Simvastatin locally applied from a biodegradable coating of osteosynthetic implants improves fracture healing comparable to BMP-2 application

Bone

Volumn 45, Issue 3, 2009, Pages 505-511

  Pauly, S ^a   Luttosch, F ^a   Morawski, M ^a   Haas, N P ^a   Schmidmaier, G ^a   Wildemann, B ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

BMP; Fracture healing; Local application; Simvastatin; Statins

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; POLYLACTIDE; POLYMER; SIMVASTATIN; TITANIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; BIOMECHANICS; BONE RADIOGRAPHY; CALLUS; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; FRACTURE HEALING; IMPLANT; INTRAMEDULLARY NAILING; KIRSCHNER WIRE; LOW DRUG DOSE; MATERIAL COATING; MECHANICAL TORSION; MORPHOMETRICS; NONHUMAN; RAT; TIBIA; TIBIA FRACTURE;

ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONY CALLUS; COATED MATERIALS, BIOCOMPATIBLE; FEMALE; FRACTURE HEALING; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; POLYESTERS; PROSTHESES AND IMPLANTS; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN;

EID: 67949091095     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.05.010     Document Type: Article

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