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Volumn 126, Issue 6, 2013, Pages 805-818

Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism

Author keywords

autophagy; neurodegeneration; oxidative stress; thalamus; vitamin B1

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; CELL MARKER; LC3 II PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; P70S6 KINASE; PHOSPHOTRANSFERASE; R 0395; RAPAMYCIN; SMALL INTERFERING RNA; THIAMINE; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 84883743082     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12268     Document Type: Article
Times cited : (30)

References (74)
  • 1
    • 0031036896 scopus 로고    scopus 로고
    • Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
    • Anglade P., Vyas S., Javoy-Agid F., et al,. (1997) Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol. Histopathol. 12, 25-31.
    • (1997) Histol. Histopathol. , vol.12 , pp. 25-31
    • Anglade, P.1    Vyas, S.2    Javoy-Agid, F.3
  • 2
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: Dual roles in life and death?
    • Baehrecke E. H., (2005) Autophagy: dual roles in life and death? Nat. Rev. 6, 505-510.
    • (2005) Nat. Rev. , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 3
    • 8044257699 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
    • Blommaart E. F., Krause U., Schellens J. P., Vreeling-Sindelarova H., and, Meijer A. J., (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem. 243, 240-246.
    • (1997) Eur. J. Biochem. , vol.243 , pp. 240-246
    • Blommaart, E.F.1    Krause, U.2    Schellens, J.P.3    Vreeling-Sindelarova, H.4    Meijer, A.J.5
  • 4
    • 19944434059 scopus 로고    scopus 로고
    • Inhibition of macroautophagy triggers apoptosis
    • Boya P., Gonzalez-Polo R. A., Casares N., et al,. (2005) Inhibition of macroautophagy triggers apoptosis. Mol. Cell. Biol. 25, 1025-1040.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 1025-1040
    • Boya, P.1    Gonzalez-Polo, R.A.2    Casares, N.3
  • 5
    • 77951227122 scopus 로고    scopus 로고
    • Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: Effects on cognitive impairments
    • Caccamo A., Majumder S., Richardson A., Strong R., and, Oddo S., (2010) Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J. Biol. Chem. 285, 13107-13120.
    • (2010) J. Biol. Chem. , vol.285 , pp. 13107-13120
    • Caccamo, A.1    Majumder, S.2    Richardson, A.3    Strong, R.4    Oddo, S.5
  • 6
    • 84869459812 scopus 로고    scopus 로고
    • Autophagy is a protective response to ethanol neurotoxicity
    • Chen G., Ke Z., Xu M,. et al. (2012a) Autophagy is a protective response to ethanol neurotoxicity. Autophagy 8, 1577-1589.
    • (2012) Autophagy , vol.8 , pp. 1577-1589
    • Chen, G.1    Ke, Z.2    Xu, M.3
  • 7
    • 83455243339 scopus 로고    scopus 로고
    • Autophagy dysregulation in amyotrophic lateral sclerosis
    • Chen S., Zhang X., Song L., and, Le W,. (2012b) Autophagy dysregulation in amyotrophic lateral sclerosis. Brain Pathol., 22, 110-116.
    • (2012) Brain Pathol. , vol.22 , pp. 110-116
    • Chen, S.1    Zhang, X.2    Song, L.3    Le, W.4
  • 10
    • 0034967586 scopus 로고    scopus 로고
    • Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer's disease
    • Gibson G. E., and, Zhang H., (2001) Abnormalities in oxidative processes in non-neuronal tissues from patients with Alzheimer's disease. J. Alzheimers Dis. 3, 329-338.
    • (2001) J. Alzheimers Dis. , vol.3 , pp. 329-338
    • Gibson, G.E.1    Zhang, H.2
  • 11
    • 0033382224 scopus 로고    scopus 로고
    • Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits
    • Gibson G. E., Park L. C., Zhang H., Sorbi S., and, Calingasan N. Y., (1999) Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits. Ann. N. Y. Acad. Sci. 893, 79-94.
    • (1999) Ann. N. Y. Acad. Sci. , vol.893 , pp. 79-94
    • Gibson, G.E.1    Park, L.C.2    Zhang, H.3    Sorbi, S.4    Calingasan, N.Y.5
  • 12
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • Hara T., Nakamura K., Matsui M., et al,. (2006) Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441, 885-889.
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3
  • 13
    • 65249119430 scopus 로고    scopus 로고
    • Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
    • Hosokawa N., Hara T., Kaizuka T., et al,. (2009) Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol. Biol. Cell 20, 1981-1991.
    • (2009) Mol. Biol. Cell , vol.20 , pp. 1981-1991
    • Hosokawa, N.1    Hara, T.2    Kaizuka, T.3
  • 14
    • 84875774545 scopus 로고    scopus 로고
    • Wernicke-korsakoff-syndrome: Under-recognized and under-treated
    • Isenberg-Grzeda E., Kutner H. E., and, Nicolson S. E., (2012) Wernicke-korsakoff-syndrome: under-recognized and under-treated. Psychosomatics 53, 507-516.
    • (2012) Psychosomatics , vol.53 , pp. 507-516
    • Isenberg-Grzeda, E.1    Kutner, H.E.2    Nicolson, S.E.3
  • 17
    • 34147093749 scopus 로고    scopus 로고
    • Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism
    • Karuppagounder S. S., Shi Q., Xu H., and, Gibson G. E., (2007) Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Neurobiol. Dis. 26, 353-362.
    • (2007) Neurobiol. Dis. , vol.26 , pp. 353-362
    • Karuppagounder, S.S.1    Shi, Q.2    Xu, H.3    Gibson, G.E.4
  • 18
    • 2442433959 scopus 로고    scopus 로고
    • Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism
    • Ke Z. J., and, Gibson G. E., (2004) Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism. Neurochem. Int. 45, 361-369.
    • (2004) Neurochem. Int. , vol.45 , pp. 361-369
    • Ke, Z.J.1    Gibson, G.E.2
  • 20
    • 20544475400 scopus 로고    scopus 로고
    • CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism
    • Ke Z. J., Calingasan N. Y., DeGiorgio L. A., Volpe B. T., and, Gibson G. E., (2005a) CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. Neurochem. Int. 47, 204-215.
    • (2005) Neurochem. Int. , vol.47 , pp. 204-215
    • Ke, Z.J.1    Calingasan, N.Y.2    Degiorgio, L.A.3    Volpe, B.T.4    Gibson, G.E.5
  • 21
    • 20444474033 scopus 로고    scopus 로고
    • CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism
    • Ke Z. J., Calingasan N. Y., Karuppagounder S. S., DeGiorgio L. A., Volpe B. T., and, Gibson G. E., (2005b) CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. J. Neuroimmunol. 164, 85-92.
    • (2005) J. Neuroimmunol. , vol.164 , pp. 85-92
    • Ke, Z.J.1    Calingasan, N.Y.2    Karuppagounder, S.S.3    Degiorgio, L.A.4    Volpe, B.T.5    Gibson, G.E.6
  • 22
    • 0034307476 scopus 로고    scopus 로고
    • Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy
    • Kegel K. B., Kim M., Sapp E., McIntyre C., Castano J. G., Aronin N., and, DiFiglia M., (2000) Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J. Neurosci. 20, 7268-7278.
    • (2000) J. Neurosci. , vol.20 , pp. 7268-7278
    • Kegel, K.B.1    Kim, M.2    Sapp, E.3    McIntyre, C.4    Castano, J.G.5    Aronin, N.6    Difiglia, M.7
  • 23
    • 35448981935 scopus 로고    scopus 로고
    • Autophagy: From phenomenology to molecular understanding in less than a decade
    • Klionsky D. J., (2007) Autophagy: from phenomenology to molecular understanding in less than a decade. Nat. Rev. 8, 931-937.
    • (2007) Nat. Rev. , vol.8 , pp. 931-937
    • Klionsky, D.J.1
  • 24
    • 84862295360 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy
    • Klionsky D. J., Abdalla F. C., Abeliovich H., et al,. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8, 445-544.
    • (2012) Autophagy , vol.8 , pp. 445-544
    • Klionsky, D.J.1    Abdalla, F.C.2    Abeliovich, H.3
  • 25
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • Komatsu M., Waguri S., Chiba T., et al,. (2006) Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441, 880-884.
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3
  • 26
    • 0020040519 scopus 로고
    • Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine
    • Kovacs A. L., Reith A., and, Seglen P. O., (1982) Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine. Exp. Cell Res. 137, 191-201.
    • (1982) Exp. Cell Res. , vol.137 , pp. 191-201
    • Kovacs, A.L.1    Reith, A.2    Seglen, P.O.3
  • 27
    • 0029966135 scopus 로고    scopus 로고
    • Neuropathology of thiamine deficiency disorders
    • Kril J. J., (1996) Neuropathology of thiamine deficiency disorders. Metab. Brain Dis. 11, 9-17.
    • (1996) Metab. Brain Dis. , vol.11 , pp. 9-17
    • Kril, J.J.1
  • 28
    • 28544435485 scopus 로고    scopus 로고
    • Lysosomes and autophagy in cell death control
    • Kroemer G., and, Jaattela M., (2005) Lysosomes and autophagy in cell death control. Nat. Rev. Cancer 5, 886-897.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 886-897
    • Kroemer, G.1    Jaattela, M.2
  • 29
    • 1842636817 scopus 로고    scopus 로고
    • Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: Relationship to selective vulnerability
    • Kruse M., Navarro D., Desjardins P., and, Butterworth R. F., (2004) Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: relationship to selective vulnerability. Neurochem. Int. 45, 49-56.
    • (2004) Neurochem. Int. , vol.45 , pp. 49-56
    • Kruse, M.1    Navarro, D.2    Desjardins, P.3    Butterworth, R.F.4
  • 30
    • 78649330723 scopus 로고    scopus 로고
    • ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics
    • Lee S., Yang G., Yong Y., et al,. (2010) ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics. Mol. Neurodegener. 5, 54.
    • (2010) Mol. Neurodegener. , vol.5 , pp. 54
    • Lee, S.1    Yang, G.2    Yong, Y.3
  • 31
    • 25144506835 scopus 로고    scopus 로고
    • Autophagy in cell death: An innocent convict?
    • Levine B., and, Yuan J., (2005) Autophagy in cell death: an innocent convict? J. Clin. Investig. 115, 2679-2688.
    • (2005) J. Clin. Investig. , vol.115 , pp. 2679-2688
    • Levine, B.1    Yuan, J.2
  • 32
  • 33
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • Liang C., Feng P., Ku B., Dotan I., Canaani D., Oh B. H., and, Jung J. U., (2006) Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 8, 688-699.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3    Dotan, I.4    Canaani, D.5    Oh, B.H.6    Jung, J.U.7
  • 34
    • 46449120732 scopus 로고    scopus 로고
    • Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
    • Liang C., Lee J. S., Inn K. S., et al,. (2008) Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol. 10, 776-787.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 776-787
    • Liang, C.1    Lee, J.S.2    Inn, K.S.3
  • 35
    • 84863456841 scopus 로고    scopus 로고
    • Conditional expression of Parkinson's disease-related mutant alpha-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1
    • Lin X., Parisiadou L., Sgobio C., et al,. (2012) Conditional expression of Parkinson's disease-related mutant alpha-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1. J. Neurosci. 32, 9248-9264.
    • (2012) J. Neurosci. , vol.32 , pp. 9248-9264
    • Lin, X.1    Parisiadou, L.2    Sgobio, C.3
  • 36
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum J. J., Bauer D. E., Kong M., Harris M. H., Li C., Lindsten T., and, Thompson C. B., (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237-248.
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6    Thompson, C.B.7
  • 37
    • 70349612498 scopus 로고    scopus 로고
    • Autophagy for the avoidance of neurodegeneration
    • Madeo F., Eisenberg T., and, Kroemer G., (2009) Autophagy for the avoidance of neurodegeneration. Genes Dev. 23, 2253-2259.
    • (2009) Genes Dev. , vol.23 , pp. 2253-2259
    • Madeo, F.1    Eisenberg, T.2    Kroemer, G.3
  • 38
    • 34548188741 scopus 로고    scopus 로고
    • Self-eating and self-killing: Crosstalk between autophagy and apoptosis
    • Maiuri M. C., Zalckvar E., Kimchi A., and, Kroemer G., (2007) Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. 8, 741-752.
    • (2007) Nat. Rev. , vol.8 , pp. 741-752
    • Maiuri, M.C.1    Zalckvar, E.2    Kimchi, A.3    Kroemer, G.4
  • 40
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: Process and function
    • Mizushima N., (2007) Autophagy: process and function. Genes Dev. 21, 2861-2873.
    • (2007) Genes Dev. , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 41
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immunoblotting
    • Mizushima N., and, Yoshimori T., (2007) How to interpret LC3 immunoblotting. Autophagy 3, 542-545.
    • (2007) Autophagy , vol.3 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 43
    • 0034113088 scopus 로고    scopus 로고
    • Thiamine deficiency in elderly people
    • O'Keeffe S. T., (2000) Thiamine deficiency in elderly people. Age Ageing 29, 99-101.
    • (2000) Age Ageing , vol.29 , pp. 99-101
    • O'Keeffe, S.T.1
  • 44
    • 41549114279 scopus 로고    scopus 로고
    • The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
    • Pan T., Kondo S., Le W., and, Jankovic J., (2008a) The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease. Brain 131, 1969-1978.
    • (2008) Brain , vol.131 , pp. 1969-1978
    • Pan, T.1    Kondo, S.2    Le, W.3    Jankovic, J.4
  • 45
    • 51549086469 scopus 로고    scopus 로고
    • Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
    • Pan T., Kondo S., Zhu W., Xie W., Jankovic J., and, Le W., (2008b) Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement. Neurobiol. Dis. 32, 16-25.
    • (2008) Neurobiol. Dis. , vol.32 , pp. 16-25
    • Pan, T.1    Kondo, S.2    Zhu, W.3    Xie, W.4    Jankovic, J.5    Le, W.6
  • 46
    • 0034667742 scopus 로고    scopus 로고
    • Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: An in vitro model for the study of cell death mechanisms in Wernicke's encephalopathy
    • Pannunzio P., Hazell A. S., Pannunzio M., Rao K. V., and, Butterworth R. F., (2000) Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: an in vitro model for the study of cell death mechanisms in Wernicke's encephalopathy. J. Neurosci. Res. 62, 286-292.
    • (2000) J. Neurosci. Res. , vol.62 , pp. 286-292
    • Pannunzio, P.1    Hazell, A.S.2    Pannunzio, M.3    Rao, K.V.4    Butterworth, R.F.5
  • 47
    • 0035576822 scopus 로고    scopus 로고
    • Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy
    • Park L. C., Albers D. S., Xu H., Lindsay J. G., Beal M. F., and, Gibson G. E., (2001) Mitochondrial impairment in the cerebellum of the patients with progressive supranuclear palsy. J. Neurosci. Res. 66, 1028-1034.
    • (2001) J. Neurosci. Res. , vol.66 , pp. 1028-1034
    • Park, L.C.1    Albers, D.S.2    Xu, H.3    Lindsay, J.G.4    Beal, M.F.5    Gibson, G.E.6
  • 48
    • 45749114895 scopus 로고    scopus 로고
    • The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
    • Pickford F., Masliah E., Britschgi M., et al,. (2008) The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J. Clin. Investig. 118, 2190-2199.
    • (2008) J. Clin. Investig. , vol.118 , pp. 2190-2199
    • Pickford, F.1    Masliah, E.2    Britschgi, M.3
  • 49
    • 20144381544 scopus 로고    scopus 로고
    • Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death
    • Pyo J. O., Jang M. H., Kwon Y. K., et al,. (2005) Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J. Biol. Chem. 280, 20722-20729.
    • (2005) J. Biol. Chem. , vol.280 , pp. 20722-20729
    • Pyo, J.O.1    Jang, M.H.2    Kwon, Y.K.3
  • 50
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu X., Yu J., Bhagat G., et al,. (2003) Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Investig. 112, 1809-1820.
    • (2003) J. Clin. Investig. , vol.112 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3
  • 51
    • 0029921648 scopus 로고    scopus 로고
    • Nitric oxide synthase activities are selectively decreased in vulnerable brain regions in thiamine deficiency
    • Rao V. L., Mousseau D. D., and, Butterworth R. F., (1996) Nitric oxide synthase activities are selectively decreased in vulnerable brain regions in thiamine deficiency. Neurosci. Lett. 208, 17-20.
    • (1996) Neurosci. Lett. , vol.208 , pp. 17-20
    • Rao, V.L.1    Mousseau, D.D.2    Butterworth, R.F.3
  • 52
    • 2642586352 scopus 로고    scopus 로고
    • Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    • Ravikumar B., Vacher C., Berger Z., et al,. (2004) Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36, 585-595.
    • (2004) Nat. Genet. , vol.36 , pp. 585-595
    • Ravikumar, B.1    Vacher, C.2    Berger, Z.3
  • 53
    • 0030020028 scopus 로고    scopus 로고
    • Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins
    • Schwab C., Steele J. C., and, McGeer P. L., (1996) Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins. Brain Res. 707, 196-205.
    • (1996) Brain Res. , vol.707 , pp. 196-205
    • Schwab, C.1    Steele, J.C.2    McGeer, P.L.3
  • 54
    • 34047268403 scopus 로고    scopus 로고
    • Wernicke's encephalopathy: New clinical settings and recent advances in diagnosis and management
    • Sechi G., and, Serra A., (2007) Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol. 6, 442-455.
    • (2007) Lancet Neurol. , vol.6 , pp. 442-455
    • Sechi, G.1    Serra, A.2
  • 55
    • 70349919804 scopus 로고    scopus 로고
    • Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
    • Simonsen A., and, Tooze S. A., (2009) Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J. Cell Biol. 186, 773-782.
    • (2009) J. Cell Biol. , vol.186 , pp. 773-782
    • Simonsen, A.1    Tooze, S.A.2
  • 56
    • 70350550208 scopus 로고    scopus 로고
    • Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
    • Spencer B., Potkar R., Trejo M., Rockenstein E., Patrick C., Gindi R., Adame A., Wyss-Coray T., and, Masliah E., (2009) Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J. Neurosci. 29, 13578-13588.
    • (2009) J. Neurosci. , vol.29 , pp. 13578-13588
    • Spencer, B.1    Potkar, R.2    Trejo, M.3    Rockenstein, E.4    Patrick, C.5    Gindi, R.6    Adame, A.7    Wyss-Coray, T.8    Masliah, E.9
  • 57
    • 34848899280 scopus 로고    scopus 로고
    • Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
    • Takahashi Y., Coppola D., Matsushita N., et al,. (2007) Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 9, 1142-1151.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 1142-1151
    • Takahashi, Y.1    Coppola, D.2    Matsushita, N.3
  • 58
    • 0026668042 scopus 로고
    • Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction
    • Takeshige K., Baba M., Tsuboi S., Noda T., and, Ohsumi Y., (1992) Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J. Cell Biol. 119, 301-311.
    • (1992) J. Cell Biol. , vol.119 , pp. 301-311
    • Takeshige, K.1    Baba, M.2    Tsuboi, S.3    Noda, T.4    Ohsumi, Y.5
  • 59
    • 33746108329 scopus 로고    scopus 로고
    • Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
    • Tanida I., Minematsu-Ikeguchi N., Ueno T., and, Kominami E., (2005) Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1, 84-91.
    • (2005) Autophagy , vol.1 , pp. 84-91
    • Tanida, I.1    Minematsu-Ikeguchi, N.2    Ueno, T.3    Kominami, E.4
  • 60
    • 0033401857 scopus 로고    scopus 로고
    • Mechanisms of selective neuronal cell death due to thiamine deficiency
    • Todd K., and, Butterworth R. F., (1999) Mechanisms of selective neuronal cell death due to thiamine deficiency. Ann. N. Y. Acad. Sci. 893, 404-411.
    • (1999) Ann. N. Y. Acad. Sci. , vol.893 , pp. 404-411
    • Todd, K.1    Butterworth, R.F.2
  • 61
    • 40549085336 scopus 로고    scopus 로고
    • Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes
    • Trincheri N. F., Follo C., Nicotra G., Peracchio C., Castino R., and, Isidoro C., (2008) Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes. Carcinogenesis 29, 381-389.
    • (2008) Carcinogenesis , vol.29 , pp. 381-389
    • Trincheri, N.F.1    Follo, C.2    Nicotra, G.3    Peracchio, C.4    Castino, R.5    Isidoro, C.6
  • 63
    • 33845742025 scopus 로고    scopus 로고
    • Thiamine deficiency induces endoplasmic reticulum stress in neurons
    • Wang X., Wang B., Fan Z., Shi X., Ke Z. J., and, Luo J., (2007) Thiamine deficiency induces endoplasmic reticulum stress in neurons. Neuroscience 144, 1045-1056.
    • (2007) Neuroscience , vol.144 , pp. 1045-1056
    • Wang, X.1    Wang, B.2    Fan, Z.3    Shi, X.4    Ke, Z.J.5    Luo, J.6
  • 64
    • 77951217000 scopus 로고    scopus 로고
    • Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class i and III phosphoinositide 3-kinase
    • Wu Y. T., Tan H. L., Shui G., Bauvy C., Huang Q., Wenk M. R., Ong C. N., Codogno P., and, Shen H. M., (2010) Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J. Biol. Chem. 285, 10850-10861.
    • (2010) J. Biol. Chem. , vol.285 , pp. 10850-10861
    • Wu, Y.T.1    Tan, H.L.2    Shui, G.3    Bauvy, C.4    Huang, Q.5    Wenk, M.R.6    Ong, C.N.7    Codogno, P.8    Shen, H.M.9
  • 65
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S., Loewith R., and, Hall M. N., (2006) TOR signaling in growth and metabolism. Cell 124, 471-484.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 66
    • 47549092694 scopus 로고    scopus 로고
    • Atg8 controls phagophore expansion during autophagosome formation
    • Xie Z., Nair U., and, Klionsky D. J., (2008) Atg8 controls phagophore expansion during autophagosome formation. Mol. Biol. Cell 19, 3290-3298.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 3290-3298
    • Xie, Z.1    Nair, U.2    Klionsky, D.J.3
  • 67
    • 77956404377 scopus 로고    scopus 로고
    • Eaten alive: A history of macroautophagy
    • Yang Z., and, Klionsky D. J., (2010) Eaten alive: a history of macroautophagy. Nat. Cell Biol. 12, 814-822.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 814-822
    • Yang, Z.1    Klionsky, D.J.2
  • 68
    • 79954615141 scopus 로고    scopus 로고
    • Neuronal MCP-1 mediates microglia recruitment and neurodegeneration induced by the mild impairment of oxidative metabolism
    • Yang G., Meng Y., Li W., Yong Y., Fan Z., Ding H., Wei Y., Luo J., and, Ke Z. J,. (2011) Neuronal MCP-1 mediates microglia recruitment and neurodegeneration induced by the mild impairment of oxidative metabolism. Brain Pathol. 21, 279-297.
    • (2011) Brain Pathol. , vol.21 , pp. 279-297
    • Yang, G.1    Meng, Y.2    Li, W.3    Yong, Y.4    Fan, Z.5    Ding, H.6    Wei, Y.7    Luo, J.8    Ke, Z.J.9
  • 69
    • 26444587508 scopus 로고    scopus 로고
    • Macroautophagy-A novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease
    • Yu W. H., Cuervo A. M., Kumar A., et al,. (2005) Macroautophagy-a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J. Cell Biol. 171, 87-98.
    • (2005) J. Cell Biol. , vol.171 , pp. 87-98
    • Yu, W.H.1    Cuervo, A.M.2    Kumar, A.3
  • 71
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z., Jin S., Yang C., Levine A. J., and, Heintz N., (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl Acad. Sci. USA 100, 15077-15082.
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 72
    • 63249118896 scopus 로고    scopus 로고
    • Senescence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism
    • Zhang Q., Ding H., Li W., Fan Z., Sun A., Luo J., and, Ke Z. J., (2009) Senescence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism. Brain Res. 1264, 111-118.
    • (2009) Brain Res. , vol.1264 , pp. 111-118
    • Zhang, Q.1    Ding, H.2    Li, W.3    Fan, Z.4    Sun, A.5    Luo, J.6    Ke, Z.J.7
  • 73
    • 78449300244 scopus 로고    scopus 로고
    • Thiamine deficiency increases beta-secretase activity and accumulation of beta-amyloid peptides
    • Zhang Q., Yang G., Li W., Fan Z., Sun A., Luo J., and, Ke Z. J., (2011) Thiamine deficiency increases beta-secretase activity and accumulation of beta-amyloid peptides. Neurobiol. Aging 32, 42-53.
    • (2011) Neurobiol. Aging , vol.32 , pp. 42-53
    • Zhang, Q.1    Yang, G.2    Li, W.3    Fan, Z.4    Sun, A.5    Luo, J.6    Ke, Z.J.7
  • 74
    • 84872184629 scopus 로고    scopus 로고
    • Thiamine Nutritional Status and Depressive Symptoms Are Inversely Associated among Older Chinese Adults
    • Zhang G., Ding H., Chen H., Ye X., Li H., Lin X., and, Ke Z., (2013) Thiamine Nutritional Status and Depressive Symptoms Are Inversely Associated among Older Chinese Adults. J. Nutr. 143, 53-58.
    • (2013) J. Nutr. , vol.143 , pp. 53-58
    • Zhang, G.1    Ding, H.2    Chen, H.3    Ye, X.4    Li, H.5    Lin, X.6    Ke, Z.7


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