-
1
-
-
33750530369
-
Acute myeloid leukemia: epidemiology and etiology
-
Deschler B., Lubbert M. Acute myeloid leukemia: epidemiology and etiology. Cancer 2006, 107:2099-2107.
-
(2006)
Cancer
, vol.107
, pp. 2099-2107
-
-
Deschler, B.1
Lubbert, M.2
-
3
-
-
84883558790
-
-
Atlanta GACS. Cancer facts and figures
-
Atlanta GACS. Cancer facts and figures. 2012.
-
(2012)
-
-
-
4
-
-
79951530814
-
Novel and emerging drugs for acute myeloid leukemia: pharmacology and therapeutic activity
-
Robak T., Szmigielska-Kapłon A., Pluta A., et al. Novel and emerging drugs for acute myeloid leukemia: pharmacology and therapeutic activity. Curr Med Chem 2011, 18:638-666.
-
(2011)
Curr Med Chem
, vol.18
, pp. 638-666
-
-
Robak, T.1
Szmigielska-Kapłon, A.2
Pluta, A.3
-
5
-
-
74549195798
-
Current and emerging therapies for acute myeloid leukemia
-
Robak T., Wierzbowska A. Current and emerging therapies for acute myeloid leukemia. Clin Ther 2009, 2:2349-2370.
-
(2009)
Clin Ther
, vol.2
, pp. 2349-2370
-
-
Robak, T.1
Wierzbowska, A.2
-
7
-
-
30444437486
-
Treatment of acute lymphoblastic leukemia
-
Pui C.H., Evans W.E. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006, 354:166-178.
-
(2006)
N Engl J Med
, vol.354
, pp. 166-178
-
-
Pui, C.H.1
Evans, W.E.2
-
8
-
-
0033786192
-
New approaches in acute lymphoblastic leukemia in adults: where do we go?
-
Hoelzer D., Gokbuget N. New approaches in acute lymphoblastic leukemia in adults: where do we go?. Semin Oncol 2000, 27:540-559.
-
(2000)
Semin Oncol
, vol.27
, pp. 540-559
-
-
Hoelzer, D.1
Gokbuget, N.2
-
10
-
-
67650685040
-
Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer
-
Parker W.B. Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer. Chem Rev 2009, 109:2880-2893.
-
(2009)
Chem Rev
, vol.109
, pp. 2880-2893
-
-
Parker, W.B.1
-
11
-
-
0038509118
-
Mechanism of action of purine analogues in chronic lymphocytic leukemia
-
Pettit A.R. Mechanism of action of purine analogues in chronic lymphocytic leukemia. Br J Haematol 2003, 121:692-702.
-
(2003)
Br J Haematol
, vol.121
, pp. 692-702
-
-
Pettit, A.R.1
-
13
-
-
33750601477
-
Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity
-
Robak T., Lech-Maranda E., Korycka A., Robak E. Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity. Curr Med Chem 2006, 13:3165-3189.
-
(2006)
Curr Med Chem
, vol.13
, pp. 3165-3189
-
-
Robak, T.1
Lech-Maranda, E.2
Korycka, A.3
Robak, E.4
-
14
-
-
67650685040
-
Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer
-
Parker W.B. Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer. Chem Rev 2009, 109:2880-2893.
-
(2009)
Chem Rev
, vol.109
, pp. 2880-2893
-
-
Parker, W.B.1
-
15
-
-
0037344916
-
Purine nucleoside analogues in the treatment of myleoid leukemias
-
Robak T. Purine nucleoside analogues in the treatment of myleoid leukemias. Leuk Lymphoma 2003, 44:391-409.
-
(2003)
Leuk Lymphoma
, vol.44
, pp. 391-409
-
-
Robak, T.1
-
16
-
-
77951628255
-
Comparison of cladribine plus cyclophosphamide with fludarabine plus cyclophosphamide as first-line therapy for chronic lymphocytic leukemia: a phase III randomized study by the Polish Adult Leukemia Group (PALG-CLL3 Study)
-
Robak T., Jamroziak K., Gora-Tybor J., et al. Comparison of cladribine plus cyclophosphamide with fludarabine plus cyclophosphamide as first-line therapy for chronic lymphocytic leukemia: a phase III randomized study by the Polish Adult Leukemia Group (PALG-CLL3 Study). J Clin Oncol 2010, 28:1863-1869.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1863-1869
-
-
Robak, T.1
Jamroziak, K.2
Gora-Tybor, J.3
-
17
-
-
79951620932
-
New nucleoside analogs for patients with hematological malignancies
-
Robak T. New nucleoside analogs for patients with hematological malignancies. Expert Opin Investig Drugs 2011, 20:343-359.
-
(2011)
Expert Opin Investig Drugs
, vol.20
, pp. 343-359
-
-
Robak, T.1
-
18
-
-
0036606777
-
Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase
-
Rodriquez C.O., Mitchell B.S., Ayres M., Eriksson S., Gandhi V. Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. Cancer Res 2002, 62:3100-3105.
-
(2002)
Cancer Res
, vol.62
, pp. 3100-3105
-
-
Rodriquez, C.O.1
Mitchell, B.S.2
Ayres, M.3
Eriksson, S.4
Gandhi, V.5
-
19
-
-
0030973344
-
Fludarabine. An update of its pharmacology and use in the treatment of haematological malignancies
-
Adkins J.C., Peters D.H., Markham A. Fludarabine. An update of its pharmacology and use in the treatment of haematological malignancies. Drugs 1997, 53:1005-1037.
-
(1997)
Drugs
, vol.53
, pp. 1005-1037
-
-
Adkins, J.C.1
Peters, D.H.2
Markham, A.3
-
20
-
-
0032949451
-
Pharmacokinetic study of single doses of oral fludarabine phosphate in patients with "low-grade" non- Hodgkin's lymphoma and B-cell chronic lymphocytic leukemia
-
Foran J.M., Oscier D., Orchard J., et al. Pharmacokinetic study of single doses of oral fludarabine phosphate in patients with "low-grade" non- Hodgkin's lymphoma and B-cell chronic lymphocytic leukemia. J Clin Oncol 1999, 17:1574-1579.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1574-1579
-
-
Foran, J.M.1
Oscier, D.2
Orchard, J.3
-
21
-
-
33644825118
-
Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (review)
-
Van den Neste E., Cardoen S., Offner F., Bontemps F. Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (review). Int J Oncol 2005, 27:1113-1124.
-
(2005)
Int J Oncol
, vol.27
, pp. 1113-1124
-
-
Van den Neste, E.1
Cardoen, S.2
Offner, F.3
Bontemps, F.4
-
22
-
-
63449116519
-
Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases
-
Robak T., Korycka A., Lech-Maranda E., Robak P. Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases. Molecules 2009, 14:1183-1226.
-
(2009)
Molecules
, vol.14
, pp. 1183-1226
-
-
Robak, T.1
Korycka, A.2
Lech-Maranda, E.3
Robak, P.4
-
23
-
-
84863514038
-
Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias
-
Robak T., Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des 2012, 18:3373-3388.
-
(2012)
Curr Pharm Des
, vol.18
, pp. 3373-3388
-
-
Robak, T.1
Robak, P.2
-
24
-
-
2942523951
-
Use of fludarabine in the treatment of acute myeloid leukemia
-
Jackson G.H. Use of fludarabine in the treatment of acute myeloid leukemia. Hematol J 2004, 5(SUPPL. 1):S62-S67.
-
(2004)
Hematol J
, vol.5
, Issue.SUPPL. 1
-
-
Jackson, G.H.1
-
25
-
-
0027213870
-
Fludarabine and arabinosylcytosine therapy of refractory and relapsed acute myelogenous leukemia
-
Estey E., Plunkett W., Gandhi V., et al. Fludarabine and arabinosylcytosine therapy of refractory and relapsed acute myelogenous leukemia. Leuk Lymphoma 1993, 9:343-350.
-
(1993)
Leuk Lymphoma
, vol.9
, pp. 343-350
-
-
Estey, E.1
Plunkett, W.2
Gandhi, V.3
-
26
-
-
0034990346
-
Fludarabine and cytarabine as a sequential infusion regimen for treatment of adults with recurrent, refractory or poor prognosis acute leukemia
-
Vidarsson B., Abonour R., Williams E.C., et al. Fludarabine and cytarabine as a sequential infusion regimen for treatment of adults with recurrent, refractory or poor prognosis acute leukemia. Leuk Lymphoma 2001, 41:321-331.
-
(2001)
Leuk Lymphoma
, vol.41
, pp. 321-331
-
-
Vidarsson, B.1
Abonour, R.2
Williams, E.C.3
-
27
-
-
78650054483
-
Continuous sequential infusion of fludarabine and cytarabine for elderly patients with acute myeloidleukaemia secondary to a previously diagnosed myelodysplastic syndrome
-
Ferrara F., Palmieri S., Izzo T., Criscuolo C., Riccardi C. Continuous sequential infusion of fludarabine and cytarabine for elderly patients with acute myeloidleukaemia secondary to a previously diagnosed myelodysplastic syndrome. Hematol Oncol 2010, 28:202-208.
-
(2010)
Hematol Oncol
, vol.28
, pp. 202-208
-
-
Ferrara, F.1
Palmieri, S.2
Izzo, T.3
Criscuolo, C.4
Riccardi, C.5
-
28
-
-
79958708036
-
Fludarabine and cytarabine in patients with acute myeloid leukemia refractory to two different courses of front-line chemotherapy
-
Mehta D.R., Foon K.A., Redner R.L., et al. Fludarabine and cytarabine in patients with acute myeloid leukemia refractory to two different courses of front-line chemotherapy. Leuk Res 2011, 35:885-888.
-
(2011)
Leuk Res
, vol.35
, pp. 885-888
-
-
Mehta, D.R.1
Foon, K.A.2
Redner, R.L.3
-
29
-
-
0033560841
-
Randomized phase II study of fludarabine+cytosine arabinoside+idarubicin ± all-trans retinoic acid ± granulocyte colony-stimulating factor in poor prognosis newly diagnosed acute myeloid leukemia and myelodysplastic syndrome
-
Estey E.H., Thall P.F., Pierce S., et al. Randomized phase II study of fludarabine+cytosine arabinoside+idarubicin ± all-trans retinoic acid ± granulocyte colony-stimulating factor in poor prognosis newly diagnosed acute myeloid leukemia and myelodysplastic syndrome. Blood 1999, 93:2478-2484.
-
(1999)
Blood
, vol.93
, pp. 2478-2484
-
-
Estey, E.H.1
Thall, P.F.2
Pierce, S.3
-
30
-
-
0028104171
-
FLAG (fludarabine+high-dose cytarabine+G-CSF): an effective and tolerable protocol for the treatment of 'poor risk' acute myeloid leukemias
-
Visani G., Tosi P., Zinzani P.L., et al. FLAG (fludarabine+high-dose cytarabine+G-CSF): an effective and tolerable protocol for the treatment of 'poor risk' acute myeloid leukemias. Leukemia 1994, 8:1842-1846.
-
(1994)
Leukemia
, vol.8
, pp. 1842-1846
-
-
Visani, G.1
Tosi, P.2
Zinzani, P.L.3
-
31
-
-
0036288274
-
De novo acute myeloid leukemia with multilineage dysplasia: treatment results and prognostic evaluation from a series of 44 patients treated with fludarabine, cytarabine and G-CSF (FLAG)
-
Ferrara F., Palmieri S., Pocali B., et al. De novo acute myeloid leukemia with multilineage dysplasia: treatment results and prognostic evaluation from a series of 44 patients treated with fludarabine, cytarabine and G-CSF (FLAG). Eur J Haematol 2002, 68:203-209.
-
(2002)
Eur J Haematol
, vol.68
, pp. 203-209
-
-
Ferrara, F.1
Palmieri, S.2
Pocali, B.3
-
32
-
-
0034098923
-
Treatment of chronic myeloid leukemia in the blastic phase with fludarabine, cytosine arabinoside and G-CSF (FLAG)
-
Tedeschi A., Montillo M., Ferrara F., et al. Treatment of chronic myeloid leukemia in the blastic phase with fludarabine, cytosine arabinoside and G-CSF (FLAG). Eur J Haematol 2000, 64:182-187.
-
(2000)
Eur J Haematol
, vol.64
, pp. 182-187
-
-
Tedeschi, A.1
Montillo, M.2
Ferrara, F.3
-
33
-
-
11144358126
-
The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients
-
Ossenkoppele G.J., Graveland W.J., Sonneveld P., et al. The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients. Blood 2004, 103:2908-2913.
-
(2004)
Blood
, vol.103
, pp. 2908-2913
-
-
Ossenkoppele, G.J.1
Graveland, W.J.2
Sonneveld, P.3
-
34
-
-
0031835792
-
Fludarabine cytarabine and G-CSF (FLAG) for the treatment of poor risk acute myeloid leukemia
-
Montillo M., Mirto S., Petti M.C., et al. Fludarabine cytarabine and G-CSF (FLAG) for the treatment of poor risk acute myeloid leukemia. Am J Hematol 1998, 58:105-109.
-
(1998)
Am J Hematol
, vol.58
, pp. 105-109
-
-
Montillo, M.1
Mirto, S.2
Petti, M.C.3
-
35
-
-
0036286493
-
FLAG-IDA regimen (fludarabine, cytarabine, idarubicin and G-CSF) in the treatment of patients with high-risk myeloid malignancies
-
de la Rubia J., Regadera A., Martín G., et al. FLAG-IDA regimen (fludarabine, cytarabine, idarubicin and G-CSF) in the treatment of patients with high-risk myeloid malignancies. Leuk Res 2002, 26:725-730.
-
(2002)
Leuk Res
, vol.26
, pp. 725-730
-
-
de la Rubia, J.1
Regadera, A.2
Martín, G.3
-
36
-
-
0032836387
-
Phase II trial or idarubicin, fludarabine, cytosine arabinoside and filigastim (Ida-FLAG) for treatment of refractory, relapsed and secondary AML
-
Steinmetz H.T., Schulz A., Staib P., et al. Phase II trial or idarubicin, fludarabine, cytosine arabinoside and filigastim (Ida-FLAG) for treatment of refractory, relapsed and secondary AML. Ann Hematol 1999, 78:418-425.
-
(1999)
Ann Hematol
, vol.78
, pp. 418-425
-
-
Steinmetz, H.T.1
Schulz, A.2
Staib, P.3
-
37
-
-
0035041047
-
Fludarabine, arabinosyl cytosine and idarubicin (FLAI) for remission induction in poor-risk acute myeloid leukemia
-
Russo D., Pricolo G., Michieli M., et al. Fludarabine, arabinosyl cytosine and idarubicin (FLAI) for remission induction in poor-risk acute myeloid leukemia. Leuk Lymphoma 2001, 40:335-343.
-
(2001)
Leuk Lymphoma
, vol.40
, pp. 335-343
-
-
Russo, D.1
Pricolo, G.2
Michieli, M.3
-
38
-
-
84871445452
-
Fludarabine, cytarabine, and attenuated-dose idarubicin (m-FLAI) combination therapy for elderly acute myeloid leukemia patients
-
Kim I., Koh Y., Yoon S.S., Park S., et al. Fludarabine, cytarabine, and attenuated-dose idarubicin (m-FLAI) combination therapy for elderly acute myeloid leukemia patients. Am J Hematol 2013, 88:10-15.
-
(2013)
Am J Hematol
, vol.88
, pp. 10-15
-
-
Kim, I.1
Koh, Y.2
Yoon, S.S.3
Park, S.4
-
39
-
-
77957240852
-
Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin (FLAG-IDA) for the treatment of children with poor-prognosis acute leukemia: the Hacettepe experience
-
Tavil B., Aytac S., Balci Y.I., et al. Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin (FLAG-IDA) for the treatment of children with poor-prognosis acute leukemia: the Hacettepe experience. Pediatr Hematol Oncol 2010, 27:517-528.
-
(2010)
Pediatr Hematol Oncol
, vol.27
, pp. 517-528
-
-
Tavil, B.1
Aytac, S.2
Balci, Y.I.3
-
40
-
-
70449558857
-
Salvage therapy for acute myeloid leukemia with fludarabine, cytarabine, and idarubicin with or without gemtuzumab ozogamicin and with concurrent or sequential G-CSF
-
Martin M.G., Augustin K.M., Uy G.L., et al. Salvage therapy for acute myeloid leukemia with fludarabine, cytarabine, and idarubicin with or without gemtuzumab ozogamicin and with concurrent or sequential G-CSF. Am J Hematol 2009, 84:733-737.
-
(2009)
Am J Hematol
, vol.84
, pp. 733-737
-
-
Martin, M.G.1
Augustin, K.M.2
Uy, G.L.3
-
41
-
-
80055107984
-
Combination treatment of flag with non-pegylated liposomal doxorubicin (MYOCET(TM)) in elderly patients with acute myeloid leukemia: a single center experience
-
Melillo L., Valente D., D'Arena G., et al. Combination treatment of flag with non-pegylated liposomal doxorubicin (MYOCET(TM)) in elderly patients with acute myeloid leukemia: a single center experience. Int J Immunopathol Pharmacol 2011, 24:703-709.
-
(2011)
Int J Immunopathol Pharmacol
, vol.24
, pp. 703-709
-
-
Melillo, L.1
Valente, D.2
D'Arena, G.3
-
42
-
-
7444243236
-
Combination of liposomal daunorubicin (DaunoXome), fludarabine, and cytarabine (FLAD) in patients with poor-risk acute leukemia
-
Clavio M., Venturino C., Pierri I., et al. Combination of liposomal daunorubicin (DaunoXome), fludarabine, and cytarabine (FLAD) in patients with poor-risk acute leukemia. Ann Hematol 2004, 83:696-703.
-
(2004)
Ann Hematol
, vol.83
, pp. 696-703
-
-
Clavio, M.1
Venturino, C.2
Pierri, I.3
-
43
-
-
2942523951
-
Use of fludarabine in the treatment of acute myeloid leukemia
-
Jackson G.H. Use of fludarabine in the treatment of acute myeloid leukemia. Hematol J 2004, 5(SUPPL. 1):S62-S67.
-
(2004)
Hematol J
, vol.5
, Issue.SUPPL. 1
-
-
Jackson, G.H.1
-
44
-
-
0022651816
-
Phase I and II study of fludarabine phosphate in leukemia therapeutic efficacy with delayed central nervous system toxicity
-
Warell R.P., Berman E. Phase I and II study of fludarabine phosphate in leukemia therapeutic efficacy with delayed central nervous system toxicity. J Clin Oncol 1986, 4:740-779.
-
(1986)
J Clin Oncol
, vol.4
, pp. 740-779
-
-
Warell, R.P.1
Berman, E.2
-
45
-
-
0022980401
-
Fludarabine phosphate (NSC 312878) infusions for the treatment of acute leukemia: phase I and neuropathological study
-
Spriggs D.R., Stopa E., Mayer R.J., Schoene W., Kufe D.W. Fludarabine phosphate (NSC 312878) infusions for the treatment of acute leukemia: phase I and neuropathological study. Cancer Res 1986, 46:5953-5958.
-
(1986)
Cancer Res
, vol.46
, pp. 5953-5958
-
-
Spriggs, D.R.1
Stopa, E.2
Mayer, R.J.3
Schoene, W.4
Kufe, D.W.5
-
46
-
-
0022443901
-
Central nervous system toxicity of fludarabine phosphate
-
Chun H.G., Leyland-Jones B.R., Caryk S.M., Hoth D.F. Central nervous system toxicity of fludarabine phosphate. Cancer Treat Rep 1986, 70:1225-1228.
-
(1986)
Cancer Treat Rep
, vol.70
, pp. 1225-1228
-
-
Chun, H.G.1
Leyland-Jones, B.R.2
Caryk, S.M.3
Hoth, D.F.4
-
47
-
-
0028073281
-
The expanding role of fludarabine in hematologic malignancies
-
Keating M.J., O'Brien S., Robertson L.E., et al. The expanding role of fludarabine in hematologic malignancies. Leuk Lymphoma 1994, 14(Suppl 2):11-16.
-
(1994)
Leuk Lymphoma
, vol.14
, Issue.SUPPL 2
, pp. 11-16
-
-
Keating, M.J.1
O'Brien, S.2
Robertson, L.E.3
-
48
-
-
6044240815
-
A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia
-
Cooper B.W., Veal G.J., Radivoyevitch T., et al. A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia. Clin Cancer Res 2004, 10:6830-6839.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6830-6839
-
-
Cooper, B.W.1
Veal, G.J.2
Radivoyevitch, T.3
-
49
-
-
1042289343
-
A fludarabine, topotecan, and cytarabine regimen is active in patients with refractory acute myelogenous leukemia
-
Giles F.J., Cortes J.E., Kantarjian H.M., O'Brien S.M., Estey E., Beran M. A fludarabine, topotecan, and cytarabine regimen is active in patients with refractory acute myelogenous leukemia. Leuk Res 2004, 28:353-357.
-
(2004)
Leuk Res
, vol.28
, pp. 353-357
-
-
Giles, F.J.1
Cortes, J.E.2
Kantarjian, H.M.3
O'Brien, S.M.4
Estey, E.5
Beran, M.6
-
50
-
-
84655170246
-
FLANG salvage chemotherapy is an effective regimen that offers a safe bridge to transplantation for patients with relapsed or refractory acute myeloid leukemia
-
Eom K.S., Min W.S., Kim H.J., et al. FLANG salvage chemotherapy is an effective regimen that offers a safe bridge to transplantation for patients with relapsed or refractory acute myeloid leukemia. Med Oncol 2011, 28(SUPPL. 1):S462-S470.
-
(2011)
Med Oncol
, vol.28
, Issue.SUPPL. 1
-
-
Eom, K.S.1
Min, W.S.2
Kim, H.J.3
-
51
-
-
10744224798
-
Mylotarg, fludarabine, cytarabine (ara-C), and cyclosporine (MFAC) regimen as post-remission therapy in acute myelogenous leukemia
-
Tsimberidou A.M., Estey E., Cortes J.E., et al. Mylotarg, fludarabine, cytarabine (ara-C), and cyclosporine (MFAC) regimen as post-remission therapy in acute myelogenous leukemia. Cancer Chemother Pharmacol 2003, 52:449-452.
-
(2003)
Cancer Chemother Pharmacol
, vol.52
, pp. 449-452
-
-
Tsimberidou, A.M.1
Estey, E.2
Cortes, J.E.3
-
52
-
-
19244365993
-
Gemtuzumab, fludarabine, cytarabine, and cyclosporine in patients with newly diagnosed acute myelogenous leukemia or high-risk myelodysplastic syndromes
-
Tsimberidou A.M., Estey E., Cortes J.E., et al. Gemtuzumab, fludarabine, cytarabine, and cyclosporine in patients with newly diagnosed acute myelogenous leukemia or high-risk myelodysplastic syndromes. Cancer 2003, 97:1481-1487.
-
(2003)
Cancer
, vol.97
, pp. 1481-1487
-
-
Tsimberidou, A.M.1
Estey, E.2
Cortes, J.E.3
-
53
-
-
84864225484
-
Twice-daily fludarabine and cytarabine combination with or without gentuzumab ozogamicin is effective in patients with relapsed/refractory acute myeloid leukemia, high-risk myelodysplastic syndrome, and blast- phase chronic myeloid leukemia
-
Jabbour E., Garcia-Manero G., Cortes J., et al. Twice-daily fludarabine and cytarabine combination with or without gentuzumab ozogamicin is effective in patients with relapsed/refractory acute myeloid leukemia, high-risk myelodysplastic syndrome, and blast- phase chronic myeloid leukemia. Clin Lymphoma Myeloma Leuk 2012, 12:244-251.
-
(2012)
Clin Lymphoma Myeloma Leuk
, vol.12
, pp. 244-251
-
-
Jabbour, E.1
Garcia-Manero, G.2
Cortes, J.3
-
54
-
-
84872048218
-
Fludarabine, cytarabine, granulocyte-colony stimulating factor and amsacrine: an effectivesalvage therapy option for acute myeloid leukemia at first relapse
-
Fong C.Y., Grigoriadis G., Hocking J., et al. Fludarabine, cytarabine, granulocyte-colony stimulating factor and amsacrine: an effectivesalvage therapy option for acute myeloid leukemia at first relapse. Leuk Lymphoma 2013, 54:336-341.
-
(2013)
Leuk Lymphoma
, vol.54
, pp. 336-341
-
-
Fong, C.Y.1
Grigoriadis, G.2
Hocking, J.3
-
55
-
-
39049106629
-
Older and new formulations of cladribine. Pharmacology and clinical efficacy in hematological malignancies
-
Robak T., Korycka A., Robak E. Older and new formulations of cladribine. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat Anticancer Drug Discov 2006, 1:23-38.
-
(2006)
Recent Pat Anticancer Drug Discov
, vol.1
, pp. 23-38
-
-
Robak, T.1
Korycka, A.2
Robak, E.3
-
56
-
-
0026799508
-
Cladribine (2-chlorodeoxyadenosine)
-
Beutler E. Cladribine (2-chlorodeoxyadenosine). Lancet 1992, 340:952-956.
-
(1992)
Lancet
, vol.340
, pp. 952-956
-
-
Beutler, E.1
-
57
-
-
0026100242
-
A phase I clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia
-
Santana V.M., Mirro J., Harwood F.C. A phase I clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia. J Clin Oncol 1991, 9:416-422.
-
(1991)
J Clin Oncol
, vol.9
, pp. 416-422
-
-
Santana, V.M.1
Mirro, J.2
Harwood, F.C.3
-
58
-
-
0026536178
-
2-Chlorodeoxyadenosine produces a high rate of complete hematologic remission in relapsed acute myeloid leukemia
-
Santana V.M., Mirro J., Kearns C. 2-Chlorodeoxyadenosine produces a high rate of complete hematologic remission in relapsed acute myeloid leukemia. J Clin Oncol 1992, 10:364-370.
-
(1992)
J Clin Oncol
, vol.10
, pp. 364-370
-
-
Santana, V.M.1
Mirro, J.2
Kearns, C.3
-
59
-
-
0035366389
-
Experience with 2-chlorodeoxyadenosine in previously untreated children with newly diagnosed acute myeloid leukemia and myelodysplastic disease
-
Krance R.A., Hurwitz C.A., Head D.R., et al. Experience with 2-chlorodeoxyadenosine in previously untreated children with newly diagnosed acute myeloid leukemia and myelodysplastic disease. J Clin Oncol 2001, 19:2804-2811.
-
(2001)
J Clin Oncol
, vol.19
, pp. 2804-2811
-
-
Krance, R.A.1
Hurwitz, C.A.2
Head, D.R.3
-
60
-
-
0027932742
-
Complete hematologic remissions induced by 2-chlorodeoxyadenosine in children with newly diagnosed acute myeloid leukemia
-
Santana V.M., Hurwitz C.A., Blakley R.L., et al. Complete hematologic remissions induced by 2-chlorodeoxyadenosine in children with newly diagnosed acute myeloid leukemia. Blood 1994, 84:1237-1242.
-
(1994)
Blood
, vol.84
, pp. 1237-1242
-
-
Santana, V.M.1
Hurwitz, C.A.2
Blakley, R.L.3
-
61
-
-
0029744389
-
Clinical and laboratory studies of 2-chlorodeoxyadenosine+cytosine arabinoside for relapsed or refractory acute myelogenous leukemia in adults
-
Kornblau S.M., Gandhi V., Andreeff H.M., et al. Clinical and laboratory studies of 2-chlorodeoxyadenosine+cytosine arabinoside for relapsed or refractory acute myelogenous leukemia in adults. Leukemia 1996, 10:1563-1569.
-
(1996)
Leukemia
, vol.10
, pp. 1563-1569
-
-
Kornblau, S.M.1
Gandhi, V.2
Andreeff, H.M.3
-
62
-
-
0030042611
-
Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic and molecular interactions
-
Gandhi V., Estey E., Keating M.J., et al. Chlorodeoxyadenosine and arabinosylcytosine in patients with acute myelogenous leukemia: pharmacokinetic, pharmacodynamic and molecular interactions. Blood 1996, 87:256-264.
-
(1996)
Blood
, vol.87
, pp. 256-264
-
-
Gandhi, V.1
Estey, E.2
Keating, M.J.3
-
63
-
-
0033843386
-
Phase II trial of 2-chlorodeoxyadenosine in patients with relapsed/refractory acute myeloid leukemia: a study of the Eastern Cooperative Oncology Group (ECOG), E5995
-
Gordon M.S., Young M.L., Tallman M.D., et al. Phase II trial of 2-chlorodeoxyadenosine in patients with relapsed/refractory acute myeloid leukemia: a study of the Eastern Cooperative Oncology Group (ECOG), E5995. Leuk Res 2000, 24:871-875.
-
(2000)
Leuk Res
, vol.24
, pp. 871-875
-
-
Gordon, M.S.1
Young, M.L.2
Tallman, M.D.3
-
64
-
-
0031964178
-
2-Chlorodeoxyadenosine with or without daunorubicin in relapsed or refractory acute myeloid leukemia
-
Van den Neste E., Martiat P., Mineur P., et al. 2-Chlorodeoxyadenosine with or without daunorubicin in relapsed or refractory acute myeloid leukemia. Ann Hematol 1998, 76:19-23.
-
(1998)
Ann Hematol
, vol.76
, pp. 19-23
-
-
Van den Neste, E.1
Martiat, P.2
Mineur, P.3
-
65
-
-
0028102950
-
Therapeutic and neurotoxic effects of 2-chlorodeoxyadenosine in adults with acute myeleoid leukemia
-
Vahdat L., Wong E., Wile M., Rosenblum M., Foley K.M., Warell R.P. Therapeutic and neurotoxic effects of 2-chlorodeoxyadenosine in adults with acute myeleoid leukemia. Blood 1994, 84:3429-3434.
-
(1994)
Blood
, vol.84
, pp. 3429-3434
-
-
Vahdat, L.1
Wong, E.2
Wile, M.3
Rosenblum, M.4
Foley, K.M.5
Warell, R.P.6
-
66
-
-
0033846491
-
Combination regimen of cladribine (2-chlorodeoxyadenosine), cytarabine and G-CSF (CLAG) as induction therapy for patients with relapsed or refractory acute myeloid leukemia
-
Robak T., Wrzesień-Kuś A., Lech-Marańda E., Kowal M., Dmoszyńska A. Combination regimen of cladribine (2-chlorodeoxyadenosine), cytarabine and G-CSF (CLAG) as induction therapy for patients with relapsed or refractory acute myeloid leukemia. Leuk Lymphoma 2000, 39:121-129.
-
(2000)
Leuk Lymphoma
, vol.39
, pp. 121-129
-
-
Robak, T.1
Wrzesień-Kuś, A.2
Lech-Marańda, E.3
Kowal, M.4
Dmoszyńska, A.5
-
67
-
-
0042333501
-
Polish Adult Leukemia Group. A multicenter, open, non-comparative, phase II study of the combination of cladribine (2-chlorodeoxyadenosine), cytarabine and G-CSF as induction therapy in refractory acute myeloid leukemia - a report of the Polish Adult Leukemia Group (PALG)
-
Wrzesień-Kuś A., Robak T., Lech-Marańda E., et al. Polish Adult Leukemia Group. A multicenter, open, non-comparative, phase II study of the combination of cladribine (2-chlorodeoxyadenosine), cytarabine and G-CSF as induction therapy in refractory acute myeloid leukemia - a report of the Polish Adult Leukemia Group (PALG). Eur J Haematol 2003, 71:155-162.
-
(2003)
Eur J Haematol
, vol.71
, pp. 155-162
-
-
Wrzesień-Kuś, A.1
Robak, T.2
Lech-Marańda, E.3
-
68
-
-
79952102924
-
Salvage chemotherapy regimens for acute myeloid leukemia: is one better? Efficacy comparison between CLAG and MEC regimens
-
Price S.L., Lancet J.E., George T.J., et al. Salvage chemotherapy regimens for acute myeloid leukemia: is one better? Efficacy comparison between CLAG and MEC regimens. Leuk Res 2011, 35:301-304.
-
(2011)
Leuk Res
, vol.35
, pp. 301-304
-
-
Price, S.L.1
Lancet, J.E.2
George, T.J.3
-
69
-
-
23944456658
-
A multicenter open, noncomparative, phase II study of the combination of cladribine (2-chlorodeoxyadenosine), cytarabine, granulocyte colony-stimulating factor and mitoxantrone as induction therapy in refractory acute myeloid leukemia: a report of the Polish Adult Leukemia Group
-
Wrzesień-Kuś A., Robak T., Wierzbowska A., et al. A multicenter open, noncomparative, phase II study of the combination of cladribine (2-chlorodeoxyadenosine), cytarabine, granulocyte colony-stimulating factor and mitoxantrone as induction therapy in refractory acute myeloid leukemia: a report of the Polish Adult Leukemia Group. Ann Hematol 2005, 84:557-564.
-
(2005)
Ann Hematol
, vol.84
, pp. 557-564
-
-
Wrzesień-Kuś, A.1
Robak, T.2
Wierzbowska, A.3
-
70
-
-
38049153331
-
Cladribine combined with high doses of arabinoside cytosine, mitoxantrone, and G-CSF (CLAG-M) is a highly effective salvage regimen in patients with refractory and relapsed acute myeloid leukemia of the poor risk: a final report of the Polish Adult Leukemia Group
-
Wierzbowska A., Robak T., Pluta A., et al. Cladribine combined with high doses of arabinoside cytosine, mitoxantrone, and G-CSF (CLAG-M) is a highly effective salvage regimen in patients with refractory and relapsed acute myeloid leukemia of the poor risk: a final report of the Polish Adult Leukemia Group. Eur J Haematol 2008, 80:115-126.
-
(2008)
Eur J Haematol
, vol.80
, pp. 115-126
-
-
Wierzbowska, A.1
Robak, T.2
Pluta, A.3
-
71
-
-
77449098778
-
Cladribine in the treatment of acute myeloid leukemia: a single-institution experience
-
Martin M.G., Welch J.S., Augustin K., Hladnik L., DiPersio J.F., Abboud C.N. Cladribine in the treatment of acute myeloid leukemia: a single-institution experience. Clin Lymphoma Myeloma 2009, 9:298-301.
-
(2009)
Clin Lymphoma Myeloma
, vol.9
, pp. 298-301
-
-
Martin, M.G.1
Welch, J.S.2
Augustin, K.3
Hladnik, L.4
DiPersio, J.F.5
Abboud, C.N.6
-
72
-
-
79960970557
-
No additional toxicity from cladribine (CdA) as primary treatment of acute myeloid leukemia in elderly patients: results from a randomized phase II study from the Leukemia Group of Middle Sweden (LGMS)
-
(Abstract)
-
Juliusson G., Lofgren C., Mollgard L., et al. No additional toxicity from cladribine (CdA) as primary treatment of acute myeloid leukemia in elderly patients: results from a randomized phase II study from the Leukemia Group of Middle Sweden (LGMS). Blood 2001, 98:123a. (Abstract).
-
(2001)
Blood
, vol.98
-
-
Juliusson, G.1
Lofgren, C.2
Mollgard, L.3
-
73
-
-
2342534391
-
Addition of cladribine to daunorubicin and cytarabine increases complete remission rate after a single course of induction treatment in acute myeloid leukemia. Multicenter phase III study
-
Hołowiecki J., Grosicki S., Robak T., et al. Addition of cladribine to daunorubicin and cytarabine increases complete remission rate after a single course of induction treatment in acute myeloid leukemia. Multicenter phase III study. Leukemia 2004, 18:989-997.
-
(2004)
Leukemia
, vol.18
, pp. 989-997
-
-
Hołowiecki, J.1
Grosicki, S.2
Robak, T.3
-
74
-
-
84864039689
-
Cladribine, but not fludarabine, added to daunorubicin and cytarabine during induction prolongs survival of patients with acute myeloid leukemia: a multicenter, randomized phase III study
-
Holowiecki J., Grosicki S., Giebel S., et al. Cladribine, but not fludarabine, added to daunorubicin and cytarabine during induction prolongs survival of patients with acute myeloid leukemia: a multicenter, randomized phase III study. J Clin Oncol 2012, 30:2441-2448.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2441-2448
-
-
Holowiecki, J.1
Grosicki, S.2
Giebel, S.3
-
75
-
-
74549219368
-
Combination of cladribine plus topotecan for recurrent or refractory pediatric acute myeloid leukemia
-
Inaba H., Stewart C.F., Crews K.R. Combination of cladribine plus topotecan for recurrent or refractory pediatric acute myeloid leukemia. Cancer 2010, 116:98-105.
-
(2010)
Cancer
, vol.116
, pp. 98-105
-
-
Inaba, H.1
Stewart, C.F.2
Crews, K.R.3
-
76
-
-
68749113904
-
Combination of cladribine and cytarabine is effective for childhood acute myeloid leukemia: results of the St Jude AML97 trial
-
Rubnitz J.E., Crews K.R., Pounds S., et al. Combination of cladribine and cytarabine is effective for childhood acute myeloid leukemia: results of the St Jude AML97 trial. Leukemia 2009, 23:1410-1416.
-
(2009)
Leukemia
, vol.23
, pp. 1410-1416
-
-
Rubnitz, J.E.1
Crews, K.R.2
Pounds, S.3
-
77
-
-
77953447199
-
Clofarabine in leukemia
-
Ghanem H., Jabbour E., Faderl S., Ghandhi V., Plunkett W., Kantarjian H. Clofarabine in leukemia. Expert Rev Hematol 2010, 3:15-22.
-
(2010)
Expert Rev Hematol
, vol.3
, pp. 15-22
-
-
Ghanem, H.1
Jabbour, E.2
Faderl, S.3
Ghandhi, V.4
Plunkett, W.5
Kantarjian, H.6
-
79
-
-
68849122744
-
Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: mechanism of action and clinical activity
-
Lech-Maranda E., Korycka A., Robak T. Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: mechanism of action and clinical activity. Mini Rev Med Chem 2009, 9:805-812.
-
(2009)
Mini Rev Med Chem
, vol.9
, pp. 805-812
-
-
Lech-Maranda, E.1
Korycka, A.2
Robak, T.3
-
80
-
-
33749263031
-
Discovery and development of clofarabine: a nucleoside analogue for treating cancer
-
Bonate P.L., Arthaud L., Cantrell W.R., Stephenson K., Secrist J.A., Weitman S. Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nat Rev Drug Discov 2006, 5:855-863.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 855-863
-
-
Bonate, P.L.1
Arthaud, L.2
Cantrell, W.R.3
Stephenson, K.4
Secrist, J.A.5
Weitman, S.6
-
81
-
-
30044450909
-
A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems
-
King K.M., Damaraju V.L., Vickers M.F., et al. A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems. Mol. Pharmacol 2006, 69:346-353.
-
(2006)
Mol. Pharmacol
, vol.69
, pp. 346-353
-
-
King, K.M.1
Damaraju, V.L.2
Vickers, M.F.3
-
82
-
-
79959587463
-
Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine)-biochemical aspects of anticancer activity
-
Majda K., Lubecka K., Kaufman-Szymczyk A., Fabianowska-Majewska K. Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine)-biochemical aspects of anticancer activity. Acta Pol Pharm 2011, 68:459-466.
-
(2011)
Acta Pol Pharm
, vol.68
, pp. 459-466
-
-
Majda, K.1
Lubecka, K.2
Kaufman-Szymczyk, A.3
Fabianowska-Majewska, K.4
-
83
-
-
0141482004
-
Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia
-
Kantarjian H., Gandhi V., Cortes J., et al. Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia. Blood 2003, 102:2379-2386.
-
(2003)
Blood
, vol.102
, pp. 2379-2386
-
-
Kantarjian, H.1
Gandhi, V.2
Cortes, J.3
-
84
-
-
0037445122
-
Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers
-
Kantarjian H.M., Gandhi V., Kozuch P., et al. Phase I clinical and pharmacology study of clofarabine in patients with solid and hematologic cancers. J Clin Oncol 2003, 21:1167-1173.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1167-1173
-
-
Kantarjian, H.M.1
Gandhi, V.2
Kozuch, P.3
-
85
-
-
18044397730
-
A Phase 2 evaluation of single agent clofarabine treatment for older patients with AML who are not considered fit forintensive chemotherapy
-
(Abstract 869)
-
Burnett A.K., Russell N., Kell J.W. A Phase 2 evaluation of single agent clofarabine treatment for older patients with AML who are not considered fit forintensive chemotherapy. Blood (ASH Annual Meeting Abstracts) 2004, 104:248a. (Abstract 869).
-
(2004)
Blood (ASH Annual Meeting Abstracts)
, vol.104
-
-
Burnett, A.K.1
Russell, N.2
Kell, J.W.3
-
86
-
-
35148869073
-
Effectiveness of clofarabine in eldery AML patients with adverse cytogenetics unfit for intensive chemotherapy
-
(Abstract 1985)
-
Burnett A.K., Baccarani M., Johnson P. Effectiveness of clofarabine in eldery AML patients with adverse cytogenetics unfit for intensive chemotherapy. Blood (ASH Annual Meeting Abstracts) 2006, 108:562a. (Abstract 1985).
-
(2006)
Blood (ASH Annual Meeting Abstracts)
, vol.108
-
-
Burnett, A.K.1
Baccarani, M.2
Johnson, P.3
-
87
-
-
9144222570
-
Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia
-
Jeha S., Gandhi V., Chan K.W., et al. Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia. Blood 2004, 103:784-789.
-
(2004)
Blood
, vol.103
, pp. 784-789
-
-
Jeha, S.1
Gandhi, V.2
Chan, K.W.3
-
88
-
-
35148887258
-
Clofarabine: past present and future
-
Kantarjian H.M., Jeha S., Ganhi V., Wess M., Faderl S. Clofarabine: past present and future. Leuk lymphoma 2007, 48:1922-1930.
-
(2007)
Leuk lymphoma
, vol.48
, pp. 1922-1930
-
-
Kantarjian, H.M.1
Jeha, S.2
Ganhi, V.3
Wess, M.4
Faderl, S.5
-
89
-
-
77449159668
-
Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavourable prognostic factors
-
Kantarjian H.M., Erba H.P., Claxton D., et al. Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavourable prognostic factors. J Clin Oncol 2010, 28:549-555.
-
(2010)
J Clin Oncol
, vol.28
, pp. 549-555
-
-
Kantarjian, H.M.1
Erba, H.P.2
Claxton, D.3
-
90
-
-
19944433802
-
Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias
-
Faderl S., Gandhi V., O'Brien S., et al. Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias. Blood 2005, 105:940-947.
-
(2005)
Blood
, vol.105
, pp. 940-947
-
-
Faderl, S.1
Gandhi, V.2
O'Brien, S.3
-
91
-
-
18044372314
-
Clofarabine plus cytarabine (Ara-C) combination is active in newly diagnosed patients (PTS)≤age 50 with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)
-
(Abstract 875)
-
Faderl S., Gandhi V., Verstovsck S. Clofarabine plus cytarabine (Ara-C) combination is active in newly diagnosed patients (PTS)≤age 50 with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Blood (ASH Annual Meeting Abstracts) 2004, 104:250a. (Abstract 875).
-
(2004)
Blood (ASH Annual Meeting Abstracts)
, vol.104
-
-
Faderl, S.1
Gandhi, V.2
Verstovsck, S.3
-
92
-
-
33745586575
-
Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50years of age or older
-
Faderl S., Verstovsek S., Cortes J., Kantarjian H.M. Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50years of age or older. Blood 2006, 108:45-51.
-
(2006)
Blood
, vol.108
, pp. 45-51
-
-
Faderl, S.1
Verstovsek, S.2
Cortes, J.3
Kantarjian, H.M.4
-
93
-
-
52649154001
-
A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome
-
Faderl S., Ravandi F., Huang X., et al. A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome. Blood 2008, 112:1638-1645.
-
(2008)
Blood
, vol.112
, pp. 1638-1645
-
-
Faderl, S.1
Ravandi, F.2
Huang, X.3
-
94
-
-
84864050584
-
Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: results from the CLASSIC I Trial
-
Faderl S., Wetzler M., Rizzieri D., et al. Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: results from the CLASSIC I Trial. J Clin Oncol 2012, 30:2492-2499.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2492-2499
-
-
Faderl, S.1
Wetzler, M.2
Rizzieri, D.3
-
95
-
-
84864372484
-
Clofarabine plus low-dose cytarabine followed by clofarabine plus low-dose cytarabine alternating with decitabine in acute myeloid leukemia frontline therapy for older patients
-
Faderl S., Ravandi F., Huang X., et al. Clofarabine plus low-dose cytarabine followed by clofarabine plus low-dose cytarabine alternating with decitabine in acute myeloid leukemia frontline therapy for older patients. Cancer 2012, 118:4471-4477.
-
(2012)
Cancer
, vol.118
, pp. 4471-4477
-
-
Faderl, S.1
Ravandi, F.2
Huang, X.3
-
96
-
-
77952491723
-
European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy
-
Burnett A.K., Russell N.H., Kell J., et al. European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy. J Clin Oncol 2010, 28:2389-2395.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2389-2395
-
-
Burnett, A.K.1
Russell, N.H.2
Kell, J.3
-
97
-
-
80053561103
-
Clofarabine with high dose cytarabine and granulocyte colony-stimulating factor (G-CSF) priming for relapsed and refractory acute myeloid leukaemia
-
Becker P.S., Kantarjian H.M., Appelbaum F.R., et al. Clofarabine with high dose cytarabine and granulocyte colony-stimulating factor (G-CSF) priming for relapsed and refractory acute myeloid leukaemia. Br J Haematol 2011, 155:182-189.
-
(2011)
Br J Haematol
, vol.155
, pp. 182-189
-
-
Becker, P.S.1
Kantarjian, H.M.2
Appelbaum, F.R.3
-
98
-
-
84862727979
-
A phase I dose-escalation study of clofarabine in combination with fractionated gemtuzumab ozogamicin in patients with refractory or relapsed acute myeloid leukemia
-
Foster M.C., Amin C., Voorhees P.M., et al. A phase I dose-escalation study of clofarabine in combination with fractionated gemtuzumab ozogamicin in patients with refractory or relapsed acute myeloid leukemia. Leuk Lymphoma 2012, 53:1331-1337.
-
(2012)
Leuk Lymphoma
, vol.53
, pp. 1331-1337
-
-
Foster, M.C.1
Amin, C.2
Voorhees, P.M.3
-
99
-
-
84155180788
-
Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107)
-
Amadori S., Stasi R., Martelli A.M., et al. Temsirolimus, an mTOR inhibitor, in combination with lower-dose clofarabine as salvage therapy for older patients with acute myeloid leukaemia: results of a phase II GIMEMA study (AML-1107). Br J Haematol 2012, 156:205-212.
-
(2012)
Br J Haematol
, vol.156
, pp. 205-212
-
-
Amadori, S.1
Stasi, R.2
Martelli, A.M.3
-
100
-
-
70349315339
-
Phase II study of clofarabine in pediatric patients with refractory or relapsed acute myeloid leukemia
-
Jeha S., Razzouk B., Rytting M., et al. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute myeloid leukemia. J Clin Oncol 2009, 27:4392-4397.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4392-4397
-
-
Jeha, S.1
Razzouk, B.2
Rytting, M.3
-
101
-
-
84861721732
-
Clofarabine, cyclophosphamide and etoposide for the treatment of relapsed or resistant acute leukemia in pediatric patients
-
Miano M., Pistorio A., Putti M.C., et al. Clofarabine, cyclophosphamide and etoposide for the treatment of relapsed or resistant acute leukemia in pediatric patients. Leuk Lymphoma 2012, 53:1693-1698.
-
(2012)
Leuk Lymphoma
, vol.53
, pp. 1693-1698
-
-
Miano, M.1
Pistorio, A.2
Putti, M.C.3
-
102
-
-
80052017961
-
Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia
-
Inaba H., Rubnitz J.E., Coustan-Smith E., et al. Phase I pharmacokinetic and pharmacodynamic study of the multikinase inhibitor sorafenib in combination with clofarabine and cytarabine in pediatric relapsed/refractory leukemia. J Clin Oncol 2011, 20:3293-3300.
-
(2011)
J Clin Oncol
, vol.20
, pp. 3293-3300
-
-
Inaba, H.1
Rubnitz, J.E.2
Coustan-Smith, E.3
-
103
-
-
70349315339
-
Phase II study of clofarabine in pediatric patients with refractory or relapsed acute myeloid leukemia
-
Jeha S., Razzouk B., Rytting M., et al. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute myeloid leukemia. J Clin Oncol 2009, 10(27):4392-4397.
-
(2009)
J Clin Oncol
, vol.10
, Issue.27
, pp. 4392-4397
-
-
Jeha, S.1
Razzouk, B.2
Rytting, M.3
-
104
-
-
33646337195
-
Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
-
Jeha S., Gaynon P.S., Razzouk B.I., et al. Phase II study of clofarabine in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. J Clin Oncol 2006, 24:1917-1923.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1917-1923
-
-
Jeha, S.1
Gaynon, P.S.2
Razzouk, B.I.3
-
105
-
-
84861339231
-
Clofarabine-based chemotherapy for relapsed/refractory adult acute lymphoblastic leukemia and lymphoblastic lymphoma. The Spanish experience
-
Barba P., Sampol A., Calbacho M. Clofarabine-based chemotherapy for relapsed/refractory adult acute lymphoblastic leukemia and lymphoblastic lymphoma. The Spanish experience. Am J Hematol 2012, 87:631-634.
-
(2012)
Am J Hematol
, vol.87
, pp. 631-634
-
-
Barba, P.1
Sampol, A.2
Calbacho, M.3
-
106
-
-
78349295261
-
Southwest Oncology Group Study S0530: a phase 2 trial of clofarabine and cytarabine for relapsed or refractory acute lymphocytic leukaemia
-
Advani A.S., Gundacker H.M., Sala-Torra O., et al. Southwest Oncology Group Study S0530: a phase 2 trial of clofarabine and cytarabine for relapsed or refractory acute lymphocytic leukaemia. Br J Haematol 2010, 151:430-434.
-
(2010)
Br J Haematol
, vol.151
, pp. 430-434
-
-
Advani, A.S.1
Gundacker, H.M.2
Sala-Torra, O.3
-
107
-
-
70349904430
-
Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children withrefractory/multiple relapsed acute lymphoblastic leukaemia
-
Locatelli F., Testi A.M., Bernardo M.E., et al. Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children withrefractory/multiple relapsed acute lymphoblastic leukaemia. Br J Haematol 2009, 147:371-378.
-
(2009)
Br J Haematol
, vol.147
, pp. 371-378
-
-
Locatelli, F.1
Testi, A.M.2
Bernardo, M.E.3
-
108
-
-
82955207681
-
Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
-
Hijiya N., Thomson B., Isakoff M.S., et al. Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia. Blood 2011, 118:6043-6049.
-
(2011)
Blood
, vol.118
, pp. 6043-6049
-
-
Hijiya, N.1
Thomson, B.2
Isakoff, M.S.3
-
109
-
-
77950483564
-
Remission re-induction chemotherapy with clofarabine, topotecan, thiotepa, and vinorelbine for patients with relapsed or refractory leukemia
-
Steinherz P.G., Shukla N., Kobos R., Steinherz L. Remission re-induction chemotherapy with clofarabine, topotecan, thiotepa, and vinorelbine for patients with relapsed or refractory leukemia. Pediatr Blood Cancer 2010, 54:687-693.
-
(2010)
Pediatr Blood Cancer
, vol.54
, pp. 687-693
-
-
Steinherz, P.G.1
Shukla, N.2
Kobos, R.3
Steinherz, L.4
-
110
-
-
79960844332
-
Early UK experience in the use of clofarabine in the treatment of relapsed and refractory pediatric acute lymphoblastic leukaemia
-
O'Connor D., Sibson K., Caswell M., et al. Early UK experience in the use of clofarabine in the treatment of relapsed and refractory pediatric acute lymphoblastic leukaemia. Br J Haematol 2011, 154:482-485.
-
(2011)
Br J Haematol
, vol.154
, pp. 482-485
-
-
O'Connor, D.1
Sibson, K.2
Caswell, M.3
-
111
-
-
33748114785
-
Nelarabine: efficacy in the treatment of clinical malignancies
-
Roecker A.M., Allison J.C., Kisor D.F. Nelarabine: efficacy in the treatment of clinical malignancies. Future Oncol 2006, 2:441-448.
-
(2006)
Future Oncol
, vol.2
, pp. 441-448
-
-
Roecker, A.M.1
Allison, J.C.2
Kisor, D.F.3
-
112
-
-
0029127419
-
2-amino-6-methoxypurine arabinoside: an agent for T-cell malignancies
-
Lambe C.U., Averett D.R., Paff M.T., et al. 2-amino-6-methoxypurine arabinoside: an agent for T-cell malignancies. Cancer Res 1995, 55:3352-3356.
-
(1995)
Cancer Res
, vol.55
, pp. 3352-3356
-
-
Lambe, C.U.1
Averett, D.R.2
Paff, M.T.3
-
113
-
-
0036606777
-
Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase
-
Rodriguez C.O., Mitchell B.S., Ayres M., Eriksson S., Gandhi V. Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. Cancer Res 2002, 62:3100-3105.
-
(2002)
Cancer Res
, vol.62
, pp. 3100-3105
-
-
Rodriguez, C.O.1
Mitchell, B.S.2
Ayres, M.3
Eriksson, S.4
Gandhi, V.5
-
114
-
-
33747146790
-
Nelarabine use in leukemias
-
Kisor D.F. Nelarabine use in leukemias. Drugs Today 2006, 42:455-465.
-
(2006)
Drugs Today
, vol.42
, pp. 455-465
-
-
Kisor, D.F.1
-
115
-
-
33748885763
-
Clofarabine and nelarabine: two new purine nucleoside analogs
-
Ghandi V., Plunkett W. Clofarabine and nelarabine: two new purine nucleoside analogs. Curr Opin Oncol 2006, 18:584-590.
-
(2006)
Curr Opin Oncol
, vol.18
, pp. 584-590
-
-
Ghandi, V.1
Plunkett, W.2
-
116
-
-
20644435369
-
Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies
-
Kurtzberg J., Ernst T.J., Keating M.J., et al. Phase I study of 506U78 administered on a consecutive 5-day schedule in children and adults with refractory hematologic malignancies. J Clin Oncol 2005, 23:3396-3403.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3396-3403
-
-
Kurtzberg, J.1
Ernst, T.J.2
Keating, M.J.3
-
117
-
-
20644464975
-
Phase II study of nelarabine (compound 506U78) in children andyoung adults with refractory T-cell malignancies: a report from the Children's Oncology Group
-
Berg S.L., Blaney S.M., Devidas M., et al. Phase II study of nelarabine (compound 506U78) in children andyoung adults with refractory T-cell malignancies: a report from the Children's Oncology Group. J Clin Oncol 2005, 23:3376-3382.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3376-3382
-
-
Berg, S.L.1
Blaney, S.M.2
Devidas, M.3
-
118
-
-
34250003760
-
Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801
-
DeAngelo D.J., Yu D., Johnson J.L., et al. Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801. Blood 2007, 109:5136-5142.
-
(2007)
Blood
, vol.109
, pp. 5136-5142
-
-
DeAngelo, D.J.1
Yu, D.2
Johnson, J.L.3
-
119
-
-
84864566041
-
Pilot study of nelarabine in combination with intensive chemotherapy in high-risk T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group
-
Dunsmore K.P., Devidas M., Linda S.B., et al. Pilot study of nelarabine in combination with intensive chemotherapy in high-risk T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group. J Clin Oncol 2012, 30:2753-2759.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2753-2759
-
-
Dunsmore, K.P.1
Devidas, M.2
Linda, S.B.3
-
120
-
-
77954613888
-
Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma
-
Commander L.A., Seif A.E., Insogna I.G., Rheingold S.R. Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma. Br J Haematol 2010, 150:345-351.
-
(2010)
Br J Haematol
, vol.150
, pp. 345-351
-
-
Commander, L.A.1
Seif, A.E.2
Insogna, I.G.3
Rheingold, S.R.4
-
121
-
-
80053345056
-
-
High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation. Blood 2011;118:3504-11
-
Gökbuget N, Basara N, Baurmann H, et al. High single-drug activity of nelarabine in relapsed T-lymphoblastic leukemia/lymphoma offers curative option with subsequent stem cell transplantation. Blood 2011;118:3504-11.
-
-
-
Gökbuget, N.1
Basara, N.2
Baurmann, H.3
-
122
-
-
36749059519
-
Nelarabine: a novel purine antimetabolite antineoplastic agent
-
Buie L.W., Epstein S.S., Lindley C.M. Nelarabine: a novel purine antimetabolite antineoplastic agent. Clin Ther 2007, 29:1887-1899.
-
(2007)
Clin Ther
, vol.29
, pp. 1887-1899
-
-
Buie, L.W.1
Epstein, S.S.2
Lindley, C.M.3
-
123
-
-
46149095502
-
FDA drug approval summary: nelarabine (Arranon) for the treatment of T-cell lymphoblastic leukemia/lymphoma
-
Cohen M.H., Johnson J.R., Justice R., Pazdur R. FDA drug approval summary: nelarabine (Arranon) for the treatment of T-cell lymphoblastic leukemia/lymphoma. Oncologist 2008, 13:709-714.
-
(2008)
Oncologist
, vol.13
, pp. 709-714
-
-
Cohen, M.H.1
Johnson, J.R.2
Justice, R.3
Pazdur, R.4
-
124
-
-
77956319533
-
Forodesine: review of preclinical and clinical data
-
Al-Kali A., Gandhi V., Ayoubi M., Keating M., Ravandi F. Forodesine: review of preclinical and clinical data. Future Oncol 2010, 6:1211-1217.
-
(2010)
Future Oncol
, vol.6
, pp. 1211-1217
-
-
Al-Kali, A.1
Gandhi, V.2
Ayoubi, M.3
Keating, M.4
Ravandi, F.5
-
125
-
-
35048849848
-
Forodesine (BCX-1777, immucillin H)-a new purine nucleoside analogue: mechanism of action and potential clinical application
-
Korycka A., Błoński J.Z., Robak T. Forodesine (BCX-1777, immucillin H)-a new purine nucleoside analogue: mechanism of action and potential clinical application. Mini Rev Med Chem 2007, 7:976-983.
-
(2007)
Mini Rev Med Chem
, vol.7
, pp. 976-983
-
-
Korycka, A.1
Błoński, J.Z.2
Robak, T.3
-
126
-
-
0242691662
-
Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase
-
Evans G.B., Furneaux R.H., Lewandowicz A., Schramm V.L., Tyler P.C. Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase. J Med Chem 2003, 46:5271-5276.
-
(2003)
J Med Chem
, vol.46
, pp. 5271-5276
-
-
Evans, G.B.1
Furneaux, R.H.2
Lewandowicz, A.3
Schramm, V.L.4
Tyler, P.C.5
-
127
-
-
0032537481
-
One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase
-
Miles R.W., Tyler P.C., Furneaux R.H., Bagdassarian C.K., Schramm V.L. One-third-the-sites transition-state inhibitors for purine nucleoside phosphorylase. Biochemistry 1998, 37:8615-8621.
-
(1998)
Biochemistry
, vol.37
, pp. 8615-8621
-
-
Miles, R.W.1
Tyler, P.C.2
Furneaux, R.H.3
Bagdassarian, C.K.4
Schramm, V.L.5
-
128
-
-
0035026893
-
Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)-a novel potent and orally active immunosuppressive agent
-
Bantia S., Miller P.J., Parker C.D., Ananth S.L., Horn L.H., Kilpatrick J.M., et al. Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)-a novel potent and orally active immunosuppressive agent. Intern Immunopharmacol 2001, 1:1199-1210.
-
(2001)
Intern Immunopharmacol
, vol.1
, pp. 1199-1210
-
-
Bantia, S.1
Miller, P.J.2
Parker, C.D.3
Ananth, S.L.4
Horn, L.H.5
Kilpatrick, J.M.6
-
129
-
-
33749365341
-
Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells
-
Balakrishnan K., Nimmanapalli R., Ravandi F., Keating M.J., Gandhi V. Forodesine, an inhibitor of purine nucleoside phosphorylase, induces apoptosis in chronic lymphocytic leukemia cells. Blood 2006, 108:2392-2398.
-
(2006)
Blood
, vol.108
, pp. 2392-2398
-
-
Balakrishnan, K.1
Nimmanapalli, R.2
Ravandi, F.3
Keating, M.J.4
Gandhi, V.5
-
130
-
-
28844495976
-
A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine)
-
Gandhi V., Kilpatrick J.M., Plunkett W., et al. A proof-of-principle pharmacokinetic, pharmacodynamic, and clinical study with purine nucleoside phosphorylase inhibitor immucillin-H (BCX-1777, forodesine). Blood 2005, 106:4253-4260.
-
(2005)
Blood
, vol.106
, pp. 4253-4260
-
-
Gandhi, V.1
Kilpatrick, J.M.2
Plunkett, W.3
-
131
-
-
80052158260
-
In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia
-
Homminga I., Zwaan C.M., Manz C.Y., et al. In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia. Blood 2011, 118:184-190.
-
(2011)
Blood
, vol.118
, pp. 184-190
-
-
Homminga, I.1
Zwaan, C.M.2
Manz, C.Y.3
-
132
-
-
33845196626
-
Forodesine (FodosineTM), a PNP inhibitor active in relapsed or refractory T-cell leukemia patients (Phase II study)
-
(Abstract 881)
-
Furman R.R., Iosava G., Isola L., et al. Forodesine (FodosineTM), a PNP inhibitor active in relapsed or refractory T-cell leukemia patients (Phase II study). Blood (ASH Annual Meeting Abstracts) 2005, 106:259a. (Abstract 881).
-
(2005)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Furman, R.R.1
Iosava, G.2
Isola, L.3
-
133
-
-
77956316341
-
Forodesine in patients with refractory/relapsed T-ALL can induce prolonged stable remission with minimal toxicity before and after allogeneic hematopoietic stem cell transplantation
-
(Abstract 5340)
-
Stelljes M., Kienast J., Berning B., et al. Forodesine in patients with refractory/relapsed T-ALL can induce prolonged stable remission with minimal toxicity before and after allogeneic hematopoietic stem cell transplantation. Blood (ASH Annual Meeting Abstracts) 2006, 106:427a. (Abstract 5340).
-
(2006)
Blood (ASH Annual Meeting Abstracts)
, vol.106
-
-
Stelljes, M.1
Kienast, J.2
Berning, B.3
-
134
-
-
37149015702
-
Forodesine treatment and post-transplant graft-versus-host disease in two patients with acute leukemia: facilitation of graft-versus-leukemia effect?
-
Gore L., Stelljes M., Quinones R. Forodesine treatment and post-transplant graft-versus-host disease in two patients with acute leukemia: facilitation of graft-versus-leukemia effect?. Semin Oncol 2007, 34(6 SUPPL. 5):S35-S39.
-
(2007)
Semin Oncol
, vol.34
, Issue.6 SUPPL. 5
-
-
Gore, L.1
Stelljes, M.2
Quinones, R.3
-
135
-
-
14944346017
-
Intravenous Forodesine (BCX-1777), a novel purine nucleoside phosphorylase (PNP) inhibitor, demonstrates clinical activity in phase I/II studies in patients with B-Cell acute lymphoblastic leukemia
-
(Abstract 2743)
-
Furman R.R., Gandhi V.V., Bennett J.C., Bantia S., Kilpatrick J.M. Intravenous Forodesine (BCX-1777), a novel purine nucleoside phosphorylase (PNP) inhibitor, demonstrates clinical activity in phase I/II studies in patients with B-Cell acute lymphoblastic leukemia. Blood (ASH Annual Meeting Abstracts) 2004, 104:750a. (Abstract 2743).
-
(2004)
Blood (ASH Annual Meeting Abstracts)
, vol.104
-
-
Furman, R.R.1
Gandhi, V.V.2
Bennett, J.C.3
Bantia, S.4
Kilpatrick, J.M.5
|