Sustained release of water-insoluble simvastatin from biodegradable hydrogel augments bone regeneration

Journal of Controlled Release

Volumn 143, Issue 2, 2010, Pages 201-206

  Tanigo, Tomomi ^a   Takaoka, Ryohei ^a   Tabata, Yasuhiko ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Bone regeneration; Gelatin hydrogel; Lactic acid oligomer; Simvastatin; Sustained release; Water insoluble drug

Indexed keywords

BONE REGENERATION; GELATIN HYDROGEL; GELATIN HYDROGELS; INSOLUBLE DRUG; SIMVASTATIN; SUSTAINED RELEASE;

BIOCOMPATIBILITY; BIODEGRADATION; BODY FLUIDS; BONE; CROSSLINKING; DRUG DELIVERY; DRUG PRODUCTS; LACTIC ACID; ORGANIC ACIDS;

HYDROGELS;

GELATIN; LACTIC ACID; SIMVASTATIN; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; BIODEGRADATION; BONE REGENERATION; CELL DIFFERENTIATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CROSS LINKING; DRUG SOLUBILITY; HYDROGEL; MOUSE; NONHUMAN; OSTEOBLAST; PARTICLE SIZE; PRIORITY JOURNAL; RABBIT; SURFACE CHARGE; SUSTAINED DRUG RELEASE; TOOTH EXTRACTION;

ANIMALS; ANTILIPEMIC AGENTS; BONE REGENERATION; CELL LINE; GELATIN; HYDROGEL; LACTIC ACID; MICELLES; RABBITS; SIMVASTATIN; SOLUBILITY; TOOTH; WATER;

EID: 77950341612     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.12.027     Document Type: Article

References (20)

1. Shi Y., Huang G. Recent developments of biodegradable and biocompatible materials based micro/nanoparticles for delivering macromolecular therapeutics. Critical Reviews in Therapeutic Drug Carrier Systems 2009, 26(1):29-84.
2. Farokhzad O.C., Langer R. Impact of nanotechnology on drug delivery. ACS Nano 2009, 3(1):16-20.
3. Tabata Y., Hijikata S., Muniruzzaman M., Ikada Y. Neovascularization effect of biodegradable gelatin microspheres incorporating basic fibroblast growth factor. Journal of Biomaterials Science 1999, 10(1):79-94.
4. Yamamoto M., Ikada Y., Tabata Y. Controlled release of growth factors based on biodegradation of gelatin hydrogel. Journal of Biomaterials Science 2001, 12(1):77-88.
5. Yamamoto M., Tabata Y., Hong L., Miyamoto S., Hashimoto N., Ikada Y. Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel. Journal of Controlled Release 2000, 64(1-3):133-142.
6. Y. Kimura, Y. Tabata (2009), Controlled release of stromal cell-derived factor-1 from gelatin hydrogels enhances angiogenesis, Journal of Biomaterials Science 21(1) (2010) 37-51.
7. Fukunaka Y., Iwanaga K., Morimoto K., Kakemi M., Tabata Y. Controlled release of plasmid DNA from cationized gelatin hydrogels based on hydrogel degradation. Journal of Controlled Release 2002, 80(1-3):333-343.
8. Konishi M., Tabata Y., Kariya M., Suzuki A., Mandai M., Nanbu K., Takakura K., Fujii S. In vivo anti-tumor effect through the controlled release of cisplatin from biodegradable gelatin hydrogel. J Control Release 2003, 92(3):301-313.
9. Matsumoto G., Kushibiki T., Kinoshita Y., Lee U., Omi Y., Kubota E., Tabata Y. Cationized gelatin delivery of a plasmid DNA expressing small interference RNA for VEGF inhibits murine squamous cell carcinoma. Cancer Science 2006, 97(4):313-321.
10. Nakamura M., Jo J., Tabata Y., Ishikawa O. Controlled delivery of T-box21 small interfering RNA ameliorates autoimmune alopecia (Alopecia Areata) in a C3H/HeJ mouse model. American Journal of Pathology 2008, 172(3):650-658.
11. Mundy G., Garrett R., Harris S., Chan J., Chen D., Rossini G., Boyce B., Zhao M., Gutierrez G. Stimulation of bone formation in vitro and in rodents by statins. Science 1999, 286(5446):1946-1949.
12. Yoon J.J., Song S.H., Lee D.S., Park T.G. Immobilization of cell adhesive RGD peptide onto the surface of highly porous biodegradable polymer scaffolds fabricated by a gas foaming/salt leaching method. Biomaterials 2004, 25(25):5613-5620.
13. Dash P.R., Read M.L., Fisher K.D., Howard K.A., Wolfert M., Oupicky D., Subr V., Strohalm J., Ulbrich K., Seymour L.W. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin. The Journal of Biological Chemistry 2000, 275(6):3793-3802.
14. Lee E.S., Oh K.T., Kim D., Youn Y.S., Bae Y.H. Tumor pH-responsive flower-like micelles of poly(l-lactic acid)-b-poly(ethylene glycol)-b-poly(l-histidine). Journal of Controlled Release 2007, 123(1):19-26.
15. Ghosh-Choudhury N., Mandal C.C., Choudhury G.G. Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation. Journal of Biological Chemistry 2007, 282(7):4983-4993.
16. Yamamoto M., Takahashi Y., Tabata Y. Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. Biomaterials 2003, 24(24):4375-4383.
17. Yoshihara Y., Nakamura H., Obata K., Yamada H., Hayakawa T., Fujikawa K., Okada Y. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids from patients with rheumatoid arthritis or osteoarthritis. Annals of Rheumatic Diseases 2000, 59(6):455-461.
18. Lalani Z., Wong M., Brey E.M., Mikos A.G., Duke P.J., Miller M.J., Johnston C., Montufar-Solis D. Spatial and temporal localization of FGF-2 and VEGF in healing tooth extraction sockets in a rabbit model. Journal of Oral and Maxillofacial Surgery 2005, 63(10):1500-1508.
19. Fisher J.P., Lalani Z., Bossano C.M., Brey E.M., Demian N., Johnston C.M., Dean D., Jansen J.A., Wong M.E., Mikos A.G. Effect of biomaterial properties on bone healing in a rabbit tooth extraction socket model. Journal of Biomedical Materials Research Part A 2004, 68(3):428-438.
20. Marei M.K., Nouh S.R., Saad M.M., Ismail N.S. Preservation and regeneration of alveolar bone by tissue-engineered implants. Tissue Engineering 2005, 11(5-6):751-767.