.3
-
7
-
-
1642458135
-
Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study
-
Fornage M, Boerwinkle E, Doris PA, et al. Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Circulation 2004; 109: 335-9.
-
(2004)
Circulation
, vol.109
, pp. 335-339
-
-
Fornage, M.1
Boerwinkle, E.2
Doris, P.A.3
-
8
-
-
45249124328
-
Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular diseases in the Diabetes Heart Study
-
Burdon KP, Lehtinen AB, Langefeld CD, et al. Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular diseases in the Diabetes Heart Study. Diab Vasc Dis Res 2008; 5: 128-34.
-
(2008)
Diab Vasc Dis Res
, vol.5
, pp. 128-134
-
-
Burdon, K.P.1
Lehtinen, A.B.2
Langefeld, C.D.3
-
9
-
-
33745222033
-
Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study
-
Lee CR, North KE, Bray MS, et al. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Hum Mol Genet 2006; 15: 1640-9.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 1640-1649
-
-
Lee, C.R.1
North, K.E.2
Bray, M.S.3
-
10
-
-
57049115027
-
Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo
-
Motoki A, Merkel MJ, Packwood WH, et al. Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo. Am J Physiol Heart Circ Physiol 2008; 295: H2128-34.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.295
-
-
Motoki, A.1
Merkel, M.J.2
Packwood, W.H.3
-
11
-
-
42649105447
-
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease
-
Monti J, Fischer J, Paskas S, et al. Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. Nat Genet 2008; 40: 529-37.
-
(2008)
Nat Genet
, vol.40
, pp. 529-537
-
-
Monti, J.1
Fischer, J.2
Paskas, S.3
-
12
-
-
69449093425
-
Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension
-
Manhiani M, Quigley JE, Knight SF, et al. Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension. Am J Physiol Renal Physiol 2009; 297: F740-748.
-
(2009)
Am J Physiol Renal Physiol
, vol.297
-
-
Manhiani, M.1
Quigley, J.E.2
Knight, S.F.3
-
13
-
-
33750529521
-
Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain
-
Inceoglu B, Jinks SL, Schmelzer KR, et al. Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Life Sci 2006; 79: 2311-9.
-
(2006)
Life Sci
, vol.79
, pp. 2311-2319
-
-
Inceoglu, B.1
Jinks, S.L.2
Schmelzer, K.R.3
-
14
-
-
57749091900
-
Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways
-
Inceoglu B, Jinks SL, Ulu A, et al. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proc Natl Acad Sci USA 2008; 105: 18901-6.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 18901-18906
-
-
Inceoglu, B.1
Jinks, S.L.2
Ulu, A.3
-
15
-
-
22244443733
-
Soluble epoxide hydrolase is a therapeutic target for acute inflammation
-
Schmelzer KR, Kubala L, Newman JW, et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci USA 2005; 102: 9772-7.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9772-9777
-
-
Schmelzer, K.R.1
Kubala, L.2
Newman, J.W.3
-
16
-
-
13844315294
-
Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor
-
Smith KR, Pinkerton KE, Watanabe T, et al. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proc Natl Acad Sci USA 2005; 102: 2186-91.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2186-2191
-
-
Smith, K.R.1
Pinkerton, K.E.2
Watanabe, T.3
-
17
-
-
33748797975
-
Enhancement of antinociception by coadministration of non-steroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors
-
Schmelzer KR, Inceoglu B, Kubala L, et al. Enhancement of antinociception by coadministration of non-steroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci USA 2006; 103: 13646-51.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 13646-13651
-
-
Schmelzer, K.R.1
Inceoglu, B.2
Kubala, L.3
-
18
-
-
74149087378
-
Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model
-
Liu JY, Yang J, Inceoglu B, et al. Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model. Biochem Pharmacol 2010; 79: 880-7.
-
(2010)
Biochem Pharmacol
, vol.79
, pp. 880-887
-
-
Liu, J.Y.1
Yang, J.2
Inceoglu, B.3
-
19
-
-
33845474465
-
Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors
-
Xu D, Li N, He Y, et al. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci USA 2006; 103: 18733-8.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 18733-18738
-
-
Xu, D.1
Li, N.2
He, Y.3
-
20
-
-
71249135631
-
3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats
-
Aboutabl ME, Zordoky BN, El-Kadi AO. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Br J Pharmacol 2009; 158: 1808-19.
-
(2009)
Br J Pharmacol
, vol.158
, pp. 1808-1819
-
-
Aboutabl, M.E.1
Zordoky, B.N.2
El-Kadi, A.O.3
-
21
-
-
58849115391
-
Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy
-
Ai D, Pang W, Li N, et al. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci USA 2009; 106: 564-9.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 564-569
-
-
Ai, D.1
Pang, W.2
Li, N.3
-
22
-
-
84873160083
-
Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease
-
Nov 23 [Epub ahead of print]
-
Elmarakby AA. Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease. J Physiol Regul Integr Comp Physiol 2011; Nov 23 [Epub ahead of print].
-
(2011)
J Physiol Regul Integr Comp Physiol
-
-
Elmarakby, A.A.1
-
23
-
-
57149086269
-
Epoxyeicosatrienoic acid prevents postischemic electrocardiogram abnormalities in an isolated heart model
-
Batchu SN, Law E, Brocks DR, et al. Epoxyeicosatrienoic acid prevents postischemic electrocardiogram abnormalities in an isolated heart model. J Mol Cell Cardiol 2009; 46: 67-74.
-
(2009)
J Mol Cell Cardiol
, vol.46
, pp. 67-74
-
-
Batchu, S.N.1
Law, E.2
Brocks, D.R.3
-
24
-
-
75749084460
-
Inhibition of soluble epoxide hydrolase by trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury
-
Chaudhary KR, Abukhashim M, Hwang SH, et al. Inhibition of soluble epoxide hydrolase by trans-4-[4-(3-adamantan-1-ylureido)-cyclohexyloxy]-benzoic acid is protective against ischemia-reperfusion injury. J Cardiovasc Pharmacol 2010; 55: 67-73.
-
(2010)
J Cardiovasc Pharmacol
, vol.55
, pp. 67-73
-
-
Chaudhary, K.R.1
Abukhashim, M.2
Hwang, S.H.3
-
25
-
-
67349123094
-
Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells
-
Katragadda D, Batchu SN, Cho WJ, et al. Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells. J Mol Cell Cardiol 2009; 46: 867-75.
-
(2009)
J Mol Cell Cardiol
, vol.46
, pp. 867-875
-
-
Katragadda, D.1
Batchu, S.N.2
Cho, W.J.3
-
26
-
-
61349115586
-
Opposite Regulation of Cholesterol Levels by the Phosphatase and Hydrolase Domains of Soluble Epoxide Hydrolase
-
Enayetallah AE, Luria A, Luo B, et al. Opposite Regulation of Cholesterol Levels by the Phosphatase and Hydrolase Domains of Soluble Epoxide Hydrolase. J Biol Chem 2008; 283: 36592-8.
-
(2008)
J Biol Chem
, vol.283
, pp. 36592-36598
-
-
Enayetallah, A.E.1
Luria, A.2
Luo, B.3
-
27
-
-
0029150467
-
Differential regulation of soluble epoxide hydrolase by clofibrate and sexual hormones in the liver and kidneys of mice
-
Pinot F, Grant DF, Spearow JL, et al. Differential regulation of soluble epoxide hydrolase by clofibrate and sexual hormones in the liver and kidneys of mice. Biochem Pharmacol 1995; 50: 501-18.
-
(1995)
Biochem Pharmacol
, vol.50
, pp. 501-518
-
-
Pinot, F.1
Grant, D.F.2
Spearow, J.L.3
-
28
-
-
58149350130
-
Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein Eknockout mouse model
-
Ulu A, Davis BB, Tsai HJ, et al. Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein Eknockout mouse model. J Cardiovasc Pharmacol 2008; 52: 314-23.
-
(2008)
J Cardiovasc Pharmacol
, vol.52
, pp. 314-323
-
-
Ulu, A.1
Davis, B.B.2
Tsai, H.J.3
-
29
-
-
69849107198
-
Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia
-
Zhang LN, Vincelette J, Cheng Y, et al. Inhibition of soluble epoxide hydrolase attenuated atherosclerosis, abdominal aortic aneurysm formation, and dyslipidemia. Arterioscler Thromb Vasc Biol 2009; 29: 1265-70.
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1265-1270
-
-
Zhang, L.N.1
Vincelette, J.2
Cheng, Y.3
-
30
-
-
77951498924
-
Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice
-
Revermann M, Schloss M, Barbosa-Sicard E, et al. Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Arterioscler Thromb Vasc Biol 2010; 30: 909-14.
-
(2010)
Arterioscler Thromb Vasc Biol
, vol.30
, pp. 909-914
-
-
Revermann, M.1
Schloss, M.2
Barbosa-Sicard, E.3
-
32
-
-
42649126674
-
Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension
-
Li J, Carroll MA, Chander PN, et al. Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension. Front Biosci; 2008; 13: 3480-7.
-
(2008)
Front Biosci
, vol.13
, pp. 3480-3487
-
-
Li, J.1
Carroll, M.A.2
Chander, P.N.3
-
33
-
-
34147160073
-
Prevention of Hypertension in DOCA-Salt Rats by an Inhibitor of Soluble Epoxide Hydrolase
-
Loch D, Hoey A, Morisseau C, et al. Prevention of Hypertension in DOCA-Salt Rats by an Inhibitor of Soluble Epoxide Hydrolase. Cell Biochem Biophys 2007; 47: 87-98.
-
(2007)
Cell Biochem Biophys
, vol.47
, pp. 87-98
-
-
Loch, D.1
Hoey, A.2
Morisseau, C.3
-
34
-
-
34548050872
-
Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats
-
Huang H, Morisseau C, Wang J, et al. Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats. Am J Physiol Renal Physiol 2007; 293: 342-9.
-
(2007)
Am J Physiol Renal Physiol
, vol.293
, pp. 342-349
-
-
Huang, H.1
Morisseau, C.2
Wang, J.3
-
35
-
-
33747611948
-
Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels
-
Olearczyk JJ, Field MB, Kim IH, et al. Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels. J Pharmacol Exp Ther 2006; 318: 1307-14.
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 1307-1314
-
-
Olearczyk, J.J.1
Field, M.B.2
Kim, I.H.3
-
36
-
-
33845439097
-
Regulation of endothelial nitricoxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids
-
Jiang JG, Chen RJ, Xiao B, et al. Regulation of endothelial nitricoxide synthase activity through phosphorylation in response to epoxyeicosatrienoic acids. Prostaglandins Other Lipid Mediat 2007; 82: 162-74.
-
(2007)
Prostaglandins Other Lipid Mediat
, vol.82
, pp. 162-174
-
-
Jiang, J.G.1
Chen, R.J.2
Xiao, B.3
-
37
-
-
41549153734
-
Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta
-
Chawengsub Y, Aggarwal NT, Nithipatikom K, et al. Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. Am J Physiol Heart Circ Physiol 2008; 294: H1348-1356.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.294
-
-
Chawengsub, Y.1
Aggarwal, N.T.2
Nithipatikom, K.3
-
38
-
-
49249116223
-
Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart
-
Gross GJ, Gauthier KM, Moore J, et al. Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. Am J Physiol Heart Circ Physiol 2008; 294: H2838-2844.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.294
-
-
Gross, G.J.1
Gauthier, K.M.2
Moore, J.3
-
39
-
-
74949142180
-
Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: Role of STAT3 signaling
-
Merkel MJ, Liu L, Cao Z, et al. Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling. Am J Physiol Heart Circ Physiol 2010; 298: 679-87.
-
(2010)
Am J Physiol Heart Circ Physiol
, vol.298
, pp. 679-687
-
-
Merkel, M.J.1
Liu, L.2
Cao, Z.3
-
40
-
-
85039663381
-
06 Epoxyeicosatrienoic acid mediated cardioprotection involves mitochondrial caveolin-1 and PKCe
-
Chaudhary KR, Cho WJ, Daniel EE, et al. 06 Epoxyeicosatrienoic acid mediated cardioprotection involves mitochondrial caveolin-1 and PKCe. Heart 2011; 97: e8.
-
(2011)
Heart
, vol.97
-
-
Chaudhary, K.R.1
Cho, W.J.2
Daniel, E.E.3
-
41
-
-
36849019028
-
Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation
-
Hutchens MP, Nakano T, Dunlap J, et al. Soluble epoxide hydrolase gene deletion reduces survival after cardiac arrest and cardiopulmonary resuscitation. Resuscitation 2008; 76: 89-94.
-
(2008)
Resuscitation
, vol.76
, pp. 89-94
-
-
Hutchens, M.P.1
Nakano, T.2
Dunlap, J.3
-
42
-
-
74049112215
-
Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease
-
Lee J, Dahl M, Grande P, et al. Genetically reduced soluble epoxide hydrolase activity and risk of stroke and other cardiovascular disease. Stroke 2010; 41: 27-33.
-
(2010)
Stroke
, vol.41
, pp. 27-33
-
-
Lee, J.1
Dahl, M.2
Grande, P.3
-
43
-
-
70449640639
-
Variation in the human soluble epoxide hydrolase gene and risk of restenosis after percutaneous coronary intervention
-
Kullmann S, Binner P, Rackebrandt K, et al. Variation in the human soluble epoxide hydrolase gene and risk of restenosis after percutaneous coronary intervention. BMC Cardiovasc Disord 2009; 9: 48.
-
(2009)
BMC Cardiovasc Disord
, vol.9
, pp. 48
-
-
Kullmann, S.1
Binner, P.2
Rackebrandt, K.3
|