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Volumn 41, Issue 7, 2010, Pages 687-692

Can low doses of simvastatin enhance fracture healing? An experimental study in rabbits

Author keywords

Biomechanics; Fracture healing; Histomorphometry; PQCT; Simvastatin

Indexed keywords

SIMVASTATIN;

EID: 77957127493     PISSN: 00201383     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.injury.2009.10.011     Document Type: Article
Times cited : (15)

References (25)
  • 1
    • 0028200059 scopus 로고
    • Comparison of properties of four inhibitors of 3-hydroxy-3- methylglutaryl-coenzyme A reductase
    • Blum CB. Comparison of properties of four inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. AmJ Cardiol 1994; 73 (14): 3D-11D.
    • (1994) AmJ Cardiol , vol.73 , Issue.14
    • Blum, C.B.1
  • 2
    • 0036909541 scopus 로고    scopus 로고
    • Safety considerations for statins
    • Bolego C, Baetta R, Bellosta S, et al. Safety considerations for statins. Curr Opin Lipidol 2002; 13 (6): 637-44.
    • (2002) Curr Opin Lipidol , vol.13 , Issue.6 , pp. 637-644
    • Bolego, C.1    Baetta, R.2    Bellosta, S.3
  • 3
    • 0034910615 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 accelerates healing in a rabbit ulnar osteotomy model
    • Bouxsein ML, Turek TJ, Blake CA. et al. Recombinant human bone morphogenetic protein-2 accelerates healing in a rabbit ulnar osteotomy model. J Bone Joint Surg Am 2001; 83-A(8): 1219-30.
    • (2001) J Bone Joint Surg Am , vol.83 A , Issue.8 , pp. 1219-1230
    • Bouxsein, M.L.1    Turek, T.J.2    Blake, C.A.3
  • 4
    • 18544410718 scopus 로고    scopus 로고
    • Inhibitors of hydroxymethylglutarylcoenzyme A reductase and risk of fracture among older women
    • Chan KA, Andrade SE, Boles M, et al. Inhibitors of hydroxymethylglutarylcoenzyme A reductase and risk of fracture among older women. Lancet 2000; 355 (9222): 2185-8.
    • (2000) Lancet , vol.355 , Issue.9222 , pp. 2185-2188
    • Chan, K.A.1    Andrade, S.E.2    Boles, M.3
  • 5
    • 0024972452 scopus 로고
    • Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme A reductase inhibitors
    • Gerson RJ, MacDonald JS. Alberts AW. et al. Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme A reductase inhibitors. Am J Med 1989; 87 (4A): 28S-38S.
    • (1989) Am J Med , vol.87 , Issue.4 A
    • Gerson, R.J.1    MacDonald, J.S.2    Alberts, A.W.3
  • 7
    • 0030809729 scopus 로고    scopus 로고
    • A methodology for the quantitative assessment of articular cartilage histomorphometry
    • Hacker SA, Healey RM, Yoshioka M, Coutts RD. A methodology for the quantitative assessment of articular cartilage histomorphometry. Osteoarthritis Cartilage 1997; 5 (5): 343-55.
    • (1997) Osteoarthritis Cartilage , vol.5 , Issue.5 , pp. 343-355
    • Hacker, S.A.1    Healey, R.M.2    Yoshioka, M.3    Coutts, R.D.4
  • 8
    • 0348142042 scopus 로고    scopus 로고
    • Statin stimulates bone morphogenetic protein-2. aggrecan, and type 2 collagen gene expression and proteoglycan synthesis in rat chondrocytes
    • Hatano H, Maruo A, Bolander ME, Sarkar G. Statin stimulates bone morphogenetic protein-2. aggrecan, and type 2 collagen gene expression and proteoglycan synthesis in rat chondrocytes. J Orthop Sci 2003; 8 (6): 842-8.
    • (2003) J Orthop Sci , vol.8 , Issue.6 , pp. 842-848
    • Hatano, H.1    Maruo, A.2    Bolander, M.E.3    Sarkar, G.4
  • 9
    • 3042774550 scopus 로고    scopus 로고
    • Simvastatin increases bone mineral density in hypercholesterolemic postmenopausal women
    • Lupattelli G, Scarponi AM, Vaudo G, et al. Simvastatin increases bone mineral density in hypercholesterolemic postmenopausal women. Metabolism 2004; 53 (6): 744-8.
    • (2004) Metabolism , vol.53 , Issue.6 , pp. 744-748
    • Lupattelli, G.1    Scarponi, A.M.2    Vaudo, G.3
  • 10
    • 0034805319 scopus 로고    scopus 로고
    • Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells
    • Maeda T, Matsunuma A, Kawane T, Horiuchi N. Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells. Biochem Biophys Res Commun 2001; 280 (3): 874-7.
    • (2001) Biochem Biophys Res Commun , vol.280 , Issue.3 , pp. 874-877
    • Maeda, T.1    Matsunuma, A.2    Kawane, T.3    Horiuchi, N.4
  • 11
    • 0035724388 scopus 로고    scopus 로고
    • Effect of statins on bone mineral density and bone histomorphometry in rodents
    • Maritz FJ, Conradie MM, Hulley PA, et al. Effect of statins on bone mineral density and bone histomorphometry in rodents. Arterioscler Thromb Vasc Biol 2001; 21 (10): 1636-41.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , Issue.10 , pp. 1636-1641
    • Maritz, F.J.1    Conradie, M.M.2    Hulley, P.A.3
  • 12
    • 0029243810 scopus 로고
    • How many women have osteoporosis now?
    • Melton LJ. 3rd: how many women have osteoporosis now? J Bone Miner Res 1995; 10 (2): 175-7.
    • (1995) J Bone Miner Res , vol.10 , Issue.2 , pp. 175-177
    • Melton III, L.J.1
  • 13
    • 0037384716 scopus 로고    scopus 로고
    • Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: A 1-year longitudinal study
    • Montagnani A. Gonnelli S. Cepollaro C. et al. Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: a 1-year longitudinal study. Bone 2003; 32 (4): 427-33.
    • (2003) Bone , vol.32 , Issue.4 , pp. 427-433
    • Montagnani, A.1    Gonnelli, S.2    Cepollaro, C.3
  • 14
    • 0033521078 scopus 로고    scopus 로고
    • Stimulation of bone formation in vitro and in rodents by statins
    • Mundy G, Garrett R. Harris S, et al. Stimulation of bone formation in vitro and in rodents by statins. Science 1999; 286 (5446): 1946-9.
    • (1999) Science , vol.286 , Issue.5446 , pp. 1946-1949
    • Mundy, G.1    Garrett, R.2    Harris, S.3
  • 16
    • 0141813534 scopus 로고    scopus 로고
    • Skeletal reconstruction by vascularized allogenic bone transplantation: Effects of statin in rats
    • Ohno T. Shigetomi M. Ihara K, et al. Skeletal reconstruction by vascularized allogenic bone transplantation: effects of statin in rats. Transplantation 2003; 76 (5): 869-71.
    • (2003) Transplantation , vol.76 , Issue.5 , pp. 869-871
    • Ohno, T.1    Shigetomi, M.2    Ihara, K.3
  • 17
    • 1642341604 scopus 로고    scopus 로고
    • Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation
    • Oxlund H, Andreassen TT. Simvastatin treatment partially prevents ovariectomy-induced bone loss while increasing cortical bone formation. Bone 2004; 34 (4): 609-18.
    • (2004) Bone , vol.34 , Issue.4 , pp. 609-618
    • Oxlund, H.1    Andreassen, T.T.2
  • 18
    • 0035901052 scopus 로고    scopus 로고
    • Effect of pravastatin on frequency of fracture in the LIPID study: Secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease
    • Reid IR, Hague W. Emberson J. et al. Effect of pravastatin on frequency of fracture in the LIPID study: secondary analysis of a randomised controlled trial. Long-term Intervention with Pravastatin in Ischaemic Disease. Lancet 2001; 357 (9255): 509-12.
    • (2001) Lancet , vol.357 , Issue.9255 , pp. 509-512
    • Reid, I.R.1    Hague, W.2    Emberson, J.3
  • 19
    • 21844436545 scopus 로고    scopus 로고
    • Comparison of the effects of pravastatin and atorvastatin on fracture incidence in the PROVE IT-TIMI 22 trial-secondary analysis of a randomized controlled trial
    • Reid IR, Tonkin A, Cannon CP. Comparison of the effects of pravastatin and atorvastatin on fracture incidence in the PROVE IT-TIMI 22 trial-secondary analysis of a randomized controlled trial. Bone 2005; 37 (2): 190-1.
    • (2005) Bone , vol.37 , Issue.2 , pp. 190-191
    • Reid, I.R.1    Tonkin, A.2    Cannon, C.P.3
  • 20
    • 3242799093 scopus 로고    scopus 로고
    • Effects of simvastatin on bone turnover and BMD: A 1-year randomized controlled trial in postmenopausal osteopenic women
    • Rejnmark L, Buus NH, Vestergaard P, et al. Effects of simvastatin on bone turnover and BMD: a 1-year randomized controlled trial in postmenopausal osteopenic women. J Bone Miner Res 2004; 19 (5): 737-44.
    • (2004) J Bone Miner Res , vol.19 , Issue.5 , pp. 737-744
    • Rejnmark, L.1    Buus, N.H.2    Vestergaard, P.3
  • 21
    • 3042590478 scopus 로고    scopus 로고
    • Hip fracture risk in statin users - A population-based Danish case-control study
    • Rejnmark L, Olsen ML, Johnsen SP, et al. Hip fracture risk in statin users - a population-based Danish case-control study. Osteoporos Int 2004; 15 (6): 452-8.
    • (2004) Osteoporos Int , vol.15 , Issue.6 , pp. 452-458
    • Rejnmark, L.1    Olsen, M.L.2    Johnsen, S.P.3
  • 22
    • 16644373330 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors and the risk of vertebral fracture
    • Schoofs MW, Sturkenboom MC, van der Klift M, et al. HMG-CoA reductase inhibitors and the risk of vertebral fracture. J Bone Miner Res 2004; 19 (9): 1525-30.
    • (2004) J Bone Miner Res , vol.19 , Issue.9 , pp. 1525-1530
    • Schoofs, M.W.1    Sturkenboom, M.C.2    Van Der Klift, M.3
  • 23
    • 0036828513 scopus 로고    scopus 로고
    • Simvastatin improves fracture healing in mice
    • Skoglund B, Forslund C, Aspenberg P. Simvastatin improves fracture healing in mice. J Bone Miner Res 2002; 17 (11): 2004-8.
    • (2002) J Bone Miner Res , vol.17 , Issue.11 , pp. 2004-2008
    • Skoglund, B.1    Forslund, C.2    Aspenberg, P.3
  • 24
    • 30344469372 scopus 로고    scopus 로고
    • Effects of simvastatin on bone mineral density and remodeling parameters in postmenopausal osteopenic subjects: 1-year followup study
    • Tikiz C, Tikiz H, Taneli F, et al. Effects of simvastatin on bone mineral density and remodeling parameters in postmenopausal osteopenic subjects: 1-year followup study. Clin Rheumatol 2005; 24 (5): 447-52.
    • (2005) Clin Rheumatol , vol.24 , Issue.5 , pp. 447-452
    • Tikiz, C.1    Tikiz, H.2    Taneli, F.3
  • 25
    • 35448981919 scopus 로고    scopus 로고
    • Locally applied simvastatin promotes fracture healing in ovariectomized rat
    • Wang JW, Xu SW, Yang DS, Lv RK. Locally applied simvastatin promotes fracture healing in ovariectomized rat. Osteoporos Int 2007; 18 (12): 1641-50.
    • (2007) Osteoporos Int , vol.18 , Issue.12 , pp. 1641-1650
    • Wang, J.W.1    Xu, S.W.2    Yang, D.S.3    Lv, R.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.