Molecular and tissue responses in the healing of rat calvarial defects after local application of simvastatin combined with alpha tricalcium phosphate

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 93, Issue 1, 2010, Pages 65-73

  Nyan, Myat ^a,b   Miyahara, Takayuki ^a   Noritake, Kanako ^a   Hao, Jia ^a   Rodriguez, Reena ^a   Kuroda, Shinji ^a   Kasugai, Shohei ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b University of Dental Medicine   (Myanmar)

Author keywords

Alpha tricalcium phosphate; BMP 2; Bone formation; Bone healing; Simvastatin; TGF

Indexed keywords

BONE FORMATION; BONE HEALING; CALVARIAL DEFECTS; CHOLESTEROL SYNTHESIS; CRITICAL STEPS; DURA MATER; GENE EXPRESSION PATTERNS; HISTOLOGICAL CHANGES; MOLECULAR MECHANISM; OSTEOPROGENITOR CELLS; SIMVASTATIN; TISSUE RESPONSE; TRI-CALCIUM PHOSPHATES; UP-REGULATION;

ANIMALS; BONE; DEFECTS; GENE EXPRESSION; TRANSMISSION CONTROL PROTOCOL;

BIOMATERIALS;

ALPHA CALCIUM PHOSPHATE; BONE MORPHOGENETIC PROTEIN 2; CALCIUM PHOSPHATE; SIMVASTATIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE REGENERATION; CALVARIA; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DURA MATER; FRACTURE HEALING; GENE EXPRESSION; MALE; NONHUMAN; OSSIFICATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; UPREGULATION;

ANIMALS; BASE SEQUENCE; BIOCOMPATIBLE MATERIALS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CALCIUM PHOSPHATES; CELL MOVEMENT; CELL PROLIFERATION; DELAYED-ACTION PREPARATIONS; DNA PRIMERS; DRUG DELIVERY SYSTEMS; GENE EXPRESSION PROFILING; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MATERIALS TESTING; OSTEOBLASTS; RATS; RATS, WISTAR; RNA, MESSENGER; SIMVASTATIN; SKULL; TIME FACTORS; TISSUE ENGINEERING; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 77949495453     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31559     Document Type: Article

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